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  1. AU="Solís-Martínez, Obed"
  2. AU="Dumitrescu, Florentina"
  3. AU="Hodge, Sarah"
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  1. Artikel: Cancer Cachexia Affects Patients with Head and Neck Cancer in All Stages of Disease: A Prospective Cross-Sectional Study

    Solís-Martínez, Obed / Álvarez-Altamirano, Karolina / Cardenas, Diana / Trujillo-Cabrera, Yanelly / Fuchs-Tarlovsky, Vanessa

    Nutrition and cancer. 2022 Jan. 2, v. 74, no. 1

    2022  

    Abstract: The aim of the study was to determine the prevalence of cancer cachexia according to the clinical stage and determine differences in body composition, usual energy intake, and pro-inflammatory profile between cachectic and non-cachectic patients newly ... ...

    Abstract The aim of the study was to determine the prevalence of cancer cachexia according to the clinical stage and determine differences in body composition, usual energy intake, and pro-inflammatory profile between cachectic and non-cachectic patients newly diagnosed with head and neck squamous cell carcinoma (HNSCC). A cross-sectional study was conducted in adult patients diagnosed with HNSCC admitted to the oncology unit before starting cancer treatment. Cancer cachexia was assessed according to Fearon criteria, and patients were divided into two groups: cachectic and non-cachectic patients. Body composition measured by bioelectrical impedance, energy intake, and biochemical and inflammatory markers were assessed. Comparative analyses were performed Student’s-T test, using one-way ANOVA, chi-square and Mann Whitney-U test. Of the 79 consecutive patients included in the analysis, 72% (n = 57; 61 ± 15 years) were classified as cachectic and 28% (n = 22;59 ± 10 years) as non-cachectic. According to clinical stage, the prevalence of cachexia was stage I = 8.8%, stage II = 15.8%, stage III = 33.3% and stage IV = 42.1% (P = 0.564) and phase angle showed to be different between these groups (P < 0.05). Body composition showed that fat-free mass and total body water were significantly lower in patients with cachexia (p < 0.05). No differences were observed in phase angle, food intake or inflammatory markers between cachectic and non-cachectic patients. Cancer-cachexia is prevalent in all clinical stages in newly diagnosed patients with HNSCC. Early identification of cancer cachexia will allow initiate specialized nutrition support in a timely manner.
    Schlagwörter adults ; bioelectrical impedance ; body water ; cachexia ; cancer therapy ; cross-sectional studies ; energy intake ; food intake ; head and neck squamous cell carcinoma ; lean body mass
    Sprache Englisch
    Erscheinungsverlauf 2022-0102
    Umfang p. 82-89.
    Erscheinungsort Taylor & Francis
    Dokumenttyp Artikel
    ZDB-ID 424433-3
    ISSN 1532-7914 ; 0163-5581
    ISSN (online) 1532-7914
    ISSN 0163-5581
    DOI 10.1080/01635581.2020.1869792
    Datenquelle NAL Katalog (AGRICOLA)

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    Verfügbar in ZB MED Köln/Königswinter

    Zs.A 1496: Hefte anzeigen Standort:
    Je nach Verfügbarkeit (siehe Angabe bei Bestand)
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  2. Artikel ; Online: Cancer Cachexia Affects Patients with Head and Neck Cancer in All Stages of Disease: A Prospective Cross-Sectional Study.

    Solís-Martínez, Obed / Álvarez-Altamirano, Karolina / Cardenas, Diana / Trujillo-Cabrera, Yanelly / Fuchs-Tarlovsky, Vanessa

    Nutrition and cancer

    2021  Band 74, Heft 1, Seite(n) 82–89

    Abstract: The aim of the study was to determine the prevalence of cancer cachexia according to the clinical stage and determine differences in body composition, usual energy intake, and pro-inflammatory profile between cachectic and non-cachectic patients newly ... ...

    Abstract The aim of the study was to determine the prevalence of cancer cachexia according to the clinical stage and determine differences in body composition, usual energy intake, and pro-inflammatory profile between cachectic and non-cachectic patients newly diagnosed with head and neck squamous cell carcinoma (HNSCC). A cross-sectional study was conducted in adult patients diagnosed with HNSCC admitted to the oncology unit before starting cancer treatment. Cancer cachexia was assessed according to Fearon criteria, and patients were divided into two groups: cachectic and non-cachectic patients. Body composition measured by bioelectrical impedance, energy intake, and biochemical and inflammatory markers were assessed. Comparative analyses were performed Student's-T test, using one-way ANOVA, chi-square and Mann Whitney-U test. Of the 79 consecutive patients included in the analysis, 72% (
    Mesh-Begriff(e) Cachexia/diagnosis ; Cachexia/epidemiology ; Cachexia/etiology ; Cross-Sectional Studies ; Head and Neck Neoplasms/complications ; Humans ; Prospective Studies ; Squamous Cell Carcinoma of Head and Neck
    Sprache Englisch
    Erscheinungsdatum 2021-01-16
    Erscheinungsland United States
    Dokumenttyp Journal Article
    ZDB-ID 424433-3
    ISSN 1532-7914 ; 0163-5581
    ISSN (online) 1532-7914
    ISSN 0163-5581
    DOI 10.1080/01635581.2020.1869792
    Datenquelle MEDical Literature Analysis and Retrieval System OnLINE

    Volltext online

    Zusatzmaterialien

    Kategorien

    Verfügbar in ZB MED Köln/Königswinter

    Zs.A 1496: Hefte anzeigen Standort:
    Je nach Verfügbarkeit (siehe Angabe bei Bestand)
    bis Jg. 1994: Bestellungen von Artikeln über das Online-Bestellformular
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  3. Artikel: Effect of Eicosapentaenoic Acid on Body Composition and Inflammation Markers in Patients with Head and Neck Squamous Cell Cancer from a Public Hospital in Mexico

    Solís-Martínez, Obed / Arturo Hernández-Cuellar / Eduardo Meaney-Mendiolea / Geraldine Phillips-Sixtos / Gloria E. Queipo-García / Guillermo M. Ceballos-Reyes / Valentina Plasa-Carvalho / Vanessa Fuchs-Tarlovsky / Yanelly Trujillo-Cabrera

    Nutrition and cancer. 2018 May 19, v. 70, no. 4

    2018  

    Abstract: Introduction: Head and neck cancer patients are at high risk of anorexia-cachexia syndrome and literature shows that Eicosapentaenoic acid (EPA) could regulate it. We aim to determine the EPA effect on body composition and pro-inflammatory markers in ... ...

    Abstract Introduction: Head and neck cancer patients are at high risk of anorexia-cachexia syndrome and literature shows that Eicosapentaenoic acid (EPA) could regulate it. We aim to determine the EPA effect on body composition and pro-inflammatory markers in patients with head neck cancer. Materials and methods: A randomized single-blind placebo-controlled clinical trial was conducted in patients with head and neck squamous cell cancer who received a polymeric diet with 2 g of EPA or a standard polymeric diet for six weeks before antineoplastic treatment. We assessed body composition by bioelectrical impedance analysis and determined IL-1β, IL-6, TNF-α and IFN-γ, CRP, serum proteins, and blood count at baseline and at the end of the study. Results: 32 patients received EPA (2 g/day) and 32 became controls. A decrease in serum levels of IL-1β, IL-6, TNF-α, and IFN-γ was observed in the experimental group, as well as regulation of body weight (−0.3 ± 5.9 vs. −2.1 ± 3.7), lean body mass (−0.2 ± 3.8 vs. −1.3 ± 3.6), body fat mass (0.2 ± 3.5 vs. −1.2 ± 3.8), and quality of life (10 ± 33 vs. 5 ± 34). Conclusion: Supplementing with 2 g/day of EPA to head and neck cancer patient during antineoplastic treatment regulates serum pro-inflammatory cytokines, body weight, lean body mass, and improve quality of life.
    Schlagwörter bioelectrical impedance ; blood proteins ; blood serum ; body fat ; body weight ; clinical trials ; diet ; eicosapentaenoic acid ; head and neck neoplasms ; hospitals ; inflammation ; interferon-gamma ; interleukin-1beta ; interleukin-6 ; lean body mass ; patients ; quality of life ; risk ; squamous cell carcinoma ; tumor necrosis factor-alpha ; Mexico
    Sprache Englisch
    Erscheinungsverlauf 2018-0519
    Umfang p. 663-670.
    Erscheinungsort Taylor & Francis
    Dokumenttyp Artikel
    ZDB-ID 2025822-7
    ISSN 1532-7914 ; 0163-5581
    ISSN (online) 1532-7914
    ISSN 0163-5581
    DOI 10.1080/01635581.2018.1460678
    Datenquelle NAL Katalog (AGRICOLA)

    Volltext online

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    Kategorien

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  4. Artikel ; Online: Effect of Eicosapentaenoic Acid on Body Composition and Inflammation Markers in Patients with Head and Neck Squamous Cell Cancer from a Public Hospital in Mexico.

    Solís-Martínez, Obed / Plasa-Carvalho, Valentina / Phillips-Sixtos, Geraldine / Trujillo-Cabrera, Yanelly / Hernández-Cuellar, Arturo / Queipo-García, Gloria E / Meaney-Mendiolea, Eduardo / Ceballos-Reyes, Guillermo M / Fuchs-Tarlovsky, Vanessa

    Nutrition and cancer

    2018  Band 70, Heft 4, Seite(n) 663–670

    Abstract: Introduction: Head and neck cancer patients are at high risk of anorexia-cachexia syndrome and literature shows that Eicosapentaenoic acid (EPA) could regulate it. We aim to determine the EPA effect on body composition and pro-inflammatory markers in ... ...

    Abstract Introduction: Head and neck cancer patients are at high risk of anorexia-cachexia syndrome and literature shows that Eicosapentaenoic acid (EPA) could regulate it. We aim to determine the EPA effect on body composition and pro-inflammatory markers in patients with head neck cancer.
    Materials and methods: A randomized single-blind placebo-controlled clinical trial was conducted in patients with head and neck squamous cell cancer who received a polymeric diet with 2 g of EPA or a standard polymeric diet for six weeks before antineoplastic treatment. We assessed body composition by bioelectrical impedance analysis and determined IL-1β, IL-6, TNF-α and IFN-γ, CRP, serum proteins, and blood count at baseline and at the end of the study.
    Results: 32 patients received EPA (2 g/day) and 32 became controls. A decrease in serum levels of IL-1β, IL-6, TNF-α, and IFN-γ was observed in the experimental group, as well as regulation of body weight (-0.3 ± 5.9 vs. -2.1 ± 3.7), lean body mass (-0.2 ± 3.8 vs. -1.3 ± 3.6), body fat mass (0.2 ± 3.5 vs. -1.2 ± 3.8), and quality of life (10 ± 33 vs. 5 ± 34).
    Conclusion: Supplementing with 2 g/day of EPA to head and neck cancer patient during antineoplastic treatment regulates serum pro-inflammatory cytokines, body weight, lean body mass, and improve quality of life.
    Mesh-Begriff(e) Adult ; Aged ; Biomarkers/analysis ; Body Composition/drug effects ; Body Weight/drug effects ; Dietary Supplements ; Eicosapentaenoic Acid/pharmacology ; Head and Neck Neoplasms/complications ; Head and Neck Neoplasms/therapy ; Humans ; Inflammation/metabolism ; Inflammation/prevention & control ; Interferon-gamma/blood ; Interleukin-8/blood ; Mexico ; Middle Aged ; Quality of Life ; Squamous Cell Carcinoma of Head and Neck/complications ; Squamous Cell Carcinoma of Head and Neck/therapy
    Chemische Substanzen Biomarkers ; CXCL8 protein, human ; Interleukin-8 ; Interferon-gamma (82115-62-6) ; Eicosapentaenoic Acid (AAN7QOV9EA)
    Sprache Englisch
    Erscheinungsdatum 2018-04-26
    Erscheinungsland United States
    Dokumenttyp Journal Article ; Randomized Controlled Trial ; Research Support, Non-U.S. Gov't
    ZDB-ID 424433-3
    ISSN 1532-7914 ; 0163-5581
    ISSN (online) 1532-7914
    ISSN 0163-5581
    DOI 10.1080/01635581.2018.1460678
    Datenquelle MEDical Literature Analysis and Retrieval System OnLINE

    Volltext online

    Zusatzmaterialien

    Kategorien

    Verfügbar in ZB MED Köln/Königswinter

    Zs.A 1496: Hefte anzeigen Standort:
    Je nach Verfügbarkeit (siehe Angabe bei Bestand)
    bis Jg. 1994: Bestellungen von Artikeln über das Online-Bestellformular
    Jg. 1995 - 2021: Lesesall (1.OG)
    ab Jg. 2022: Lesesaal (EG)

    Über subito bestellen

    Dieser Service ist kostenpflichtig (siehe Lieferbedingungen von subito). Bestellungen, die einen Artikel nebst Supplementary Material umfassen, werden grundsätzlich wie mehrfache Bestellungen bearbeitet. Gebühren fallen in diesen Fällen für jede einzelne Bestellung an.

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