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Article ; Online: Unifying Public Health Surveillance: A Scoping Review of Global Use of the Youth Risk Behavior Survey.

Jones, P'Ashe / Yala, Joy Atieno / Knight, Kristina N / Song, Jessica M / Adkins, Sarah M L / Battaglia-Hoffman, Grace / Trapl, Erika S

The Journal of adolescent health : official publication of the Society for Adolescent Medicine

2024

Abstract: Purpose: The Youth Risk Behavior Survey (YRBS) is a well-established surveillance tool designed to document the health risk behaviors of youth. However, there is limited insight into the use of the survey outside of the United States. The aim of this ... ...

Abstract	Purpose: The Youth Risk Behavior Survey (YRBS) is a well-established surveillance tool designed to document the health risk behaviors of youth. However, there is limited insight into the use of the survey outside of the United States. The aim of this scoping review was to assess the global presence and utilization of the YRBS. Methods: A structured electronic search of all publication years (through February 2020) was conducted to identify articles in PubMed and EBSCOhost. The search identified 128 articles that used the YRBS beyond the United States. Results: More than one-third of all countries, territories, and dependencies were represented in the articles, with the greatest use among upper-middle and high-income economies and those in the East Asia and Pacific geographic region. Priority health-risk behaviors identified were alcohol and other drug use (51%), tobacco use (48%), and unintentional and intentional injuries (44%). The articles predominantly suggested that the survey data be used to influence programs, policies, and practices (57%). Discussion: The development and proliferation of surveillance systems has allowed for important contributions to public health. Extensive use of the YRBS is notable; however, greater efforts are needed to support more systematic and collaborative approaches for evaluating youth behaviors around the world.
Language	English
Publishing date	2024-05-14
Publishing country	United States
Document type	Journal Article ; Review
ZDB-ID	1063374-1
ISSN	1879-1972 ; 1054-139X
ISSN (online)	1879-1972
ISSN	1054-139X
DOI	10.1016/j.jadohealth.2024.03.001
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Article ; Online: The travelling particles: community dynamics of biofilms on microplastics transferred along a salinity gradient.

Song, Jessica / Beule, Lukas / Jongmans-Hochschulz, Elanor / Wichels, Antje / Gerdts, Gunnar

ISME communications

2022 Volume 2, Issue 1, Page(s) 35

Abstract: Microplastics (MP), as novel substrata for microbial colonization within aquatic ecosystems, are a matter of growing concern due to their potential to propagate foreign or invasive species across different environments. MP are known to harbour a ... ...

Abstract	Microplastics (MP), as novel substrata for microbial colonization within aquatic ecosystems, are a matter of growing concern due to their potential to propagate foreign or invasive species across different environments. MP are known to harbour a diversity of microorganisms, yet little is understood of the dynamics of their biofilms and their capacity to successfully displace these microorganisms across different aquatic ecosystems typically marked by steep salinity gradients. To address this, we performed an in situ sequential incubation experiment to simulate MP transport from riverine to coastal seawaters using synthetic (high-density polyethylene, HDPE and tyre wear, TW) and natural (Wood) substrata. Bacterial communities on incubated particles were compared to each other as well as to those in surrounding waters, and their dynamics along the gradient investigated. All communities differed significantly from each other in their overall structure along the salinity gradient and were shaped by different ecological processes. While HDPE communities were governed by environmental selection, those on TW and Wood were dominated by stochastic events of dispersal and drift. Upon transfer into coastal seawaters, an almost complete turnover was observed among HDPE and TW communities. While synthetic particles displaced a minor proportion of communities across the salinity gradient, some of these comprised putatively pathogenic and resistant taxa. Our findings present an extensive assessment of MP biofilms and their dynamics upon displacement across different aquatic systems, presenting new insights into the role of MP as transport vectors.
Language	English
Publishing date	2022-04-11
Publishing country	England
Document type	Journal Article
ISSN	2730-6151
ISSN (online)	2730-6151
DOI	10.1038/s43705-022-00117-4
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Article ; Online: Reconstitution of a telomeric replicon organized by CST.

Zaug, Arthur J / Goodrich, Karen J / Song, Jessica J / Sullivan, Ashley E / Cech, Thomas R

Nature

2022 Volume 608, Issue 7924, Page(s) 819–825

Abstract: Telomeres, the natural ends of linear chromosomes, comprise repeat-sequence DNA and associated ... ...

Abstract	Telomeres, the natural ends of linear chromosomes, comprise repeat-sequence DNA and associated proteins
MeSH term(s)	DNA Primase/metabolism ; DNA Replication ; DNA, Single-Stranded/genetics ; DNA, Single-Stranded/metabolism ; G-Quadruplexes ; Humans ; Replicon/genetics ; Shelterin Complex/genetics ; Shelterin Complex/metabolism ; Telomerase/metabolism ; Telomere/genetics ; Telomere/metabolism
Chemical Substances	DNA, Single-Stranded ; Shelterin Complex ; DNA Primase (EC 2.7.7.-) ; Telomerase (EC 2.7.7.49)
Language	English
Publishing date	2022-07-13
Publishing country	England
Document type	Journal Article
ZDB-ID	120714-3
ISSN	1476-4687 ; 0028-0836
ISSN (online)	1476-4687
ISSN	0028-0836
DOI	10.1038/s41586-022-04930-8
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Article ; Online: Hemodynamic Effects of Anti-Vascular Endothelial Growth Factor Injections on Optical Coherence Tomography Angiography in Diabetic Macular Edema Eyes.

Song, Jessica / Huang, Bonnie B / Ong, Janice X / Konopek, Nicholas / Fawzi, Amani A

Translational vision science & technology

2022 Volume 11, Issue 10, Page(s) 5

Abstract: Purpose: To evaluate retinal hemodynamic responses to anti-vascular endothelial growth factor (VEGF) injection in eyes with diabetic macular edema using optical coherence tomography angiography (OCTA). We performed a comparison of two different ... ...

Abstract	Purpose: To evaluate retinal hemodynamic responses to anti-vascular endothelial growth factor (VEGF) injection in eyes with diabetic macular edema using optical coherence tomography angiography (OCTA). We performed a comparison of two different thresholding methods to identify the most accurate for studying the vessel density (VD) in diabetic macular edema eyes. Methods: The study prospectively included 26 eyes of 22 subjects (aged 60.2 ± 13.7 years) who underwent OCTA scan before and after anti-VEGF injection (mean interval between OCTA = 31.1 ± 17.3 days). We analyzed adjusted flow index, VD, and Skeletonized vessel length density in the parafoveal area (3-mm annulus with a 1-mm inner circle), along with full-thickness fovea avascular zone area and central foveal thickness (CFT). Using averaged scans VD as the ground truth, we compared two different algorithms for VD at the different plexuses. Longitudinal changes were assessed using a generalized linear model correcting for central foveal thickness and Q-score. Results: We found significantly decreased adjusted flow index in the DCP layer (P = 0.010) at the follow-up. Furthermore, foveal avascular zone (P < 0.001) and central foveal thickness (P = 0.003) showed significant decrease on follow-up compared with baseline. Comparing the thresholding algorithms showed that vessel length density-based thresholding was more accurate for quantifying the DCP VD. Conclusions: The adjusted flow index decreased significantly in the DCP layer on follow-up OCTA scan, suggesting vascular flow disruption and decreased deep retinal perfusion after anti-VEGF injection. Our results also highlight the fact that the choice of thresholding method is particularly critical for DCP quantification in eyes with diabetic macular edema. Translational relevance: Findings confirmed impaired deep retinal capillary flow after anti-VEGF injection.
MeSH term(s)	Diabetes Mellitus ; Diabetic Retinopathy/diagnostic imaging ; Diabetic Retinopathy/drug therapy ; Fluorescein Angiography/methods ; Fundus Oculi ; Hemodynamics ; Humans ; Macular Edema/diagnostic imaging ; Macular Edema/drug therapy ; Retinal Vessels/diagnostic imaging ; Retrospective Studies ; Tomography, Optical Coherence/methods ; Vascular Endothelial Growth Factors
Chemical Substances	Vascular Endothelial Growth Factors
Language	English
Publishing date	2022-09-29
Publishing country	United States
Document type	Journal Article ; Research Support, N.I.H., Extramural
ZDB-ID	2674602-5
ISSN	2164-2591 ; 2164-2591
ISSN (online)	2164-2591
ISSN	2164-2591
DOI	10.1167/tvst.11.10.5
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Article: Topographic Relationship between Telangiectasia and Cone Mosaic Disruption in Macular Telangiectasia Type 2.

Zandi, Roya / Song, Jessica / Micevych, Paul S / Fawzi, Amani A

Journal of clinical medicine

2020 Volume 9, Issue 10

Abstract: In this cross-sectional observational study, we investigated the relationship between photoreceptor layer disruption and telangiectasia in patients diagnosed with early stage macular telangiectasia type 2 (MacTel). A total of 31 eyes (17 patients) with ... ...

Abstract	In this cross-sectional observational study, we investigated the relationship between photoreceptor layer disruption and telangiectasia in patients diagnosed with early stage macular telangiectasia type 2 (MacTel). A total of 31 eyes (17 patients) with MacTel were imaged with adaptive optics scanning laser ophthalmoscopy (AOSLO) and optical coherence tomography angiography (OCTA). Confocal AOSLO was used to visualize dark regions of nonwaveguiding outer segments, which we refer to as "photoreceptor lesions". En-face OCTA images of the deep capillary plexus (DCP) were used in conjunction with confocal AOSLO to evaluate the topographic relationship between areas of capillary telangiectasias and photoreceptor lesions. Among seven eyes with early stage MacTel (stage 0-2 based on OCT), we identified ten photoreceptor lesions, all of which were located within parafoveal quadrants containing DCP telangiectasia on OCTA. Seven of the lesions corresponded to the intact ellipsoid zone on spectral-domain OCT (SD-OCT), and three of these also corresponded to the intact interdigitation zone. This work demonstrates a topographic relationship between AOSLO photoreceptor lesions and DCP telangiectasias, and it also suggests that these lesions with normal SD-OCT appearance may represent areas of photoreceptors at risk for dysfunction. Thus, confocal AOSLO may have a meaningful role in detecting early photoreceptor abnormalities in eyes with MacTel.
Language	English
Publishing date	2020-09-29
Publishing country	Switzerland
Document type	Journal Article
ZDB-ID	2662592-1
ISSN	2077-0383
ISSN	2077-0383
DOI	10.3390/jcm9103149
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Article ; Online: Caspofungin: Pharmacodynamics, pharmacokinetics, clinical uses and treatment outcomes.

Song, Jessica C / Stevens, David A

Critical reviews in microbiology

2016 Volume 42, Issue 5, Page(s) 813–846

Abstract: Over the past decade, echinocandins have emerged as first-line antifungal agents for many Candida infections. The echinocandins have a unique mechanism of action, inhibiting the synthesis of β-1,3-d-glucan polymers, key components of the cell wall in ... ...

Abstract	Over the past decade, echinocandins have emerged as first-line antifungal agents for many Candida infections. The echinocandins have a unique mechanism of action, inhibiting the synthesis of β-1,3-d-glucan polymers, key components of the cell wall in pathogenic fungi. Caspofungin was the first echinocandin antifungal agent to become licensed for use. The objectives of this review are to summarize the existing published data on caspofungin, under the subject headings of chemistry and mechanism of action, spectrum of activity, pharmacodynamics, pharmacokinetics, clinical studies, safety, drug interactions, dosing, and an overview of the drug's current place in therapy.
MeSH term(s)	Animals ; Antifungal Agents/pharmacokinetics ; Antifungal Agents/therapeutic use ; Clinical Trials as Topic ; Echinocandins/pharmacokinetics ; Echinocandins/therapeutic use ; Economics, Pharmaceutical ; Fungi/drug effects ; Fungi/genetics ; Fungi/metabolism ; Humans ; Lipopeptides/pharmacokinetics ; Lipopeptides/therapeutic use ; Mycoses/drug therapy ; Mycoses/microbiology ; Treatment Outcome
Chemical Substances	Antifungal Agents ; Echinocandins ; Lipopeptides ; caspofungin (F0XDI6ZL63)
Language	English
Publishing date	2016-09
Publishing country	England
Document type	Journal Article ; Review
ZDB-ID	1053620-6
ISSN	1549-7828 ; 1040-841X
ISSN (online)	1549-7828
ISSN	1040-841X
DOI	10.3109/1040841X.2015.1068271
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Article: The Travelling Particles: Investigating microplastics as possible transport vectors for multidrug resistant E. coli in the Weser estuary (Germany)

Song, Jessica / Gerdts, Gunnar / Imirzalioglu, Can / Jongmans-Hochschulz, Elanor / Mauder, Norman / Wichels, Antje

Science of the total environment. 2020 June 10, v. 720

2020

Abstract: The prevalence of multidrug-resistant Gram-negative bacteria in aquatic environments has been a long withstanding health concern, namely extended-spectrum beta-lactamase (ESBL) producing Escherichia coli. Given increasing reports on microplastic (MP) ... ...

Abstract	The prevalence of multidrug-resistant Gram-negative bacteria in aquatic environments has been a long withstanding health concern, namely extended-spectrum beta-lactamase (ESBL) producing Escherichia coli. Given increasing reports on microplastic (MP) pollution in these environments, it has become crucial to better understand the role of MP particles as transport vectors for such multidrug-resistant bacteria. In this study, an incubation experiment was designed where particles of both synthetic and natural material (HDPE, tyre wear, and wood) were sequentially incubated at multiple sites along a salinity gradient from the Lower Weser estuary (Germany) to the offshore island Helgoland (German Bight, North Sea). Following each incubation period, particle biofilms and water samples were assessed for ESBL-producing E. coli, first by the enrichment and detection of E. coli using Fluorocult® LMX Broth followed by cultivation on CHROMAgarTM ESBL media to select for ESBL-producers. Results showed that general E. coli populations were present on the surfaces of wood particles across all sites but none were found to produce ESBLs. Additionally, neither HDPE nor tyre wear particles were found to harbour any E. coli. Conversely, ESBL-producing E. coli were present in surrounding waters from all sites, 64% of which conferred resistances against up to 3 other antibiotic groups, additional to the beta-lactam resistances intrinsic to ESBL-producers. This study provides a first look into the potential of MP to harbour and transport multidrug-resistant E. coli across different environments and the approach serves as an important precursor to further studies on other potentially harmful MP-colonizing species.
Keywords	antibiotics ; aquatic environment ; beta-lactamase ; beta-lactamase bacteria ; beta-lactams ; biofilm ; Escherichia coli ; estuaries ; Gram-negative bacteria ; microplastics ; multiple drug resistance ; pollution ; polyethylene ; salinity ; tires ; wood ; Germany ; North Sea
Language	English
Dates of publication	2020-0610
Publishing place	Elsevier B.V.
Document type	Article
ZDB-ID	121506-1
ISSN	1879-1026 ; 0048-9697
ISSN (online)	1879-1026
ISSN	0048-9697
DOI	10.1016/j.scitotenv.2020.137603
Database	NAL-Catalogue (AGRICOLA)

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Article ; Online: Comparison of Uveitis Incidence by Medication in Juvenile Idiopathic Arthritis and Implications for Screening.

Bison, Henry S / Janetos, Timothy M / Gao, Hans M / Zhang, David L / Song, Jessica / Bohnsack, Brenda L

American journal of ophthalmology

2022 Volume 247, Page(s) 70–78

Abstract: Purpose: To determine uveitis incidence in juvenile idiopathic arthritis (JIA) patients treated with disease-modifying antirheumatic drugs (DMARD) medications, and to evaluate uveitis risk-stratification protocols.: Design: Retrospective clinical ... ...

Abstract	Purpose: To determine uveitis incidence in juvenile idiopathic arthritis (JIA) patients treated with disease-modifying antirheumatic drugs (DMARD) medications, and to evaluate uveitis risk-stratification protocols. Design: Retrospective clinical cohort study. Methods: Medical records of patients with JIA seen by ophthalmology at a single institution from April 2014 to April 2022 and ≥18 months' follow-up were reviewed. Exclusion criteria included uveitis history prior to study period, Still disease, or <18 months' follow-up. Patient characteristics, medications, and uveitis status were recorded. Factors associated with uveitis development were analyzed and statistically significant metrics used to determine empiric risk-stratification criteria. These criteria and American College of Rheumatology (ACR) risk-stratification guidelines were applied retroactively to determine predictive power. Results: One hundred eighty-four patients met inclusion criteria and were included. Twenty-one new cases of uveitis developed during the study period. There were no statistically significant differences between no DMARD treatment, methotrexate (MTX), and etanercept (ETA) groups in uveitis incidence, whereas the adalimumab (ADA) and other biologics groups had no uveitis cases. Under the empirically determined criteria, the ratio of uveitis incidence between high- and low-risk groups was 8.21 (2.68-33.55; P < .0001), whereas it was 1.90 (0.72-4.93; P = .15) under the ACR criteria. Conclusion: Patients on MTX, ETA, and no DMARD treatment were comparable in JIA-associated uveitis incidence, whereas there were no new cases with ADA or other biologics. Further, we found increased predictive power in the empiric criteria in comparison to current ACR risk stratification.
MeSH term(s)	Humans ; Arthritis, Juvenile/complications ; Cohort Studies ; Retrospective Studies ; Incidence ; Antirheumatic Agents/adverse effects ; Adalimumab/adverse effects ; Methotrexate/therapeutic use ; Uveitis/diagnosis ; Etanercept/adverse effects ; Biological Products/adverse effects ; Treatment Outcome
Chemical Substances	Antirheumatic Agents ; Adalimumab (FYS6T7F842) ; Methotrexate (YL5FZ2Y5U1) ; Etanercept (OP401G7OJC) ; Biological Products
Language	English
Publishing date	2022-11-11
Publishing country	United States
Document type	Journal Article
ZDB-ID	80030-2
ISSN	1879-1891 ; 0002-9394
ISSN (online)	1879-1891
ISSN	0002-9394
DOI	10.1016/j.ajo.2022.11.010
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Article ; Online: The travelling particles

Song, Jessica / Beule, Lukas / Jongmans-Hochschulz, Elanor / Wichels, Antje / Gerdts, Gunnar

community dynamics of biofilms on microplastics transferred along a salinity gradient

2022

Abstract	Microplastics (MP), as novel substrata for microbial colonization within aquatic ecosystems, are a matter of growing concern due to their potential to propagate foreign or invasive species across different environments. MP are known to harbour a diversity of microorganisms, yet little is understood of the dynamics of their biofilms and their capacity to successfully displace these microorganisms across different aquatic ecosystems typically marked by steep salinity gradients. To address this, we performed an in situ sequential incubation experiment to simulate MP transport from riverine to coastal seawaters using synthetic (high-density polyethylene, HDPE and tyre wear, TW) and natural (Wood) substrata. Bacterial communities on incubated particles were compared to each other as well as to those in surrounding waters, and their dynamics along the gradient investigated. All communities differed significantly from each other in their overall structure along the salinity gradient and were shaped by different ecological processes. While HDPE communities were governed by environmental selection, those on TW and Wood were dominated by stochastic events of dispersal and drift. Upon transfer into coastal seawaters, an almost complete turnover was observed among HDPE and TW communities. While synthetic particles displaced a minor proportion of communities across the salinity gradient, some of these comprised putatively pathogenic and resistant taxa. Our findings present an extensive assessment of MP biofilms and their dynamics upon displacement across different aquatic systems, presenting new insights into the role of MP as transport vectors.
Keywords	Text ; ddc:630
Language	English
Publisher	Springer Science and Business Media LLC
Publishing country	de
Document type	Article ; Online
Database	BASE - Bielefeld Academic Search Engine (life sciences selection)

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Article ; Online: Psychological interventions for individuals with Ehlers-Danlos syndrome and hypermobility spectrum disorder: a scoping review.

Song, Jessica Z / Luong, Dorothy / Feldman, Estée C H / Tran, Susan / Perrier, Laure / Eubanks, Kathleen / Bayley, Mark / Kastner, Monika / Slepian, Maxwell / Munce, Sarah E P

Orphanet journal of rare diseases

2023 Volume 18, Issue 1, Page(s) 254

Abstract: Purpose: To identify the nature and extent of the evidence on psychological interventions among individuals with Ehlers-Danlos Syndrome (EDS) and Hypermobility Spectrum Disorder (HSD).: Materials and methods: Eligible studies reported on ... ...

Abstract	Purpose: To identify the nature and extent of the evidence on psychological interventions among individuals with Ehlers-Danlos Syndrome (EDS) and Hypermobility Spectrum Disorder (HSD). Materials and methods: Eligible studies reported on psychological interventions for individuals of all ages with EDS and/or HSD. All studies published in English were included, with no restrictions to publication year or status. MEDLINE, CINAHL, EMBASE, and PsycINFO were searched. Two reviewers independently screened studies and abstracted data. Results: This scoping review included 10 studies reporting on EDS, HSD, or both. Only cohort studies and case studies were identified. Four studies investigated Cognitive Behavioural Therapy (CBT), one investigated Dialectical Behavioural Therapy (DBT), two investigated psychoeducation, two investigated Intensive Interdisciplinary Pain Treatment (IIPT), and one investigated Acceptance Commitment Therapy (ACT). Interventions targeted pain management, self-destructive behaviours, and related psychological issues (e.g., depression/anxiety). Sample sizes were small (n < 50) for most studies and interventions were generally poorly described. Conclusions: There is a critical need for high-quality research surrounding psychological interventions for individuals with EDS/HSD. Psychological interventions for these individuals are understudied and existing studies lack validity. Researchers should investigate psychological interventions for individuals with all types of EDS/HSD with high-quality studies to validate findings from the existing studies.
MeSH term(s)	Humans ; Psychosocial Intervention ; Ehlers-Danlos Syndrome/therapy ; Pain ; Sample Size
Language	English
Publishing date	2023-08-31
Publishing country	England
Document type	Journal Article ; Review ; Research Support, Non-U.S. Gov't
ZDB-ID	2225857-7
ISSN	1750-1172 ; 1750-1172
ISSN (online)	1750-1172
ISSN	1750-1172
DOI	10.1186/s13023-023-02799-y
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