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  1. Article: Headache syndromes in Sierra Leone, West Africa.

    Solbrig, M V

    Headache

    1991  Volume 31, Issue 6, Page(s) 419

    MeSH term(s) Headache/physiopathology ; Humans ; Sierra Leone ; Syndrome
    Language English
    Publishing date 1991-06
    Publishing country United States
    Document type Comment ; Letter
    ZDB-ID 410130-3
    ISSN 1526-4610 ; 0017-8748
    ISSN (online) 1526-4610
    ISSN 0017-8748
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  2. Article: Acute parkinsonism in suspected herpes simplex encephalitis.

    Solbrig, M V / Nashef, L

    Movement disorders : official journal of the Movement Disorder Society

    1993  Volume 8, Issue 2, Page(s) 233–234

    MeSH term(s) Adult ; Antibodies, Viral/analysis ; Female ; Herpes Simplex/diagnosis ; Herpes Simplex/physiopathology ; Humans ; Immunoglobulin G/analysis ; Meningoencephalitis/diagnosis ; Meningoencephalitis/physiopathology ; Neurologic Examination ; Parkinson Disease, Postencephalitic/diagnosis ; Parkinson Disease, Postencephalitic/physiopathology ; Simplexvirus/immunology
    Chemical Substances Antibodies, Viral ; Immunoglobulin G
    Language English
    Publishing date 1993-04
    Publishing country United States
    Document type Case Reports ; Journal Article
    ZDB-ID 607633-6
    ISSN 1531-8257 ; 0885-3185
    ISSN (online) 1531-8257
    ISSN 0885-3185
    DOI 10.1002/mds.870080226
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  3. Article: Cocaine sensitivity in Borna disease virus-infected rats.

    Solbrig, M V / Koob, G F / Lipkin, W I

    Pharmacology, biochemistry, and behavior

    1998  Volume 59, Issue 4, Page(s) 1047–1052

    Abstract: Borna disease virus (BDV) is a neurotropic RNA virus that infects warm-blooded animals to cause disturbances of movement and behavior. Studies in infected rats have demonstrated behavioral sensitivity to direct and indirect dopamine (DA) agonists; ... ...

    Abstract Borna disease virus (BDV) is a neurotropic RNA virus that infects warm-blooded animals to cause disturbances of movement and behavior. Studies in infected rats have demonstrated behavioral sensitivity to direct and indirect dopamine (DA) agonists; however, behavioral responses to an indirect DA agonist with a pure presynaptic effect have not been analyzed. Rats infected with BDV had an enhanced response to the locomotor, behavioral, and convulsant effects of cocaine at intraperitoneal doses of 7.5, 15, and 30 mg/kg. The basis for this sensitivity was examined by striatal DA uptake site and D1 and D2 receptor autoradiography. DA uptake sites, labeled with [3H] mazindol, were reduced in medial caudate-putamen (CP), and binding of [3H] raclopride to D2 sites was reduced in medial and ventral striatal areas. The topography of DA uptake and D2 site loss corresponds to the distribution of BDV viral nucleic acids in CP and overlays the medial striatal areas that function in conditioned reward. The BDV-infected rat provides a model of cocaine sensitivity based on viral central nervous system infection and may have relevance for studies of cocaine abuse in the context of other viral encephalopathies, such as those associated with HIV infection.
    MeSH term(s) Animals ; Autoradiography ; Behavior, Animal/drug effects ; Borna Disease/psychology ; Caudate Nucleus/drug effects ; Caudate Nucleus/metabolism ; Cocaine/pharmacology ; Dopamine Uptake Inhibitors/pharmacology ; In Situ Hybridization ; Male ; Mazindol/pharmacology ; Motor Activity/drug effects ; Putamen/drug effects ; Putamen/metabolism ; Rats ; Rats, Inbred Lew
    Chemical Substances Dopamine Uptake Inhibitors ; Mazindol (C56709M5NH) ; Cocaine (I5Y540LHVR)
    Language English
    Publishing date 1998-04
    Publishing country United States
    Document type Journal Article ; Research Support, Non-U.S. Gov't ; Research Support, U.S. Gov't, P.H.S.
    ZDB-ID 191042-5
    ISSN 1873-5177 ; 0091-3057
    ISSN (online) 1873-5177
    ISSN 0091-3057
    DOI 10.1016/s0091-3057(97)00507-8
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  4. Article: Naloxone-induced seizures in rats infected with Borna disease virus.

    Solbrig, M V / Koob, G F / Lipkin, W I

    Neurology

    1996  Volume 46, Issue 4, Page(s) 1170–1171

    Abstract: The opioid antagonist naloxone is widely used in the emergency treatment of nontraumatic coma. Although it is uncommon for serious side effects to result from administration of opiate antagonists, we report that naloxone can have epileptogenic effects in ...

    Abstract The opioid antagonist naloxone is widely used in the emergency treatment of nontraumatic coma. Although it is uncommon for serious side effects to result from administration of opiate antagonists, we report that naloxone can have epileptogenic effects in the context of encephalitis. In an experimental model of viral encephalitis, rats infected with Borna disease virus developed myoclonic, generalized clonic, or atonic seizures; behavior arrest; and staring spells when treated with naloxone. These findings suggest a novel neuropharmacologic link, through opioid peptide systems, between epilepsy and encephalitis and disclose a potential contraindication to use of opioid antagonists in nontraumatic coma.
    MeSH term(s) Animals ; Borna Disease/drug therapy ; Contraindications ; Dyskinesia, Drug-Induced/drug therapy ; Encephalitis, Viral/drug therapy ; Male ; Naloxone/adverse effects ; Naloxone/therapeutic use ; Rats ; Rats, Inbred Lew ; Seizures/chemically induced
    Chemical Substances Naloxone (36B82AMQ7N)
    Language English
    Publishing date 1996-04
    Publishing country United States
    Document type Journal Article ; Research Support, Non-U.S. Gov't ; Research Support, U.S. Gov't, P.H.S.
    ZDB-ID 207147-2
    ISSN 1526-632X ; 0028-3878
    ISSN (online) 1526-632X
    ISSN 0028-3878
    DOI 10.1212/wnl.46.4.1170
    Database MEDical Literature Analysis and Retrieval System OnLINE

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    Zs.MO 374: Show issues

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  5. Article: Behavioral disturbances and pharmacology of Borna disease.

    Solbrig, M V / Fallon, J H / Lipkin, W I

    Current topics in microbiology and immunology

    1995  Volume 190, Page(s) 93–101

    MeSH term(s) Animals ; Borna Disease/psychology ; Borna Disease/virology ; Brain/virology ; Dopamine/physiology ; Humans ; Mental Disorders/etiology ; Ventral Tegmental Area/physiology
    Chemical Substances Dopamine (VTD58H1Z2X)
    Language English
    Publishing date 1995
    Publishing country Germany
    Document type Journal Article ; Review
    ISSN 0070-217X
    ISSN 0070-217X
    DOI 10.1007/978-3-642-78618-1_6
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  6. Article: Borna disease virus: implications for human neuropsychiatric illness.

    Lipkin, W I / Schneemann, A / Solbrig, M V

    Trends in microbiology

    1995  Volume 3, Issue 2, Page(s) 64–69

    Abstract: The cause of Borna disease, a neurological syndrome affecting mammals and birds, has recently been shown to be infection with an RNA virus. Molecular genetic analysis suggests that Borna disease virus represents a new viral taxon. It has a wide host ... ...

    Abstract The cause of Borna disease, a neurological syndrome affecting mammals and birds, has recently been shown to be infection with an RNA virus. Molecular genetic analysis suggests that Borna disease virus represents a new viral taxon. It has a wide host range and is tropic for specific circuits in the central nervous system. There is indirect evidence that links it to diseases of the human central nervous system.
    MeSH term(s) Animals ; Borna Disease ; Borna disease virus/classification ; Borna disease virus/genetics ; Central Nervous System/virology ; Child ; Humans ; Mood Disorders/virology ; Schizophrenia/virology
    Language English
    Publishing date 1995-02
    Publishing country England
    Document type Journal Article ; Research Support, Non-U.S. Gov't ; Research Support, U.S. Gov't, P.H.S. ; Review
    ZDB-ID 1158963-2
    ISSN 1878-4380 ; 0966-842X
    ISSN (online) 1878-4380
    ISSN 0966-842X
    DOI 10.1016/s0966-842x(00)88877-0
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  7. Article: A neural substrate of hyperactivity in borna disease: changes in brain dopamine receptors.

    Solbrig, M V / Koob, G F / Joyce, J N / Lipkin, W I

    Virology

    1996  Volume 222, Issue 2, Page(s) 332–338

    Abstract: Rats experimentally infected with the neurotropic RNA virus, Borna disease virus, have a hyperactive movement disorder. Because locomotor activity is modulated by the nucleus accumbens (N. Acc.) dopamine (DA) system, high-affinity DA uptake, DA D1, D2, ... ...

    Abstract Rats experimentally infected with the neurotropic RNA virus, Borna disease virus, have a hyperactive movement disorder. Because locomotor activity is modulated by the nucleus accumbens (N. Acc.) dopamine (DA) system, high-affinity DA uptake, DA D1, D2, and D3 receptor binding sites were examined in N. Acc. subregions of normal and infected rats by quantitative receptor autoradiography. The N. Acc. of infected rats had decreased mazindol and D2 and D3 radioligand binding in the core and decreased D3 radioligand binding in rostral subregions. The abnormalities observed in the N. Acc. DA system of infected rats may offer insights into the potential viral pathogenesis of psychiatric conditions with a dopaminergic substrate such as schizophrenia and affective disorders.
    MeSH term(s) Animals ; Autoradiography ; Borna Disease/metabolism ; Borna Disease/physiopathology ; Borna Disease/virology ; Borna disease virus ; Hyperkinesis/etiology ; Hyperkinesis/metabolism ; In Situ Hybridization ; Male ; Nucleus Accumbens/metabolism ; Nucleus Accumbens/virology ; RNA, Viral/analysis ; Rats ; Rats, Inbred Lew ; Receptors, Dopamine/metabolism ; Receptors, Dopamine D1/metabolism ; Receptors, Dopamine D2/metabolism ; Receptors, Dopamine D3
    Chemical Substances Drd3 protein, rat ; RNA, Viral ; Receptors, Dopamine ; Receptors, Dopamine D1 ; Receptors, Dopamine D2 ; Receptors, Dopamine D3
    Language English
    Publishing date 1996-08-15
    Publishing country United States
    Document type Journal Article ; Research Support, Non-U.S. Gov't ; Research Support, U.S. Gov't, P.H.S.
    ZDB-ID 200425-2
    ISSN 1096-0341 ; 0042-6822
    ISSN (online) 1096-0341
    ISSN 0042-6822
    DOI 10.1006/viro.1996.0430
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  8. Article: Developmental-stage-specific plasmid supercoiling in Chlamydia trachomatis.

    Solbrig, M V / Wong, M L / Stephens, R S

    Molecular microbiology

    1990  Volume 4, Issue 9, Page(s) 1535–1541

    Abstract: Chlamydia trachomatis elementary body (EB) and reticulate body (RB) developmental stages have polymorphic plasmid DNA. Several plasmid forms separated by gel electrophoresis were identified as topoisomers by treatment with topoisomerase I. Among these ... ...

    Abstract Chlamydia trachomatis elementary body (EB) and reticulate body (RB) developmental stages have polymorphic plasmid DNA. Several plasmid forms separated by gel electrophoresis were identified as topoisomers by treatment with topoisomerase I. Among these topoisomers was one form unique to EBs and one form unique to RBs. The unique EB plasmid topoisomer was characterized as highly supercoiled, on the basis of band migrations by gel electrophoresis and its appearance by electron microscopy. The unusual physical state of this topoisomer was probably mediated, in part, by DNA-specific structural proteins. The unique RB plasmid topoisomer was a supercoiled form of lower superhelical density than the other identified topoisomers. Developmental-stage-specific differences in super-helical density of plasmid DNA suggest cause-and-effect relationships between DNA topology and metabolic activity in RBs and metabolic quiescence in EBs.
    MeSH term(s) Blotting, Southern ; Chlamydia trachomatis/genetics ; Chlamydia trachomatis/growth & development ; Chlamydia trachomatis/ultrastructure ; DNA Topoisomerases, Type I/metabolism ; DNA Topoisomerases, Type II/metabolism ; DNA, Bacterial/chemistry ; DNA, Superhelical/chemistry ; Densitometry ; Microscopy, Electron ; Nucleic Acid Conformation ; Plasmids ; Polymorphism, Restriction Fragment Length ; Single-Strand Specific DNA and RNA Endonucleases/metabolism
    Chemical Substances DNA, Bacterial ; DNA, Superhelical ; Single-Strand Specific DNA and RNA Endonucleases (EC 3.1.30.1) ; DNA Topoisomerases, Type I (EC 5.99.1.2) ; DNA Topoisomerases, Type II (EC 5.99.1.3)
    Language English
    Publishing date 1990-09
    Publishing country England
    Document type Journal Article ; Research Support, Non-U.S. Gov't ; Research Support, U.S. Gov't, P.H.S.
    ZDB-ID 619315-8
    ISSN 1365-2958 ; 0950-382X
    ISSN (online) 1365-2958
    ISSN 0950-382X
    DOI 10.1111/j.1365-2958.1990.tb02064.x
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  9. Article: Tardive dyskinetic syndrome in rats infected with Borna disease virus.

    Solbrig, M V / Koob, G F / Fallon, J H / Lipkin, W I

    Neurobiology of disease

    1994  Volume 1, Issue 3, Page(s) 111–119

    Abstract: Tardive Dyskinesia (TD) is a hyperkinetic movement disorder caused by chronic treatment of psychiatric patients with dopamine (DA) receptor blocking drugs (Stacy & Jankovic 1991). Although TD is one of the most important and frequently encountered ... ...

    Abstract Tardive Dyskinesia (TD) is a hyperkinetic movement disorder caused by chronic treatment of psychiatric patients with dopamine (DA) receptor blocking drugs (Stacy & Jankovic 1991). Although TD is one of the most important and frequently encountered iatrogenic disorders in clinical medicine, its pathophysiology is poorly understood. We have observed a hyperkinetic movement disorder in rats experimentally infected with a neurotropic RNA virus, Borna disease virus, that may provide important insights into the pathophysiology of TD. Like TD patients, infected rats show prominent orofacial dyskinesias. In keeping with the dopamine (Goetz & Klawans 1982) and anatomic (Fibiger & Lloyd 1984) hypotheses of TD, the Borna disease rat model shows enhanced behavioural sensitivity to DA agonists and selective striatal cell damage. There is also evidence of DA deafferentation and heterogeneous reduction of D2 binding in the caudate-putamen, particularly from sites implicated in oral behaviour. These observations on a virus-induced movement disorder offer novel approaches to TD pathogenesis.
    MeSH term(s) Animals ; Autoradiography ; Borna Disease/complications ; Borna Disease/metabolism ; Dopamine/analysis ; Dopamine Agonists/pharmacology ; Dyskinesia, Drug-Induced/etiology ; Dyskinesia, Drug-Induced/metabolism ; Male ; Motor Activity/drug effects ; RNA, Viral/analysis ; Rats ; Rats, Inbred Lew ; Receptors, Dopamine D2/analysis
    Chemical Substances Dopamine Agonists ; RNA, Viral ; Receptors, Dopamine D2 ; Dopamine (VTD58H1Z2X)
    Language English
    Publishing date 1994-12
    Publishing country United States
    Document type Journal Article ; Research Support, Non-U.S. Gov't ; Research Support, U.S. Gov't, P.H.S.
    ZDB-ID 1211786-9
    ISSN 1095-953X ; 0969-9961
    ISSN (online) 1095-953X
    ISSN 0969-9961
    DOI 10.1006/nbdi.1994.0014
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  10. Article: Rhabdomyolysis in leptospirosis (Weil's disease).

    Solbrig, M V / Sher, J H / Kula, R W

    The Journal of infectious diseases

    1987  Volume 156, Issue 4, Page(s) 692–693

    MeSH term(s) Female ; Humans ; Middle Aged ; Muscles/pathology ; Rhabdomyolysis/pathology ; Weil Disease/pathology
    Language English
    Publishing date 1987-10
    Publishing country United States
    Document type Case Reports ; Journal Article
    ZDB-ID 3019-3
    ISSN 1537-6613 ; 0022-1899
    ISSN (online) 1537-6613
    ISSN 0022-1899
    DOI 10.1093/infdis/156.4.692
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