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  1. Article ; Online: Getting to the Root of Branched Ubiquitin Chains: A Review of Current Methods and Functions.

    Waltho, Anita / Sommer, Thomas

    Methods in molecular biology (Clifton, N.J.)

    2022  Volume 2602, Page(s) 19–38

    Abstract: Nearly 20 years since the first branched ubiquitin (Ub) chains were identified by mass spectrometry, our understanding of these chains and their function is still evolving. This is due to the limitations of classical Ub research techniques in identifying ...

    Abstract Nearly 20 years since the first branched ubiquitin (Ub) chains were identified by mass spectrometry, our understanding of these chains and their function is still evolving. This is due to the limitations of classical Ub research techniques in identifying these chains and the vast complexity of potential branched chains. Considering only lysine or N-terminal methionine attachment sites, there are already 28 different possible branch points. Taking into account recently discovered ester-linked ubiquitination, branch points of more than two linkage types, and the higher-order chain structures within which branch points exist, the diversity of branched chains is nearly infinite. This review breaks down the complexity of these chains into their general functions, what we know so far about the different linkage combinations, branched chain-optimized methodologies, and the future perspectives of branched chain research.
    MeSH term(s) Ubiquitin ; Ubiquitination ; Research Design ; Esters ; Genetic Linkage
    Chemical Substances Ubiquitin ; Esters
    Language English
    Publishing date 2022-11-29
    Publishing country United States
    Document type Review ; Journal Article
    ISSN 1940-6029
    ISSN (online) 1940-6029
    DOI 10.1007/978-1-0716-2859-1_2
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  2. Book ; Thesis: Grundwasserdynamik und Grundwasserbeschaffenheit in der anthropogen überprägten Flussaue der Unstrut

    Sommer, Thomas

    (Proceedings des Dresdner Grundwasserforschungszentrums e.V. ; 20 : Dissertation)

    2001  

    Title variant Auswirkungen anthropogener Überprägungen von Flußauen auf deren Grundwasserdyamik und -beschaffenheit am Beispiel der Unstrut (Thüringen)
    Author's details Thomas Sommer. [Hrsg. Dresdner Grundwasserforschungszentrum e. V.]
    Series title Proceedings des Dresdner Grundwasserforschungszentrums e.V. ; 20 : Dissertation
    Collection
    Language German
    Size VIII, 163 S., [8] Bl. : Ill., graph. Darst., Kt.
    Publisher Dresdner Grundwasserforschungszentrum
    Publishing place Dresden
    Publishing country Germany
    Document type Book ; Thesis
    Thesis / German Habilitation thesis Jena, Univ., Diss., 2000 u.d.T. : Sommer, Thomas: Auswirkungen anthropogener Überprägungen von Flußauen auf deren Grundwasserdynamik und -beschaffenheit am Beispiel der Unstrut (Thüringen)
    HBZ-ID HT013087496
    Database Catalogue ZB MED Nutrition, Environment, Agriculture

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    In stock of ZB MED Bonn / Germany

    Shelf markLoan statusLocation
    008/3907 available for loan (reading room) Freihandmagazin (U1)

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  3. Article ; Online: Mechanisms of substrate processing during ER-associated protein degradation.

    Christianson, John C / Jarosch, Ernst / Sommer, Thomas

    Nature reviews. Molecular cell biology

    2023  Volume 24, Issue 11, Page(s) 777–796

    Abstract: Maintaining proteome integrity is essential for long-term viability of all organisms and is overseen by intrinsic quality control mechanisms. The secretory pathway of eukaryotes poses a challenge for such quality assurance as proteins destined for ... ...

    Abstract Maintaining proteome integrity is essential for long-term viability of all organisms and is overseen by intrinsic quality control mechanisms. The secretory pathway of eukaryotes poses a challenge for such quality assurance as proteins destined for secretion enter the endoplasmic reticulum (ER) and become spatially segregated from the cytosolic machinery responsible for disposal of aberrant (misfolded or otherwise damaged) or superfluous polypeptides. The elegant solution provided by evolution is ER-membrane-bound ubiquitylation machinery that recognizes misfolded or surplus proteins or by-products of protein biosynthesis in the ER and delivers them to 26S proteasomes for degradation. ER-associated protein degradation (ERAD) collectively describes this specialized arm of protein quality control via the ubiquitin-proteasome system. But, instead of providing a single strategy to remove defective or unwanted proteins, ERAD represents a collection of independent processes that exhibit distinct yet overlapping selectivity for a wide range of substrates. Not surprisingly, ER-membrane-embedded ubiquitin ligases (ER-E3s) act as central hubs for each of these separate ERAD disposal routes. In these processes, ER-E3s cooperate with a plethora of specialized factors, coordinating recognition, transport and ubiquitylation of undesirable secretory, membrane and cytoplasmic proteins. In this Review, we focus on substrate processing during ERAD, highlighting common threads as well as differences between the many routes via ERAD.
    Language English
    Publishing date 2023-08-01
    Publishing country England
    Document type Journal Article ; Review
    ZDB-ID 2031313-5
    ISSN 1471-0080 ; 1471-0072
    ISSN (online) 1471-0080
    ISSN 1471-0072
    DOI 10.1038/s41580-023-00633-8
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  4. Book ; Online ; Thesis: Rho GTPases orchestrate flow-mechanical coupling and adaptive migration in endothelium

    Sommer, Thomas [Gutachter] / Gerhardt, Holger [Gutachter] / Szulcek, Robert [Gutachter]

    2024  

    Author's details Gutachter: Thomas Sommer, Holger Gerhardt, Robert Szulcek
    Keywords Biowissenschaften, Biologie ; Life Science, Biology
    Subject code sg570
    Language English
    Publisher Humboldt-Universität zu Berlin
    Publishing place Berlin
    Document type Book ; Online ; Thesis
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  5. Article ; Online: Thioester and Oxyester Linkages in the Ubiquitin System.

    Ferri-Blazquez, Alba / Jarosch, Ernst / Sommer, Thomas

    Methods in molecular biology (Clifton, N.J.)

    2022  Volume 2602, Page(s) 3–18

    Abstract: The traditional textbook describes ubiquitylation as the conjugation of ubiquitin to a target by forming a covalent bond connecting ubiquitin's carboxy-terminal glycine residue with an acceptor amino acid like lysine or amino-terminal methionine in the ... ...

    Abstract The traditional textbook describes ubiquitylation as the conjugation of ubiquitin to a target by forming a covalent bond connecting ubiquitin's carboxy-terminal glycine residue with an acceptor amino acid like lysine or amino-terminal methionine in the substrate protein. While this adequately depicts a significant fraction of cellular ubiquitylation processes, a growing number of ubiquitin modifications do not follow this rule. Recent data demonstrate that ubiquitin can also be efficiently attached to other amino acids, such as cysteine, serine, and threonine, via ester bonding. Initially observed for a virus-encoded ubiquitin ligase, which targets a cysteine residue in a host protein to initiate its degradation, ester-linked ubiquitylation is now shown to also drive regular cellular processes. These ubiquitylation events expand the complexity and diversity of ubiquitin signaling and broaden the capability of cellular messages in the so-called ubiquitin code. Still, questions on the prevalence, relevance, and involvement in physiological and cellular functions await clearing. In this review, we aim to summarize our knowledge on ester-linked ubiquitylation and introduce experimental strategies to circumvent technical issues that complicate analysis of this uncommon posttranslational modification.
    MeSH term(s) Ubiquitin ; Cysteine ; Ubiquitination ; Protein Processing, Post-Translational ; Amino Acids ; Esters
    Chemical Substances Ubiquitin ; Cysteine (K848JZ4886) ; Amino Acids ; Esters
    Language English
    Publishing date 2022-11-29
    Publishing country United States
    Document type Review ; Journal Article
    ISSN 1940-6029
    ISSN (online) 1940-6029
    DOI 10.1007/978-1-0716-2859-1_1
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  6. Book ; Online ; Thesis: The assembly and disassembly of the IL-1 signaling pathway

    Deliz-Aguirre, Rafael [Verfasser] / Narayanan, Arjun [Gutachter] / Romagnani, Chiara [Gutachter] / Sommer, Thomas [Gutachter]

    2024  

    Author's details Rafael Deliz-Aguirre ; Gutachter: Arjun Narayanan, Chiara Romagnani, Thomas Sommer
    Keywords Biowissenschaften, Biologie ; Life Science, Biology
    Subject code sg570
    Language English
    Publisher Humboldt-Universität zu Berlin
    Publishing place Berlin
    Document type Book ; Online ; Thesis
    Database Digital theses on the web

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  7. Book ; Online: Toxikologische Charakterisierung von Nanomaterialien für die diagnostische Bildgebung in der Medizin - Nanomed

    Sommer, Thomas

    Abschlussbericht

    2012  

    Title variant Nanomed
    Author's details Thomas Sommer
    Language German
    Size Online-Ressource (16 S., 688 KB), graph. Darst.
    Publisher Technische Informationsbibliothek u. Universitätsbibliothek ; PerkinElmer chemagen Technologie GmbH
    Publishing place Hannover ; Baesweiler
    Document type Book ; Online
    Note Auch als gedr. Ausg. vorhanden ; Förderkennzeichen BMBF 03X0104B. - Verbund-Nr. 01072233 ; Unterschiede zwischen dem gedruckten Dokument und der elektronischen Ressource können nicht ausgeschlossen werden
    Database Library catalogue of the German National Library of Science and Technology (TIB), Hannover

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  8. Book ; Online ; Thesis: Exploiting proteasome function in senescence-associated proteotoxicity as target principle in lymphoma therapy

    Sommer, Thomas Gutachter] / [Schmitt, Clemens Alexander [Gutachter] / Krönke, Jan [Gutachter]

    2022  

    Author's details Gutachter: Thomas Sommer, Clemens A. Schmitt, Jan Krönke
    Keywords Biowissenschaften, Biologie ; Life Science, Biology
    Subject code sg570
    Language English
    Publisher Humboldt-Universität zu Berlin
    Publishing place Berlin
    Document type Book ; Online ; Thesis
    Database Digital theses on the web

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  9. Article: Krankenhaus: (Doch keine) obligatorische Schlichtung bei Vergütungsstreitigkeiten. BSG, Urt. v. 23.6.2015 - B 1 KR 26/14 R m. Anm. Dr. Thomas Sommer

    Sommer, Thomas

    Gesundheitsrecht

    2015  Volume 14, Issue 8, Page(s) 482

    Language German
    Document type Article
    ZDB-ID 2092255-3
    ISSN 1610-1197
    Database Current Contents Medicine

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    In stock of ZB MED Cologne/Königswinter

    Zs.A 6441: Show issues Location:
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  10. Article ; Online: Absorption, Biokinetics, and Metabolism of the Dopamine D2 Receptor Agonist Hordenine (

    Sommer, Thomas / Göen, Thomas / Budnik, Nadja / Pischetsrieder, Monika

    Journal of agricultural and food chemistry

    2020  Volume 68, Issue 7, Page(s) 1998–2006

    Abstract: Hordenine, a natural constituent of germinated barley, is a biased agonist of the dopamine D2 receptor. This pilot study investigated the biokinetics of hordenine and its metabolites in four volunteers consuming beer equal to 0.075 mg hordenine/kg body ... ...

    Abstract Hordenine, a natural constituent of germinated barley, is a biased agonist of the dopamine D2 receptor. This pilot study investigated the biokinetics of hordenine and its metabolites in four volunteers consuming beer equal to 0.075 mg hordenine/kg body weight. A new ultrahigh-performance liquid chromatography method coupled to electrospray ionization tandem mass spectrometry (UHPLC-ESI-MS/MS) method determined maximum plasma concentrations of 12.0-17.3 nM free hordenine after 0-60 min. Hordenine phase-II metabolism was first dominated by sulfation, but later by glucuronidation. The elimination half-lives in plasma were 52.7-66.4 min for free hordenine and about 60/80 min longer for hordenine sulfate and hordenine glucuronide. Urinary excretion peaked 2-3.5 h after consumption and accumulated to 3.78 μmol within 24 h, corresponding to 9.9% of the ingested dose. The observed hordenine levels in plasma seem too low to provoke direct interaction with the dopamine D2 receptor related to food reward, but synergistic or additive effects with alcohol or
    MeSH term(s) Adult ; Beer/analysis ; Chromatography, High Pressure Liquid ; Dopamine Agonists/blood ; Dopamine Agonists/pharmacokinetics ; Dopamine Agonists/urine ; Female ; Humans ; Male ; Middle Aged ; Receptors, Dopamine D2/chemistry ; Receptors, Dopamine D2/metabolism ; Tandem Mass Spectrometry ; Tyramine/analogs & derivatives ; Tyramine/blood ; Tyramine/pharmacokinetics ; Tyramine/urine ; Young Adult
    Chemical Substances Dopamine Agonists ; Receptors, Dopamine D2 ; hordenine (K3489CA082) ; Tyramine (X8ZC7V0OX3)
    Language English
    Publishing date 2020-02-05
    Publishing country United States
    Document type Journal Article
    ZDB-ID 241619-0
    ISSN 1520-5118 ; 0021-8561
    ISSN (online) 1520-5118
    ISSN 0021-8561
    DOI 10.1021/acs.jafc.9b06029
    Database MEDical Literature Analysis and Retrieval System OnLINE

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