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Book ; Online: Magnetic Flux Ropes: From the Sun to the Earth and Beyond

Liu, Rui / Zhang, Jie / Wang, Yuming / Song, Hongqiang

2020

Keywords	Science: general issues ; Astronomy, space & time ; Sun ; magnetic flux rope ; magnetic twist ; coronal mass ejection ; filament eruption ; magnetic cloud
Size	1 electronic resource (126 pages)
Publisher	Frontiers Media SA
Document type	Book ; Online
Note	English ; Open Access
HBZ-ID	HT021230684
ISBN	9782889663361 ; 2889663361
Database	ZB MED Catalogue: Medicine, Health, Nutrition, Environment, Agriculture

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Article ; Online: Identifying the shared genes and KEGG pathways of Resolvin D1-targeted network and osteoarthritis using bioinformatics.

Jiang, Wenjun / Wang, Xiaoying / Su, Siwei / Du, Sen / Song, Hongqiang

Bioengineered

2022 Volume 13, Issue 4, Page(s) 9839–9854

Abstract: Osteoarthritis (OA) is a common chronic degenerative disease characterized by the loss of articular cartilage, which causes loss of joint function and reduce quality of life. Resolvin D1 (RvD1) has shown interesting anti-inflammatory effects; however, ... ...

Abstract	Osteoarthritis (OA) is a common chronic degenerative disease characterized by the loss of articular cartilage, which causes loss of joint function and reduce quality of life. Resolvin D1 (RvD1) has shown interesting anti-inflammatory effects; however, the mechanism of action of RvD1 in OA remains unclear. The aim of this study was to investigate the potential mechanism of RvD1 in OA by bioinformatics and partial in vitro mechanisms. Here, 106 shared differentially expressed genes (DEGs) were identified based on the GSE82107, GSE55235, GSE55457 dataset; 700 DEGs were identified based on GSE169077. Enrichment analyses of these genes were then successively conducted. RvD1-targeted genes and KEGG pathways are identified by STITCH. 27 shared KEGG pathways were identified among RvD1-targeted pathways and OA. Furthermore, cell apoptosis assay, western blotting, real-time fluorescent quantitative PCR (qRT-PCR), enzyme linked immunosorbent assay (ELISA) were used to confirm the expression levels of the key genes of shared Kyoto Encyclopedia of Genes and Genomes (KEGG) pathways between RvD1-targeted and OA in IL-1β treated rat knee chondrocytes. The results showed that RvD1-targeted pathways and the expression of nuclear p65, p53, and p-JNK were inhibited in the RvD1 group compared with the IL-1β group. Thus, the findings indicate that RvD1 may inhibit the development of OA through NF/kB, p53, MAPK/JNK, PI3K-AKT signaling pathways, and act as a treatment for OA.
MeSH term(s)	Animals ; Computational Biology ; Docosahexaenoic Acids ; Osteoarthritis/genetics ; Osteoarthritis/metabolism ; Phosphatidylinositol 3-Kinases/metabolism ; Quality of Life ; Rats ; Tumor Suppressor Protein p53
Chemical Substances	Tumor Suppressor Protein p53 ; resolvin D1 ; Docosahexaenoic Acids (25167-62-8)
Language	English
Publishing date	2022-04-18
Publishing country	United States
Document type	Journal Article
ZDB-ID	2737830-5
ISSN	2165-5987 ; 2165-5979
ISSN (online)	2165-5987
ISSN	2165-5979
DOI	10.1080/21655979.2022.2061288
Database	MEDical Literature Analysis and Retrieval System OnLINE

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Article ; Online: Resolvin D1 inhibits the proliferation of osteoarthritis fibroblast-like synoviocytes through the Hippo-YAP signaling pathway.

Su, Siwei / Jiang, Wenjun / Wang, Xiaoying / Du, Sen / Qi, Jianhong / Jia, Qingwei / Song, Hongqiang

BMC musculoskeletal disorders

2022 Volume 23, Issue 1, Page(s) 149

Abstract: Objective: Osteoarthritis (OA) is a disease characterized by cartilage degradation and structural destruction. Resolvin D1 (RvD1), a specialized proresolving mediator (SPM) derived from omega-3 fatty acids, has been preliminarily proven to show anti- ... ...

Abstract	Objective: Osteoarthritis (OA) is a disease characterized by cartilage degradation and structural destruction. Resolvin D1 (RvD1), a specialized proresolving mediator (SPM) derived from omega-3 fatty acids, has been preliminarily proven to show anti-inflammatory and antiapoptotic effects in OA. However, the mechanisms of RvD1 in osteoarthritis fibroblast-like synoviocytes (OA-FLSs) need to be clarified. Methods: Synovial and fibroblast-like synoviocytes were obtained from OA patients and healthy individuals. MTT and EdU assays were performed to determine cell cytotoxicity and proliferation. The protein expression levels of cyclin D1, cyclin B1, PCNA, p53, MMP-13, YAP, p-YAP, and LATS1 were detected by western blot analysis. The release levels of IL-1β were detected by ELISA. The cell cycle was assessed by flow cytometry. Immunofluorescence was used to detect the levels of YAP in OA-FLSs. Results: RvD1 inhibited OA-FLS proliferation and reduced MMP-13 and IL-1β secretion in the concentrations of 20 nM and 200 nM. Furthermore, RvD1 induced G2 cell cycle arrest in OA-FLSs via the Hippo-YAP signaling pathway and promoted YAP phosphorylation. However, RvD1 had no effects on normal FLSs. Conclusions: RvD1 inhibits OA-FLS proliferation by promoting YAP phosphorylation and protects chondrocytes by inhibiting the secretion of MMP-13 and IL-1β, providing an experimental basis for RvD1 treatment of OA.
MeSH term(s)	Cell Proliferation ; Cells, Cultured ; Docosahexaenoic Acids ; Fibroblasts ; Humans ; Osteoarthritis/drug therapy ; Signal Transduction ; Synovial Membrane ; Synoviocytes
Chemical Substances	resolvin D1 ; Docosahexaenoic Acids (25167-62-8)
Language	English
Publishing date	2022-02-15
Publishing country	England
Document type	Journal Article
ZDB-ID	2041355-5
ISSN	1471-2474 ; 1471-2474
ISSN (online)	1471-2474
ISSN	1471-2474
DOI	10.1186/s12891-022-05095-1
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Book ; Online: Quantification of the Writhe Number Evolution of Solar Filament Axes

Zhou, Zhenjun / Jiang, Chaowei / Song, Hongqiang / Wang, Yuming / Hao, Yongqiang / Cui, Jun

2023

Abstract: Solar filament eruptions often show complex and dramatic geometric deformation that is highly relevant to the underlying physical mechanism triggering the eruptions. It has been well known that the writhe of filament axes is a key parameter ... ...

Abstract	Solar filament eruptions often show complex and dramatic geometric deformation that is highly relevant to the underlying physical mechanism triggering the eruptions. It has been well known that the writhe of filament axes is a key parameter characterizing its global geometric deformation, but a quantitative investigation of the development of writhe during its eruption is still lacking. Here we introduce the Writhe Application Toolkit (WAT) which can be used to characterize accurately the topology of filament axes. This characterization is achieved based on the reconstruction and writhe number computation of three-dimensional paths of the filament axes from dual-perspective observations. We apply this toolkit to four dextral filaments located in the northern hemisphere with a counterclockwise (CCW) rotation during their eruptions. Initially, all these filaments possess a small writhe number (=<0.20) indicating a weak helical deformation of the axes. As the CCW rotation kicks in, their writhe numbers begin to decrease and reach large negative values. Combined with the extended C\u{a}lug\u{a}reanu theorem, the absolute value of twist is deduced to decrease during the rotation. Such a quantitative analysis strongly indicates a consequence of the conversion of twist into writhe for the studied events.
Keywords	Astrophysics - Solar and Stellar Astrophysics ; Physics - Space Physics
Subject code	612
Publishing date	2023-02-22
Publishing country	us
Document type	Book ; Online
Database	BASE - Bielefeld Academic Search Engine (life sciences selection)

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Article ; Online: Reliability and validity of the novel self-reported spine functional scale (SSFS) in healthy participants.

Li, Wei / Ding, Jie / Hao, Xiujuan / Jiang, Wenjun / Song, Hongqiang / Zhang, Yanming / Tan, Yan

Journal of orthopaedic surgery and research

2021 Volume 16, Issue 1, Page(s) 529

Abstract: Objectives: To develop the novel self-reported spine functional scale (SSFS) and conduct reliability and validity analysis, so that the public can better understand their own spine function in a more simple and scientific way, so as to effectively ... ...

Abstract	Objectives: To develop the novel self-reported spine functional scale (SSFS) and conduct reliability and validity analysis, so that the public can better understand their own spine function in a more simple and scientific way, so as to effectively prevent spinal disorders and improve the quality of life through targeted rehabilitation therapeutic measures. Methods: This study was approved by an institutional review board, and all subjects gave informed consent to participate. Results: (1) Using Spearman correlation analysis to evaluate the content validity, each item was significantly correlated with the total score, and the project design was reasonable. The exploratory factor analysis method is used to evaluate the structural validity of the scale, and the standing position and the lying position of the posture evaluation can be attributed to the factor 2, which is called posture evaluation: the cervical flexor strength, the flat support, the prone back, and the supine knee. The back arch of the wall and the angel on the wall is attributed to factor 1, called the overall spine function test, and the cumulative contribution rate of the two factors was 46.057%. Confirmatory factor analysis showed that the two-factor model fits well (χ Discussion: The reliability and validity analyses of this study verified the reliability and scientificity of SSFS in the young healthy population. Body weight had a significant influence on SSFS score, and the performance levels were different for the two sexes. Conclusion: The novel Self-Reported Spine Functional Scale (SSFS) has high reliability and validity and is applicable to the self-assessment and maintenance of spinal health and the prevention of related spinal disorders in the young healthy population. Body weight has a significant influence on the SSFS score in healthy young people. Overweight and obese males were found to be more likely to have spinal dysfunction, while underweight males displayed poor cervical flexor muscle strength. Underweight females were found to have better overall spinal function and stronger cervical flexor muscle strength.
MeSH term(s)	Healthy Volunteers ; Humans ; Obesity ; Overweight ; Psychometrics ; Quality of Life ; Reproducibility of Results ; Self Report ; Spinal Diseases ; Surveys and Questionnaires ; Thinness
Language	English
Publishing date	2021-08-25
Publishing country	England
Document type	Journal Article
ZDB-ID	2252548-8
ISSN	1749-799X ; 1749-799X
ISSN (online)	1749-799X
ISSN	1749-799X
DOI	10.1186/s13018-021-02620-1
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Book ; Online: Heating of quiescent coronal loops caused by nearby eruptions observed with the Solar Dynamics Observatory and the Solar Upper Transition Region Imager

Li, Leping / Tian, Hui / Chen, Huadong / Song, Hongqiang / Hou, Zhenyong / Bai, Xianyong / Ji, Kaifan / Deng, Yuanyong

2023

Abstract: How structures, e.g., magnetic loops, in the upper atmosphere, i.e., the transition region and corona, are heated and sustained is one of the major unresolved issues in solar and stellar physics. Various theoretical and observational studies on the ... ...

Abstract	How structures, e.g., magnetic loops, in the upper atmosphere, i.e., the transition region and corona, are heated and sustained is one of the major unresolved issues in solar and stellar physics. Various theoretical and observational studies on the heating of coronal loops have been undertaken. The heating of quiescent loops caused by eruptions is, however, rarely observed. In this study, employing data from the Solar Dynamics Observatory (SDO) and Solar Upper Transition Region Imager (SUTRI), we report the heating of quiescent loops associated with nearby eruptions. In active regions (ARs) 13092 and 13093, a long filament and a short filament, and their overlying loops are observed on 2022 September 4. In AR 13093, a warm channel erupted toward the northeast, whose material moved along its axis toward the northwest under the long filament, turned to the west above the long filament, and divided into two branches falling to the solar surface. Subsequently, the short filament erupted toward the southeast. Associated with these two eruptions, the quiescent loops overlying the long filament appeared in SDO/Atmospheric Imaging Assembly (AIA) high-temperature images, indicating the heating of loops. During the heating, signature of magnetic reconnection between loops is identified, including the inflowing motions of loops, and the formation of X-type structures and newly reconnected loops. The heated loops then cooled down. They appeared sequentially in AIA and SUTRI lower-temperature images. All the results suggest that the quiescent loops are heated by reconnection between loops caused by the nearby warm channel and filament eruptions. Comment: 20 pages, 12 figures, accepted for publication in ApJ
Keywords	Astrophysics - Solar and Stellar Astrophysics
Subject code	660
Publishing date	2023-03-28
Publishing country	us
Document type	Book ; Online
Database	BASE - Bielefeld Academic Search Engine (life sciences selection)

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Article ; Online: Promoting the proliferation of osteoarthritis chondrocytes by resolvin D1 regulating the NLRP3/caspase-1 signaling pathway.

Wang, Xiaoying / Yang, Mingfeng / Yu, Guanghui / Qi, Jianhong / Jia, Qingwei / Liu, Shuai / Jiang, Wenjun / Su, Siwei / Chi, Zhiwei / Wang, Ruonan / Liu, Minghan / Song, Hongqiang

Cellular signalling

2023 Volume 113, Page(s) 110960

Abstract: Osteoarthritis (OA) is a degenerative joint disease commonly found in middle-aged and older people. Chondrocytes are the only cells in joint cartilage that are difficult to heal after pyroptosis, and they will aggravate the wear and tear of joint ... ...

Abstract	Osteoarthritis (OA) is a degenerative joint disease commonly found in middle-aged and older people. Chondrocytes are the only cells in joint cartilage that are difficult to heal after pyroptosis, and they will aggravate the wear and tear of joint cartilage and affect the progression of OA. Pyroptosis is a novel form of programmed cell death, and the classical pyroptosis pathway is a programmed cell death pattern mediated by inflammatory cysteine protease-1. Activation of NLRP3 leads to activation and cleavage of caspase-1 precursors, which in turn leads to activation and cleavage of GSDMD proteins and the release of proinflammatory factors. Resolvin D1 (RvD1) is a specialized pro-resolving mediator (SPM) derived from omega-3 unsaturated fatty acids that reduces inflammation and catabolic responses in OA chondrocytes. However, it is unclear whether RvD1 promotes OA chondrocyte proliferation and thus joint cartilage repair. Our results show that RvD1 regulates the NLRP3/caspase-1 signaling pathway by inhibiting the expression of caspase-1, promoting the proliferation of OA chondrocytes, promoting the repair of articular cartilage in rats and delaying the progression of osteoarthritis.
MeSH term(s)	Humans ; Middle Aged ; Rats ; Animals ; Aged ; NLR Family, Pyrin Domain-Containing 3 Protein/metabolism ; Chondrocytes/metabolism ; Caspase 1/metabolism ; Osteoarthritis/metabolism ; Signal Transduction ; Cell Proliferation
Chemical Substances	NLR Family, Pyrin Domain-Containing 3 Protein ; resolvin D1 ; Caspase 1 (EC 3.4.22.36)
Language	English
Publishing date	2023-11-15
Publishing country	England
Document type	Journal Article ; Research Support, Non-U.S. Gov't
ZDB-ID	1002702-6
ISSN	1873-3913 ; 0898-6568
ISSN (online)	1873-3913
ISSN	0898-6568
DOI	10.1016/j.cellsig.2023.110960
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Article ; Online: Investigation on failure behavior of collapse column in China's coal mine based on discontinuous deformation numerical method.

Zuo, Jianping / Hong, Zijie / Peng, Suping / Shi, Yue / Song, Hongqiang / Li, Meng / Zhang, Zishan

PloS one

2019 Volume 14, Issue 8, Page(s) e0219733

Abstract: Karst collapse column is a serious geological disaster in China's coal mines. There are various karst collapse columns in coal mine areas, such as Huainan, Huaibei, Xingtai, Lu'an. And they have seriously affected mining safety and geological environment. ...

Abstract	Karst collapse column is a serious geological disaster in China's coal mines. There are various karst collapse columns in coal mine areas, such as Huainan, Huaibei, Xingtai, Lu'an. And they have seriously affected mining safety and geological environment. The present research is focused on analyzing subsidence mechanism and dynamic collapse process. Based on mechanical analysis of thin plate theory, a detailed model of collapse column slipping and bending fracture is constructed to gather the critical conditions of the collapse column roof. The sensitivity parameters analysis shows that both the radius and roof thickness of cave have a great influence on the sliding instability and bending fracture. Meanwhile, the buried depth also affects bending failure. The discontinuous deformation analysis (DDA) method is used to simulate and analyze the collapse process. The numerical results indicate that the stability of inverted funnel collapse column is dominated by the bending stress of roof strata. The movement of columnar collapse column is mainly caused by sliding instability. However, the funnel collapse column is relatively stable, and does not change in the same condition. The displacement field analysis shows that the collapse range of inverted funnel collapse column is obviously larger than that of columnar collapse column, in which its maximum displacement is approximately 1.5 times that of the columnar collapse column. There is no large area collapse on the upper part of the funnel collapse column, and the block system is relatively stable. The principal stress field analysis proves the above results.
MeSH term(s)	China ; Coal Mining ; Environmental Monitoring ; Geological Phenomena ; Mechanical Phenomena ; Models, Theoretical
Language	English
Publishing date	2019-08-06
Publishing country	United States
Document type	Journal Article ; Research Support, Non-U.S. Gov't
ISSN	1932-6203
ISSN (online)	1932-6203
DOI	10.1371/journal.pone.0219733
Database	MEDical Literature Analysis and Retrieval System OnLINE

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Book ; Online: Why "solar tsunamis" rarely leave their imprints in the chromosphere

Zheng, Ruisheng / Liu, Yihan / Liu, Wenlong / Wang, Bing / Hou, Zhenyong / Feng, Shiwei / Kong, Xiangliang / Huang, Zhenghua / Song, Hongqiang / Tian, Hui / Chen, Pengfei / Erdélyi, Robertus / Chen, Yao

2023

Abstract: Solar coronal waves frequently appear as bright disturbances that propagate globally from the eruption center in the solar atmosphere, just like the tsunamis in the ocean on Earth. Theoretically, coronal waves can sweep over the underlying chromosphere ... ...

Abstract	Solar coronal waves frequently appear as bright disturbances that propagate globally from the eruption center in the solar atmosphere, just like the tsunamis in the ocean on Earth. Theoretically, coronal waves can sweep over the underlying chromosphere and leave an imprint in the form of Moreton wave, due to the enhanced pressure beneath their coronal wavefront. Despite the frequent observations of coronal waves, their counterparts in the chromosphere are rarely detected. Why the chromosphere rarely bears the imprints of solar tsunamis remained a mystery since their discovery three decades ago. To resolve this question, all coronal waves and associated Moreton waves in the last decade have been initially surveyed, though the detection of Moreton waves could be hampered by utilising the low-quality H$\alpha$ data from Global Oscillations Network Group. Here, we present 8 cases (including 5 in Appendix) of the coexistence of coronal and Moreton waves in inclined eruptions where it is argued that the extreme inclination is key to providing an answer to address the question. For all these events, the lowest part of the coronal wavefront near the solar surface appears very bright, and the simultaneous disturbances in the solar transition region and the chromosphere predominantly occur beneath the bright segment. Therefore, evidenced by observations, we propose a scenario for the excitation mechanism of the coronal-Moreton waves in highly inclined eruptions, in which the lowest part of a coronal wave can effectively disturb the chromosphere even for a weak (e.g., B-class) solar flare. Comment: 24 pages, 14 figures
Keywords	Astrophysics - Solar and Stellar Astrophysics ; Physics - Space Physics
Subject code	551
Publishing date	2023-04-28
Publishing country	us
Document type	Book ; Online
Database	BASE - Bielefeld Academic Search Engine (life sciences selection)

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Article ; Online: Reliability of cartilage digestion and FDA-EB fluorescence staining for the detection of chondrocyte viability in osteochondral grafts.

Qi, Jianhong / Cao, Famin / Han, Yunning / Xie, Di / Song, Hongqiang / Chen, Bin / Zhou, Lu

Cell and tissue banking

2018 Volume 19, Issue 3, Page(s) 399–404

Abstract: The purpose of this study is to evaluate the reliability of cartilage digestion and fluorescein diacetate-ethidium bromide (FDA-EB) fluorescence staining for the detection of chondrocyte viability in osteochondral grafts. Sixteen fresh osteochondral ... ...

Abstract	The purpose of this study is to evaluate the reliability of cartilage digestion and fluorescein diacetate-ethidium bromide (FDA-EB) fluorescence staining for the detection of chondrocyte viability in osteochondral grafts. Sixteen fresh osteochondral grafts were harvested from pig knee condyles, and the articular cartilage tissue was preserved. Each cartilage graft was cut into two 70-µm thick pieces and randomly allocated to Group A or Group B. The cell viability of Group A was detected using FDA-EB fluorescence staining of the digested cartilage, and the viability of Group B was detected with FDA-EB fluorescence staining of cartilage sections. Comparisons of chondrocyte viability and correlation analyses of the two groups were performed using the paired sample t test and Pearson correlation test, respectively. No significant difference was found in the chondrocyte viability between Groups A and B (p > 0.05), and a strong correlation was observed (r = 0.70, p < 0.05). Therefore, cartilage digestion with FDA-EB fluorescence staining is a reliable method for detecting chondrocyte viability in osteochondral grafts.
MeSH term(s)	Animals ; Cartilage, Articular/cytology ; Cell Survival ; Chondrocytes/cytology ; Ethidium/analysis ; Fluoresceins/analysis ; Fluorescence ; Fluorescent Dyes/analysis ; Knee Joint/cytology ; Male ; Microtomy/methods ; Staining and Labeling/methods ; Swine
Chemical Substances	Fluoresceins ; Fluorescent Dyes ; Ethidium (EN464416SI) ; diacetylfluorescein (YL39R93PRE)
Language	English
Publishing date	2018-02-16
Publishing country	Netherlands
Document type	Journal Article
ZDB-ID	2170897-6
ISSN	1573-6814 ; 1389-9333
ISSN (online)	1573-6814
ISSN	1389-9333
DOI	10.1007/s10561-018-9685-2
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