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  1. AU="Song, Jiwu"
  2. AU="Terwilliger, Gordon"
  3. AU="Elhamzaoui, Hamza"
  4. AU="Béganton, Benoît"
  5. AU=Smith Zachary D.
  6. AU="Dotta, Federico"
  7. AU="Palmer, Andre"
  8. AU="Cai, Biao"
  9. AU="Leroux, Michel R"
  10. AU="Thomson, Jaidyn"
  11. AU="Novillo-Del Álamo, Blanca"
  12. AU="Deps, Patrícia D"

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  1. Artikel ; Online: The Role of BTBD7 in Normal Development and Tumor Progression.

    Liu, Yun / Song, Jiwu / Gu, Jianchang / Xu, Shuangshuang / Wang, Xiaolan / Liu, Yunxia

    Technology in cancer research & treatment

    2023  Band 22, Seite(n) 15330338231167732

    Abstract: BTB/POZ domain-containing protein 7 (BTBD7) has a relative molecular weight of 126KD and contains two conserved BTB/POZ protein sequences. BTBD7 has been shown to play an essential role in normal human development, precancerous lesions, heat-stress ... ...

    Abstract BTB/POZ domain-containing protein 7 (BTBD7) has a relative molecular weight of 126KD and contains two conserved BTB/POZ protein sequences. BTBD7 has been shown to play an essential role in normal human development, precancerous lesions, heat-stress response, and tumor progression. BTBD7 promotes branching morphogenesis during development and participates in the salivary gland, lung, and tooth formation. Furthermore, many studies have shown that aberrant expression of BTBD7 promotes heat stress response and the progression of precancerous lesions. BTBD7 has also been found to play an important role in cancer. High expression of BTBD7 affects tumor progression by regulating multiple pathways. Therefore, a complete understanding of BTBD7 is crucial for exploring human development and tumor progression. This paper reviews the research progress of BTBD7, which lays a foundation for the application of BTBD7 in regenerative medicine and as a biomarker for tumor prediction or potential therapeutic target.
    Mesh-Begriff(e) Humans ; Neoplasm Proteins/metabolism ; Adaptor Proteins, Signal Transducing/metabolism ; Lung/metabolism ; Salivary Glands/metabolism ; Precancerous Conditions/genetics ; Cell Line, Tumor ; Epithelial-Mesenchymal Transition ; Cell Movement
    Chemische Substanzen Neoplasm Proteins ; Adaptor Proteins, Signal Transducing ; BTBD7 protein, human
    Sprache Englisch
    Erscheinungsdatum 2023-04-02
    Erscheinungsland United States
    Dokumenttyp Journal Article ; Review ; Research Support, Non-U.S. Gov't
    ZDB-ID 2146365-7
    ISSN 1533-0338 ; 1533-0346
    ISSN (online) 1533-0338
    ISSN 1533-0346
    DOI 10.1177/15330338231167732
    Datenquelle MEDical Literature Analysis and Retrieval System OnLINE

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  2. Artikel ; Online: Comparison of venetoclax and ivosidenib/enasidenib for unfit newly diagnosed patients with acute myeloid leukemia and

    Wang, Lida / Song, Jiwu / Xiao, Xiangming / Li, Dianfang / Liu, Tianmeng / He, Xiaopo

    Journal of chemotherapy (Florence, Italy)

    2023  Band 36, Heft 3, Seite(n) 202–207

    Abstract: Because of lacking of head-to-head comparison between venetoclax ... ...

    Abstract Because of lacking of head-to-head comparison between venetoclax and
    Mesh-Begriff(e) Humans ; Network Meta-Analysis ; Leukemia, Myeloid, Acute/drug therapy ; Leukemia, Myeloid, Acute/genetics ; Azacitidine/therapeutic use ; Mutation ; Antineoplastic Combined Chemotherapy Protocols/therapeutic use ; Isocitrate Dehydrogenase/genetics ; Aminopyridines ; Glycine/analogs & derivatives ; Bridged Bicyclo Compounds, Heterocyclic ; Pyridines ; Triazines ; Sulfonamides
    Chemische Substanzen enasidenib (3T1SS4E7AG) ; ivosidenib (Q2PCN8MAM6) ; venetoclax (N54AIC43PW) ; Azacitidine (M801H13NRU) ; IDH1 protein, human (EC 1.1.1.42.) ; Isocitrate Dehydrogenase (EC 1.1.1.41) ; Aminopyridines ; Glycine (TE7660XO1C) ; Bridged Bicyclo Compounds, Heterocyclic ; Pyridines ; Triazines ; Sulfonamides
    Sprache Englisch
    Erscheinungsdatum 2023-08-20
    Erscheinungsland England
    Dokumenttyp Meta-Analysis ; Journal Article ; Review
    ZDB-ID 1036294-0
    ISSN 1973-9478 ; 1120-009X
    ISSN (online) 1973-9478
    ISSN 1120-009X
    DOI 10.1080/1120009X.2023.2247200
    Datenquelle MEDical Literature Analysis and Retrieval System OnLINE

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  3. Artikel ; Online: LncRNA LINC00460: Function and mechanism in human cancer.

    Chen, Xi / Song, Jiwu / Wang, Xiaoxiao / Sun, Dongyuan / Liu, Yunxia / Jiang, Yingying

    Thoracic cancer

    2021  Band 13, Heft 1, Seite(n) 3–14

    Abstract: Long non-coding RNAs (LncRNAs), which are more than 200 nucleotides in length and with limited protein-coding potential, play vital roles in the pathogenesis, tumorigenesis, and angiogenesis of cancers. Aberrant expression of lncRNAs has been detected in ...

    Abstract Long non-coding RNAs (LncRNAs), which are more than 200 nucleotides in length and with limited protein-coding potential, play vital roles in the pathogenesis, tumorigenesis, and angiogenesis of cancers. Aberrant expression of lncRNAs has been detected in various carcinomas and may be correlated with oncogenesis by affecting related genes expression. Recently, an increasing number of studies have reported on long intergenic non-protein coding RNA 460 (LINC00460) in human tumor fields. LINC00460 is upregulated in diverse cancer tissues and cells. The upregulated expression level of LINC00460 is correlated with larger tumor size, tumor node metastasis (TNM) stage, lymph node metastasis, and shorter overall survival. The regulatory mechanism of LINC00460 was complex and diverse. LINC00460 could act as a competitive endogenous RNA (ceRNA), directly bind with proteins or regulate multiple pathways, which affected tumor progression. Moreover, LINC00460 was also identified to increase drug resistance, and therefore, weaken the effectiveness of tumor treatment. It has become increasingly important to investigate the roles of LINC00460 in various cancers by different mechanisms. Therefore, a more comprehensive understanding of LINC00460 is crucial to expound on the cellular function and molecular mechanism of human cancers. In this review, we refer to studies concerning LINC00460 and provide the basis for the evaluation of LINC00460 as a predicted biomarker or potential therapeutic target in malignancies, and also provide ideas for the future research of lncRNAs similar to LINC00460.
    Mesh-Begriff(e) Biomarkers, Tumor/genetics ; Gene Expression Regulation, Neoplastic/genetics ; Humans ; Neoplasms/genetics ; Neoplasms/pathology ; RNA, Long Noncoding/genetics ; Up-Regulation
    Chemische Substanzen Biomarkers, Tumor ; RNA, Long Noncoding
    Sprache Englisch
    Erscheinungsdatum 2021-11-25
    Erscheinungsland Singapore
    Dokumenttyp Journal Article ; Research Support, Non-U.S. Gov't ; Review
    ZDB-ID 2625856-0
    ISSN 1759-7714 ; 1759-7706
    ISSN (online) 1759-7714
    ISSN 1759-7706
    DOI 10.1111/1759-7714.14238
    Datenquelle MEDical Literature Analysis and Retrieval System OnLINE

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  4. Artikel ; Online: Comparison of lorlatinib, alectinib and brigatinib in ALK inhibitor-naive/untreated ALK-positive advanced non-small-cell lung cancer: a systematic review and network meta-analysis.

    Wang, Lida / Sheng, Zhixin / Zhang, Junying / Song, Jiwu / Teng, Lili / Liu, Liping / Li, Qianpeng / Wang, Baohong / Li, Bin

    Journal of chemotherapy (Florence, Italy)

    2021  Band 34, Heft 2, Seite(n) 87–96

    Abstract: Because of lacking of head-to-head comparison among lorlatinib, alectinib and brigatinib for patients with ALK inhibitor-naive or untreated (ALK inhibitor-naive and chemotherapy-naive) ALK-positive advanced non-small-cell lung cancer (NSCLC), the optimal ...

    Abstract Because of lacking of head-to-head comparison among lorlatinib, alectinib and brigatinib for patients with ALK inhibitor-naive or untreated (ALK inhibitor-naive and chemotherapy-naive) ALK-positive advanced non-small-cell lung cancer (NSCLC), the optimal option for these patients still remains undefined. We searched published reports that described the activity and safety of those novel ALK inhibitors (lorlatinib, alectinib and brigatinib) for ALK inhibitor-naive or untreated (ALK inhibitor-naive and chemotherapy-naive) ALK-positive advanced NSCLC. Five randomized controlled trials were identified, covering 1111 subjects. In the network meta-analysis, lorlatinib seemed to prolong progression free survival than brigatinib (Hazard Ratio: 0.57,
    Mesh-Begriff(e) Aminopyridines ; Anaplastic Lymphoma Kinase ; Carbazoles ; Carcinoma, Non-Small-Cell Lung/drug therapy ; Humans ; Lactams ; Lung Neoplasms/drug therapy ; Network Meta-Analysis ; Organophosphorus Compounds ; Piperidines ; Protein Kinase Inhibitors/therapeutic use ; Pyrazoles ; Pyrimidines
    Chemische Substanzen Aminopyridines ; Carbazoles ; Lactams ; Organophosphorus Compounds ; Piperidines ; Protein Kinase Inhibitors ; Pyrazoles ; Pyrimidines ; Anaplastic Lymphoma Kinase (EC 2.7.10.1) ; brigatinib (HYW8DB273J) ; alectinib (LIJ4CT1Z3Y) ; lorlatinib (OSP71S83EU)
    Sprache Englisch
    Erscheinungsdatum 2021-06-17
    Erscheinungsland England
    Dokumenttyp Journal Article ; Meta-Analysis ; Systematic Review
    ZDB-ID 1036294-0
    ISSN 1973-9478 ; 1120-009X
    ISSN (online) 1973-9478
    ISSN 1120-009X
    DOI 10.1080/1120009X.2021.1937782
    Datenquelle MEDical Literature Analysis and Retrieval System OnLINE

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  5. Artikel: [Three dimensional finite element analysis of the influence of stress on occlusal surface of the mandibular first molar].

    Gao, Guo-ning / Wang, Guo-you / Song, Ji-wu / Lu, Shou-yi

    Shanghai kou qiang yi xue = Shanghai journal of stomatology

    2016  Band 25, Heft 2, Seite(n) 162–167

    Abstract: Purpose: Use of three-dimensional finite element to analyze stress distribution and transient displacement of mandibular first molar both at the occlusal surface level, to investigate the biomechanical basis of vertical root fracture occurring in the ... ...

    Abstract Purpose: Use of three-dimensional finite element to analyze stress distribution and transient displacement of mandibular first molar both at the occlusal surface level, to investigate the biomechanical basis of vertical root fracture occurring in the mesial root.
    Methods: Mimics finite element software was used to build the horizontal and tilt abrasion of the mandibular first permanent molar. Each status was then divided into 4 kinds of wearing degree and 8 models were then established including sliced 1, sliced 2, sliced 3, sliced 4 and miter 5°,miter10°,miter15°,miter20° respectively. 200 N of bite force was loaded on the occlusal surface using MSC. Marc nonlinear finite element analysis software was used to investigate the distribution of stress and transient displacement.
    Results: When distal tipping angle of the abrasion plane of mandibular first molar increased from 5° to 15°, the angle between instant displacement contours and tooth long axis become smaller, the mesial root suffered from the biggest stress concentration and thus the possibility of longitudinal root fracture increased.
    Conclusions: When the abrasion plane of mandibular first molar tilted distally, the possibility of the mesial root longitudinal fracture increased.
    Mesh-Begriff(e) Bite Force ; Finite Element Analysis ; Humans ; Imaging, Three-Dimensional ; Mandible ; Molar ; Stress, Mechanical ; Tooth ; Tooth Root
    Sprache Chinesisch
    Erscheinungsdatum 2016-04
    Erscheinungsland China
    Dokumenttyp Journal Article
    ZDB-ID 2269714-7
    ISSN 1006-7248
    ISSN 1006-7248
    Datenquelle MEDical Literature Analysis and Retrieval System OnLINE

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  6. Artikel ; Online: Targeting the chromatin structural changes of antitumor immunity.

    Li, Nian-Nian / Lun, Deng-Xing / Gong, Ningning / Meng, Gang / Du, Xin-Ying / Wang, He / Bao, Xiangxiang / Li, Xin-Yang / Song, Ji-Wu / Hu, Kewei / Li, Lala / Li, Si-Ying / Liu, Wenbo / Zhu, Wanping / Zhang, Yunlong / Li, Jikai / Yao, Ting / Mou, Leming / Han, Xiaoqing /
    Hao, Furong / Hu, Yongcheng / Liu, Lin / Zhu, Hongguang / Wu, Yuyun / Liu, Bin

    Journal of pharmaceutical analysis

    2023  Band 14, Heft 4, Seite(n) 100905

    Abstract: Epigenomic imbalance drives abnormal transcriptional processes, promoting the onset and progression of cancer. Although defective gene regulation generally affects carcinogenesis and tumor suppression networks, tumor immunogenicity and immune cells ... ...

    Abstract Epigenomic imbalance drives abnormal transcriptional processes, promoting the onset and progression of cancer. Although defective gene regulation generally affects carcinogenesis and tumor suppression networks, tumor immunogenicity and immune cells involved in antitumor responses may also be affected by epigenomic changes, which may have significant implications for the development and application of epigenetic therapy, cancer immunotherapy, and their combinations. Herein, we focus on the impact of epigenetic regulation on tumor immune cell function and the role of key abnormal epigenetic processes, DNA methylation, histone post-translational modification, and chromatin structure in tumor immunogenicity, and introduce these epigenetic research methods. We emphasize the value of small-molecule inhibitors of epigenetic modulators in enhancing antitumor immune responses and discuss the challenges of developing treatment plans that combine epigenetic therapy and immunotherapy through the complex interaction between cancer epigenetics and cancer immunology.
    Sprache Englisch
    Erscheinungsdatum 2023-11-29
    Erscheinungsland China
    Dokumenttyp Journal Article ; Review
    ZDB-ID 2630174-X
    ISSN 2214-0883 ; 2095-1779
    ISSN (online) 2214-0883
    ISSN 2095-1779
    DOI 10.1016/j.jpha.2023.11.012
    Datenquelle MEDical Literature Analysis and Retrieval System OnLINE

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  7. Artikel ; Online: BTB/POZ domain-containing protein 7 is inversely associated with fibronectin expression in salivary adenoid cystic carcinoma.

    Liu, Yunxia / Song, Jiwu / Zhang, Jun / Yang, Liu / Liu, Zongxia / Wang, Xuxia

    Oral surgery, oral medicine, oral pathology and oral radiology

    2017  Band 125, Heft 5, Seite(n) 468–477

    Abstract: Objective: This study aimed to investigate the relationship between BTB/POZ domain-containing protein 7 (BTBD7) and fibronectin (FN) expression in salivary adenoid cystic carcinoma (SACC) and the function of BTBD7 in proliferation, migration, and ... ...

    Abstract Objective: This study aimed to investigate the relationship between BTB/POZ domain-containing protein 7 (BTBD7) and fibronectin (FN) expression in salivary adenoid cystic carcinoma (SACC) and the function of BTBD7 in proliferation, migration, and invasion of SACC cells.
    Study design: The BTBD7 and FN expression in SACC and nontumor salivary tissues as well as SACC cells were characterized by immunohistochemistry and immunofluorescence. The effect of BTBD7 silencing on the proliferation, migration, and invasion of SACC-LM cells were determined by wound healing and transwell invasion assays.
    Results: The percentages of SACC with positive BTBD7 expression were significantly higher than those of SACC with FN expression. BTBD7 silencing significantly increased the relative levels of FN expression and inhibited the proliferation, migration, and invasion of SACC-LM cells.
    Conclusions: The study data indicated that BTBD7 was inversely associated with FN expression in SACC. BTBD7 may inhibit FN expression, but it promotes the proliferation, migration, and invasion of SACC-LM cells. Hence, BTBD7 may be associated with metastasis and a new therapeutic target for intervention of SACC.
    Mesh-Begriff(e) BTB-POZ Domain ; Blotting, Western ; Carcinoma, Adenoid Cystic/metabolism ; Carcinoma, Adenoid Cystic/pathology ; Cell Line, Tumor ; Cell Movement ; Cell Proliferation ; Fibronectins/metabolism ; Humans ; Immunoenzyme Techniques ; Middle Aged ; Neoplasm Invasiveness ; Neoplasm Proteins/metabolism ; Neoplasm Staging ; Real-Time Polymerase Chain Reaction ; Salivary Gland Neoplasms/metabolism ; Salivary Gland Neoplasms/pathology
    Chemische Substanzen BTBD7 protein, human ; Fibronectins ; Neoplasm Proteins
    Sprache Englisch
    Erscheinungsdatum 2017-12-28
    Erscheinungsland United States
    Dokumenttyp Journal Article ; Research Support, Non-U.S. Gov't
    ZDB-ID 2650843-6
    ISSN 2212-4411 ; 2212-4403
    ISSN (online) 2212-4411
    ISSN 2212-4403
    DOI 10.1016/j.oooo.2017.12.004
    Datenquelle MEDical Literature Analysis and Retrieval System OnLINE

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