Article: PIWIL2 Regulates the Proliferation, Apoptosis and Colony Formation of Colorectal Cancer Cell Line.
Iranian journal of biotechnology
2023 Volume 21, Issue 1, Page(s) e3176
Abstract: Background: Tumor cells proliferation and apoptosis inhibition are the mechanisms through which the Colorectal Cancer (CRC) progression, metastasis and chemoresistance are promoted pathologically, offering clinical advantages for characterizing their ... ...
| Abstract | Background: Tumor cells proliferation and apoptosis inhibition are the mechanisms through which the Colorectal Cancer (CRC) progression, metastasis and chemoresistance are promoted pathologically, offering clinical advantages for characterizing their molecular regulators. Objectives: In this study, to unravel the role of PIWIL2 as a potential CRC oncogenic regulator, we examined the effect of its overexpression on proliferation, apoptosis and colony formation of SW480 colon cancer cell line. Material and methods: Established SW480-P (overexpression of Results: At the molecular level, Conclusions: PIWIL2 plays important roles to promote cancer cell proliferation and colonization via the cell cycle acceleration and inhibition of apoptosis, the mechanisms through which this gene seems to contribute to CRC development, metastasis and chemoresistance, hence potentially highlighting PIWIL2 targeted therapy as a valuable tool for CRC treatment. |
|---|---|
| Language | English |
| Publishing date | 2023-01-01 |
| Publishing country | Iran |
| Document type | Journal Article |
| ZDB-ID | 2223669-7 |
| ISSN | 2322-2921 ; 1728-3043 |
| ISSN (online) | 2322-2921 |
| ISSN | 1728-3043 |
| DOI | 10.30498/ijb.2022.307054.3176 |
| Database | MEDical Literature Analysis and Retrieval System OnLINE |
More links
Kategorien
Order via subito
This service is chargeable due to the Delivery terms set by subito. Orders including an article and supplementary material will be classified as separate orders. In these cases, fees will be demanded for each order.