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Article ; Online: Patterns of Adverse Childhood Experiences and Psychiatric Disorders Among Adolescents with ADHD: A Latent Class Analysis.

Song, Jihee

2023

Abstract: There is limited existing research on whether specific combinations of Adverse Childhood Experiences (ACEs) are associated with different psychiatric disorders among adolescents with ADHD. This study aimed to address this gap by identifying classes of ... ...

Abstract	There is limited existing research on whether specific combinations of Adverse Childhood Experiences (ACEs) are associated with different psychiatric disorders among adolescents with ADHD. This study aimed to address this gap by identifying classes of ACEs and examining their association with behavioral problems, anxiety, and depression in adolescents with ADHD aged 11-17 (n = 1,806), using data from the 2018 National Survey of Children's Health (NSCH). A latent class analysis revealed a four-class solution: (1) low-risk ACEs (61.6%), (2) moderate-risk ACEs (25.2%), (3) high discrimination and neighborhood violence exposure (7.6%), and (4) high-risk ACEs (5.6%). The "high-risk ACEs" and the "high discrimination and neighborhood violence exposure" class showed a higher likelihood of behavioral problems and depression, and anxiety and depression respectively. These findings provide some insight into the ACE patterns that are more likely to be associated with mental health problems among adolescents with ADHD.
Language	English
Publishing date	2023-12-18
Publishing country	United States
Document type	Journal Article
ZDB-ID	223895-0
ISSN	1573-3327 ; 0009-398X
ISSN (online)	1573-3327
ISSN	0009-398X
DOI	10.1007/s10578-023-01645-3
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Article: Genetic Mutations That Confer Fluoride Resistance Modify Gene Expression and Virulence Traits of Streptococcus mutans

Lee, Hyeon-Jeong / Song, Jihee / Kim, Jeong Nam

Microorganisms. 2021 Apr. 15, v. 9, no. 4

2021

Abstract: Fluoride is an inorganic monatomic anion that is widely used as an anti-cariogenic agent for the control of caries development. The aims of this study were to identify the mutated genes that give rise to fluoride-resistant (FR) strains of the cariogenic ... ...

Abstract	Fluoride is an inorganic monatomic anion that is widely used as an anti-cariogenic agent for the control of caries development. The aims of this study were to identify the mutated genes that give rise to fluoride-resistant (FR) strains of the cariogenic pathogen Streptococcus mutans and explore how genetic alterations in the genome of an S. mutans FR strain optimize the metabolism(s) implicated in the expression of virulence-associated traits. Here, we derived an S. mutans FR strain from a wild-type UA159 strain by continuous shifts to a medium supplemented with increasing concentrations of fluoride. The FR strain exhibited a slow growth rate and low yield under aerobic and oxidative stress conditions and was highly sensitive to acid stress. Notably, microscopy observation displayed morphological changes in which the FR strain had a slightly shorter cell length. Next, using the sequencing analyses, we found six mutations in the FR genome, which decreased the gene expression of the phosphoenolpyruvate-dependent phosphotransferase system (PTS). Indeed, the ability to intake carbohydrates was relatively reduced in the FR strain. Collectively, our results provide evidence that the genetic mutations in the genome of the FR strain modulate the expression of gene(s) for carbon metabolism(s) and cellular processes, leading to diminished fitness with respect to virulence and persistence.
Keywords	Streptococcus mutans ; carbon metabolism ; fluorides ; gene expression ; microscopy ; oxidative stress ; pathogens ; virulence
Language	English
Dates of publication	2021-0415
Publishing place	Multidisciplinary Digital Publishing Institute
Document type	Article
Note	NAL-AP-2-clean
ZDB-ID	2720891-6
ISSN	2076-2607
ISSN	2076-2607
DOI	10.3390/microorganisms9040849
Database	NAL-Catalogue (AGRICOLA)

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Article: Genetic Mutations That Confer Fluoride Resistance Modify Gene Expression and Virulence Traits of

Lee, Hyeon-Jeong / Song, Jihee / Kim, Jeong Nam

Microorganisms

2021 Volume 9, Issue 4

Abstract	Fluoride is an inorganic monatomic anion that is widely used as an anti-cariogenic agent for the control of caries development. The aims of this study were to identify the mutated genes that give rise to fluoride-resistant (FR) strains of the cariogenic pathogen
Language	English
Publishing date	2021-04-15
Publishing country	Switzerland
Document type	Journal Article
ZDB-ID	2720891-6
ISSN	2076-2607
ISSN	2076-2607
DOI	10.3390/microorganisms9040849
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Article: Exploring an Innovative Approach to Enhance Discussion Board Engagement.

Hamadi, Hanadi / Tafili, Aurora / Kates, Frederick R / Larson, Samantha A / Ellison, Carlyn / Song, Jihee

TechTrends : for leaders in education & training

2023 , Page(s) 1–11

Abstract: Online discussion boards are a standard learning management system (LMS) instructional tool used in the emerging online learning pedagogy. This pilot study examined an innovative approach that differs from how discussion boards have been commonly used. ... ...

Abstract	Online discussion boards are a standard learning management system (LMS) instructional tool used in the emerging online learning pedagogy. This pilot study examined an innovative approach that differs from how discussion boards have been commonly used. Using a retrospective, cross-sectional design, we evaluated the effect of shifting from traditional teacher and student-generated prompts to using student-generated videos with higher-order discussion questions to gauge student perceptions of peer feedback and engagement. Participants were graduate students in a health care administration course at a large university. Overall students' perceptions of creating and responding to student-generated prompts were positive. Students responded that they were more engaged and thought more critically about the content with this shift from the traditional way of using discussion boards. As digital technology reshapes higher education, it is essential to reflect and evaluate the effectiveness of current LMS applications and standard procedures to improve educational delivery.
Language	English
Publishing date	2023-04-24
Publishing country	United States
Document type	Journal Article
ZDB-ID	2144706-8
ISSN	1559-7075 ; 8756-3894
ISSN (online)	1559-7075
ISSN	8756-3894
DOI	10.1007/s11528-023-00850-0
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Article ; Online: Behavioral and mental health problems in adolescents with ADHD: Exploring the role of family resilience.

Song, Jihee / Fogarty, Kate / Suk, Ryan / Gillen, Martie

Journal of affective disorders

2021 Volume 294, Page(s) 450–458

Abstract: Background: Family resilience and its role in behavioral and mental health problems has not been well documented among U.S. adolescents, especially those with ADHD.: Methods: Using data from the 2016 and 2017 National Survey of Children's Health ( ... ...

Abstract	Background: Family resilience and its role in behavioral and mental health problems has not been well documented among U.S. adolescents, especially those with ADHD. Methods: Using data from the 2016 and 2017 National Survey of Children's Health (NSCH), we examined associations between family resilience connection index (FRCI) and conduct problems, depression, anxiety, and substance abuse in adolescents with ADHD aged 11-17 (n=4,169). Data were analyzed using multivariate logistic regression and chi-square tests. Results: Adolescents with ADHD who had a lower FRCI score were more likely to have conduct problems (OR:1.64, CI:1.13-2.38) and depression (OR: 3.08, CI: 2.12-4.49). There were small differences between adjusted and unadjusted odds after controlling for adverse childhood experience and other covariates. Limitation: We could not assert prediction or causation, only associations among variables, due to the cross-sectional design of the 2016-2017 NSCH; however, a major advantage of the NSCH is that it includes a nationally representative sample of children and allows inferences to be made for understanding of the adolescents with ADHD in the U.S. Conclusion: Findings suggest that family resilience may serve as a protective factor that leads to decreasing conduct problems, despite experiencing adversity in childhood. Targeting family resilience, in terms of teaching families ways to cope with adversities such as: a child's diagnosis of ADHD; behavioral problems, and/or other adverse experiences in children's environments, has great potential to reduce adolescents' conduct and mental health problems.
MeSH term(s)	Adolescent ; Attention Deficit Disorder with Hyperactivity/epidemiology ; Child ; Cross-Sectional Studies ; Family Health ; Humans ; Mental Health ; Resilience, Psychological
Language	English
Publishing date	2021-07-22
Publishing country	Netherlands
Document type	Journal Article
ZDB-ID	135449-8
ISSN	1573-2517 ; 0165-0327
ISSN (online)	1573-2517
ISSN	0165-0327
DOI	10.1016/j.jad.2021.07.073
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Article ; Online: Complete chloroplast genome of

Kim, Wonhee / Ryu, Seah / Song, Ji-Hee / Sim, Sunhee

Mitochondrial DNA. Part B, Resources

2021 Volume 6, Issue 12, Page(s) 3416–3417

Abstract: We determined the complete chloroplast genome sequence of the ... ...

Abstract	We determined the complete chloroplast genome sequence of the peatmoss
Language	English
Publishing date	2021-11-22
Publishing country	England
Document type	Journal Article
ISSN	2380-2359
ISSN (online)	2380-2359
DOI	10.1080/23802359.2021.1999186
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Article ; Online: The Impact of the Affordable Care Act on Dental Care: An Integrative Literature Review.

Song, Jihee / Kim, Jeong Nam / Tomar, Scott / Wong, Lauren N

International journal of environmental research and public health

2021 Volume 18, Issue 15

Abstract: The goal of the Patient Protection and Affordable Care Act (ACA) is to increase access to health insurance and decrease health care cost while improving health care quality. With more articles examining the relationship between one of the ACA provisions ... ...

Abstract	The goal of the Patient Protection and Affordable Care Act (ACA) is to increase access to health insurance and decrease health care cost while improving health care quality. With more articles examining the relationship between one of the ACA provisions and dental health outcomes, we systematically reviewed the effect of the ACA on dental care coverage and access to dental services. We searched literature using the National Library of Medicine's Medline (PubMed) and Thomson Reuters' Web of Science between January 2010 and November 2020. We identified 33 articles related to dental coverage, and access/utilization of dental care services. This systematic review of studies showed that the ACA resulted in gains in dental coverage for adults and children, whereas results were mixed with dental care access. Overall, we found that the policy led to a decrease in cost barriers, an increase in private dental coverage for young adults, and increased dental care use among low-income childless adults. The implementation of the ACA was not directly associated with dental insurance coverage among people in the U.S. However, results suggest positive spillover effects of the ACA on dental care coverage and utilization by people in the national level dataset.
MeSH term(s)	Child ; Dental Care ; Health Services Accessibility ; Humans ; Insurance Coverage ; Insurance, Health ; Motivation ; Patient Protection and Affordable Care Act ; United States ; Young Adult
Language	English
Publishing date	2021-07-25
Publishing country	Switzerland
Document type	Journal Article ; Research Support, Non-U.S. Gov't ; Review ; Systematic Review
ZDB-ID	2175195-X
ISSN	1660-4601 ; 1661-7827
ISSN (online)	1660-4601
ISSN	1661-7827
DOI	10.3390/ijerph18157865
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Article ; Online: The health care utilization model: Application to dental care use for Black and Hispanic children.

Song, Jihee / Tomar, Scott / Duncan, R Paul / Fogarty, Kate / Johns, Tracy / Kim, Jeong Nam

Journal of public health dentistry

2020 Volume 81, Issue 3, Page(s) 188–197

Abstract: Objectives: To explore the pathway associated with dental service use among Hispanic and non-Hispanic Black children, applying Andersen's model of health care service utilization.: Methods: Samples of Hispanic (n = 5,055) and non-Hispanic (NH) Black ( ...

Abstract	Objectives: To explore the pathway associated with dental service use among Hispanic and non-Hispanic Black children, applying Andersen's model of health care service utilization. Methods: Samples of Hispanic (n = 5,055) and non-Hispanic (NH) Black (n = 2,695) children aged 2-17 years from the 2016 National Survey of Children's Health (NSCH) were included in this study. We used structural equation modeling (SEM) to examine the path of the relationship between dental care visits and the three groups of characteristics in Andersen's behavioral model. Results: In the models for Hispanic and non-Hispanic Black children, parents' educational attainment directly and positively affected income and having insurance. Also, insurance (Hispanic children: β = 0.17, P ≤ 0.01; NH Black children: β = 0.25, P ≤ 0.01) and age of the child (Hispanic children: β = 0.14, P ≤ 0.01; NH Black: β = 0.21, P ≤ 0.01) directly and positively affected dental care use. However, there was no direct effect of the need factor on dental care use in either model. Conclusions: Children may receive dental services that eliminate acute dental problems, probably as a result of the ACA and CHIP coverage. The patterns of findings suggest the need for policy changes to improve pediatric dental coverage and promote professional recommendations for effective dental hygiene.
MeSH term(s)	Child ; Dental Care ; Health Services Accessibility ; Hispanic Americans ; Humans ; Insurance, Health ; Patient Acceptance of Health Care ; United States
Language	English
Publishing date	2020-12-01
Publishing country	United States
Document type	Journal Article
ZDB-ID	410719-6
ISSN	1752-7325 ; 0022-4006
ISSN (online)	1752-7325
ISSN	0022-4006
DOI	10.1111/jphd.12430
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Article ; Online: Early Performance of Hospital Value-based Purchasing Program in Medicare: A Systematic Review.

Hong, Young-Rock / Nguyen, Oliver / Yadav, Sandhya / Etzold, Emma / Song, Jihee / Duncan, R Paul / Turner, Kea

Medical care

2020 Volume 58, Issue 8, Page(s) 734–743

Abstract: Background: Under the Affordable Care Act, the Centers for Medicare and Medicaid Services has greatly expanded inpatient fee-for-value programs including the Hospital Value-based Purchasing (HVBP) program. Existing evidence from the HVBP program is ... ...

Abstract	Background: Under the Affordable Care Act, the Centers for Medicare and Medicaid Services has greatly expanded inpatient fee-for-value programs including the Hospital Value-based Purchasing (HVBP) program. Existing evidence from the HVBP program is mixed. There is a need for a systematic review of the HVBP program to inform discussions on how to improve the program's effectiveness. Objective: To review and summarize studies that evaluated the HVBP program's impact on clinical processes, patient satisfaction, costs and outcomes, or assessed hospital characteristics associated with performance on the program. Design: We searched the MEDLINE/PubMed, Scopus, ProQuest database for literature published between January 2013 and July 2019 using the Preferred Reporting Items for Systematic Reviews and Meta-Analysis guidelines. Results: Of 988 studies reviewed, 33 studies that met the selection criteria were included. A small group of studies (n=7) evaluated the impact of the HVBP program, and no impact on processes or patient outcomes was reported. None of the included studies evaluated the effect of HVBP program on health care costs. Other studies (n=28) evaluated the hospital characteristics associated with HVBP performance, suggesting that safety-net hospitals reportedly performed worse on several quality and cost measures. Other hospital characteristics' associations with performance were unclear. Conclusions: Our findings suggest that the current HVBP does not lead to meaningful improvements in quality of care or patient outcomes and may negatively affect safety-net hospitals. More rigorous and comprehensive adjustment is needed for more valid hospital comparisons.
MeSH term(s)	Humans ; Medicare/economics ; Medicare/standards ; Medicare/trends ; Patient Protection and Affordable Care Act/economics ; Patient Protection and Affordable Care Act/standards ; Patient Protection and Affordable Care Act/trends ; Program Evaluation ; United States ; Value-Based Purchasing/standards ; Value-Based Purchasing/trends
Language	English
Publishing date	2020-07-20
Publishing country	United States
Document type	Journal Article ; Systematic Review
ZDB-ID	411646-x
ISSN	1537-1948 ; 0025-7079
ISSN (online)	1537-1948
ISSN	0025-7079
DOI	10.1097/MLR.0000000000001354
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Article: Actin-sequestering protein, thymosin-beta-4 (TB4), inhibits caspase-3 activation in paclitaxel-induced tumor cell death.

Moon, Eun-Yi / Song, Ji-Hee / Yang, Kyu-Hwan

Oncology research

2008 Volume 16, Issue 11, Page(s) 507–516

Abstract: Thymosin-beta-4 (TB4) as an actin-sequestering peptide has been detected outside of cells in blood plasma or in wound fluid. TB4 induces tumor metastasis and paclitaxel resistance, which is the most significant obstacle to successful therapy in tumors. ... ...

Abstract	Thymosin-beta-4 (TB4) as an actin-sequestering peptide has been detected outside of cells in blood plasma or in wound fluid. TB4 induces tumor metastasis and paclitaxel resistance, which is the most significant obstacle to successful therapy in tumors. Here we investigated the inhibitory effect of TB4 peptides on tumor cell death by paclitaxel. The effect of TB4 peptides was assayed by the measurement of caspase-3 activity, G2/M arrest, and Bcl-2 phosphorylation. Cell survival rate was increased and caspase-3 activity was decreased by the treatment with TB4 peptides. In contrast, small interfering RNA (siRNA) of TB4 inhibited cell viability and augmented caspase-3 activity. Significant changes in Bcl-2 phosphorylation were detected by TB4 peptide treatment or by the overexpression of TB4 gene in Hela cells. The reduced population in G2/M phase by TB4 peptide treatment was correlated with the decreased expression of cyclin B1. The data were confirmed in gastric tumor cell lines, SNU 638 (low TB4 level) and SNU 668 (high TB4 level), which were established from clinically isolated gastric tumors. In conclusion, soluble TB4 peptides produced in cancer cells could be an obstacle to treat tumors with paclitaxel. Therefore, TB4 could be a novel target to control paclitaxel resistance.
MeSH term(s)	Antineoplastic Agents, Phytogenic/pharmacology ; Apoptosis/drug effects ; Caspase 3/drug effects ; Caspase 3/metabolism ; Cell Line, Tumor ; Cell Survival ; Cyclin B/genetics ; Cyclin B1 ; Drug Resistance, Neoplasm ; G2 Phase ; Gene Expression Regulation ; HeLa Cells ; Humans ; Paclitaxel/pharmacology ; Phosphorylation ; Proto-Oncogene Proteins c-bcl-2/metabolism ; RNA, Small Interfering/metabolism ; Thymosin/metabolism
Chemical Substances	Antineoplastic Agents, Phytogenic ; CCNB1 protein, human ; Cyclin B ; Cyclin B1 ; Proto-Oncogene Proteins c-bcl-2 ; RNA, Small Interfering ; thymosin beta(4) (549LM7U24W) ; Thymosin (61512-21-8) ; Caspase 3 (EC 3.4.22.-) ; Paclitaxel (P88XT4IS4D)
Language	English
Publishing date	2008-02-21
Publishing country	United States
Document type	Journal Article ; Research Support, Non-U.S. Gov't
ZDB-ID	1114699-0
ISSN	1555-3906 ; 0965-0407
ISSN (online)	1555-3906
ISSN	0965-0407
DOI	10.3727/096504007783438349
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