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  1. Article ; Online: Exploring the relationship among soccer-related knowledge, attitude, practice, and self-health in Chinese campus soccer education.

    Song, Honglin / Li, Yutao / Zhang, Zhenhang / Liu, Tianbiao

    iScience

    2024  Volume 27, Issue 4, Page(s) 109409

    Abstract: China has promoted campus soccer for over a decade due to its potential health benefits. The study aimed to explore soccer knowledge (SK), soccer attitude (SA), soccer practice (SP), and health status among Chinese freshmen and sophomore undergraduates ... ...

    Abstract China has promoted campus soccer for over a decade due to its potential health benefits. The study aimed to explore soccer knowledge (SK), soccer attitude (SA), soccer practice (SP), and health status among Chinese freshmen and sophomore undergraduates who had received campus soccer education. Of the 7419 participants, 1,069 were valid and included in the analysis. Structural equation modeling (SEM) results indicated SK is positively associated with SA (p < 0.001), but negatively with SP (p < 0.01). SA was positively linked to SP (p < 0.001). SK indirectly affected SP through SA (Z = 13.677). Random forest-tree-structured Parzen estimators (RF-TPE) with SHAP indicated SP holds primary importance with a strong negative impact on health. Additionally, differences in rankings for SK, SA, and SP were observed among gender and urban-rural groups. These results reveal current campus soccer education is suboptimal to health promotion.
    Language English
    Publishing date 2024-03-04
    Publishing country United States
    Document type Journal Article
    ISSN 2589-0042
    ISSN (online) 2589-0042
    DOI 10.1016/j.isci.2024.109409
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  2. Article ; Online: Short-stranded DNA segment-modulated LAMP/H

    Ye, Jingjing / Huang, Weixiang / Jia, Xinyue / Song, Honglin / Zhou, Yifu / Yuan, Ruo / Xu, Wenju

    Analytica chimica acta

    2024  Volume 1295, Page(s) 342329

    Abstract: Background: Modulating loop-mediated isothermal amplification (mLAMP) by short-stranded DNA segment trigger (T) to generate byproducts H: Results: Here in this work, we are inspired to explore two-step loop-mediated amplification, firstly forming T- ... ...

    Abstract Background: Modulating loop-mediated isothermal amplification (mLAMP) by short-stranded DNA segment trigger (T) to generate byproducts H
    Results: Here in this work, we are inspired to explore two-step loop-mediated amplification, firstly forming T-activated double-loop dumbbell structure (DLDS) intermediate by a recognition hairpin and a hairpin precursor, and next DLDS-guided mLAMP process with the aid of two primers to yield mLAMP/H
    Significance: It is clear that we have creatively constructed a unique electrochemical biosensor for disease detection. Benefited from the rational combination of mLAMP and CHA, our electrochemical strategy is highly sensitive, specific and simplified, and would provide a new paradigm to construct various mLAMP/H
    MeSH term(s) Electrochemical Techniques ; DNA/chemistry ; MicroRNAs/genetics ; DNA Primers ; Catalysis ; Biosensing Techniques/methods ; Limit of Detection
    Chemical Substances DNA (9007-49-2) ; MicroRNAs ; DNA Primers
    Language English
    Publishing date 2024-02-02
    Publishing country Netherlands
    Document type Journal Article
    ZDB-ID 1483436-4
    ISSN 1873-4324 ; 0003-2670
    ISSN (online) 1873-4324
    ISSN 0003-2670
    DOI 10.1016/j.aca.2024.342329
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  3. Article ; Online: Elite male table tennis matches diagnosis using SHAP and a hybrid LSTM-BPNN algorithm.

    Song, Honglin / Li, Yutao / Zou, Xiaofeng / Hu, Ping / Liu, Tianbiao

    Scientific reports

    2023  Volume 13, Issue 1, Page(s) 11533

    Abstract: This study adopts a new approach, SHapley Additive exPlanation (SHAP), to diagnose the table tennis matches based on a hybrid algorithm, namely Long Short-Term Memory-Back Propagation Neural Network (LSTM-BPNN). 100 male singles competitions (8535 ... ...

    Abstract This study adopts a new approach, SHapley Additive exPlanation (SHAP), to diagnose the table tennis matches based on a hybrid algorithm, namely Long Short-Term Memory-Back Propagation Neural Network (LSTM-BPNN). 100 male singles competitions (8535 rallies) from 2019 to 2022 are analyzed by a hybrid technical-tactical analysis theory, which hybridizes the double three-phase and four-phase evaluation theories. A k-means cluster analysis is conducted to classify 59 players' winning rates into three levels (high, medium, and low). The results show that LSTM-BPNN has excellent performance (MSE = 0.000355, MAE = 0.014237, RMSE = 0.018853, and [Formula: see text] = 0.988311) compared with six typical artificial intelligence algorithms. Using LSTM-BPNN to calculate the SHAP value of each feature, the global results find that the receive-attack and serve-attack phases of the ending match have essential impacts on the mutual winning probabilities. Finally, case applications show that the SHAP can directly obtain each feature importance on one or more matches, which is more objective and reliable than the traditional simulation method. This research explores an innovative way to understand and analyze matches, and these results have implications for the performance analysis of table tennis and related racket sports.
    MeSH term(s) Male ; Humans ; Tennis ; Athletic Performance ; Artificial Intelligence ; Neural Networks, Computer ; Algorithms
    Language English
    Publishing date 2023-07-17
    Publishing country England
    Document type Journal Article ; Research Support, Non-U.S. Gov't
    ZDB-ID 2615211-3
    ISSN 2045-2322 ; 2045-2322
    ISSN (online) 2045-2322
    ISSN 2045-2322
    DOI 10.1038/s41598-023-37746-1
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  4. Article ; Online: The effects of forest therapy on public mental health and circular economy: A policy support model in Japan.

    Zhang, Shujian / Teng, Junfei / Zeng, Yan / Song, Honglin / Gu, Zhijun

    Frontiers in public health

    2022  Volume 10, Page(s) 1042589

    Abstract: Background: Forest therapy has gained popularity in Japan and even other nations/regions due to its health benefits. In addition, forest therapy has contributed to the development of circular economy and industrial upgrading. Japanese successful ... ...

    Abstract Background: Forest therapy has gained popularity in Japan and even other nations/regions due to its health benefits. In addition, forest therapy has contributed to the development of circular economy and industrial upgrading. Japanese successful practice can serve as a model for other countries in the Asia-Pacific region. To this end, the aim of this study was to determine whether forest therapy can improve the whole well-being of the participants and has a positive effect on the development of circular economy in the region.
    Methods: Both empirical and inductive research methods were used; empirical approach was conducted to perform comparative analysis of regional data that was retrieved from the research project of Japanese Forestry Agency in 2015. Specifically, the efficacy of forest therapy on physical (blood glucose, blood pressure, body weight) and mental (sleep quality e.g.,) health outcomes among 815 participants was investigated. Regional data are from the statistics of Iiyama City from 1990 to 2005. After the concept of forest therapy became popular in the late 1990s, this element had a great positive impact on the economic benefits of Ishiyama City and other major forest scenic areas. We summarize and analyze a series of policies made by relevant departments of the Japanese government in the years from 2019 to 2021 to promote forest therapy and related circular industry development.
    Results: Significant (pre-to-post participation) changes in physical measure was observed. Firstly, mean weight of those overweight participants decreased across three different time points (pre-test/enrollment = 79.7 kg, 3-month participation = 77.2, and 6-month participation = 76.8 kg), while overall mean weight of the participants decreased to 61, 60.5, and 60.4 kg, respectively. Secondly, Participant with normal weight showed a decrease on mean HbA1C (from 6.09 to 6.06) at Week 24, while overweight participants demonstrated a slight change 6.03-6.01 after 6 months the average HOMA-IR for overweight participants decreased from 3.5 to 2.5 at Week 24, while participants with normal weight demonstrated a decrease from 2.2 to 1.7 at Week 24. Forest Therapy has emerged in Japan since Mid-1990s and has attracted a large number of tourists all over the world due to its unique health benefits.
    Conclusion: Forest therapy in Japan has positive effects on whole well-being of Japanese residents and it has helped public mental health promotion and economic growth. Under the guidance and support of government policies, it can promote the development of circular economy and industrial transformation and set a model of Japanese forest therapy development for other countries in the Asia-Pacific region.
    MeSH term(s) Humans ; Mental Health ; Japan ; Overweight ; Forests ; Policy
    Language English
    Publishing date 2022-10-28
    Publishing country Switzerland
    Document type Journal Article
    ZDB-ID 2711781-9
    ISSN 2296-2565 ; 2296-2565
    ISSN (online) 2296-2565
    ISSN 2296-2565
    DOI 10.3389/fpubh.2022.1042589
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  5. Article ; Online: WDR5 drives the development of cervical squamous cell carcinoma by inducing epithelial-mesenchymal transition and cancer-associated fibroblasts formation.

    Sun, Fangli / Mo, Linmei / Lan, Ying / Lu, Qiuping / Wu, Nengxian / Song, Honglin

    Pathology, research and practice

    2022  Volume 238, Page(s) 154076

    Abstract: Background: WD repeat domain 5 (WDR5) has been indicated to be involved in tumor progression, however, its role in cervical cancer (CC) has not been investigated yet.: Methods: A total of 350 pairs of CC tissues and para-carcinoma tissues (PCT) were ... ...

    Abstract Background: WD repeat domain 5 (WDR5) has been indicated to be involved in tumor progression, however, its role in cervical cancer (CC) has not been investigated yet.
    Methods: A total of 350 pairs of CC tissues and para-carcinoma tissues (PCT) were collected. Primary human cervical epithelial cells (hCECs) and cancer-associated fibroblasts (CAFs) were isolated from cervical cancer tissues. MM102 was used to block the interaction between WDR5 and mixed lineage leukemia protein-1 (MLL1), and it was used in vivo to investigate its therapeutic value.
    Results: WDR5 was up-regulated in cervical squamous cell carcinoma (CSCC) tissues compared to that in PCT. C-X-C motif chemokine ligand 8 (CXCL8) was indicated to be the target gene of WDR5. Highly expressed CXCL8 promoted epithelial-mesenchymal transition (EMT) to form CAFs, and enhanced the cytokine secretions in CAFs to promote CSCC progression. CXCL8 expression was regulated by the interaction between WDR5 and MLL1, and blocking the interaction between these two proteins using MM102 significantly suppressed tumor growth in mice models.
    Conclusions: WDR5 plays a key role in CSCC progression by inducing CXCL8 expression and promoting the transformation of CAFs from epithelial cells.
    Language English
    Publishing date 2022-08-17
    Publishing country Germany
    Document type Journal Article
    ZDB-ID 391889-0
    ISSN 1618-0631 ; 0344-0338
    ISSN (online) 1618-0631
    ISSN 0344-0338
    DOI 10.1016/j.prp.2022.154076
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  6. Article ; Online: Risk Factors for Ovarian Cancer by BRCA Status: A Collaborative Case-Only Analysis.

    Gersekowski, Kate / Na, Renhua / Alsop, Kathryn / Delahunty, Rachel / Goode, Ellen L / Cunningham, Julie M / Winham, Stacey J / Pharoah, Paul D P / Song, Honglin / Webb, Penelope M

    Cancer epidemiology, biomarkers & prevention : a publication of the American Association for Cancer Research, cosponsored by the American Society of Preventive Oncology

    2024  Volume 33, Issue 4, Page(s) 586–592

    Abstract: Background: Women with an inherited pathogenic variant in BRCA1 or BRCA2 have a greatly increased risk of developing ovarian cancer, but the importance of behavioral factors is less clear. We used a case-only design to compare the magnitude of ... ...

    Abstract Background: Women with an inherited pathogenic variant in BRCA1 or BRCA2 have a greatly increased risk of developing ovarian cancer, but the importance of behavioral factors is less clear. We used a case-only design to compare the magnitude of associations with established reproductive, hormonal, and lifestyle risk factors between BRCA mutation carriers and noncarriers.
    Methods: We pooled data from five studies from the Ovarian Cancer Association Consortium including 637 BRCA carriers and 4,289 noncarriers. Covariate-adjusted generalized linear mixed models were used to estimate interaction risk ratios (IRR) and 95% confidence intervals (CI), with BRCA (carrier vs. noncarrier) as the response variable.
    Results: IRRs were above 1.0 for known protective factors including ever being pregnant (IRR = 1.29, 95% CI; 1.00-1.67) and ever using the oral contraceptive pill (1.30, 95% CI; 1.07-1.60), suggesting the protective effects of these factors may be reduced in carriers compared with noncarriers. Conversely, the IRRs for risk factors including endometriosis and menopausal hormone therapy were below 1.0, suggesting weaker positive associations among BRCA carriers. In contrast, associations with lifestyle factors including smoking, physical inactivity, body mass index, and aspirin use did not appear to differ by BRCA status.
    Conclusions: Our results suggest that associations with hormonal and reproductive factors are generally weaker for those with a pathogenic BRCA variant than those without, while associations with modifiable lifestyle factors are similar for carriers and noncarriers.
    Impact: Advice to maintain a healthy weight, be physically active, and refrain from smoking will therefore benefit BRCA carriers as well as noncarriers.
    MeSH term(s) Female ; Humans ; Pregnancy ; BRCA1 Protein/genetics ; BRCA2 Protein/genetics ; Mutation ; Ovarian Neoplasms/epidemiology ; Ovarian Neoplasms/genetics ; Risk Factors ; Smoking/adverse effects
    Chemical Substances BRCA1 Protein ; BRCA2 Protein
    Language English
    Publishing date 2024-02-01
    Publishing country United States
    Document type Journal Article
    ZDB-ID 1153420-5
    ISSN 1538-7755 ; 1055-9965
    ISSN (online) 1538-7755
    ISSN 1055-9965
    DOI 10.1158/1055-9965.EPI-23-0984
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    Zs.A 3693: Show issues Location:
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    Jg. 1995 - 2021: Lesesall (2.OG)
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  7. Article ; Online: DGUOK-AS1 promotes cell proliferation in cervical cancer via acting as a ceRNA of miR-653-5p.

    Wu, Nanchang / Song, Honglin / Ren, Yaoyao / Tao, Shan / Li, Shiting

    Cell biochemistry and function

    2020  Volume 38, Issue 7, Page(s) 870–879

    Abstract: Cervical cancer (CC) holds the second highest incidence and is the fourth dominating cause of cancer-induced death in women. It has been widely accepted that long noncoding RNAs (lncRNAs) are implicated in pathological and physiological activities of CC. ...

    Abstract Cervical cancer (CC) holds the second highest incidence and is the fourth dominating cause of cancer-induced death in women. It has been widely accepted that long noncoding RNAs (lncRNAs) are implicated in pathological and physiological activities of CC. However, the research of lncRNAs is still in the initial stage. The biological function of lncRNA deoxyguanosine kinase antisense RNA 1 (DGUOK-AS1) in human cancers has not been reported yet. We found that DGUOK-AS1 was aberrantly upregulated in cervical squamous cell carcinoma and endocervical adenocarcinoma (CESC) tissues through TCGA database. Real-time quantitative polymerase chain reaction (RT-qPCR) also verified the high expression of DGUOK-AS1 in CC cell lines. Loss-of-function assays indicated that DGUOK-AS1 silence repressed CC cell growth. In addition, dual-luciferase reporter and RNA immunoprecipitation (RIP) experiments validated the binding relation between miR-653-5p and DGUOK-AS1 or EMSY. Results of the rescue assays elucidated that EMSY overexpression or miR-653-5p downregulation reversed the suppressive function of DGUOK-AS1 knockdown on cell growth and DNA repair in CC. To sum up, this research highlighted that DGUOK-AS1 could promote CC cell proliferation via serving as a ceRNA of miR-653-5p to release EMSY, which might inspire us to discover novel strategies for CC treatment. SIGNIFICANCE OF THE STUDY: DGUOK-AS1 knockdown hinders proliferation of CC cells. DGUOK-AS1 sequesters miR-653-5p to elevate EMSY in CC. EMSY is required for DGUOK-AS1 to induce cell proliferation and repress DNA damage in CC.
    MeSH term(s) 3' Untranslated Regions ; Adult ; Antagomirs/metabolism ; Base Sequence ; Cell Line, Tumor ; Cell Proliferation ; Female ; Humans ; MicroRNAs/antagonists & inhibitors ; MicroRNAs/genetics ; MicroRNAs/metabolism ; Middle Aged ; Neoplasm Proteins/antagonists & inhibitors ; Neoplasm Proteins/genetics ; Neoplasm Proteins/metabolism ; Nuclear Proteins/antagonists & inhibitors ; Nuclear Proteins/genetics ; Nuclear Proteins/metabolism ; RNA Interference ; RNA, Long Noncoding/antagonists & inhibitors ; RNA, Long Noncoding/genetics ; RNA, Long Noncoding/metabolism ; RNA, Small Interfering/metabolism ; Repressor Proteins/antagonists & inhibitors ; Repressor Proteins/genetics ; Repressor Proteins/metabolism ; Sequence Alignment ; Uterine Cervical Neoplasms/genetics ; Uterine Cervical Neoplasms/pathology
    Chemical Substances 3' Untranslated Regions ; Antagomirs ; EMSY protein, human ; MIRN653 microRNA, human ; MicroRNAs ; Neoplasm Proteins ; Nuclear Proteins ; RNA, Long Noncoding ; RNA, Small Interfering ; Repressor Proteins
    Language English
    Publishing date 2020-04-13
    Publishing country England
    Document type Journal Article
    ZDB-ID 283643-9
    ISSN 1099-0844 ; 0263-6484
    ISSN (online) 1099-0844
    ISSN 0263-6484
    DOI 10.1002/cbf.3506
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    Zs.A 1994: Show issues Location:
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    Jg. 1995 - 2021: Lesesall (1.OG)
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  8. Article ; Online: The 'Ironclad friendship' of China-Cambodia, lays the first step in the foundation of early diagnosis and treatment of asymptomatic congenital heart Defects- A multi-national screening and intervention project, 2017-2020.

    Song, Honglin / Li, Xi / Lu, Jiang / Song, Junjie / Wang, Teng / Gao, Min / Zhang, Xingyi / Ma, Min / Shi, Yi / Fang, Jiayu / Fu, Hongchen / Wang, Huadan / Duo, Lin / Tang, Mingjing / Pang, Linhong

    BMC cardiovascular disorders

    2023  Volume 23, Issue 1, Page(s) 288

    Abstract: Background: Congenital heart disease (CHD) is the leading cause of mortality in childhood worldwide. However, a large number of children with CHD are not diagnosed promptly in low- and middle-income regions, due to limited healthcare resources and lack ... ...

    Abstract Background: Congenital heart disease (CHD) is the leading cause of mortality in childhood worldwide. However, a large number of children with CHD are not diagnosed promptly in low- and middle-income regions, due to limited healthcare resources and lack the ability of prenatal and postnatal ultrasound examinations. The research on asymptomatic CHD in the community is still blank, resulting in a large number of children with asymptomatic CHD can not be found and treated in time. Through the China-Cambodia collaborative health care initiative, the project team conducted research, screened children's CHD through a sampling survey in China and Cambodia, collected relevant data, and retrospectively analyzed the data of all eligible patients.
    Objectives: The project aimed to evaluate the prevalence of asymptomatic CHD in a sample population of 3-18years old and effects on their growth status and treatment outcomes.
    Methods: We examined the prevalence of 'asymptomatic CHD' among 3-18years old children and adolescents at the township/county levels in the two participating. A total of eight provinces in China and five provinces in Cambodia were analyzed from 2017 to 2020. During 1 year follow-up after treatment, the differences in heights and weights of the treated and control groups were evaluated.
    Results: Among the 3,068,075 participants screened from 2017 to 2020, 3967 patients with asymptomatic CHD requiring treatment were identified [0.130%, 95% confidence interval (CI) 0.126 -0.134%]. The prevalence rate of CHD ranged from 0.02 to 0.88%, and was negatively related to local per capita GDP (p = 0.028). The average height of 3310 treated CHD patients were 2.23% (95% CI: -2.51%~-1.9%) lower than that of the standard group and the average weight was - 6.41% (95% CI: -7.17%~-5.65%) lower, the developmental gap widening with advancing age. One year after treatment, the relative height difference remained comparable while that, in weight was reduced by 5.68% (95% CI: 4.27% ~7.09%).
    Conclusions: Asymptomatic CHD now is often overlooked and is an emerging public health challenge. Early detection and treatment are essential to lower the potential burden of heart diseases in children and adolescents.
    MeSH term(s) Child ; Female ; Adolescent ; Pregnancy ; Humans ; Cambodia ; Retrospective Studies ; Friends ; Heart Defects, Congenital/diagnostic imaging ; Heart Defects, Congenital/epidemiology ; China/epidemiology ; Early Diagnosis
    Language English
    Publishing date 2023-06-07
    Publishing country England
    Document type Journal Article ; Research Support, Non-U.S. Gov't
    ZDB-ID 2059859-2
    ISSN 1471-2261 ; 1471-2261
    ISSN (online) 1471-2261
    ISSN 1471-2261
    DOI 10.1186/s12872-023-03314-8
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  9. Article ; Online: A Multi-Institutional Retrospective Analysis of Oncologic Outcomes for Patients With Locally Advanced Cervical Cancer Undergoing Platinum-Based Adjuvant Chemotherapy After Concurrent Chemoradiotherapy.

    Wu, Ning / Su, Xing / Song, Honglin / Li, Ying / Gu, Fei / Sun, Xiaoge / Li, Xiaofan / Cheng, Guanghui

    Cancer control : journal of the Moffitt Cancer Center

    2021  Volume 28, Page(s) 1073274821989307

    Abstract: Objective: To evaluated the oncologic outcomes associated with platinum-based adjuvant chemotherapy following concurrent chemoradiotherapy (CCRT) in the management of patients with locally advanced cervical cancer (LACC).: Methods: A total of 695 ... ...

    Abstract Objective: To evaluated the oncologic outcomes associated with platinum-based adjuvant chemotherapy following concurrent chemoradiotherapy (CCRT) in the management of patients with locally advanced cervical cancer (LACC).
    Methods: A total of 695 patients with FIGO stage IB2, IIA2, IIB-IVA LACC treated at 6 medical facilities were enrolled and divided into 2 groups: 478 were assigned to CCRT alone (CCRT group) and 217 to adjuvant chemotherapy after CCRT (CCRT-ACT group). The treatment outcomes were retrospectively compared and reported after the propensity score matching (PSM) analysis.
    Results: With a median follow-up of 56.4 months, no statistically significant differences were found in overall survival (OS), disease-free survival (DFS), progression-free survival (PFS) and distance metastasis-free survival (DMFS) between 2 groups. In CCRT-ACT group, patients with lymph nodes involvement or squamous cell carcinoma (SCC) had significantly longer DMFS, but no significant benefit in survival outcomes were observed with more than 2 cycles of adjuvant chemotherapy. Moreover, patients with a high level of CA125 (>20.5U/mL) or SCC-Ag (>22.8μg/L) had a relatively better DFS or PFS, and grade 3-4 acute hematological toxicity, late urinary and lower gastrointestinal complications and diarrhea symptom were more frequent in CCRT-ACT group.
    Conclusions: Adjuvant chemotherapy after CCRT has a potential role in further improving disease control for LACC patients with lymph nodal-metastasis or SCC with a high level of CA125 or SCC-Ag. Due to increased treatment-related complications and diarrhea symptom affecting the quality of life, post-CCRT adjuvant chemotherapy with excessive cycles was not be considered as the most appropriate choice in general.
    MeSH term(s) Adult ; Aged ; Antineoplastic Combined Chemotherapy Protocols/therapeutic use ; Carboplatin/therapeutic use ; Chemoradiotherapy ; Chemotherapy, Adjuvant ; Cisplatin/therapeutic use ; Disease-Free Survival ; Female ; Humans ; Middle Aged ; Neoplasm Staging ; Quality of Life ; Retrospective Studies ; Treatment Outcome ; Uterine Cervical Neoplasms/drug therapy ; Uterine Cervical Neoplasms/mortality ; Uterine Cervical Neoplasms/pathology ; Uterine Cervical Neoplasms/therapy
    Chemical Substances Carboplatin (BG3F62OND5) ; Cisplatin (Q20Q21Q62J)
    Language English
    Publishing date 2021-02-16
    Publishing country United States
    Document type Journal Article ; Multicenter Study
    ZDB-ID 1328503-8
    ISSN 1526-2359 ; 1073-2748
    ISSN (online) 1526-2359
    ISSN 1073-2748
    DOI 10.1177/1073274821989307
    Database MEDical Literature Analysis and Retrieval System OnLINE

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    Zs.A 4467: Show issues Location:
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    Jg. 1995 - 2021: Lesesall (2.OG)
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  10. Article ; Online: Germline BRCA variants, lifestyle and ovarian cancer survival.

    Gersekowski, Kate / Delahunty, Rachel / Alsop, Kathryn / Goode, Ellen L / Cunningham, Julie M / Winham, Stacey J / Pharoah, Paul / Song, Honglin / Jordan, Susan / Fereday, Sian / DeFazio, Anna / Friedlander, Michael / Obermair, Andreas / Webb, Penelope M

    Gynecologic oncology

    2022  Volume 165, Issue 3, Page(s) 437–445

    Abstract: Objective: Women with ovarian cancer who have a pathogenic germline variant in BRCA1 or BRCA2 (BRCA) have been shown to have better 5-year survival after diagnosis than women who are BRCA-wildtype (non-carriers). Modifiable lifestyle factors, including ... ...

    Abstract Objective: Women with ovarian cancer who have a pathogenic germline variant in BRCA1 or BRCA2 (BRCA) have been shown to have better 5-year survival after diagnosis than women who are BRCA-wildtype (non-carriers). Modifiable lifestyle factors, including smoking, physical activity and body mass index (BMI) have previously been associated with ovarian cancer survival; however, it is unknown whether these associations differ by germline BRCA status.
    Methods: We investigated measures of lifestyle prior to diagnosis in two cohorts of Australian women with invasive epithelial ovarian cancer, using Cox proportional hazards regression to calculate adjusted hazard ratios (HRs) and 95% confidence intervals (CIs).
    Results: In the combined studies (n = 1923), there was little association between physical activity, BMI or alcohol intake and survival, and no difference by BRCA status. However, the association between current smoking status before diagnosis and poorer survival was stronger for BRCA variant carriers (HR 1.98; 95% CI 1.20-3.27) than non-carriers (HR 1.18; 95% CI 0.96-1.46; p-interaction 0.02). We saw a similar differential association with smoking when we pooled results from two additional cohorts from the USA and UK (n = 2120). Combining the results from all four studies gave a pooled-HR of 1.94 (95% CI 1.28-2.94) for current smoking among BRCA variant carriers compared to 1.08 (0.90-1.29) for non-carriers.
    Conclusions: Our results suggest that the adverse effect of smoking on survival may be stronger for women with a BRCA variant than those without. Thus, while smoking cessation may improve outcomes for all women with ovarian cancer, it might provide a greater benefit for BRCA variant carriers.
    MeSH term(s) Australia/epidemiology ; BRCA1 Protein/genetics ; BRCA2 Protein/genetics ; Carcinoma, Ovarian Epithelial/genetics ; Female ; Genes, BRCA1 ; Genes, BRCA2 ; Germ Cells ; Germ-Line Mutation ; Humans ; Life Style ; Ovarian Neoplasms/genetics ; Smoking/adverse effects ; Smoking/epidemiology
    Chemical Substances BRCA1 Protein ; BRCA2 Protein
    Language English
    Publishing date 2022-04-07
    Publishing country United States
    Document type Journal Article ; Research Support, U.S. Gov't, Non-P.H.S. ; Research Support, N.I.H., Extramural ; Research Support, Non-U.S. Gov't
    ZDB-ID 801461-9
    ISSN 1095-6859 ; 0090-8258
    ISSN (online) 1095-6859
    ISSN 0090-8258
    DOI 10.1016/j.ygyno.2022.03.020
    Database MEDical Literature Analysis and Retrieval System OnLINE

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