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  1. Article ; Online: Frequently asked questions on erectile dysfunction: evaluating artificial intelligence answers with expert mentorship.

    Baturu, Muharrem / Solakhan, Mehmet / Kazaz, Tanyeli Guneyligil / Bayrak, Omer

    International journal of impotence research

    2024  

    Abstract: The present study assessed the accuracy of artificiaI intelligence-generated responses to frequently asked questions on erectile dysfunction. A cross-sectional analysis involved 56 erectile dysfunction-related questions searched on Google, categorized ... ...

    Abstract The present study assessed the accuracy of artificiaI intelligence-generated responses to frequently asked questions on erectile dysfunction. A cross-sectional analysis involved 56 erectile dysfunction-related questions searched on Google, categorized into nine sections: causes, diagnosis, treatment options, treatment complications, protective measures, relationship with other illnesses, treatment costs, treatment with herbal agents, and appointments. Responses from ChatGPT 3.5, ChatGPT 4, and BARD were evaluated by two experienced urology experts using the F1 and global quality scores (GQS) for accuracy, relevance, and comprehensibility. ChatGPT 3.5 and ChatGPT 4 achieved higher GQS than BARD in categories such as causes (4.5 ± 0.54, 4.5 ± 0.51, 3.15 ± 1.01, respectively, p < 0.001), treatment options (4.35 ± 0.6, 4.5 ± 0.43, 2.71 ± 1.38, respectively, p < 0.001), protective measures (5.0 ± 0, 5.0 ± 0, 4 ± 0.5, respectively, p = 0.013), relationships with other illnesses (4.58 ± 0.58, 4.83 ± 0.25, 3.58 ± 0.8, respectively, p = 0.006), and treatment with herbal agents (3 ± 0.61, 3.33 ± 0.83, 1.8 ± 1.09, respectively, p = 0.043). F1 scores in categories: causes (1), diagnosis (0.857), treatment options (0.726), and protective measures (1), indicated their alignment with the guidelines. There was no significant difference between ChatGPT 3.5 and ChatGPT 4 regarding answer quality, but both outperformed BARD in the GQS. These results emphasize the need to continually enhance and validate AI-generated medical information, underscoring the importance of artificiaI intelligence systems in delivering reliable information on erectile dysfunction.
    Language English
    Publishing date 2024-05-07
    Publishing country England
    Document type Journal Article
    ZDB-ID 1034295-3
    ISSN 1476-5489 ; 0955-9930
    ISSN (online) 1476-5489
    ISSN 0955-9930
    DOI 10.1038/s41443-024-00898-3
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    Zs.A 2910: Show issues Location:
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  2. Article: Is Peyronie's an IgG4-related disease?

    Solakhan, Mehmet / Kısacık, Bünyamin

    European journal of rheumatology

    2020  Volume 8, Issue 1, Page(s) 27–30

    Abstract: Objective: We believe that IgG4 may have a role in the pathogenesis of Peyronie's disease (PD), and this role could be particularly beneficial for developing new strategies; therefore, we aimed to investigate the role of IgG4 in PD.: Methods: This ... ...

    Abstract Objective: We believe that IgG4 may have a role in the pathogenesis of Peyronie's disease (PD), and this role could be particularly beneficial for developing new strategies; therefore, we aimed to investigate the role of IgG4 in PD.
    Methods: This study included 3 groups with a total of 139 subjects: (I) PD group (n=61), (II) control group (n=48), and (III) benign prostatic hyperplasia (BPH) group (n=30). IgG4 measurement was performed using the enzyme-linked immunosorbent assay. Plaque size, penile curvature, and the presence of concomitant impotence were evaluated in the PD group. Impotence was assessed based on the International Index of Erectile Function (IIEF).
    Results: A significant difference was observed between the PD and control groups and between the PD and BPH groups with regard to IgG4 levels, while no significant difference was found between the BPH and control groups (p=0.0001, p=0.002, and p=0.07, respectively). The IgG4 levels were significantly higher in the PD than in the other groups. The cutoff value determined between the groups was 87.5, 82, and 31.5, respectively. Mean plaque size was 2.0±1.01 cm, and a significant relationship was found between plaque size and IgG4 concentration (p=0.02). Mean penile curvature was 35.6±25.1°, and a significant relationship was found between penile curvature of >60° and IgG4 concentration (p=0.001). Mean IIEF score was 19 (range, 7-25). Moreover, no significant relationship was found between erectile dysfunction and IgG4 concentration. Penile pain was present in 24 (39.3%) patients with PD.
    Conclusion: The IgG4 levels were significantly increased in patients with PD, which implies that IgG4 may have a role in the pathogenesis of PD. This finding could be particularly beneficial for developing new strategies. Future studies with larger patient series are needed to substantiate our findings.
    Language English
    Publishing date 2020-07-27
    Publishing country Turkey
    Document type Journal Article
    ZDB-ID 2873727-1
    ISSN 2148-4279 ; 2147-9720
    ISSN (online) 2148-4279
    ISSN 2147-9720
    DOI 10.5152/eurjrheum.2020.20101
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  3. Article ; Online: Role of native Thiol, total Thiol and dynamic Disulphide in diagnosis of patient with prostate cancer and prostatitis.

    Solakhan, Mehmet / Cicek, Hulya / Orhan, Nuri / Yildirim, Mustafa

    International braz j urol : official journal of the Brazilian Society of Urology

    2019  Volume 45, Issue 3, Page(s) 495–502

    Abstract: Background: Our study investigates whether Native Thiol, Total Thiol and disulphide levels measured in serum of patients with prostate cancer and prostatitis and of healthy subjects, have any role in differential diagnosis.: Materials and methods: ... ...

    Abstract Background: Our study investigates whether Native Thiol, Total Thiol and disulphide levels measured in serum of patients with prostate cancer and prostatitis and of healthy subjects, have any role in differential diagnosis.
    Materials and methods: Patients followed up for histopathologically verified diagnosis of prostate cancer and prostatitis in 2016-2017 at the Medicalpark Gaziantep Hospital Urology Clinic were included in the study. Native Thiol (NT), Total Thiol (TT), Dynamic Disulphide (DD) levels in serum were measured by a novel automated method.
    Results: NT, TT, DD, NT / TT ratios, DD / TT ratio and DD / NT ratio were measured as 118.4 ± 36.8μmoL / L, 150.3 ± 45.3μmoL / L, 15.9 ± 7μmoL / L, 78.8 ± 7μmoL / L, 10.5 ± 3.5μmoL / L, 13.8 ± 5.8μmoL / L respectively in patients with prostate cancer; as 116.4 ± 40.5μmoL / L, 147.5 ± 50.1μmoL / L, 15.5 ± 8.7μmoL / L, 79.7 ± 9μmoL / L, 10.1 ± 4.5μmoL / L, 13.5 ± 7.2μmoL / L in patients with prostatitis and as 144.1 ± 21.2μmoL / L, 191 ± 32.3μmoL / L, 23.4 ± 10.1μmoL / L, 76.1 ± 98.3μmoL / L, 11.9 ± 4.1μmoL / L, 16.4 ± 6.9μmoL / L in healthy subjects. Significant difference was detected between groups of NT, TT and DD levels (p = 0.008, p = 0.001, p = 0.002). No significant difference was detected in terms of the NT / TT, DD / TT and DD / NT rates (p = 0.222, p = 0.222, p = 0.222).
    Conclusions: Serum NT, TT, DD levels in patients with prostatitis and prostate cancer were found significantly lower compared to the control group. This indicates that just as inflammation, prostate cancer also increases oxidative stress on tissues.
    MeSH term(s) Aged ; Analysis of Variance ; Biomarkers, Tumor/blood ; Case-Control Studies ; Diagnosis, Differential ; Disulfides/blood ; Humans ; Male ; Middle Aged ; Oxidative Stress/physiology ; Prostatic Neoplasms/blood ; Prostatic Neoplasms/diagnosis ; Prostatitis/blood ; Prostatitis/diagnosis ; Reference Values ; Reproducibility of Results ; Retrospective Studies ; Risk Assessment ; Risk Factors ; Statistics, Nonparametric ; Sulfhydryl Compounds/blood
    Chemical Substances Biomarkers, Tumor ; Disulfides ; Sulfhydryl Compounds
    Language English
    Publishing date 2019-01-25
    Publishing country Brazil
    Document type Journal Article
    ZDB-ID 2206649-4
    ISSN 1677-6119 ; 1677-5538
    ISSN (online) 1677-6119
    ISSN 1677-5538
    DOI 10.1590/S1677-5538.IBJU.2018.0469
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    Zs.A 6174: Show issues Location:
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  4. Article ; Online: Comparison of Two Different Anesthesia Methods in Patients Undergoing Percutaneous Nephrolithotomy.

    Solakhan, Mehmet / Bulut, Ersan / Erturhan, Mehmet Sakip

    Urology journal

    2019  Volume 16, Issue 3, Page(s) 246–250

    Abstract: Purpose: The study aims to compare the effectiveness, safety and costs of two different anesthesia methods in percutaneous nephrolithotomy (PCNL) operations.: Material and method: In our study, data was retrospectively examined of 1657 patients who ... ...

    Abstract Purpose: The study aims to compare the effectiveness, safety and costs of two different anesthesia methods in percutaneous nephrolithotomy (PCNL) operations.
    Material and method: In our study, data was retrospectively examined of 1657 patients who underwent PCNL due to renal calculi between 2009 and 2017. Patients were separated into two groups according to the type of anesthesia; as those who underwent PCNL by general anesthesia (GA) (n = 572) and those under spinal anesthe-sia(SA) (n = 1085). Standard PCNL technique was used in both groups. Gender, age, operation duration, period of hospitalization, stone-free ratio, post-operative narcotic analgesic need and complications were compared between these two groups.
    Results: A total of 1657 patients consisting of 1064 (64.2%) male patients and 593 (35.8%) female patients were included in the study. The average age of the all patients was 33.2 ± 12.4 (range 16-74) years. The two groups were similar in terms of mean age, gender, stone size, stone location and body mass index. Mean operation time was sig-nificantly shorter in the SA group than in the GA group (81.8 ± 33.9 minute vs. 118.2 ± -42.9 minute respectively, P < .001). Mean period of hospitalization was remarkable shorter in the SA group than in the GA group (30.0 ± 9.9 hours vs. 38.4 ± 11.2 hours respectively, P < .001). Post-operative narcotic analgesic need rate was significantly higher in the GA group than in the SA group (33.4% vs. 10.9%, respectively, P < .001). Anesthesia cost was found significantly lower in the SA group than in the GA group (USD 21.3±2.8 vs. USD 83.6 ± 9.5, respectively, P < .001). Significant difference was not observed between both groups in terms of stone-free ratio, amount of bleed-ing, fluoroscopy time, pre-operative and post-operative complications.
    Conclusion: Compared to those performed with GA, PCNL performed with SA is a safe, effective and low-cost method.
    MeSH term(s) Adolescent ; Adult ; Aged ; Anesthesia, General/adverse effects ; Anesthesia, General/economics ; Anesthesia, Spinal/adverse effects ; Anesthesia, Spinal/economics ; Costs and Cost Analysis ; Female ; Humans ; Kidney Calculi/surgery ; Male ; Middle Aged ; Nephrolithotomy, Percutaneous ; Retrospective Studies ; Treatment Outcome ; Young Adult
    Language English
    Publishing date 2019-06-17
    Publishing country Iran
    Document type Comparative Study ; Journal Article
    ZDB-ID 2251940-3
    ISSN 1735-546X ; 1735-1308
    ISSN (online) 1735-546X
    ISSN 1735-1308
    DOI 10.22037/uj.v0i0.4291
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  5. Article ; Online: A neural network-based algorithm for predicting the spontaneous passage of ureteral stones.

    Solakhan, Mehmet / Seckiner, Serap Ulusam / Seckiner, Ilker

    Urolithiasis

    2019  Volume 48, Issue 6, Page(s) 527–532

    Abstract: In this study, a prototype artificial neural network model (ANN) was used to estimate the stone passage rate and to determine the effectivity of predictive factors on this rate in patients with ureteral stones. The retrospective study included a total of ...

    Abstract In this study, a prototype artificial neural network model (ANN) was used to estimate the stone passage rate and to determine the effectivity of predictive factors on this rate in patients with ureteral stones. The retrospective study included a total of 192 patients with ureteral stones, comprising 128 (66.7%) men and 64 (33.3%) women. Patients were divided into two groups. Group 1 (n: 125) consisted of people who spontaneously passed their stones, Group 2 (n: 67) consisted of people who could not pass stones spontaneously. The groups were compared with regard to the relationship between input data and stone passage rate by using both ANN and standard statistical tests. To implement the ANN, the patients were randomly divided into three groups: (a) training group (n = 132), (b) validation group (n = 30), and (c) test group (n = 30). The accuracy rate of ANN in the estimation of the stone passage ratio was 99.1% in the group a, 89.9% in the group b, and 87.3% in the group c. It was revealed that certain criteria (stone size, body weight, pain score, ESR, and CRP) were relatively more significant for saving treatment cost and time and for avoiding unnecessary treatment. ANN can be highly useful for the avoidance of unnecessary interventions in patients with ureteral stones as it showed remarkably high performance in the estimation of stone passage rate (99.16%).
    MeSH term(s) Adult ; Algorithms ; Female ; Forecasting ; Humans ; Male ; Middle Aged ; Neural Networks, Computer ; Random Allocation ; Remission, Spontaneous ; Retrospective Studies ; Ureteral Calculi
    Language English
    Publishing date 2019-10-30
    Publishing country Germany
    Document type Journal Article
    ZDB-ID 2703553-0
    ISSN 2194-7236 ; 2194-7228
    ISSN (online) 2194-7236
    ISSN 2194-7228
    DOI 10.1007/s00240-019-01167-5
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    Zs.A 928: Show issues Location:
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  6. Article ; Online: Course of Urological Problems in Children with Spinal Dysraphism: Long-Term Follow-Up Results.

    Solakhan, Mehmet / Oktay, Kadir / Guzel, Ebru / Bayrak, Omer / Guzel, Aslan

    Pediatric neurosurgery

    2020  Volume 55, Issue 2, Page(s) 101–105

    Abstract: Background/aims: We aimed to evaluate the course of urinary problems in children with spinal dysraphism.: Methods: This multicenter study evaluated data on pediatric patients diagnosed with spinal dysraphism between 2010 and 2019. The neurological ... ...

    Abstract Background/aims: We aimed to evaluate the course of urinary problems in children with spinal dysraphism.
    Methods: This multicenter study evaluated data on pediatric patients diagnosed with spinal dysraphism between 2010 and 2019. The neurological and urological conditions of the patients were examined retrospectively. This study focused on the course of urological problems. Urodynamic examinations including urodynamic bladder capacity, bladder pressure in maximal capacity, compliance, detrusor hyperactivity, uroflowmetry, and residual urine amount were evaluated. All patients underwent urinary system ultrasonography, urinalysis, hemogram and biochemical tests, and urodynamics at admission and follow-ups.
    Results: A total 62 patients (35 males, 27 females) with a mean age of 7.50 ± 4.01 years and age range of 1-16 years were included in the study. Ultrasonographic evaluation revealed normal results in 32 patients and abnormal findings, including moderate-to-severe calyceal dilatation, parenchymal thinning, and residual urine, in 30 patients. At the time of diagnosis, culture-positive urinary tract infection was detected in 22 patients, and leukocyte and/or bacterial positivity was detected in 18 patients. The differences between bladder capacity, bladder pressure at maximal capacity, compliance, and detrusor hyperactivity at first admission and post-treatment were statistically significant (p < 0.05). Vesicoureteral reflux was also detected in 25 patients. Thirty patients underwent oral anticholinergic and antibiotic prophylaxis, while 17 additionally underwent clean intermittent catheterization. Five patients underwent intravesical Botox injection, clean intermittent catheterization, and medical treatment, and 10 patients underwent augmentation cystoplasty.
    Conclusion: The prevalence of urinary tract problems is high in patients with spinal dysraphism for whom early diagnosis is very important for both urologic and neurosurgical considerations. Early follow-up of urodynamics should be performed, and treatment should be carried out if necessary. Regular follow-up and appropriate treatment have positive effects on the quality of life of these patients and may also prevent the occurrence of severe renal dysfunction.
    MeSH term(s) Adolescent ; Child ; Child, Preschool ; Female ; Follow-Up Studies ; Humans ; Infant ; Male ; Spinal Dysraphism/diagnostic imaging ; Spinal Dysraphism/epidemiology ; Time Factors ; Urinary Bladder Diseases/diagnostic imaging ; Urinary Bladder Diseases/epidemiology
    Language English
    Publishing date 2020-07-17
    Publishing country Switzerland
    Document type Journal Article ; Multicenter Study
    ZDB-ID 1091757-3
    ISSN 1423-0305 ; 1016-2291
    ISSN (online) 1423-0305
    ISSN 1016-2291
    DOI 10.1159/000509053
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    Zs.A 1133: Show issues Location:
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  7. Article ; Online: Efficacy of mirabegron in medical expulsive therapy.

    Solakhan, Mehmet / Bayrak, Omer / Bulut, Ersan

    Urolithiasis

    2018  Volume 47, Issue 3, Page(s) 303–307

    Abstract: To show the efficacy of mirabegron for medical expulsive treatment, in patients had intramural located distal ureteral stone. A 80 patients had intramural ureteral stone were assessed retrospectively between April 2017 and January 2018. Mirabegron 50 mg/ ... ...

    Abstract To show the efficacy of mirabegron for medical expulsive treatment, in patients had intramural located distal ureteral stone. A 80 patients had intramural ureteral stone were assessed retrospectively between April 2017 and January 2018. Mirabegron 50 mg/day + diclofenac 100 mg/day (group 1, n = 40), and only diclofenac 100 mg/day (group 2, n = 40) were administered to patients, consecutively. Age, gender, stone size, laterality, and severity of hydronephrosis were recorded. Spontaneous stone expulsion rates (SER), stone expulsion time, and the number of daily colic episodes were evaluated. In the group 1, one (2.5%) patient was excluded due to nasopharyngitis, and one (2.5%) patient was excluded due to 5 mmHg systolic blood pressure increase. In addition, four (10%) patients in group 1, and six (15%) patients in group 2, who did not attend follow-up examinations, were excluded from the study. There was not any statistically significant difference between the two groups in terms of age, gender, stone location, severity of hydronephrosis, stone size (p = 0.736, p = 0.310, p = 0.467, p = 0.801, p = 0.761, consecutively). Spontaneous expulsion ratios were calculated as 73.52% in group 1, and 47.05% in group 2 (p = 0.026). However, there was not any statistically significant difference in terms of stone expulsion time (p = 0.979). SER for patients had ≤ 6 mm stones was higher in group 1 (87.5 vs 52.49%, p = 0.031). In addition, group 2 patients had more pain episodes (1.02 ± 0.52 vs. 1.29 ± 0.57, p = 0.049). In the current study, mirabegron has been shown to be an efficient, safe and a new treatment modality, with lower side effect profile for the intramural located distal ureteral stones.
    MeSH term(s) Acetanilides/therapeutic use ; Adult ; Female ; Humans ; Male ; Middle Aged ; Prospective Studies ; Retrospective Studies ; Thiazoles/therapeutic use ; Treatment Outcome ; Ureteral Calculi/drug therapy ; Urological Agents/therapeutic use
    Chemical Substances Acetanilides ; Thiazoles ; Urological Agents ; mirabegron (MVR3JL3B2V)
    Language English
    Publishing date 2018-08-04
    Publishing country Germany
    Document type Journal Article
    ZDB-ID 2703553-0
    ISSN 2194-7236 ; 2194-7228
    ISSN (online) 2194-7236
    ISSN 2194-7228
    DOI 10.1007/s00240-018-1075-5
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  8. Article: Aggressive course in a patient with mucin-producing urothelial-type adenocarcinoma of the prostate: A case report and review of the literature.

    Solakhan, Mehmet / Erturhan, Mehmet Sakıp / Sevinç, Alper / Çetin, Safiye

    Turkish journal of urology

    2018  Volume 45, Issue Supp. 1, Page(s) S135–S138

    Abstract: Prostate cancer is one of the frequently seen types of cancers in men. The most frequent histological type of prostate cancer is the acinar adenocarcinoma. Mucin-producing urothelial-type adenocarcinoma of the prostate is a very rare subtype. The mucin- ... ...

    Abstract Prostate cancer is one of the frequently seen types of cancers in men. The most frequent histological type of prostate cancer is the acinar adenocarcinoma. Mucin-producing urothelial-type adenocarcinoma of the prostate is a very rare subtype. The mucin-producing urothelial-type adenocarcinoma of the prostate has microscopic similarities with colon and bladder adenocarcinoma. It has a more aggressive clinical course and does not respond to androgen deprivation therapy. A 77-year-old male patient diagnosed with mucinous prostate cancer was presented in the current case report.
    Language English
    Publishing date 2018-12-19
    Publishing country Turkey
    Document type Journal Article
    ISSN 2149-3235
    ISSN 2149-3235
    DOI 10.5152/tud.2018.30837
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  9. Article ; Online: A novel diagnostic tool for the detection of bladder cancer: Measurement of urinary high mobility group box-1.

    Benlier, Necla / Solakhan, Mehmet / Yıldırım, Zeliha / Kaya, Vildan / Yıldırım, Ömer Aydın / Orhan, Nuri / Çiçek, Hülya / Yıldırım, Mustafa

    Urologic oncology

    2020  Volume 38, Issue 8, Page(s) 685.e11–685.e16

    Abstract: Objective: We aimed to investigate the diagnostic value of urinary High Mobility Group Box-1 (HMGB1) level as a noninvasive tool that can be potentially used for diagnosis and during follow-up in patients with bladder cancer patients.: Method: The ... ...

    Abstract Objective: We aimed to investigate the diagnostic value of urinary High Mobility Group Box-1 (HMGB1) level as a noninvasive tool that can be potentially used for diagnosis and during follow-up in patients with bladder cancer patients.
    Method: The study was conducted in a total of 121 participants including 61 patients diagnosed with primary bladder cancer, 30 patients with an acute urinary tract infection and 30 healthy controls. Age, gender and urinary HMGB1 levels of the study groups were evaluated. The association of clinical features (tumor diameter, number of foci, pathological grade, muscle invasion) with urinary HMGB1 levels was investigated in patients with bladder cancer.
    Results: All 3 groups showed a normal age and gender distribution with no significant difference among them (P = 0.775 and P = 0.967, respectively). A significant difference was detected in urinary HMGB1 levels among the 3 groups (P < 0.001). When urinary HMGB1 levels were compared between patients with high grade vs. low grade tumors, the mean HMGB1 level was 44.39 pg/ml (12.1-505.2) in patients with low grade tumors and 280 pg/ml (18.7-2685.3) in patients with high grade tumors (P < 0.001). Patients with a greater number of tumor foci had higher HMGB1 levels in comparison to patients with a single tumor focus (P = 0.008). Urinary HMGB1 levels were higher in patients with a tumor diameter of ≥3 cm than in patients with a tumor diameter less than 3 cm (P = 0.001). Patients with muscle-invasive bladder cancer exhibited higher urinary HMGB1 levels compared to patients with non-muscle-invasive bladder cancer (P = 0.033). The cut-off values derived from the ROC analysis were 63.30 pg/ml for distinguishing bladder cancer from urinary tract infection, 30.94 pg/ml for urinary tract infection versus control group and 38.70 pg/ml for bladder cancer vs. control group, respectively. Sensitivity was 59% and specificity was found 77%.
    Conclusion: In future controlled studies involving larger patient groups, urinary HMGB1 levels can be used for diagnostic and screening purposes in bladder cancer patients.
    MeSH term(s) Adult ; Aged ; Biomarkers, Tumor/urine ; Female ; HMGB1 Protein/urine ; Humans ; Male ; Middle Aged ; Urinary Bladder Neoplasms/diagnosis ; Urinary Bladder Neoplasms/urine
    Chemical Substances Biomarkers, Tumor ; HMGB1 Protein
    Language English
    Publishing date 2020-04-17
    Publishing country United States
    Document type Journal Article ; Research Support, Non-U.S. Gov't
    ZDB-ID 1336505-8
    ISSN 1873-2496 ; 1078-1439
    ISSN (online) 1873-2496
    ISSN 1078-1439
    DOI 10.1016/j.urolonc.2020.03.025
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  10. Article ; Online: Comparison of dorsal intercostal perforator artery flap and primary closure in myelomeningocele repair.

    Atalay, Tugay / Oktay, Kadir / Guzel, Ebru / Tekes, Lutfi / Solakhan, Mehmet / Ozkiraz, Servet / Celik, Bahattin / Guzel, Aslan

    Child's nervous system : ChNS : official journal of the International Society for Pediatric Neurosurgery

    2020  Volume 37, Issue 1, Page(s) 229–233

    Abstract: Purpose: Of the many suggested techniques, we used dorsal intercostal perforator artery flap (DIPAF) for the closure of myelomeningocele defects. This study compared the outcomes of primary closure and DIPAF in the closure of myelomeningoceles.: ... ...

    Abstract Purpose: Of the many suggested techniques, we used dorsal intercostal perforator artery flap (DIPAF) for the closure of myelomeningocele defects. This study compared the outcomes of primary closure and DIPAF in the closure of myelomeningoceles.
    Methods: Data of 24 patients that underwent myelomeningocele surgery at a single institution between November 2015 and September 2019 were retrospectively reviewed.
    Results: The primary closure group had 13 patients (54.17%) and the DIPAF group had 11 (45.83%). The mean age was 7.91 ± 13.27 days (1-60 days). Twelve patients were female and 12 were male. In 22 patients, the myelomeningocele sacs were in the lumbosacral region, while in 2, they were in the thoracolumbar region. The mean defect sizes were 14.20 ± 4.62 cm
    Conclusion: This surgical treatment protects neural tissue, prevent CSF leakage, and reduce central nervous system infection rates in myelomeningocele patients. Closure technique with the fasciocutaneous skin flap has more satisfying results than primary closure.
    MeSH term(s) Adolescent ; Adult ; Arteries ; Child ; Female ; Humans ; Male ; Meningomyelocele/surgery ; Perforator Flap ; Reconstructive Surgical Procedures ; Retrospective Studies ; Treatment Outcome ; Young Adult
    Language English
    Publishing date 2020-07-14
    Publishing country Germany
    Document type Journal Article
    ZDB-ID 605988-0
    ISSN 1433-0350 ; 0302-2803 ; 0256-7040
    ISSN (online) 1433-0350
    ISSN 0302-2803 ; 0256-7040
    DOI 10.1007/s00381-020-04796-z
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