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Article ; Online: Untargeted metabolomics reveals potential plasma biomarkers for diagnosis of primary aldosteronism using liquid chromatography-mass spectrometry.

Song, Jing-Jing / Cai, Jun / Ma, Wen-Jun / Lou, Ying / Bian, Jin / Zhao, Beibei / She, Xuhui / Liu, Xiao-Ning

2024 , Page(s) e5855

Abstract: Metabolite profiling has the potential to comprehensively bridge phenotypes and complex heterogeneous physiological and pathological states. We performed a metabolomics study using parallel liquid chromatography-mass spectrometry (LC-MS) combined with ... ...

Abstract	Metabolite profiling has the potential to comprehensively bridge phenotypes and complex heterogeneous physiological and pathological states. We performed a metabolomics study using parallel liquid chromatography-mass spectrometry (LC-MS) combined with multivariate data analysis to screen for biomarkers of primary aldosteronism (PA) from a cohort of 111 PA patients and 218 primary hypertension (PH) patients. Hydrophilic interaction chromatography and reversed-phase liquid chromatography separations were employed to obtain a global plasma metabolome of endogenous metabolites. The satisfactory classification between PA and PH patients was obtained using the MVDA model. A total of 35 differential metabolites were screened out and identified. A diagnostic biomarker panel was established using the least absolute shrinkage and selection operator (LASSO) binary logistic regression model and receiver operating characteristic analysis. Joint analysis with clinical indicators, including plasma supine aldosterone level, plasma orthostatic aldosterone level, body mass index, and blood potassium, revealed that the combination of metabolite biomarker panel and plasma supine aldosterone has the best clinical diagnostic efficacy.
Language	English
Publishing date	2024-03-05
Publishing country	England
Document type	Journal Article
ZDB-ID	632848-9
ISSN	1099-0801 ; 0269-3879
ISSN (online)	1099-0801
ISSN	0269-3879
DOI	10.1002/bmc.5855
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Article ; Online: A novel comprehensive strategy for high-thoroughly studying released compounds during the combustion process of herbs. A case study for Artemisia argyi Levl. et Vant.

Ma, Feng-Lian / Liu, Jia-Nan / Wang, Xing-Cai / Ma, Gui-Mei / Song, Jing-Jing / Chai, Guo-Bi / Lv, Yi / Zhang, Qi-Dong / Yu, Yong-Jie / She, Yuanbin

Journal of chromatography. A

2024 Volume 1716, Page(s) 464653

Abstract: The comprehensive study of compound variations in released smoke during the combustion process is a great challenge in many scientific fields related to analytical chemistry like traditional Chinese medicine, environment analysis, food analysis, etc. In ... ...

Abstract	The comprehensive study of compound variations in released smoke during the combustion process is a great challenge in many scientific fields related to analytical chemistry like traditional Chinese medicine, environment analysis, food analysis, etc. In this work, we propose a new comprehensive strategy for efficiently and high-thoroughly characterizing compounds in the online released complex smokes: (i) A smoke capture device was designed for efficiently collecting chemical constituents to perform gas chromatography-mass spectrometry (GC-MS) based untargeted analysis. (ii) An advanced data analysis tool, AntDAS-GCMS, was used for automatically extracting compounds in the original acquired GC-MS data files. Additionally, a GC-MS data analysis guided instrumental parameter optimizing strategy was proposed for the optimization of parameters in the smoke capture device. The developed strategy was demonstrated by the study of compound variations in the smoke of traditional Chinese medicine, Artemisia argyi Levl. et Vant. The results indicated that more than 590 components showed significant differences among released smokes of various moxa velvet ratios. Finally, about 88 compounds were identified, of which phenolic compounds were the most abundant, followed by aromatics, alkenes, alcohols and furans. In conclusion, we may provide a novel approach to the studies of compounds in online released smoke.
MeSH term(s)	Artemisia/chemistry ; Medicine, Chinese Traditional ; Smoke ; Gas Chromatography-Mass Spectrometry/methods
Chemical Substances	Smoke
Language	English
Publishing date	2024-01-12
Publishing country	Netherlands
Document type	Journal Article
ZDB-ID	1171488-8
ISSN	1873-3778 ; 0021-9673
ISSN (online)	1873-3778
ISSN	0021-9673
DOI	10.1016/j.chroma.2024.464653
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Article: Bibliometric and visual analysis of transcranial direct current stimulation in the web of science database from 2000 to 2022

Sun, Weiming / Song, JingJing / Dong, Xiangli / Kang, Xizhen / He, Binjun / Zhao, Wentao / Li, Zhaoting / Feng, Zhen / Chen, Xiuping

Frontiers in human neuroscience

2022 Volume 16, Page(s) 1049572

Abstract: Objective: This study aimed to evaluate the current research hotspots and development tendency of Transcranial Direct Current Stimulation (tDCS) in the field of neurobiology from a bibliometric perspective by providing visualized information to ... ...

Abstract	Objective: This study aimed to evaluate the current research hotspots and development tendency of Transcranial Direct Current Stimulation (tDCS) in the field of neurobiology from a bibliometric perspective by providing visualized information to scientists and clinicians. Materials and methods: Publications related to tDCS published between 2000 and 2022 were retrieved from the Web of Science Core Collection (WOSCC) on May 5, 2022. Bibliometric features including the number of publications and citations, citation frequency, H-index, journal impact factors, and journal citation reports were summarized using Microsoft Office Excel. Co-authorship, citation, co-citation, and co-occurrence analyses among countries, institutions, authors, co-authors, journals, publications, references, and keywords were analyzed and visualized using CiteSpace (version 6.1.R3). Results: A total of 4,756 publications on tDCS fulfilled the criteria we designed and then were extracted from the WOSCC. The United States (1,190 publications, 25.02%) and Harvard University (185 publications, 3.89%) were the leading contributors among all the countries and institutions, respectively. NITSCHE MA and FREGNI F, two key researchers, have made great achievements in tDCS. Conclusion: This was the first-ever study of peer-reviewed publications relative to tDCS using several scientometric and visual analytic methods to quantitatively and qualitatively reveal the current research status and trends in the field of tDCS. Through the bibliometric method, we gained an in-depth understanding of the current research status and development trend on tDCS. Our research and analysis results might provide some practical sources for academic scholars and clinicians.
Language	English
Publishing date	2022-12-01
Publishing country	Switzerland
Document type	Journal Article
ZDB-ID	2425477-0
ISSN	1662-5161
ISSN	1662-5161
DOI	10.3389/fnhum.2022.1049572
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Article: Detrimental impact of hypoxia on the mortality, growth, reproduction, and enzyme activities of planktonic mysid Neomysis awatschensis

Wang, Qiao-ning / Li, Xiao-dong / Yan, Tian / Song, Jing-jing / Yu, Ren-cheng / Zhou, Ming-jiang

Aquatic ecology. 2021 Sept., v. 55, no. 3

2021

Abstract: In recent years, marine hypoxia has frequently occurred in global coastal and estuarine waters with detrimental impacts on marine fauna. In this work, we examined the impact of hypoxia on the mortality, growth, reproduction, and enzyme activities of the ... ...

Abstract	In recent years, marine hypoxia has frequently occurred in global coastal and estuarine waters with detrimental impacts on marine fauna. In this work, we examined the impact of hypoxia on the mortality, growth, reproduction, and enzyme activities of the mysid Neomysis awatschensis. The mortality rate of adult mysids increased by 100% within 4 h under the hypoxia treatment (2 mg/L), while that of juveniles was 53.33 ± 5.77% after 96 h. The long-term low dissolved oxygen (DO) treatment (5 mg/L for 30 d) significantly reduced the fatty acid content of mysids. A significant reproductive inhibition was also observed: the total juvenile productions in the treatment with DO at 4, 5, and 6 mg/L were only 6.5%, 24%, and 60% of the control group (DO at 8.5 mg/L), respectively. The total superoxide dismutase activity increased significantly in low oxygen treatments. Catalase and lactate dehydrogenase activities first increased and then decreased with the dropping DO concentrations. These results suggest that hypoxia has multiple impacts on marine zooplankton. This may adversely affect higher trophic level organisms and the structure and function of marine ecosystems.
Keywords	Neomysis ; adults ; catalase ; estuaries ; fatty acid composition ; fauna ; hypoxia ; juveniles ; lactate dehydrogenase ; mortality ; oxygen ; reproduction ; superoxide dismutase ; trophic levels ; zooplankton
Language	English
Dates of publication	2021-09
Size	p. 849-859.
Publishing place	Springer Netherlands
Document type	Article
ZDB-ID	1411979-1
ISSN	1573-5125 ; 1386-2588
ISSN (online)	1573-5125
ISSN	1386-2588
DOI	10.1007/s10452-021-09864-3
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Article ; Online: Negative serum (1,3) -β-D-glucan has a low power to exclude Pneumocystis jirovecii pneumonia (PJP) in HIV-uninfected patients with positive qPCR.

Huang, Yuan / Yi, Jie / Song, Jing-Jing / Du, Li-Jun / Li, Xiao-Meng / Cheng, Lin-Lin / Yan, Song-Xin / Li, Hao-Long / Liu, Yong-Mei / Zhan, Hao-Ting / Dou, Ya-Ling / Li, Yong-Zhe

Annals of clinical microbiology and antimicrobials

2023 Volume 22, Issue 1, Page(s) 102

Abstract: Objective: The current study evaluated the diagnostic performance of serum (1,3)-beta-D Glucan (BDG) in differentiating PJP from P. jirovecii-colonization in HIV-uninfected patients with P. jirovecii PCR-positive results.: Methods: This was a single- ... ...

Abstract	Objective: The current study evaluated the diagnostic performance of serum (1,3)-beta-D Glucan (BDG) in differentiating PJP from P. jirovecii-colonization in HIV-uninfected patients with P. jirovecii PCR-positive results. Methods: This was a single-center retrospective study between 2019 and 2021. The diagnosis of PJP was based on the following criteria: detection of P. jirovecii in sputum or BAL specimen by qPCR or microscopy; Meet at least two of the three criteria: (1) have respiratory symptoms of cough and/or dyspnea, hypoxia; (2) typical radiological picture findings; (3) receiving a complete PJP treatment. After exclusion, the participants were divided into derivation and validation cohorts. The derivation cohort defined the cut-off value of serum BDG. Then, it was verified using the validation cohort. Results: Two hundred and thirteen HIV-uninfected patients were enrolled, with 159 PJP and 54 P. jirovecii-colonized patients. BDG had outstanding specificity, LR, and PPV for PJP in both the derivation (90.00%, 8.900, and 96.43%) and the validation (91.67%, 9.176, and 96.30%) cohorts at ≥ 117.7 pg/mL. However, it had lower sensitivity and NPV in the derivation cohort (89.01% and 72.97%), which was even lower in the validation cohort (76.47% and 57.89%). Of note, BDG ≥ 117.7 pg/mL has insufficient diagnostic efficacy for PJP in patients with lung cancer, interstitial lung disease (ILD) and nephrotic syndrome. And although lymphocytes, B cells, and CD4 Conclusions: Serum BDG ≥ 117.7 pg/mL could effectively distinguish P. jirovecii-colonization from infection in qPCR-positive HIV-uninfected patients with infectious diseases, solid tumors (excluding lung cancer), autoimmune or inflammatory disorders, and hematological malignancies. Of note, for patients with lung cancer, ILD, and nephrotic diseases, PJP should be cautiously excluded at BDG < 117.7 pg/mL.
MeSH term(s)	Humans ; Pneumonia, Pneumocystis/diagnosis ; Pneumocystis carinii/genetics ; Glucans ; Retrospective Studies ; beta-Glucans ; Lung Neoplasms ; HIV Infections/complications ; Lung Diseases, Interstitial
Chemical Substances	Glucans ; beta-Glucans
Language	English
Publishing date	2023-11-20
Publishing country	England
Document type	Journal Article
ZDB-ID	2097873-X
ISSN	1476-0711 ; 1476-0711
ISSN (online)	1476-0711
ISSN	1476-0711
DOI	10.1186/s12941-023-00650-7
Database	MEDical Literature Analysis and Retrieval System OnLINE

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Article: Association of triglyceride-glucose index with atherosclerotic cardiovascular disease and mortality among familial hypercholesterolemia patients.

Wen, Jun / Pan, Qi / Du, Lei-Lei / Song, Jing-Jing / Liu, Yu-Peng / Meng, Xiang-Bin / Zhang, Kuo / Gao, Jun / Shao, Chun-Li / Wang, Wen-Yao / Zhou, Hao / Tang, Yi-Da

Diabetology & metabolic syndrome

2023 Volume 15, Issue 1, Page(s) 39

Abstract: Background: Familial hypercholesterolemia (FH) is an inherited metabolic disorder with a high level of low-density lipoprotein cholesterol and the worse prognosis. The triglyceride-glucose (TyG) index, an emerging tool to reflect insulin resistance (IR), ...

Abstract	Background: Familial hypercholesterolemia (FH) is an inherited metabolic disorder with a high level of low-density lipoprotein cholesterol and the worse prognosis. The triglyceride-glucose (TyG) index, an emerging tool to reflect insulin resistance (IR), is positively associated with a higher risk of atherosclerotic cardiovascular disease (ASCVD) in healthy individuals, but the value of TyG index has never been evaluated in FH patients. This study aimed to determine the association between the TyG index and glucose metabolic indicators, insulin resistance (IR) status, the risk of ASCVD and mortality among FH patients. Methods: Data from National Health and Nutrition Examination Survey (NHANES) 1999-2018 were utilized. 941 FH individuals with TyG index information were included and categorized into three groups: < 8.5, 8.5-9.0, and > 9.0. Spearman correlation analysis was used to test the association of TyG index and various established glucose metabolism-related indicators. Logistic and Cox regression analysis were used to assess the association of TyG index with ASCVD and mortality. The possible nonlinear relationships between TyG index and the all-cause or cardiovascular death were further evaluated on a continuous scale with restricted cubic spline (RCS) curves. Results: TyG index was positively associated with fasting glucose, HbA1c, fasting insulin and the homeostatic model assessment of insulin resistance (HOMA-IR) index (all p < 0.001). The risk of ASCVD increased by 74% with every 1 unit increase of TyG index (95%CI: 1.15-2.63, p = 0.01). During the median 114-month follow-up, 151 all-cause death and 57 cardiovascular death were recorded. Strong U/J-shaped relations were observed according to the RCS results (p = 0.0083 and 0.0046 for all-cause and cardiovascular death). A higher TyG index was independently associated with both all-cause death and cardiovascular death. Results remained similar among FH patients with IR (HOMA-IR ≥ 2.69). Moreover, addition of TyG index showed helpful discrimination of both survival from all-cause death and cardiovascular death (p < 0.05). Conclusion: TyG index was applicable to reflect glucose metabolism status in FH adults, and a high TyG index was an independent risk factor of both ASCVD and mortality.
Language	English
Publishing date	2023-03-09
Publishing country	England
Document type	Journal Article
ZDB-ID	2518786-7
ISSN	1758-5996
ISSN	1758-5996
DOI	10.1186/s13098-023-01009-w
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Article ; Online: First observation of conjoined twins in Oryzias melastigma.

Yu, Dao De / Wu, Hai Yi / Zhang, Zhi Peng / Chi, Wen Dan / Liu, Kai Kai / Liu, Ming / Wang, Ming Qi / Song, Jing Jing

Journal of fish diseases

2021 Volume 44, Issue 8, Page(s) 853–856

MeSH term(s)	Animals ; Oryzias/abnormalities ; Oryzias/embryology ; Twins, Conjoined/classification ; Twins, Conjoined/embryology
Language	English
Publishing date	2021-03-25
Publishing country	England
Document type	Journal Article
ZDB-ID	432109-1
ISSN	1365-2761 ; 0140-7775
ISSN (online)	1365-2761
ISSN	0140-7775
DOI	10.1111/jfd.13365
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Article ; Online: Inhibition of Smad3 in macrophages promotes Aβ efflux from the brain and thereby ameliorates Alzheimer's pathology.

Xu, Lu / Pan, Cai-Long / Wu, Xiang-Hui / Song, Jing-Jing / Meng, Ping / Li, Lei / Wang, Li / Zhang, Zhiren / Zhang, Zhi-Yuan

Brain, behavior, and immunity

2021 Volume 95, Page(s) 154–167

Abstract: Impaired amyloid-β (Aβ) clearance is believed to be a primary cause of Alzheimer's disease (AD), and peripheral abnormalities in Aβ clearance have recently been linked to AD pathogenesis and progression. Data from recent genome-wide association studies ... ...

Abstract	Impaired amyloid-β (Aβ) clearance is believed to be a primary cause of Alzheimer's disease (AD), and peripheral abnormalities in Aβ clearance have recently been linked to AD pathogenesis and progression. Data from recent genome-wide association studies have linked genetic risk factors associated with altered functions of more immune cells to AD pathology. Here, we first identified correlations of Smad3 signaling activation in peripheral macrophages with AD progression and phagocytosis of Aβ. Then, manipulating the Smad3 signaling regulated macrophage phagocytosis of Aβ and induced switch of macrophage inflammatory phenotypes in our cell cultures. In our mouse models, flag-tagged or fluorescent-dye conjugated Aβ was injected into the lateral ventricles or tail veins, and traced. Interestingly, blocking Smad3 signaling efficiently increased Aβ clearance by macrophages, reduced Aβ in the periphery and thereby enhanced Aβ efflux from the brain. Moreover, in our APP/PS1 transgenic AD model mice, Smad3 inhibition significantly attenuated Aβ deposition and neuroinflammation, and ameliorated cognitive deficits, probably by enhancing the peripheral clearance of Aβ. In conclusion, enhancing Aβ clearance by peripheral macrophages through Smad3 inhibition attenuated AD-related pathology and cognitive deficits, which may provide a new perspective for understanding AD and finding novel therapeutic approaches.
MeSH term(s)	Alzheimer Disease ; Amyloid beta-Peptides/metabolism ; Amyloid beta-Protein Precursor/genetics ; Animals ; Brain/metabolism ; Disease Models, Animal ; Genome-Wide Association Study ; Macrophages/metabolism ; Mice ; Mice, Inbred C57BL ; Mice, Transgenic ; Smad3 Protein
Chemical Substances	Amyloid beta-Peptides ; Amyloid beta-Protein Precursor ; Smad3 Protein ; Smad3 protein, mouse
Language	English
Publishing date	2021-03-15
Publishing country	Netherlands
Document type	Journal Article ; Research Support, Non-U.S. Gov't
ZDB-ID	639219-2
ISSN	1090-2139 ; 0889-1591
ISSN (online)	1090-2139
ISSN	0889-1591
DOI	10.1016/j.bbi.2021.03.013
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Zs.A 2276: Show issues			Location: Je nach Verfügbarkeit (siehe Angabe bei Bestand) bis Jg. 1994: Bestellungen von Artikeln über das Online-Bestellformular Jg. 1995 - 2021: Lesesall (2.OG) ab Jg. 2022: Lesesaal (EG)
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Article: Immunomodulation: The next target of mesenchymal stem cell-derived exosomes in the context of ischemic stroke.

Shan, Xiao-Qian / Luo, Yong-Yin / Chang, Jun / Song, Jing-Jing / Hao, Nan / Zhao, Lan

World journal of stem cells

2019 Volume 15, Issue 3, Page(s) 52–70

Abstract: Ischemic stroke (IS) is the most prevalent form of brain disease, characterized by high morbidity, disability, and mortality. However, there is still a lack of ideal prevention and treatment measures in clinical practice. Notably, the transplantation ... ...

Abstract	Ischemic stroke (IS) is the most prevalent form of brain disease, characterized by high morbidity, disability, and mortality. However, there is still a lack of ideal prevention and treatment measures in clinical practice. Notably, the transplantation therapy of mesenchymal stem cells (MSCs) has been a hot research topic in stroke. Nevertheless, there are risks associated with this cell therapy, including tumor formation, coagulation dysfunction, and vascular occlusion. Also, a growing number of studies suggest that the therapeutic effect after transplantation of MSCs is mainly attributed to MSC-derived exosomes (MSC-Exos). And this cell-free mediated therapy appears to circumvent many risks and difficulties when compared to cell therapy, and it may be the most promising new strategy for treating stroke as stem cell replacement therapy. Studies suggest that suppressing inflammation
Language	English
Publishing date	2019-11-14
Publishing country	United States
Document type	Journal Article ; Review
ZDB-ID	2583482-4
ISSN	1948-0210
ISSN	1948-0210
DOI	10.4252/wjsc.v15.i3.52
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Article: Expression Analysis of DgD14, DgBRC1 and DgLsL in the Process of Chrysanthemum Lateral Bud Formation

Luo, Cheng / Wang, Xin-Jie / Ran, Ai-Ning / Song, Jing-Jing / Li, Xin / Ma, Qi-Qi / Pan, Yuan-Zhi / Liu, Qing-Lin / Jiang, Bei-Bei

Agriculture (Basel). 2021 Dec. 03, v. 11, no. 12

2021

Abstract: The growth of lateral bud can greatly affect the development of apical bud and reduce the quality of single-flower cut chrysanthemum. However, the wide use of artificial bud removal in production leads to the increase on production cost. Therefore, it is ...

Abstract	The growth of lateral bud can greatly affect the development of apical bud and reduce the quality of single-flower cut chrysanthemum. However, the wide use of artificial bud removal in production leads to the increase on production cost. Therefore, it is important to study the lateral bud development mechanism in chrysanthemum for plant type regulation and genetic improvement. Auxin (IAA), cytokinins (CKs) and strigolactones (SLs) have direct or indirect effects on the formation of lateral buds. D14, BRC1 and LsL are key factors regulating the signal pathways of hormones, but their regulation mechanisms on the development of lateral buds in chrysanthemum are still unclear. In this study, single-flower cut chrysanthemum ‘Jinba’ and spray cut chrysanthemum ‘Fenyan’ were used as experimental materials. Quantitative real-time PCR was used to observe the effects of apical bud removal and exogenous hormones on the growth of lateral buds and the expression levels of DgD14, DgBRC1 and DgLsL, so as to clarify the expression characteristics of three genes in the process of lateral bud formation. The results showed that GA was effective in promoting the growth of lateral buds, whereas IAA and ABA had little effects on lateral bud growth or even inhibited. Removing apical dominance can significantly affect the expression levels of three genes, which regulated the formation and elongation of lateral buds. Additionally, the three genes showed different responses to different hormone treatments. DgD14 had a significant response to GA, but a gentle response to ABA. The expression levels of DgBRC1 varied in different trends, and it responded to IAA in a more dramatic way. The levels of DgLsL reached the peaks quickly before decreased in most experimental groups, and its response to GA was extraordinary severe.
Keywords	Chrysanthemum ; agriculture ; apical dominance ; cytokinins ; genetic improvement ; quantitative polymerase chain reaction ; strigolactones
Language	English
Dates of publication	2021-1203
Publishing place	Multidisciplinary Digital Publishing Institute
Document type	Article
ZDB-ID	2651678-0
ISSN	2077-0472
ISSN	2077-0472
DOI	10.3390/agriculture11121221
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