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Book ; Online: Business, Open Innovation and Art

Song, Beibei / Formica, Piero / Springborg, Claus

2020

Keywords	Film, TV & radio ; classical guitar study ; divergent thinking ; creativity training ; creative problem-solving ; innovation ; entrepreneurship ; management ; Beuys ; social sculpture ; ecology ; open innovation ; social innovation ; sustainable development ; collaboration ; cross-disciplinary ; intuitive thinking ; qualitative thinking ; communication ; team building ; problem solving ; risk taking ; design ; creativity ; business ; education ; training ; professional development ; creative thinking ; theories ; arts ; arts-based methods ; Art Thinking ; Design Thinking ; strategy ; Art Hacking ; arts-based intervention ; creative leadership ; idea generation ; art-thinking ; choreography ; climate change ; dance ; food culture ; light design ; light pollution ; phenomenology ; sustainability ; visual art ; artscience collaboration ; artist-in-residence ; artist residency program ; arts-based initiatives ; artscience ; interdisciplinary collaboration ; art and technology ; art and innovation
Size	1 electronic resource (155 pages)
Publisher	MDPI - Multidisciplinary Digital Publishing Institute
Publishing place	Basel, Switzerland
Document type	Book ; Online
Note	English ; Open Access
HBZ-ID	HT021046923
ISBN	9783039366163 ; 3039366165
Database	ZB MED Catalogue: Medicine, Health, Nutrition, Environment, Agriculture

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Article ; Online: Research on Curriculum Reform of Higher Education Major Based on OBE Education Concept

Song Beibei

SHS Web of Conferences, Vol 162, p

2023 Volume 01006

Abstract: As an important venue for continuously exporting talents to China society, universities shoulder the task of adapting to the strategic development needs of China and educating people. However, at this stage, with the acceleration of the popularization of ...

Abstract	As an important venue for continuously exporting talents to China society, universities shoulder the task of adapting to the strategic development needs of China and educating people. However, at this stage, with the acceleration of the popularization of tertiary education, the traditional instructional mode has been unable to meet the new requirements of personnel training. Teaching reform, as an important part of improving instructional level, has been paid more and more attention by universities. Universities are constantly improving themselves in teaching methods, curriculum, personnel training and goal setting, so as to promote the output of compound talents. OBE education concept emphasizes students’ learning achievements and belongs to a new educational concept. Once put forward, it has been highly valued and widely concerned by the education sector, which has guided the correct direction for the pursuit of excellent education in major universities at present. This article introduces the connotation and core elements of OBE education concept; This article analyzes the present situation and existing problems of educational management in universities. On this basis, based on the concept of OBE education, this article puts forward the corresponding strategies to improve the instructional mode in universities, so as to promote the sustainable reform of the courses of education majors in universities, and thus improve the quality of talent training in universities.
Keywords	obe educational concept ; teaching mode ; curriculum revolution ; Social Sciences ; H
Subject code	370
Language	English
Publishing date	2023-01-01T00:00:00Z
Publisher	EDP Sciences
Document type	Article ; Online
Database	BASE - Bielefeld Academic Search Engine (life sciences selection)

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Article ; Online: Impact of electronic cigarette usage on the onset of respiratory symptoms and COPD among Chinese adults.

Song, Beibei / Li, Honglin / Zhang, Huiran / Jiao, Libin / Wu, Siyu

Scientific reports

2024 Volume 14, Issue 1, Page(s) 5598

Abstract: The prevalence of dual usage and the relatively low cessation rate among e-cigarette (EC) users suggest that ECs have not demonstrated significant effectiveness as a smoking cessation tool. Furthermore, there has been a substantial increase in the ... ...

Abstract	The prevalence of dual usage and the relatively low cessation rate among e-cigarette (EC) users suggest that ECs have not demonstrated significant effectiveness as a smoking cessation tool. Furthermore, there has been a substantial increase in the prevalence of EC usage in recent years. Therefore, the objective of this study is to investigate the association between EC use and the incidence of respiratory symptoms and chronic obstructive pulmonary disease (COPD). A total of 10,326 participants aged between 20 and 55 years, without any respiratory diseases or COPD, were recruited for the study. These individuals attended employee physical examinations conducted at 16 public hospitals in Hebei province, China from 2015 to 2020. Logistic regression models were utilized to assess the association between EC use and the risk of respiratory symptoms and COPD using risk ratios along with their corresponding 95% confidence intervals. Restricted cubic spline functions were employed to investigate the dose-response non-linear relationship. The robustness of the logistic regression models was evaluated through subgroup analyses, and sensitivity analyses. During the 5-year follow-up period, a total of 1071 incident cases of respiratory symptoms and 146 incident cases of COPD were identified in this cohort study. After adjusting for relevant confounding factors, EC users demonstrated a respective increase in the risk of reporting respiratory symptoms and COPD by 28% and 8%. Furthermore, dual users who used both ECs and combustible cigarettes exhibited an elevated risk of incident respiratory symptoms and COPD by 41% and 18%, respectively, compared to those who had never used non-users of any cigarette products. The association between daily EC consumption and the development of respiratory symptoms, as well as COPD, demonstrated a significant J-shaped pattern. The potential adverse association between the consumption of ECs, particularly when used in combination with combustible cigarettes, and the development of respiratory symptoms and COPD necessitates careful consideration. Policymakers should approach ECs cautiously as a prospective smoking cessation tool.
MeSH term(s)	Adult ; Humans ; Young Adult ; Middle Aged ; Electronic Nicotine Delivery Systems ; Cohort Studies ; Prospective Studies ; Pulmonary Disease, Chronic Obstructive/epidemiology ; Pulmonary Disease, Chronic Obstructive/etiology ; Pulmonary Disease, Chronic Obstructive/diagnosis ; Smoking Cessation
Language	English
Publishing date	2024-03-07
Publishing country	England
Document type	Journal Article
ZDB-ID	2615211-3
ISSN	2045-2322 ; 2045-2322
ISSN (online)	2045-2322
ISSN	2045-2322
DOI	10.1038/s41598-024-56368-9
Database	MEDical Literature Analysis and Retrieval System OnLINE

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Article ; Online: Myocardial infarction caused by in situ thrombosis of a patent foramen ovale assessed by optical coherence tomography.

Liu, Wenhao / Song, Beibei / Li, Bo

European heart journal

2023 Volume 45, Issue 5, Page(s) 403

MeSH term(s)	Humans ; Foramen Ovale, Patent/complications ; Foramen Ovale, Patent/diagnostic imaging ; Tomography, Optical Coherence ; Myocardial Infarction/etiology ; Thrombosis/etiology ; Thrombosis/complications
Language	English
Publishing date	2023-11-15
Publishing country	England
Document type	Journal Article
ZDB-ID	603098-1
ISSN	1522-9645 ; 0195-668X
ISSN (online)	1522-9645
ISSN	0195-668X
DOI	10.1093/eurheartj/ehad753
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Article ; Online: Simultaneous detection of seven bacterial pathogens transmitted by flies using the reverse line blot hybridization assay.

Ma, Yonghua / Niu, Qingli / Sun, Xiaolin / Li, Yuanyuan / Gou, Huitian / Wang, Zexiang / Song, Beibei

Parasites & vectors

2024 Volume 17, Issue 1, Page(s) 82

Abstract: Background: Traditional methods for detecting insect-borne bacterial pathogens are time-consuming and require specialized laboratory facilities, limiting their applicability in areas without access to such resources. Consequently, rapid and efficient ... ...

Abstract	Background: Traditional methods for detecting insect-borne bacterial pathogens are time-consuming and require specialized laboratory facilities, limiting their applicability in areas without access to such resources. Consequently, rapid and efficient detection methods for insect-borne bacterial diseases have become a pressing need in disease prevention and control. Methods: We aligned the ribosomal 16S rRNA sequences of seven bacterial species (Staphylococcus aureus, Shigella flexneri, Aeromonas caviae, Vibrio vulnificus, Salmonella enterica, Proteus vulgaris, and Yersinia enterocolitica) by DNASTAR Lasergene software. Using DNASTAR Lasergene and Primer Premier software, we designed universal primers RLB-F and RLB-R, two species-specific probes for each pathogen, and a universal probe (catch-all). The PCR products of seven standard strains were hybridized with specific oligonucleotide probes fixed on the membrane for specific experimental procedures. To evaluate the sensitivity of PCR-RLB, genomic DNA was serially diluted from an initial copy number of 10 Results: The established PCR-RLB assay is capable of detecting bacterial strains of about 10 Conclusions: Overall, this research shows that the rapid and efficient PCR-RLB detection technology could be a useful for surveillance and therefore effective prevention and control the spread of insect-borne diseases. Meanwhile, the experimental results indicate that urban sanitation and vector transmission sources are important influencing factors for pathogen transmission.
MeSH term(s)	Animals ; Bacteria/genetics ; Bacteria/isolation & purification ; Diptera/genetics ; Nucleic Acid Hybridization/methods ; RNA, Ribosomal, 16S/genetics ; Sensitivity and Specificity ; Staphylococcus aureus
Chemical Substances	RNA, Ribosomal, 16S
Language	English
Publishing date	2024-02-22
Publishing country	England
Document type	Journal Article
ZDB-ID	2409480-8
ISSN	1756-3305 ; 1756-3305
ISSN (online)	1756-3305
ISSN	1756-3305
DOI	10.1186/s13071-024-06170-3
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Article: The potential of mercury methylation and demethylation by 15 species of marine microalgae

Li, Ying / Li, Dan / Song, Beibei / Li, Yanbin

Water research. 2022 May 15, v. 215

2022

Abstract: Mercury (Hg) and its compounds are a kind of worldwide concerned persistent toxic pollutants. As the major primary producer in the ocean, microalgae are expected to play an important role in the cycling and accumulation of Hg in marine ecosystems by ... ...

Abstract	Mercury (Hg) and its compounds are a kind of worldwide concerned persistent toxic pollutants. As the major primary producer in the ocean, microalgae are expected to play an important role in the cycling and accumulation of Hg in marine ecosystems by either uptake Hg species from seawater or involving in the transformations of Hg species. However, there is still lack of clear knowledge on whether microalgae can induce the methylation and demethylation of Hg in aquatic environments. In this study, Hg isotope dilution and isotope addition techniques were utilized to determine the methylation and demethylation potential of Hg at concentrations comparable to that in natural environments by 15 common marine microalgae (8 species of Diatoms, 4 species of Dinoflagellates, 2 species of Chlorophyta and 1 species of Chrysophyte). Methylation of inorganic Hg was found to be negligible in the culture of all tested marine microalgae, while 6 species could significantly induce the demethylation of methylmercury (MeHg). The rates of microalgae mediated MeHg demethylation were at the same order of magnitude as that of photodemethylation, indicating that marine microalgae may play an important role in the degradation of MeHg in marine environments. Further studies suggest that the demethylation of MeHg by the microalgae may be mainly caused by their extracellular secretions (via photo-induce demethylation) and associated bacteria, rather than the direct demethylation of MeHg by microalgae cells. In addition, it was found that thiol groups may be the major component in microalgal extracellular secretions that lead to the photo-demethylation of MeHg.
Keywords	Chlorophyta ; Miozoa ; demethylation ; isotope dilution technique ; isotopes ; mercury ; methylation ; methylmercury compounds ; microalgae ; research ; seawater ; thiols ; toxicity
Language	English
Dates of publication	2022-0515
Publishing place	Elsevier Ltd
Document type	Article
ZDB-ID	202613-2
ISSN	1879-2448 ; 0043-1354
ISSN (online)	1879-2448
ISSN	0043-1354
DOI	10.1016/j.watres.2022.118266
Database	NAL-Catalogue (AGRICOLA)

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Article ; Online: Electrical Stimulation Enabled via Electrospun Piezoelectric Polymeric Nanofibers for Tissue Regeneration.

Xia, Guangbo / Song, Beibei / Fang, Jian

Research (Washington, D.C.)

2022 Volume 2022, Page(s) 9896274

Abstract: Electrical stimulation has demonstrated great effectiveness in the modulation of cell ... ...

Abstract	Electrical stimulation has demonstrated great effectiveness in the modulation of cell fate
Language	English
Publishing date	2022-08-02
Publishing country	United States
Document type	Journal Article ; Review
ISSN	2639-5274
ISSN (online)	2639-5274
DOI	10.34133/2022/9896274
Database	MEDical Literature Analysis and Retrieval System OnLINE

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Article ; Online: The potential of mercury methylation and demethylation by 15 species of marine microalgae.

Li, Ying / Li, Dan / Song, Beibei / Li, Yanbin

Water research

2022 Volume 215, Page(s) 118266

Abstract	Mercury (Hg) and its compounds are a kind of worldwide concerned persistent toxic pollutants. As the major primary producer in the ocean, microalgae are expected to play an important role in the cycling and accumulation of Hg in marine ecosystems by either uptake Hg species from seawater or involving in the transformations of Hg species. However, there is still lack of clear knowledge on whether microalgae can induce the methylation and demethylation of Hg in aquatic environments. In this study, Hg isotope dilution and isotope addition techniques were utilized to determine the methylation and demethylation potential of Hg at concentrations comparable to that in natural environments by 15 common marine microalgae (8 species of Diatoms, 4 species of Dinoflagellates, 2 species of Chlorophyta and 1 species of Chrysophyte). Methylation of inorganic Hg was found to be negligible in the culture of all tested marine microalgae, while 6 species could significantly induce the demethylation of methylmercury (MeHg). The rates of microalgae mediated MeHg demethylation were at the same order of magnitude as that of photodemethylation, indicating that marine microalgae may play an important role in the degradation of MeHg in marine environments. Further studies suggest that the demethylation of MeHg by the microalgae may be mainly caused by their extracellular secretions (via photo-induce demethylation) and associated bacteria, rather than the direct demethylation of MeHg by microalgae cells. In addition, it was found that thiol groups may be the major component in microalgal extracellular secretions that lead to the photo-demethylation of MeHg.
MeSH term(s)	Demethylation ; Ecosystem ; Mercury ; Methylation ; Microalgae/metabolism
Chemical Substances	Mercury (FXS1BY2PGL)
Language	English
Publishing date	2022-03-09
Publishing country	England
Document type	Journal Article
ZDB-ID	202613-2
ISSN	1879-2448 ; 0043-1354
ISSN (online)	1879-2448
ISSN	0043-1354
DOI	10.1016/j.watres.2022.118266
Database	MEDical Literature Analysis and Retrieval System OnLINE

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Article ; Online: Potential effects of individual and combined exposure to tetraconazole and cadmium on zebrafish from the perspective of enantioselectivity and intestinal microbiota.

Di, Shanshan / Li, Ying / Song, Beibei / Guo, Chao / Qi, Peipei / Wang, Zhiwei / Liu, Zhenzhen / Zhao, Huiyu / Wang, Xinquan

The Science of the total environment

2024 Volume 921, Page(s) 170899

Abstract: As the wide use of pesticides, they could form combined pollution with heavy metals, which would affect their environmental behaviors and toxic effects. Particularly, the effects would be more intricate for chiral pesticides. In this study, the ... ...

Abstract	As the wide use of pesticides, they could form combined pollution with heavy metals, which would affect their environmental behaviors and toxic effects. Particularly, the effects would be more intricate for chiral pesticides. In this study, the accumulation and dissipation trends of tetraconazole enantiomers in zebrafish were investigated by individual and combined exposure of cadmium (Cd) and tetraconazole (including racemate and enantiomers) after confirming the absolute configuration of tetraconazole enantiomer. For the enantiomer treatments, Cd enhanced the accumulation of S-(+)-tetraconazole, but declined the concentrations of R-(-)-tetraconazole in zebrafish. The dissipation half-lives of tetraconazole enantiomers were extended by 1.65-1.44 times after the combined exposure of Cd and enantiomers. The community richness and diversity of intestinal microbiota were reduced in all treatments, and there were significant differences in R + Cd treatment. There was synergistic effect between Cd and S-(+)-tetraconazole for the effects on the relative abundances of Fusobacteria, Firmicutes, Proteobacteria, Actinobacteria, and Bacteroidetes. For R-(-)-tetraconazole, Cd mainly exhibited antagonistic effects. In the combined exposure of Cd and S-(+)-tetraconazole, the relative abundance changes of Cetobacterium (Fusobacteria, increase) and Edwardsiella (Proteobacteria, decrease) might affect the carbohydrate metabolism and energy metabolism, and led to the increase of S-(+)-tetraconazole bioaccumulation concentration. In the combined exposure of Cd and R-(-)-tetraconazole, Cd could increase the relative abundance of Edwardsiella (Proteobacteria), and affect the amino acid metabolism, which might reduce the bioaccumulation concentration of R-(-)-tetraconazole. This study reported for the first time that the abundance of intestinal microbiota in zebrafish might affect the bioaccumulation and dissipation of tetraconazole enantiomers, and would provide new insight for the study of combined pollutions.
MeSH term(s)	Animals ; Cadmium/metabolism ; Gastrointestinal Microbiome ; Zebrafish/metabolism ; Pesticides ; Proteobacteria/metabolism ; Chlorobenzenes ; Fluorocarbons ; Triazoles
Chemical Substances	Cadmium (00BH33GNGH) ; tetraconazole (8FGY868T0G) ; Pesticides ; Chlorobenzenes ; Fluorocarbons ; Triazoles
Language	English
Publishing date	2024-02-11
Publishing country	Netherlands
Document type	Journal Article
ZDB-ID	121506-1
ISSN	1879-1026 ; 0048-9697
ISSN (online)	1879-1026
ISSN	0048-9697
DOI	10.1016/j.scitotenv.2024.170899
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Je nach Verfügbarkeit (siehe Angabe bei Bestand)
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ab Jg. 2022: Lesesaal (EG)

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Article: Long non-coding RNA MEG3 regulates CSE-induced apoptosis and inflammation via regulating miR-218 in 16HBE cells

Song, Beibei / Ye, Liyun / Wu, Siyu / Jing, Zeng

Biochemical and biophysical research communications. 2020 Jan. 08, v. 521, no. 2

2020

Abstract: Chronic obstructive pulmonary disease (COPD) is a prevalent disease worldwide, mainly caused by cigarette smoking. Maternally expressed gene 3 (MEG3) functions as the lncRNA and is upregulated in COPD patients and human bronchial epithelial cells after ... ...

Abstract	Chronic obstructive pulmonary disease (COPD) is a prevalent disease worldwide, mainly caused by cigarette smoking. Maternally expressed gene 3 (MEG3) functions as the lncRNA and is upregulated in COPD patients and human bronchial epithelial cells after fine particulate matter (PM2.5) treatment. However, the molecular mechanism of MEG3 in COPD remains unknown. The expression of MEG3 and miR-218 in COPD tissues and cigarette smoke extract (CSE)-treated 16HBE cells was detected by RT-qPCR. The effects of MEG3 and miR-218 on proliferation and apoptosis in (CSE)-treated 16HBE cells were analyzed by CCK-8 and flow cytometry assay, respectively. The protein levels of inflammatory cytokines (IL-1β IL-6 and TNF-α) were detected in 16HBE cells by ELISA. MEG3 and miR-218 binding interaction was predicted by LncBase Predicted v.2 and further confirmed by dual luciferase reporter assay and RNA Immunoprecipitation (RIP) assay. MEG3 was upregulated in COPD tissues and inversely related to FEV1%. MEG3 was upregulated in (CSE)-treated 16HBE cells, and knockdown of MEG3 mitigated CSE-repressed proliferation and CSE-triggered apoptosis or inflammation. MiR-218 was demonstrated as a target miRNA of MEG3. MiR-218 was downregulated in COPD tissues and (CSE)-treated or MEG3 overexpressed 16HBE cells. MiR-218 overexpression attenuated CSE-blocked proliferation and CSE-induced apoptosis or inflammation. Deficiency of MEG3 counteracted CSE-blocked proliferation CSE-induced apoptotic rate and inflammatory cytokine (IL-1β IL-6 and TNF-α) levels, while introduction of anti-miR-218 reversed these effects. MEG3 regulated CSE-inhibited proliferation and CSE-induced apoptosis or inflammation by targeting miR-218, providing a possible therapeutic target for treatment of CSE-induced COPD.
Keywords	apoptosis ; cigarettes ; epithelium ; flow cytometry ; genes ; humans ; inflammation ; interleukin-6 ; luciferase ; microRNA ; non-coding RNA ; particulates ; precipitin tests ; research ; respiratory tract diseases ; smoke ; therapeutics
Language	English
Dates of publication	2020-0108
Size	p. 368-374.
Publishing place	Elsevier Inc.
Document type	Article
Note	NAL-AP-2-clean
ZDB-ID	205723-2
ISSN	0006-291X ; 0006-291X
ISSN (online)	0006-291X
ISSN	0006-291X
DOI	10.1016/j.bbrc.2019.10.135
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