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Article ; Online: Genetic characteristics of a highly metastatic basal cell adenocarcinoma arising in buccal mucosa.

Kim, DoYeon / Choi, KyungUn / Park, HaeRyoun / Song, JaeMin

2024 Volume 149, Page(s) 106681

MeSH term(s)	Humans ; Mouth Mucosa/pathology ; Adenocarcinoma/genetics ; Adenocarcinoma/pathology ; Salivary Gland Neoplasms/genetics ; Salivary Gland Neoplasms/pathology
Language	English
Publishing date	2024-01-05
Publishing country	England
Document type	Letter
ZDB-ID	1120465-5
ISSN	1879-0593 ; 0964-1955 ; 1368-8375
ISSN (online)	1879-0593
ISSN	0964-1955 ; 1368-8375
DOI	10.1016/j.oraloncology.2023.106681
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Zs.A 4869: Show issues			Location: Je nach Verfügbarkeit (siehe Angabe bei Bestand) bis Jg. 1994: Bestellungen von Artikeln über das Online-Bestellformular Jg. 1995 - 2021: Lesesall (2.OG) ab Jg. 2022: Lesesaal (EG)
Zs.A 456: Show issues			Location: Je nach Verfügbarkeit (siehe Angabe bei Bestand) bis Jg. 1994: Bestellungen von Artikeln über das Online-Bestellformular Jg. 1995 - 2021: Lesesall (1.OG) ab Jg. 2022: Lesesaal (EG)

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Article ; Online: Classification of laryngeal diseases including laryngeal cancer, benign mucosal disease, and vocal cord paralysis by artificial intelligence using voice analysis.

Kim, Hyun-Bum / Song, Jaemin / Park, Seho / Lee, Yong Oh

Scientific reports

2024 Volume 14, Issue 1, Page(s) 9297

Abstract: Voice change is often the first sign of laryngeal cancer, leading to diagnosis through hospital laryngoscopy. Screening for laryngeal cancer solely based on voice could enhance early detection. However, identifying voice indicators specific to laryngeal ... ...

Abstract	Voice change is often the first sign of laryngeal cancer, leading to diagnosis through hospital laryngoscopy. Screening for laryngeal cancer solely based on voice could enhance early detection. However, identifying voice indicators specific to laryngeal cancer is challenging, especially when differentiating it from other laryngeal ailments. This study presents an artificial intelligence model designed to distinguish between healthy voices, laryngeal cancer voices, and those of the other laryngeal conditions. We gathered voice samples of individuals with laryngeal cancer, vocal cord paralysis, benign mucosal diseases, and healthy participants. Comprehensive testing was conducted to determine the best mel-frequency cepstral coefficient conversion and machine learning techniques, with results analyzed in-depth. In our tests, laryngeal diseases distinguishing from healthy voices achieved an accuracy of 0.85-0.97. However, when multiclass classification, accuracy ranged from 0.75 to 0.83. These findings highlight the challenges of artificial intelligence-driven voice-based diagnosis due to overlaps with benign conditions but also underscore its potential.
MeSH term(s)	Humans ; Laryngeal Neoplasms/diagnosis ; Vocal Cord Paralysis/diagnosis ; Vocal Cord Paralysis/physiopathology ; Artificial Intelligence ; Male ; Middle Aged ; Female ; Aged ; Adult ; Voice/physiology ; Laryngeal Diseases/diagnosis ; Laryngeal Diseases/classification ; Machine Learning ; Laryngoscopy/methods
Language	English
Publishing date	2024-04-23
Publishing country	England
Document type	Journal Article ; Research Support, Non-U.S. Gov't
ZDB-ID	2615211-3
ISSN	2045-2322 ; 2045-2322
ISSN (online)	2045-2322
ISSN	2045-2322
DOI	10.1038/s41598-024-58817-x
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Article: Anti-infective potential of catechins and their derivatives against viral hepatitis.

Song, Jae-Min

Clinical and experimental vaccine research

2018 Volume 7, Issue 1, Page(s) 37–42

Abstract: Polyphenols including catechins from green tea ( ...

Abstract	Polyphenols including catechins from green tea (
Language	English
Publishing date	2018-01-29
Publishing country	Korea (South)
Document type	Journal Article ; Review
ZDB-ID	2684652-4
ISSN	2287-366X ; 2287-3651
ISSN (online)	2287-366X
ISSN	2287-3651
DOI	10.7774/cevr.2018.7.1.37
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Article ; Online: Advances in novel influenza vaccines: a patent review.

Song, Jae-Min

Journal of microbiology (Seoul, Korea)

2016 Volume 54, Issue 6, Page(s) 403–412

Abstract: The threat of a major human influenza pandemic such as the avian H5N1 or the 2009 new H1N1 has emphasized the need for effective prevention strategies to combat these pathogens. Although egg based influenza vaccines have been well established for a long ... ...

Abstract	The threat of a major human influenza pandemic such as the avian H5N1 or the 2009 new H1N1 has emphasized the need for effective prevention strategies to combat these pathogens. Although egg based influenza vaccines have been well established for a long time, it remains an ongoing public health need to develop alternative production methods that ensures improved safety, efficacy, and ease of administration compared with conventional influenza vaccines. This article is intended to cover some of the recent advances and related patents on the development of influenza vaccines including live attenuated, cell based, genomic and synthetic peptide vaccines.
MeSH term(s)	Animals ; Drug Discovery/legislation & jurisprudence ; Humans ; Influenza Vaccines/genetics ; Influenza Vaccines/immunology ; Influenza, Human/prevention & control ; Influenza, Human/virology ; Patents as Topic ; Vaccination
Chemical Substances	Influenza Vaccines
Language	English
Publishing date	2016-06
Publishing country	Korea (South)
Document type	Journal Article ; Review
ZDB-ID	2012399-1
ISSN	1976-3794 ; 1225-8873
ISSN (online)	1976-3794
ISSN	1225-8873
DOI	10.1007/s12275-016-6176-7
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Article: Comparative study of bone regeneration using fibrin sealant with xenograft in rabbit sinus: pilot study.

Choi, Won-Hyuk / Kim, Yong-Deok / Song, Jae-Min / Shin, Sang-Hun

Maxillofacial plastic and reconstructive surgery

2021 Volume 43, Issue 1, Page(s) 5

Abstract: Background: Stability of the grafted bone volume is one of the important factors to the success of alveolar bone grafts. For this, platelet-rich plasma (PRP) or fibrin sealant is mixed with the bone graft material. Bio-Oss® is a protein-free bovine ... ...

Abstract	Background: Stability of the grafted bone volume is one of the important factors to the success of alveolar bone grafts. For this, platelet-rich plasma (PRP) or fibrin sealant is mixed with the bone graft material. Bio-Oss® is a protein-free bovine mineral commonly used in bone graft procedures. The grafting particles are commonly combined with a standard fibrin sealant (Tisseel®) to fabricate a plastic implantable product. The purpose of this experiment was to evaluate the efficacy of fibrin sealant (Tisseel®) in bone regeneration performance in a rabbit maxillary sinus model. Methods: A total of five 3.5 kg weight New Zealand white rabbits were used for the study. After elevating the sinus membrane in both maxillary sinus cavities, Bio-Oss® mixed with normal saline (group 1) was filled into the right side, and Tisseel® mixed Bio-Oss® (group 2) was inserted into the other side. The bone mineral density and bone volume were analyzed with microscopic computed tomography (micro-CT) and histomorphometric 12 weeks after application. Results: Histologically, new bone formation rate was 14.8%, and grafted bone rate was 70.5% in group 1. In group 2, they were 18.5% and 60.4%, respectively. According to micro-CT analysis, bone mineral density (mg/cm Conclusions: The findings from this study suggest that, although the difference in the bone formation between group 1 and group 2 appears to be insignificant, group 2 had an advantage in using smaller amount of bone substances to achieve the reliable bone formation.
Language	English
Publishing date	2021-02-10
Publishing country	England
Document type	Journal Article
ISSN	2288-8101
ISSN	2288-8101
DOI	10.1186/s40902-021-00290-x
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Article: Comparison of time and cost between conventional surgical planning and virtual surgical planning in orthognathic surgery in Korea.

Park, Si-Yeon / Hwang, Dae-Seok / Song, Jae-Min / Kim, Uk-Kyu

Maxillofacial plastic and reconstructive surgery

2021 Volume 43, Issue 1, Page(s) 18

Abstract: Background: The purpose of this study was to measure the time of the conventional surgical planning (CSP) and virtual surgical planning (VSP) in orthognathic surgery and to compare them in terms of cost.: Material and method: This is a retrospective ... ...

Abstract	Background: The purpose of this study was to measure the time of the conventional surgical planning (CSP) and virtual surgical planning (VSP) in orthognathic surgery and to compare them in terms of cost. Material and method: This is a retrospective study of the patients who underwent orthognathic surgery at the OOOOO University Dental Hospital from December 2017 to August 2018. All the patients were analyzed through both CSP and VSP, and all the surgical stents were fabricated through manual and 3-dimensional (3D) printing. The predictor variables were the planning method (CSP vs. VSP) and the surgery type (group I: Le Fort I osteotomy+bilateral sagittal split osteotomy [LFI+BSSO] or group II: only bilateral sagittal split osteotomy [BSSO]), and the outcomes were the time and cost. The results were analyzed using paired t test. Results: Thirty patients (12 females, 18 males) met the inclusion criteria, and 17 patients were excluded from the study due to missing or incomplete data. There were 20 group I patients (LFI+BSSO regardless of genioplasty) and 10 group II patients (BSSO regardless of genioplasty). The average time of CSP for group I was 385±7.8 min, and that for group II was 195±8.33 min. The time reduction rate of VSP compared with CSP was 62.8% in group I and 41.5% in group II. On the other hand, there was no statistically significant cost reduction. Conclusions: The time investment in VSP in this study was significantly smaller than that in CSP, and the difference was greater in group I than in group II.
Language	English
Publishing date	2021-06-21
Publishing country	England
Document type	Journal Article
ZDB-ID	2815852-0
ISSN	2288-8101 ; 2288-8586
ISSN	2288-8101 ; 2288-8586
DOI	10.1186/s40902-021-00305-7
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Article ; Online: Immunological link between periodontitis and type 2 diabetes deciphered by single-cell RNA analysis.

Lee, Hansong / Joo, Ji-Young / Song, Jae-Min / Kim, Hyun-Joo / Kim, Yun Hak / Park, Hae Ryoun

Clinical and translational medicine

2023 Volume 13, Issue 12, Page(s) e1503

Abstract: Background: Type 2 diabetes mellitus (DM) is a complex metabolic disorder that causes various complications, including periodontitis (PD). Although a bidirectional relationship has been reported between DM and PD, their immunological relationship ... ...

Abstract	Background: Type 2 diabetes mellitus (DM) is a complex metabolic disorder that causes various complications, including periodontitis (PD). Although a bidirectional relationship has been reported between DM and PD, their immunological relationship remains poorly understood. Therefore, this study aimed to compare the immune response in patients with PD alone and in those with both PD and DM (PDDM) to expand our knowledge of the complicated connection between PD and DM. Methods: Peripheral blood mononuclear cells were collected from 11 healthy controls, 10 patients with PD without DM, and six patients with PDDM, followed by analysis using single-cell RNA sequencing. The differences among groups were then compared based on intracellular and intercellular perspectives. Results: Compared to the healthy state, classical monocytes exhibited the highest degree of transcriptional change, with elevated levels of pro-inflammatory cytokines in both PD and PDDM. DM diminished the effector function of CD8+ T and natural killer (NK) cells as well as completely modified the differentiation direction of these cells. Interestingly, a prominent pathway, RESISTIN, which is known to increase insulin resistance and susceptibility to diabetes, was found to be activated under both PD and PDDM conditions. In particular, CAP1+ classical monocytes from patients with PD and PDDM showed elevated nuclear factor kappa B-inducing kinase activity. Conclusions: Overall, this study elucidates how the presence of DM contributes to the deterioration of T/NK cell immunity and the immunological basis connecting PD to DM.
MeSH term(s)	Humans ; Diabetes Mellitus, Type 2/complications ; Leukocytes, Mononuclear ; Periodontitis/genetics ; Periodontitis/complications ; Periodontitis/metabolism ; Cytokines/metabolism ; Killer Cells, Natural
Chemical Substances	Cytokines
Language	English
Publishing date	2023-12-11
Publishing country	United States
Document type	Journal Article ; Research Support, Non-U.S. Gov't
ZDB-ID	2697013-2
ISSN	2001-1326 ; 2001-1326
ISSN (online)	2001-1326
ISSN	2001-1326
DOI	10.1002/ctm2.1503
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Article: Primary repair of untreated cleft palate in an elderly patient: a case report.

Lee, Jun Sang / Lee, Jae-Yeol / Kim, Yong-Deok / Song, Jae-Min / Choi, Won Hyuk

Journal of the Korean Association of Oral and Maxillofacial Surgeons

2021 Volume 47, Issue 1, Page(s) 47–50

Abstract: Untreated adult or elderly cleft lip and palate patients are rarely seen, but studies on delayed primary palatal closure have been performed in the less developed Asian and African countries, where access to medical care is difficult. A 64-year-old woman ...

Abstract	Untreated adult or elderly cleft lip and palate patients are rarely seen, but studies on delayed primary palatal closure have been performed in the less developed Asian and African countries, where access to medical care is difficult. A 64-year-old woman visited our clinic with untreated cleft palate with a 40×20-mm-wide defect in the medial palate. Two-flap palatoplasty under general anesthesia was performed to close the cleft palate. After 1 month, the result was favorable without any complications including oronasal fistula. Cleft palate primary repair in an elderly patient is rare and has some surgical problems that are associated with a wide range of defects, but good results can be obtained if surgery is performed well with appropriate considerations.
Language	English
Publishing date	2021-02-25
Publishing country	Korea (South)
Document type	Case Reports
ZDB-ID	2763851-0
ISSN	2234-5930 ; 2234-7550
ISSN (online)	2234-5930
ISSN	2234-7550
DOI	10.5125/jkaoms.2021.47.1.47
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Article ; Online: Is it worth applying self-irrigation after third molar extraction? A randomised controlled trial.

Jang, Hyo-Jin / Choi, Youn-Kyung / Kwon, Eun-Young / Choi, Won-Hyuk / Song, Jae-Min

The British journal of oral & maxillofacial surgery

2021 Volume 60, Issue 7, Page(s) 877–883

Abstract: In this study, we aimed to examine the effectiveness of self-irrigation following the extraction of mandibular third molars. A randomised controlled clinical trial was conducted with 155 patients who had undergone extraction of a mandibular third molar. ... ...

Abstract	In this study, we aimed to examine the effectiveness of self-irrigation following the extraction of mandibular third molars. A randomised controlled clinical trial was conducted with 155 patients who had undergone extraction of a mandibular third molar. The irrigation group was instructed to self-irrigate the extraction socket with tap water using a syringe three times a day, starting seven days after the tooth extraction. The incidence of complications and mouth opening, halitosis, plaque/gingival index, and oral health-related quality of life (OHRQoL) were measured. The irrigation group showed a lower incidence of complications than the non-irrigation group. The halitosis, plaque, and gingival scores were lower by mean (SD) 19.66 (5.19), 0.58 (0.06), and 0.62 (0.08), respectively, in the irrigation group than in the non-irrigation group (p = 0.0001). A greater amount of food packing was associated with higher halitosis, plaque, and gingival scores and poorer OHRQoL (p < 0.05). Further, more frequent irrigation was associated with lower halitosis, plaque, and gingival scores and better OHRQoL (p ≤ 0.016). Self-irrigation of the extraction socket using a syringe containing tap water is a very effective method for keeping the extraction socket clean. This technique reduced halitosis, improved plaque and gingival indices, and increased OHRQoL.
MeSH term(s)	Dry Socket/etiology ; Dry Socket/prevention & control ; Halitosis/complications ; Humans ; Mandible ; Molar, Third/surgery ; Quality of Life ; Tooth Extraction/adverse effects ; Tooth, Impacted/complications ; Water
Chemical Substances	Water (059QF0KO0R)
Language	English
Publishing date	2021-07-22
Publishing country	Scotland
Document type	Journal Article ; Randomized Controlled Trial
ZDB-ID	605685-4
ISSN	1532-1940 ; 0266-4356
ISSN (online)	1532-1940
ISSN	0266-4356
DOI	10.1016/j.bjoms.2021.07.010
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Article: Comparison of time and cost between conventional surgical planning and virtual surgical planning in orthognathic surgery in Korea.

Park, Si-Yeon / Hwang, Dae-Seok / Song, Jae-Min / Kim, Uk-Kyu

Maxillofacial plastic and reconstructive surgery

2019 Volume 41, Issue 1, Page(s) 35

Abstract	Background: The purpose of this study was to measure the time of the conventional surgical planning (CSP) and virtual surgical planning (VSP) in orthognathic surgery and to compare them in terms of cost. Material and method: This is a retrospective study of the patients who underwent orthognathic surgery at the Pusan National University Dental Hospital from December 2017 to August 2018. All the patients were analyzed through both CSP and VSP, and all the surgical stents were fabricated through manual and three-dimensional (3D) printing. The predictor variables were the planning method (CSP vs. VSP) and the surgery type (group I: Le Fort I osteotomy + bilateral sagittal split osteotomy [LFI+BSSO] or group II: only bilateral sagittal split osteotomy [BSSO]), and the outcomes were the time and cost. The results were analyzed using the paired Results: Thirty patients (12 females, 18 males) met the inclusion criteria, and 17 patients were excluded from the study due to missing or incomplete data. There were 20 group I patients (LFI+BSSO regardless of genioplasty) and 10 group II patients (BSSO regardless of genioplasty). The average time of CSP for group I was 385 ± 7.8 min, and that for group II was 195 ± 8.33 min. The time reduction rate of VSP compared with CSP was 62.8% in group I and 41.5% in group II. On the other hand, there was no statistically significant cost reduction. Conclusions: The time investment in VSP in this study was significantly smaller than that in CSP, and the difference was greater in group I than in group II.
Language	English
Publishing date	2019-09-12
Publishing country	England
Document type	Journal Article
ZDB-ID	2815852-0
ISSN	2288-8101 ; 2288-8586
ISSN	2288-8101 ; 2288-8586
DOI	10.1186/s40902-019-0220-6
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