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Article ; Online: Notch, RORC and IL-23 signals cooperate to promote multi-lineage human innate lymphoid cell differentiation

Carys A. Croft / Anna Thaller / Solenne Marie / Jean-Marc Doisne / Laura Surace / Rui Yang / Anne Puel / Jacinta Bustamante / Jean-Laurent Casanova / James P. Di Santo

Nature Communications, Vol 13, Iss 1, Pp 1-

2022  Volume 14

Abstract: Innate lymphoid cells (ILC) are effector cells that rapidly respond to immune evading stimuli, and despite their functional diversity arise from common precursors. Authors here show how the Notch signalling pathway orchestrates ILC development from ... ...

Abstract Innate lymphoid cells (ILC) are effector cells that rapidly respond to immune evading stimuli, and despite their functional diversity arise from common precursors. Authors here show how the Notch signalling pathway orchestrates ILC development from circulating human ILC precursors via RORC and its target IL-23R.
Keywords Science ; Q
Language English
Publishing date 2022-07-01T00:00:00Z
Publisher Nature Portfolio
Document type Article ; Online
Database BASE - Bielefeld Academic Search Engine (life sciences selection)

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