LIVIVO - Search results -

Search results

Result 1 - 10 of total 18

Search options

Article: Calamusins J-K: new anti-angiogenic sesquiterpenes from Sarcophyton glaucum

Shaaban, Mohamed / Yassin, Faten Y / Soltan, Maha M

Natural product research. 2021 Dec. 17, v. 35, no. 24

2021

Abstract: Chemical investigation of the organic extract of the marine soft coral Sarcophyton glaucum from Red Sea, Egypt, afforded two new hydroazulenes; calamusin J (1) and its hydroperoxide derivative calamusin K (2) in addition to eight known compounds. ... ...

Abstract	Chemical investigation of the organic extract of the marine soft coral Sarcophyton glaucum from Red Sea, Egypt, afforded two new hydroazulenes; calamusin J (1) and its hydroperoxide derivative calamusin K (2) in addition to eight known compounds. Structure of compounds 1-2 were confirmed by intensive NMR and mass spectrometry studies. The coral extract and the obtained compounds were examined against a set of diverse microorganisms. The in vitro anti-cancer properties were assessed against colon (Caco-2) and breast (MCF-7) cell lines together with their exerted cytotoxicity on the immortalized normal epithelium (hTERT-RPE1) cell type. The anti-angiogenic power was also highlighted through suppressing MCF-7 cell migration and the significant inactivation of VEGFR2 enzyme. Compounds 1,2 are the most potent angiogenic inhibitors (represented by 1.2- and 1.4-fold enzyme inactivation, respectively) relative to sorafenib. The polyhydroxy sterol; 5α-3β,6α,11-trihydroxy-24-methyl-9,11-seco-5a-cholest-7-en-9-one (S4) inhibited effectively the growth of Caco-2 and MCF-7 with GI₅₀ of 0.62 and 2.3 µM, respectively.
Keywords	Sarcophyton ; breasts ; cell movement ; colon ; corals ; cytotoxicity ; enzyme inactivation ; epithelium ; human cell lines ; mass spectrometry ; research ; sesquiterpenoids ; sterols ; vascular endothelial growth factor receptor-2 ; Egypt ; Red Sea
Language	English
Dates of publication	2021-1217
Size	p. 5720-5731.
Publishing place	Taylor & Francis
Document type	Article
ZDB-ID	2185747-7
ISSN	1478-6427 ; 1478-6419
ISSN (online)	1478-6427
ISSN	1478-6419
DOI	10.1080/14786419.2020.1828404
Database	NAL-Catalogue (AGRICOLA)

Order via subito

This service is chargeable due to the Delivery terms set by subito. Orders including an article and supplementary material will be classified as separate orders. In these cases, fees will be demanded for each order.

Article: Bioactive compounds from Matricaria chamomilla: structure identification, in vitro antiproliferative, antimigratory, antiangiogenic, and antiadenoviral activities

Shaaban, Mohamed / El-Hagrassi, Ali M. / Osman, Abeer F. / Soltan, Maha M.

Zeitschrift für Naturforschung. 2022 Mar. 28, v. 77, no. 3-4

2022

Abstract: During our exploring the anticancer activity of some medicinal plants and their major metabolites, the aerial parts of the Egyptian Matricaria chamomilla (flowers and stems) were studied. GC–MS analysis of the organic soluble extracts of the flowers and ... ...

Abstract	During our exploring the anticancer activity of some medicinal plants and their major metabolites, the aerial parts of the Egyptian Matricaria chamomilla (flowers and stems) were studied. GC–MS analysis of the organic soluble extracts of the flowers and stems fractions revealed the presence of 43 and 45 compounds, respectively. Individual chromatographic purification of the flowers and stems’ extracts afforded three major compounds. Structures of these compounds were identified by 1D- and 2D-NMR and HRESI-MS spectroscopic data as bisabolol oxide A (1) and (E)-tonghaosu (2) (as mixture of ratio 2:1) from the flowers extract, meanwhile apigenin-7-β-d-glucoside (3) from the stems fraction. Biologically, the chamomile extracts announced significant antiproliferative activities exceeded in potency by ∼1.5 fold in case of the stem, recording GI₅₀ 13.16 and 17.04 μg/mL against Caco-2 and MCF-7, respectively. Both fractions were approximately equipotent against the migration of the same cell type down to 10 μg/mL together, compounds 1, 2 but not 3, showed considerable growth inhibition of the same cells at GI₅₀ 13.36 and 11.83 μg/mL, respectively. Interestingly, they were able to suppress Caco-2 colon cancer cells migration at 5.8 μg/mL and potently inactivate the VEGFR2 angiogenic enzyme (1.5-fold relative to sorafenib. The obtained compounds and corresponding chamomile extracts were evaluated against Adeno-7 virus, revealing that both chamomiles’ extracts (flowers and stems) and their corresponding obtained compounds (1–3) were potent in their depletion to the Adeno 7 infectivity titer, however, the flower extract and compounds 1–2 were more effective than those of the stem extract and its end-product (3).
Keywords	Matricaria chamomilla ; antineoplastic activity ; chamomile ; colorectal neoplasms ; flower extracts ; growth retardation ; metabolites ; pathogenicity ; spectral analysis ; stem extracts ; viruses
Language	English
Dates of publication	2022-0328
Size	p. 85-94.
Publishing place	De Gruyter
Document type	Article
ZDB-ID	124636-7
ISSN	1865-7125 ; 0341-0382 ; 0341-0471 ; 0939-5075
ISSN (online)	1865-7125
ISSN	0341-0382 ; 0341-0471 ; 0939-5075
DOI	10.1515/znc-2021-0083
Database	NAL-Catalogue (AGRICOLA)

In stock of ZB MED Bonn / Germany

Z 4' 47/11 c: Show issues
Z 9.9: Show issues

Order via subito

Inter-library loan at ZB MED

Your chosen title can be delivered directly to ZB MED Cologne location if you are registered as a user at ZB MED Cologne.

Details ▾
- See ZB MED holdings
- Order with fees

Article ; Online: Calamusins J-K: new anti-angiogenic sesquiterpenes from

Shaaban, Mohamed / Yassin, Faten Y / Soltan, Maha M

Natural product research

2020 Volume 35, Issue 24, Page(s) 5720–5731

Abstract: Chemical investigation of the organic extract of the marine soft ... ...

Abstract	Chemical investigation of the organic extract of the marine soft coral
MeSH term(s)	Animals ; Anthozoa ; Antineoplastic Agents/pharmacology ; Caco-2 Cells ; Humans ; MCF-7 Cells ; Sesquiterpenes/pharmacology
Chemical Substances	Antineoplastic Agents ; Sesquiterpenes
Language	English
Publishing date	2020-10-05
Publishing country	England
Document type	Journal Article
ZDB-ID	2185747-7
ISSN	1478-6427 ; 1478-6419
ISSN (online)	1478-6427
ISSN	1478-6419
DOI	10.1080/14786419.2020.1828404
Database	MEDical Literature Analysis and Retrieval System OnLINE

Order via subito

Article: In vitro chemotherapeutic and antiangiogenic properties of cardenolides from Acokanthera oblongifolia (Hochst.) Codd

Soltan, Maha M. / Abd-Alla, Howaida I. / Hassan, Amal Z. / Hanna, Atef G.

Zeitschrift für Naturforschung. 2021 July 27, v. 76, no. 7-8

2021

Abstract: Acovenoside A (Acov-A) and acobioside A (Acob-A) were isolated from Acokanthera oblongifolia. Their anticancer properties were explored regarding, antiproliferative and antiangiogenic activities. The study included screening phase against six cancer cell ...

Abstract	Acovenoside A (Acov-A) and acobioside A (Acob-A) were isolated from Acokanthera oblongifolia. Their anticancer properties were explored regarding, antiproliferative and antiangiogenic activities. The study included screening phase against six cancer cell lines followed by mechanistic investigation against HepG2 cancer cell line. The sulforhodamine-B (SRB) was used to determine their growth inhibitory power. In the other hand, flow cytometry techniques were recorded the cell death type and cell cycle analysis. The clonogenic (colony formation) and wound healing assays, enzyme-linked immunosorbent assay (ELISA) and molecular docking, were performed to evaluate the antiangiogenesis capability. Both compounds were strongly, inhibited four cancer cell lines at GI₅₀ less than 100 nM. The in vitro mechanistic investigation against HepG2 resulted in cell accumulations at G2M phase and induction of apoptosis upon treating cells separately, with 400 nM Acov-A and 200 nM Acob-A. Interestingly, the same concentrations were able to activate caspase-3 by 7.2 and 4.8-fold, respectively. Suppressing the clonogenic capacity of HepG2 cells (20 and 40 nM) and inhibiting the migration of the colon Caco-2 cancer cells were provoke the results of vascular endothelial growth factor receptor2 (VEGFR2) kinase enzyme inactivation. The docked study was highly supportive, to the antiangiogenic approach of both cardenolides. The isolated cardenolides could orchestrate pivotal events in fighting cancer.
Keywords	Acokanthera ; apoptosis ; cardenolides ; caspase-3 ; cell cycle ; colon ; drug therapy ; enzyme inactivation ; enzyme-linked immunosorbent assay ; flow cytometry ; neoplasm cells ; vascular endothelial growth factor receptor-2 ; vascular endothelial growth factors
Language	English
Dates of publication	2021-0727
Size	p. 337-346.
Publishing place	De Gruyter
Document type	Article
ZDB-ID	124636-7
ISSN	1865-7125 ; 0341-0382 ; 0341-0471 ; 0939-5075
ISSN (online)	1865-7125
ISSN	0341-0382 ; 0341-0471 ; 0939-5075
DOI	10.1515/znc-2020-0302
Database	NAL-Catalogue (AGRICOLA)

In stock of ZB MED Bonn / Germany

Z 4' 47/11 c: Show issues
Z 9.9: Show issues

Order via subito

Inter-library loan at ZB MED

Your chosen title can be delivered directly to ZB MED Cologne location if you are registered as a user at ZB MED Cologne.

Details ▾
- See ZB MED holdings
- Order with fees

Article: Monascin and monascinol, azaphilonoid pigments from Mortierella polycephala AM1: in silico and in vitro targeting of the angiogenic VEGFR2 kinase

Shaaban, Mohamed / Magdy El-Metwally, Mohammad / Mekawey, Amal A. I. / Abdelwahab, Ahmed B. / Soltan, Maha M.

Zeitschrift für Naturforschung. 2022 Jan. 27, v. 77, no. 1-2

2022

Abstract: The fungus, Mortierella polycephala is one of the most productive sources of anticancer bioactive compounds namely those of pigment nature. During our investigation of the produced bioactive metabolites by the terrestrial M. polycephala AM1 isolated from ...

Abstract	The fungus, Mortierella polycephala is one of the most productive sources of anticancer bioactive compounds namely those of pigment nature. During our investigation of the produced bioactive metabolites by the terrestrial M. polycephala AM1 isolated from Egyptian poultry feather waste, two main azaphilonoid pigments, monascin (1) and monascinol (2) were obtained as major products; their structures were identified by 1D (¹H&¹³C) and 2D (¹H–¹H COSY, HMBC) NMR and HRESI-MS spectroscopic data. Biologically, cytotoxic activities of these compounds were broadly studied compared with the fungal extract. To predict the biological target for the presumed antitumor activity, an in silico study was run toward three proteins, topoisomerase IIα, topoisomerase IIβ, and VEGFR2 kinase. Monascinol (2) was expected to be moderately active against VEGFR2 kinase without any anticipated inhibition toward topo II isoforms. The in vitro study confirmed the docked investigation consistently and introduced monascinol (2) rather than its counterpart (1) as a potent inhibitor to the tested VEGFR2 kinase. Taxonomically, the fungus was identified using morphological and genetic assessments.
Keywords	Mortierella ; antineoplastic activity ; computer simulation ; cytotoxicity ; fungi ; metabolites ; poultry ; spectral analysis ; vascular endothelial growth factor receptor-2 ; wastes
Language	English
Dates of publication	2022-0127
Size	p. 11-19.
Publishing place	De Gruyter
Document type	Article
ZDB-ID	124636-7
ISSN	1865-7125 ; 0341-0382 ; 0341-0471 ; 0939-5075
ISSN (online)	1865-7125
ISSN	0341-0382 ; 0341-0471 ; 0939-5075
DOI	10.1515/znc-2021-0095
Database	NAL-Catalogue (AGRICOLA)

In stock of ZB MED Bonn / Germany

Z 4' 47/11 c: Show issues
Z 9.9: Show issues

Order via subito

Inter-library loan at ZB MED

Your chosen title can be delivered directly to ZB MED Cologne location if you are registered as a user at ZB MED Cologne.

Details ▾
- See ZB MED holdings
- Order with fees

Article ; Online: Bioactive compounds from

Shaaban, Mohamed / El-Hagrassi, Ali M / Osman, Abeer F / Soltan, Maha M

Zeitschrift fur Naturforschung. C, Journal of biosciences

2021 Volume 77, Issue 3-4, Page(s) 85–94

Abstract: During our exploring the anticancer activity of some medicinal plants and their major metabolites, the aerial parts of the ... ...

Abstract	During our exploring the anticancer activity of some medicinal plants and their major metabolites, the aerial parts of the Egyptian
MeSH term(s)	Caco-2 Cells ; Flowers/chemistry ; Humans ; Matricaria/chemistry ; Oils, Volatile/analysis ; Plant Extracts/chemistry ; Plants, Medicinal
Chemical Substances	Oils, Volatile ; Plant Extracts
Language	English
Publishing date	2021-06-22
Publishing country	Germany
Document type	Journal Article
ZDB-ID	124636-7
ISSN	1865-7125 ; 0341-0382 ; 0341-0471 ; 0939-5075
ISSN (online)	1865-7125
ISSN	0341-0382 ; 0341-0471 ; 0939-5075
DOI	10.1515/znc-2021-0083
Database	MEDical Literature Analysis and Retrieval System OnLINE

In stock of ZB MED Cologne/Königswinter

Zs.A 962: Show issues

Location:
Je nach Verfügbarkeit (siehe Angabe bei Bestand)
bis Jg. 1994: Bestellungen von Artikeln über das Online-Bestellformular
Jg. 1995 - 2021: Lesesall (1.OG)
ab Jg. 2022: Lesesaal (EG)

Order via subito

Details ▾
- See ZB MED holdings
- Order with fees

Article ; Online: In vitro

Soltan, Maha M / Abd-Alla, Howaida I / Hassan, Amal Z / Hanna, Atef G

Zeitschrift fur Naturforschung. C, Journal of biosciences

2021 Volume 76, Issue 7-8, Page(s) 337–346

Abstract: Acovenoside A (Acov-A) and acobioside A (Acob-A) were isolated ... ...

Abstract	Acovenoside A (Acov-A) and acobioside A (Acob-A) were isolated from
MeSH term(s)	Angiogenesis Inhibitors/chemistry ; Angiogenesis Inhibitors/isolation & purification ; Angiogenesis Inhibitors/pharmacology ; Antineoplastic Agents/chemistry ; Antineoplastic Agents/isolation & purification ; Antineoplastic Agents/pharmacology ; Apocynaceae/chemistry ; Apoptosis/drug effects ; Caco-2 Cells ; Cardenolides/chemistry ; Cardenolides/isolation & purification ; Cardenolides/pharmacology ; Cell Cycle/drug effects ; Cell Line, Tumor ; Cell Proliferation/drug effects ; HCT116 Cells ; Hep G2 Cells ; Humans ; MCF-7 Cells ; Molecular Docking Simulation ; Molecular Structure ; Plant Leaves/chemistry ; Protein Binding/drug effects ; Vascular Endothelial Growth Factor Receptor-2/metabolism
Chemical Substances	Angiogenesis Inhibitors ; Antineoplastic Agents ; Cardenolides ; acovenoside A (663-95-6) ; Vascular Endothelial Growth Factor Receptor-2 (EC 2.7.10.1)
Language	English
Publishing date	2021-06-01
Publishing country	Germany
Document type	Journal Article
ZDB-ID	124636-7
ISSN	1865-7125 ; 0341-0382 ; 0341-0471 ; 0939-5075
ISSN (online)	1865-7125
ISSN	0341-0382 ; 0341-0471 ; 0939-5075
DOI	10.1515/znc-2020-0302
Database	MEDical Literature Analysis and Retrieval System OnLINE

In stock of ZB MED Cologne/Königswinter

Zs.A 962: Show issues

Location:
Je nach Verfügbarkeit (siehe Angabe bei Bestand)
bis Jg. 1994: Bestellungen von Artikeln über das Online-Bestellformular
Jg. 1995 - 2021: Lesesall (1.OG)
ab Jg. 2022: Lesesaal (EG)

Order via subito

Details ▾
- See ZB MED holdings
- Order with fees

Article ; Online: Monascin and monascinol, azaphilonoid pigments from

Shaaban, Mohamed / Magdy El-Metwally, Mohammad / Mekawey, Amal A I / Abdelwahab, Ahmed B / Soltan, Maha M

Zeitschrift fur Naturforschung. C, Journal of biosciences

2021 Volume 77, Issue 1-2, Page(s) 11–19

Abstract: The fungus, ...

Abstract	The fungus,
MeSH term(s)	Antineoplastic Agents/pharmacology ; Heterocyclic Compounds, 3-Ring ; Mortierella
Chemical Substances	Antineoplastic Agents ; Heterocyclic Compounds, 3-Ring ; monascin (W74D2M37FX)
Language	English
Publishing date	2021-07-16
Publishing country	Germany
Document type	Journal Article
ZDB-ID	124636-7
ISSN	1865-7125 ; 0341-0382 ; 0341-0471 ; 0939-5075
ISSN (online)	1865-7125
ISSN	0341-0382 ; 0341-0471 ; 0939-5075
DOI	10.1515/znc-2021-0095
Database	MEDical Literature Analysis and Retrieval System OnLINE

In stock of ZB MED Cologne/Königswinter

Zs.A 962: Show issues

Location:
Je nach Verfügbarkeit (siehe Angabe bei Bestand)
bis Jg. 1994: Bestellungen von Artikeln über das Online-Bestellformular
Jg. 1995 - 2021: Lesesall (1.OG)
ab Jg. 2022: Lesesaal (EG)

Order via subito

Details ▾
- See ZB MED holdings
- Order with fees

Article ; Online: Antiproliferative and Antiangiogenic Properties of New VEGFR-2-targeting 2-thioxobenzo[

Abuelizz, Hatem A / Marzouk, Mohamed / Bakheit, Ahmed H / Awad, Hanem M / Soltan, Maha M / Naglah, Ahmed M / Al-Salahi, Rashad

Molecules (Basel, Switzerland)

2020 Volume 25, Issue 24

Abstract: A series of 3-ethyl(methyl)-2-thioxo-2,3-dihydrobenzo[ ...

Abstract	A series of 3-ethyl(methyl)-2-thioxo-2,3-dihydrobenzo[
MeSH term(s)	Angiogenesis Inhibitors/chemistry ; Angiogenesis Inhibitors/pharmacology ; Antineoplastic Agents/chemistry ; Antineoplastic Agents/pharmacology ; Apoptosis/drug effects ; Cell Cycle/drug effects ; Cell Proliferation/drug effects ; Cell Survival/drug effects ; Dose-Response Relationship, Drug ; Drug Design ; Drug Screening Assays, Antitumor ; Hep G2 Cells ; Humans ; MCF-7 Cells ; Molecular Targeted Therapy ; Quinazolines/chemistry ; Quinazolines/pharmacology ; Structure-Activity Relationship ; Vascular Endothelial Growth Factor Receptor-2/metabolism
Chemical Substances	Angiogenesis Inhibitors ; Antineoplastic Agents ; Quinazolines ; Vascular Endothelial Growth Factor Receptor-2 (EC 2.7.10.1)
Language	English
Publishing date	2020-12-15
Publishing country	Switzerland
Document type	Journal Article
ZDB-ID	1413402-0
ISSN	1420-3049 ; 1431-5165 ; 1420-3049
ISSN (online)	1420-3049
ISSN	1431-5165 ; 1420-3049
DOI	10.3390/molecules25245944
Database	MEDical Literature Analysis and Retrieval System OnLINE

In stock of ZB MED Cologne/Königswinter

Zs.MO 81: Show issues

Order via subito

Details ▾
- See ZB MED holdings
- Order with fees

Article ; Online: Synthesis and biological evaluation of novel 5-chloro-

Galal, Alaaeldin M F / Soltan, Maha M / Ahmed, Esam R / Hanna, Atef G

MedChemComm

2018 Volume 9, Issue 9, Page(s) 1511–1528

Abstract: A novel series of sulfonamide derivatives, coupled with a salicylamide scaffold, was designed and synthesized. The structures of the synthesized compounds were established ... ...

Abstract	A novel series of sulfonamide derivatives, coupled with a salicylamide scaffold, was designed and synthesized. The structures of the synthesized compounds were established using
Language	English
Publishing date	2018-07-26
Publishing country	England
Document type	Journal Article
ZDB-ID	2545949-1
ISSN	2040-2511 ; 2040-2503
ISSN (online)	2040-2511
ISSN	2040-2503
DOI	10.1039/c8md00214b
Database	MEDical Literature Analysis and Retrieval System OnLINE

Order via subito

To top

More links

Kategorien

Order via subito

More links

Kategorien

In stock of ZB MED Bonn / Germany

Order via subito

Inter-library loan at ZB MED

More links

Kategorien

Order via subito

More links

Kategorien

In stock of ZB MED Bonn / Germany

Order via subito

Inter-library loan at ZB MED

More links

Kategorien

In stock of ZB MED Bonn / Germany

Order via subito

Inter-library loan at ZB MED

More links

Kategorien

In stock of ZB MED Cologne/Königswinter

Order via subito

More links

Kategorien

In stock of ZB MED Cologne/Königswinter

Order via subito

More links

Kategorien

In stock of ZB MED Cologne/Königswinter

Order via subito

More links

Kategorien

In stock of ZB MED Cologne/Königswinter

Order via subito

More links

Kategorien

Order via subito