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  1. AU="Somenath Mitra"
  2. AU=Zhao Limei AU=Zhao Limei
  3. AU="Feng, Sheau-Line"
  4. AU="Goldman, Nick"
  5. AU="Oumezzine, Ma"
  6. AU="Elena D. Nosyreva"
  7. AU="Birara, Sunita"
  8. AU=Banegas Matthew P. AU=Banegas Matthew P.
  9. AU="Mendelow, Alexander David"
  10. AU="Pereira, Taci"
  11. AU="Natalie Taylor"
  12. AU="Moradi, Tayebeh"
  13. AU="Ramesh C. Santra"
  14. AU="Selvarajah, Aravinda"
  15. AU="Vaisman, Adva"
  16. AU="Rádiková, Žofia"
  17. AU=Poulin Stphane P.

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  1. Artikel ; Online: Synthesis of Microwave Functionalized, Nanostructured Polylactic Co-Glycolic Acid ( nf PLGA) for Incorporation into Hydrophobic Dexamethasone to Enhance Dissolution

    Mohammad Saiful Islam / Somenath Mitra

    Nanomaterials, Vol 13, Iss 943, p

    2023  Band 943

    Abstract: The low solubility and slow dissolution of hydrophobic drugs is a major challenge for the pharmaceutical industry. In this paper, we present the synthesis of surface-functionalized poly(lactic-co-glycolic acid) (PLGA) nanoparticles for incorporation into ...

    Abstract The low solubility and slow dissolution of hydrophobic drugs is a major challenge for the pharmaceutical industry. In this paper, we present the synthesis of surface-functionalized poly(lactic-co-glycolic acid) (PLGA) nanoparticles for incorporation into corticosteroid dexamethasone to improve its in vitro dissolution profile. The PLGA crystals were mixed with a strong acid mixture, and their microwave-assisted reaction led to a high degree of oxidation. The resulting nanostructured, functionalized PLGA ( nf PLGA), was quite water-dispersible compared to the original PLGA, which was non-dispersible. SEM-EDS analysis showed 53% surface oxygen concentration in the nf PLGA compared to the original PLGA, which had only 25%. The nf PLGA was incorporated into dexamethasone (DXM) crystals via antisolvent precipitation. Based on SEM, RAMAN, XRD, TGA and DSC measurements, the nf PLGA-incorporated composites retained their original crystal structures and polymorphs. The solubility of DXM after nf PLGA incorporation (DXM– nf PLGA) increased from 6.21 mg/L to as high as 87.1 mg/L and formed a relatively stable suspension with a zeta potential of −44.3 mV. Octanol–water partitioning also showed a similar trend as the logP reduced from 1.96 for pure DXM to 0.24 for DXM– nf PLGA. In vitro dissolution testing showed 14.0 times higher aqueous dissolution of DXM– nf PLGA compared to pure DXM. The time for 50% (T 50 ) and 80% (T 80 ) of gastro medium dissolution decreased significantly for the nf PLGA composites; T 50 reduced from 57.0 to 18.0 min and T 80 reduced from unachievable to 35.0 min. Overall, the PLGA, which is an FDA-approved, bioabsorbable polymer, can be used to enhance the dissolution of hydrophobic pharmaceuticals and this can lead to higher efficacy and lower required dosage.
    Schlagwörter hydrophobic drug ; FDA polymer ; microwave functionalization ; dexamethasone ; in vitro dissolution ; absorption bioavailability ; Chemistry ; QD1-999
    Thema/Rubrik (Code) 500
    Sprache Englisch
    Erscheinungsdatum 2023-03-01T00:00:00Z
    Verlag MDPI AG
    Dokumenttyp Artikel ; Online
    Datenquelle BASE - Bielefeld Academic Search Engine (Lebenswissenschaftliche Auswahl)

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  2. Artikel ; Online: Reduction and Elimination of Humic Acid Fouling in Air Sparged Membrane Distillation Using Nanocarbon Immobilized Membrane

    Mitun Chandra Bhoumick / Sagar Roy / Somenath Mitra

    Molecules, Vol 27, Iss 2896, p

    2022  Band 2896

    Abstract: In this paper, we present the treatment of humic acid solution via carbon nanotube immobilized membrane (CNIM) distillation assisted by air sparging (AS). Carbon nanotubes offer excellent hydrophobicity to the modified membrane surface and actively ... ...

    Abstract In this paper, we present the treatment of humic acid solution via carbon nanotube immobilized membrane (CNIM) distillation assisted by air sparging (AS). Carbon nanotubes offer excellent hydrophobicity to the modified membrane surface and actively transport water vapor molecules through the membrane to generate higher vapor flux and better rejection of humic acid. The introduction of air sparging in the membrane distillation (MD) system has changed the humic substance fouling by changing the colloidal behavior of the deposits. This modified MD system can sustain a higher run time of separation and has enhanced the evaporation efficiency by 20% more than the regular membrane distillation. The air sparging has reduced the deposition by 30% in weight and offered lesser fouling of membrane surface even after a longer operating cycle. The water vapor flux increased with temperature and decreased as the volumetric concentrating factor (VCF) increased. The mass transfer coefficient was found to be the highest for the air sparged—carbon nanotube immobilized membrane (AS-CNIM) integrated membrane distillation. While the highest change in mass transfer coefficient (MTC) was found for polytetrafluoroethylene (PTFE) membrane with air sparging at 70 °C.
    Schlagwörter air sparging ; membrane fouling ; carbon nanotubes ; hydrophobic membrane and evaporation efficiency ; Organic chemistry ; QD241-441
    Thema/Rubrik (Code) 660
    Sprache Englisch
    Erscheinungsdatum 2022-05-01T00:00:00Z
    Verlag MDPI AG
    Dokumenttyp Artikel ; Online
    Datenquelle BASE - Bielefeld Academic Search Engine (Lebenswissenschaftliche Auswahl)

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  3. Artikel ; Online: Controlling the Dissolution Rate of Hydrophobic Drugs by Incorporating Carbon Nanotubes with Different Levels of Carboxylation

    Kun Chen / Somenath Mitra

    Applied Sciences, Vol 9, Iss 7, p

    2019  Band 1475

    Abstract: We present the anti-solvent precipitation of hydrophobic drugs griseofulvin (GF) and sulfamethoxazole (SMZ) in the presence of carboxylated carbon nanotubes (f-CNTs). The aqueous dispersed f-CNTs were directly incorporated into the drug particles during ... ...

    Abstract We present the anti-solvent precipitation of hydrophobic drugs griseofulvin (GF) and sulfamethoxazole (SMZ) in the presence of carboxylated carbon nanotubes (f-CNTs). The aqueous dispersed f-CNTs were directly incorporated into the drug particles during the precipitation process. f-CNTs with different levels of carboxylation were tested where the hydrophilicity was varied by altering the C:COOH ratio. The results show that the hydrophilic f-CNTs dramatically enhanced the dissolution rate for both drugs, and the enhancement corresponded to the hydrophilicity of f-CNTs. The time to reach 80% dissolution (t80) reduced from 52.5 min for pure SMZ to 16.5 min when incorporated f-CNTs that had a C:COOH ratio of 23.2 were used, and to 11.5 min when the ratio dropped to 16. A corresponding decrease was observed for SMZ for the above-mentioned f-CNTs. The study clearly demonstrates that it is possible to control the dissolution rate of hydrophobic drugs by altering the level of carboxylation of the incorporated CNTs.
    Schlagwörter hydrophobic drugs ; drug delivery ; functionalized carbon nanotubes ; dissolution rate ; nanomedicine ; Technology ; T ; Engineering (General). Civil engineering (General) ; TA1-2040 ; Biology (General) ; QH301-705.5 ; Physics ; QC1-999 ; Chemistry ; QD1-999
    Thema/Rubrik (Code) 500
    Sprache Englisch
    Erscheinungsdatum 2019-04-01T00:00:00Z
    Verlag MDPI AG
    Dokumenttyp Artikel ; Online
    Datenquelle BASE - Bielefeld Academic Search Engine (Lebenswissenschaftliche Auswahl)

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  4. Artikel ; Online: Development of a Carbon Nanotube-Enhanced FAS Bilayer Amphiphobic Coating for Biological Fluids

    Sumona Paul / Lingfen Rao / Louis H. Stein / Arash Salemi / Somenath Mitra

    Nanomaterials, Vol 13, Iss 24, p

    2023  Band 3138

    Abstract: This study reports the development of a novel amphiphobic coating. The coating is a bilayer arrangement, where carbon nanotubes (CNTs) form the underlayer and fluorinated alkyl-silane (FAS) forms the overlayer, resulting in the development of highly ... ...

    Abstract This study reports the development of a novel amphiphobic coating. The coating is a bilayer arrangement, where carbon nanotubes (CNTs) form the underlayer and fluorinated alkyl-silane (FAS) forms the overlayer, resulting in the development of highly amphiphobic coatings suitable for a wide range of substrates. The effectiveness of these coatings is demonstrated through enhanced contact angles for water and artificial blood plasma fluid on glass, stainless steel, and porous PTFE. The coatings were characterized using Fourier-transform infrared spectroscopy (FTIR), scanning electron microscopy (SEM), thermogravimetric analysis (TGA), atomic force microscopy (AFM), and contact angle (CA) measurements. The water contact angles achieved with the bilayer coating were 106 ± 2°, 116 ± 2°, and 141 ± 2° for glass, stainless steel, and PTFE, respectively, confirming the hydrophobic nature of the coating. Additionally, the coating displayed high repellency for blood plasma, exhibiting contact angles of 102 ± 2°, 112 ± 2°, and 134 ± 2° on coated glass, stainless steel, and PTFE surfaces, respectively. The presence of the CNT underlayer improved plasma contact angles by 29%, 21.7%, and 16.5% for the respective surfaces. The presence of the CNT layer improved surface roughness significantly, and the average roughness of the bilayer coating on glass, stainless steel, and PTFE was measured to be 488 nm, 301 nm, and 274 nm, respectively. Mechanistically, the CNT underlayer contributed to the surface roughness, while the FAS layer provided high amphiphobicity. The maximum effect was observed on modified glass, followed by stainless steel and PTFE surfaces. These findings highlight the promising potential of this coating method across diverse applications, particularly in the biomedical industry, where it can help mitigate complications associated with device–fluid interactions.
    Schlagwörter nanomaterial coatings ; biomedical devices ; hydrophobicity ; amphiphobic surface ; carbon nanotubes ; fluoroalkyl silane ; Chemistry ; QD1-999
    Thema/Rubrik (Code) 620
    Sprache Englisch
    Erscheinungsdatum 2023-12-01T00:00:00Z
    Verlag MDPI AG
    Dokumenttyp Artikel ; Online
    Datenquelle BASE - Bielefeld Academic Search Engine (Lebenswissenschaftliche Auswahl)

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  5. Artikel ; Online: Stepwise Reduction of Graphene Oxide (GO) and Its Effects on Chemical and Colloidal Properties

    Samar Azizighannad / Somenath Mitra

    Scientific Reports, Vol 8, Iss 1, Pp 1-

    2018  Band 8

    Abstract: Abstract Graphene Oxides (GO) typically contains different oxygen containing groups such as hydroxyl, carboxyl and epoxy, and reduced GO (r-GO) represents a family of material with diverse chemical properties. In an effort to understand how properties of ...

    Abstract Abstract Graphene Oxides (GO) typically contains different oxygen containing groups such as hydroxyl, carboxyl and epoxy, and reduced GO (r-GO) represents a family of material with diverse chemical properties. In an effort to understand how properties of r-GO change as GO is reduced, a stepwise reduction of the same GO to r-GO containing different levels of oxygen was carried out, and their corresponding chemical and colloidal properties are reported. Starting with GO containing 49 percent oxygen, r-GOs containing 31, 19 and 9 percent oxygen were synthesized. The aqueous behavior in terms of solubility gradually decreased from 7.4 µg/ml for GO to nearly zero for r-GO with 9% oxygen, while dispersibility under sonication decreased from 8 to 2.5 µg/ml for the same samples. Hydrophobicity index as measured as the octanol water partition coefficient decreased from −3.89 to 5.2% as oxygen content dropped from 49 to 9%. Colloidal behavior was also dramatically affected by reduction, and critical coagulation concentration (CCC) dropped from 28 to 15 in presence of 0.5 mmole/l NaCl and from 6 to 2 in presence of 0.5 mmole/l MgCl2 as the oxygen in the original GO was reduced to 9%.
    Schlagwörter Medicine ; R ; Science ; Q
    Sprache Englisch
    Erscheinungsdatum 2018-07-01T00:00:00Z
    Verlag Nature Portfolio
    Dokumenttyp Artikel ; Online
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  6. Artikel ; Online: Dry Reforming of Methane over a Ruthenium/Carbon Nanotube Catalyst

    Yuan Zhu / Kun Chen / Robert Barat / Somenath Mitra

    ChemEngineering, Vol 4, Iss 1, p

    2020  Band 16

    Abstract: In this study, CH 4 dry reforming was demonstrated on a novel microwave-synthesized ruthenium (Ru)/carbon nanotube (CNT) catalyst. The catalyst was tested in an isothermal laboratory-packed bed reactor, with gas analysis by gas chromatography/thermal ... ...

    Abstract In this study, CH 4 dry reforming was demonstrated on a novel microwave-synthesized ruthenium (Ru)/carbon nanotube (CNT) catalyst. The catalyst was tested in an isothermal laboratory-packed bed reactor, with gas analysis by gas chromatography/thermal conductivity detection. The catalyst demonstrated excellent dry-reforming activity at modest temperatures (773–973 K) and pressure (3.03 × 10 5 Pa). Higher reaction temperatures favored increased conversion of CH 4 and CO 2 , and increased H 2 /CO product ratios. Slight coke deposition, estimated by carbon balance, was observed at higher temperatures and higher feed CH 4 /CO 2 . A robust global kinetic model composed of three reversible reactions—dry reforming, reverse water gas shift, and CH 4 decomposition—simulates observed outlet species concentrations and reactant conversions using this Ru/CNT catalyst over the temperature range of this study. This engineering kinetic model for the Ru/CNT catalyst predicts a somewhat higher selectivity and yield for H 2 , and less for CO, in comparison to previously published results for a similarly prepared Pt_Pd/CNT catalyst from our group.
    Schlagwörter catalysis ; ruthenium ; reforming ; carbon nanotubes ; methane ; carbon dioxide ; Chemistry ; QD1-999
    Thema/Rubrik (Code) 660
    Sprache Englisch
    Erscheinungsdatum 2020-03-01T00:00:00Z
    Verlag MDPI AG
    Dokumenttyp Artikel ; Online
    Datenquelle BASE - Bielefeld Academic Search Engine (Lebenswissenschaftliche Auswahl)

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  7. Artikel ; Online: Removal and Recovery of Methyl Tertiary Butyl Ether (MTBE) from Water Using Carbon Nanotube and Graphene Oxide Immobilized Membranes

    Worawit Intrchom / Sagar Roy / Somenath Mitra

    Nanomaterials, Vol 10, Iss 3, p

    2020  Band 578

    Abstract: Methyl tert-butyl ether (MTBE) is a widely used gasoline additive that has high water solubility, and is difficult to separate from contaminated ground and surface waters. We present the development in functionalized carbon nanotube-immobilized membranes ...

    Abstract Methyl tert-butyl ether (MTBE) is a widely used gasoline additive that has high water solubility, and is difficult to separate from contaminated ground and surface waters. We present the development in functionalized carbon nanotube-immobilized membranes (CNIM-f) and graphene oxide-immobilized membranes (GOIM) for enhanced separation of MTBE via sweep gas membrane distillation (SGMD). Both types of modified membranes demonstrated high performance in MTBE removal from its aqueous mixture. Among the membranes studied, CNIM-f provided the best performance in terms of flux, removal efficiency, mass transfer coefficients and overall selectivity. The immobilization f-CNTs and GO altered the surface characteristics of the membrane and enhanced partition coefficients, and thus assisted MTBE transport across the membrane. The MTBE flux reached as high as 1.4 kg/m 2 h with f-CNTs, which was 22% higher than that of the unmodified PTFE membrane. The maximum MTBE removal using CNIM-f reached 56% at 0.5 wt % of the MTBE in water, and at a temperature of 30 °C. With selectivity as high as 60, MTBE recovery from contaminated water is very viable using these nanocarbon-immobilized membranes.
    Schlagwörter mtbe separation ; functionalized carbon nanotube immobilized membranes (cnim-f) ; graphene oxide immobilized membranes (goim) ; sweep gas membrane distillation (sgmd) ; flux enhancement ; Chemistry ; QD1-999
    Thema/Rubrik (Code) 660
    Sprache Englisch
    Erscheinungsdatum 2020-03-01T00:00:00Z
    Verlag MDPI AG
    Dokumenttyp Artikel ; Online
    Datenquelle BASE - Bielefeld Academic Search Engine (Lebenswissenschaftliche Auswahl)

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  8. Artikel ; Online: Nano Carbon Doped Polyacrylamide Gel Electrolytes for High Performance Supercapacitors

    Samar Azizighannad / Zhiqian Wang / Zain Siddiqui / Vivek Kumar / Somenath Mitra

    Molecules, Vol 26, Iss 2631, p

    2021  Band 2631

    Abstract: Novel polyacrylamide gel electrolytes (PGEs) doped with nano carbons with enhanced electrochemical, thermal, and mechanical properties are presented. Carboxylated carbon nanotubes (fCNTs), graphene oxide sheets (GO), and the hybrid of fCNT/GO were ... ...

    Abstract Novel polyacrylamide gel electrolytes (PGEs) doped with nano carbons with enhanced electrochemical, thermal, and mechanical properties are presented. Carboxylated carbon nanotubes (fCNTs), graphene oxide sheets (GO), and the hybrid of fCNT/GO were embedded in the PGEs to serve as supercapacitor (SC) electrolytes. Thermal stability of the unmodified PGE increased with the addition of the nano carbons which led to lower capacitance degradation and longer cycling life of the SCs. The fCNT/GO-PGE showed the best thermal stability, which was 50% higher than original PGE. Viscoelastic properties of PGEs were also improved with the incorporation of GO and fCNT/GO. Oxygen-containing functional groups in GO and fCNT/GO hydrogen bonded with the polymer chains and improved the elasticity of PGEs. The fCNT-PGE demonstrated a slightly lower viscous strain uninform distribution of CNTs in the polymer matrix and the defects formed within. Furthermore, ion diffusion between GO layers was enhanced in fCNT/GO-PGE because fCNT decreased the aggregation of GO sheets and improved the ion channels, increasing the gel ionic conductivity from 41 to 132 mS cm −1 . Finally, MnO 2 -based supercapacitors using PGE, fCNT-PGE, GO-PGE, and fCNT/GO-PGE electrolytes were fabricated with the electrode-specific capacitance measured to be 39.5, 65.5, 77.6, and 83.3 F·g −1 , respectively. This research demonstrates the effectiveness of nano carbons as dopants in polymer gel electrolytes for property enhancements.
    Schlagwörter polymer electrolyte ; gel electrolyte ; supercapacitor ; graphene oxide ; carbon nanotube ; Organic chemistry ; QD241-441
    Thema/Rubrik (Code) 540
    Sprache Englisch
    Erscheinungsdatum 2021-04-01T00:00:00Z
    Verlag MDPI AG
    Dokumenttyp Artikel ; Online
    Datenquelle BASE - Bielefeld Academic Search Engine (Lebenswissenschaftliche Auswahl)

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  9. Artikel ; Online: Data related to the synthesis, characterization and electrochemical performance of high capacity sodium manganese periodate electrodes

    Zhiqian Wang / Xianyang Meng / Kun Chen / Somenath Mitra

    Data in Brief, Vol 25, Iss , Pp - (2019)

    2019  

    Abstract: Sodium manganese periodate compounds were synthesized to serve as high capacity cathodes. The composition and morphology of resulting products were characterized by scanning electron microscopy (SEM), energy-dispersive X-ray spectroscopy (EDX), X-ray ... ...

    Abstract Sodium manganese periodate compounds were synthesized to serve as high capacity cathodes. The composition and morphology of resulting products were characterized by scanning electron microscopy (SEM), energy-dispersive X-ray spectroscopy (EDX), X-ray Diffraction (XRD) and thermogravimetric analysis (TGA). Composite cathodes made from the synthesized periodates were used to fabricate batteries with zinc anode and acetic acid electrolyte. Electrode formulations were optimized using nanocarbon conductive additives. For the full design and mechanism related to the sodium manganese periodate electrode with specific capacity as high as 750 mAh g−1, please refer to our research article “High Capacity Aqueous Periodate Batteries Featuring a Nine-Electron Transfer Process” [1]. Keywords: Periodate, Sodium manganese periodate, Battery, Carbon nanotube, Graphene oxide
    Schlagwörter Computer applications to medicine. Medical informatics ; R858-859.7 ; Science (General) ; Q1-390
    Thema/Rubrik (Code) 540
    Sprache Englisch
    Erscheinungsdatum 2019-08-01T00:00:00Z
    Verlag Elsevier
    Dokumenttyp Artikel ; Online
    Datenquelle BASE - Bielefeld Academic Search Engine (Lebenswissenschaftliche Auswahl)

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  10. Artikel ; Online: Hydrophilic and Functionalized Nanographene Oxide Incorporated Faster Dissolving Megestrol Acetate

    Mohammad Saiful Islam / Faradae Renner / Kimberly Foster / Martin S. Oderinde / Kevin Stefanski / Somenath Mitra

    Molecules, Vol 26, Iss 1972, p

    2021  Band 1972

    Abstract: The aim of this work is to present an approach to enhance the dissolution of progestin medication, megestrol acetate (also known as MEGACE), for improving the dissolution rate and kinetic solubility by incorporating nano graphene oxide (nGO). An ... ...

    Abstract The aim of this work is to present an approach to enhance the dissolution of progestin medication, megestrol acetate (also known as MEGACE), for improving the dissolution rate and kinetic solubility by incorporating nano graphene oxide (nGO). An antisolvent precipitation process was investigated for nGO-drug composite preparation, where prepared composites showed crystalline properties that were similar to the pure drug but enhanced aqueous dispersibility and colloidal stability. To validate the efficient release profile of composite, in vitro dissolution testing was carried out using United States Pharmacopeia, USP-42 paddle method, with gastric pH (1.4) and intestinal pH (6.5) solutions to mimic in vivo conditions. Pure MA is practically insoluble (2 µg/mL at 37 °C). With the incorporation of nGO, it was possible to dissolve nearly 100% in the assay. With the incorporation of 1.0% of nGO, the time required to dissolve 50% and 80% of drug, namely T 50 and T 80 , decreased from 138.0 min to 27.0 min, and the drug did not dissolve for 97.0 min in gastric media, respectively. Additionally, studies done in intestinal media have revealed T 50 did not dissolve for 92.0 min. This work shows promise in incorporating functionalized nanoparticles into the crystal lattice of poorly soluble drugs to improve dissolution rate.
    Schlagwörter enhanced dissolution ; nano graphene oxide ; oral medication ; paddle method ; gastrointestinal pH ; megestrol acetate ; Organic chemistry ; QD241-441
    Thema/Rubrik (Code) 500
    Sprache Englisch
    Erscheinungsdatum 2021-03-01T00:00:00Z
    Verlag MDPI AG
    Dokumenttyp Artikel ; Online
    Datenquelle BASE - Bielefeld Academic Search Engine (Lebenswissenschaftliche Auswahl)

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