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  1. Article ; Online: Evaluating the therapeutic and reconstructive efficacy of flap transplantation techniques in managing nasal tissue deficiency resulting from post-rhinoplasty surgical infections.

    Song, Lei / Liu, Xiuyan

    International wound journal

    2024  Volume 21, Issue 2, Page(s) e14566

    Abstract: Rhinoplasty is a frequently performed aesthetic surgery with a high procedural volume. Despite the operational ease and safety profile of biocompatible materials such as silicone and inflatable prosthetics, postoperative complications like surgical site ... ...

    Abstract Rhinoplasty is a frequently performed aesthetic surgery with a high procedural volume. Despite the operational ease and safety profile of biocompatible materials such as silicone and inflatable prosthetics, postoperative complications like surgical site infections can lead to significant clinical challenges. These complications necessitate effective therapeutic and reconstructive interventions. This study aims to evaluate the efficacy of different flap transplantation techniques for early treatment of post-rhinoplasty nasal tissue deficiencies. A retrospective study was conducted from May 2018 to May 2023, involving 38 patients divided into a control group receiving standard anti-infective treatment and an observation group undergoing early flap grafting procedures. Efficacy was evaluated using objective metrics-namely, nasal appearance, function and flap condition-each assessed through a 10-point scoring system, and subjective metrics such as patient satisfaction gauged through self-administered questionnaires. Statistical analyses were performed using SPSS version 27.0. Both groups were statistically comparable in terms of demographics such as age, marital status and educational background. The observation group displayed significantly improved outcomes in terms of nasal aesthetics (mean score 7.92 ± 1.00), nasal function (mean score 8.47 ± 0.51) and flap condition (mean score 7.89 ± 1.12) compared to the control group. Flap transplantation techniques demonstrated superior therapeutic and reconstructive efficacy in the management of nasal tissue deficiencies arising from post-rhinoplasty surgical infections. These findings contribute to evidence-based recommendations for optimal clinical practice.
    MeSH term(s) Humans ; Rhinoplasty/methods ; Retrospective Studies ; Nose/surgery ; Plastic Surgery Procedures ; Surgical Flaps/surgery ; Treatment Outcome
    Language English
    Publishing date 2024-02-20
    Publishing country England
    Document type Journal Article
    ZDB-ID 2170920-8
    ISSN 1742-481X ; 1742-4801
    ISSN (online) 1742-481X
    ISSN 1742-4801
    DOI 10.1111/iwj.14566
    Database MEDical Literature Analysis and Retrieval System OnLINE

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    Zs.A 6006: Show issues Location:
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  2. Article ; Online: Identification of immune cell infiltration profiles in renal cell carcinoma and their clinical significance.

    Wang, Le / Song, Lei

    Medicine

    2023  Volume 102, Issue 19, Page(s) e33732

    Abstract: Renal cell carcinoma (RCC) is the most common malignancy of the urinary system, accounting for 3.7% of all new malignancies. The prognosis of RCC patients is still poor, especially patients in advanced stage. Limited studies have fully clarified the role ...

    Abstract Renal cell carcinoma (RCC) is the most common malignancy of the urinary system, accounting for 3.7% of all new malignancies. The prognosis of RCC patients is still poor, especially patients in advanced stage. Limited studies have fully clarified the role of immune cell infiltration profiles in the prognosis and immunotherapy of RCC. In current study, we evaluated the abundance of the 22 tumor-infiltrating immune cells (TIICs) with CIBERSORT methods. The correlation between TIICs and clinicopathological parameters, tumor immune dysfunction and exclusion (TIDE) score and immunophenoscore (IPS) of RCC patients were also explored. Significant correlations were obtained between TIICs subpopulation and specific clinicopathologic parameters of RCC, including age, gender, tumor grade, clinical stage, T stage and distant metastasis. Moreover, RCC patients with high level of memory activated CD4 T cells, follicular helper T cells and regulatory T cells had a worse overall survival (OS) rate. RCC patients with high level of CD 8 + T cells and M1 macrophages had a lower TIDE score and higher anti-CTLA IPS, higher anti-PD1 IPS as well as higher anti-PD1/CTLA4 IPS. Our results clarified the immune cell infiltration profiles of RCC. RCC patients with high level of CD 8 + T cell and M1 macrophages had a lower TIDE score and higher IPS, suggesting that RCC patients with high level of CD 8 + T cell and M1 macrophages may benefit from immunotherapy.
    MeSH term(s) Humans ; Carcinoma, Renal Cell/pathology ; Kidney Neoplasms/pathology ; Clinical Relevance ; Prognosis ; Macrophages
    Language English
    Publishing date 2023-04-27
    Publishing country United States
    Document type Journal Article
    ZDB-ID 80184-7
    ISSN 1536-5964 ; 0025-7974
    ISSN (online) 1536-5964
    ISSN 0025-7974
    DOI 10.1097/MD.0000000000033732
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  3. Article: Editorial: Phytochemicals targeting autophagy in treatment of bacterial infection and malignancies.

    Bai, Xiaoxue / Song, Lei

    Frontiers in pharmacology

    2023  Volume 14, Page(s) 1205764

    Language English
    Publishing date 2023-05-15
    Publishing country Switzerland
    Document type Editorial
    ZDB-ID 2587355-6
    ISSN 1663-9812
    ISSN 1663-9812
    DOI 10.3389/fphar.2023.1205764
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  4. Article ; Online: Role of mitochondrial dysfunction and oxidative stress in sensorineural hearing loss.

    Tan, Winston J T / Song, Lei

    Hearing research

    2023  Volume 434, Page(s) 108783

    Abstract: Sensorineural hearing loss (SNHL) can either be genetically inherited or acquired as a result of aging, noise exposure, or ototoxic drugs. Although the precise pathophysiological mechanisms underlying SNHL remain unclear, an overwhelming body of evidence ...

    Abstract Sensorineural hearing loss (SNHL) can either be genetically inherited or acquired as a result of aging, noise exposure, or ototoxic drugs. Although the precise pathophysiological mechanisms underlying SNHL remain unclear, an overwhelming body of evidence implicates mitochondrial dysfunction and oxidative stress playing a central etiological role. With its high metabolic demands, the cochlea, particularly the sensory hair cells, stria vascularis, and spiral ganglion neurons, is vulnerable to the damaging effects of mitochondrial reactive oxygen species (ROS). Mitochondrial dysfunction and consequent oxidative stress in cochlear cells can be caused by inherited mitochondrial DNA (mtDNA) mutations (hereditary hearing loss and aminoglycoside-induced ototoxicity), accumulation of acquired mtDNA mutations with age (age-related hearing loss), mitochondrial overdrive and calcium dysregulation (noise-induced hearing loss and cisplatin-induced ototoxicity), or accumulation of ototoxic drugs within hair cell mitochondria (drug-induced hearing loss). In this review, we provide an overview of our current knowledge on the role of mitochondrial dysfunction and oxidative stress in the development of SNHL caused by genetic mutations, aging, exposure to excessive noise, and ototoxic drugs. We also explore the advancements in antioxidant therapies for the different forms of acquired SNHL that are being evaluated in preclinical and clinical studies.
    MeSH term(s) Humans ; Ototoxicity/metabolism ; Hearing Loss, Sensorineural/chemically induced ; Hearing Loss, Sensorineural/genetics ; Hearing Loss, Sensorineural/drug therapy ; Oxidative Stress ; Hearing Loss, Noise-Induced/metabolism ; DNA, Mitochondrial/genetics ; DNA, Mitochondrial/metabolism ; DNA, Mitochondrial/therapeutic use ; Mitochondria/metabolism
    Chemical Substances DNA, Mitochondrial
    Language English
    Publishing date 2023-04-29
    Publishing country Netherlands
    Document type Journal Article ; Review
    ZDB-ID 282629-x
    ISSN 1878-5891 ; 0378-5955
    ISSN (online) 1878-5891
    ISSN 0378-5955
    DOI 10.1016/j.heares.2023.108783
    Database MEDical Literature Analysis and Retrieval System OnLINE

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    In stock of ZB MED Cologne/Königswinter

    Zs.A 1467: Show issues Location:
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  5. Article: Clinical Significance of Procalcitonin, Lactic Acid, and Endotoxin Testing for Children With Severe Pneumonia and Sepsis.

    Lu, Yan / Song, Lei

    Alternative therapies in health and medicine

    2023  Volume 29, Issue 3, Page(s) 218–223

    Abstract: Context: Sepsis is a common complication of severe pediatric pneumonia, characterized by difficulty in treatment, a high treatment cost, high morbidity and mortality, and poor prognosis. The levels of three indicators, procalcitonin (PCT), lactic acid ( ... ...

    Abstract Context: Sepsis is a common complication of severe pediatric pneumonia, characterized by difficulty in treatment, a high treatment cost, high morbidity and mortality, and poor prognosis. The levels of three indicators, procalcitonin (PCT), lactic acid (Lac), and endotoxin (ET), can vary greatly in children with severe pneumonia complicated by sepsis.
    Objective: The study aimed to investigate the clinical significance of PCT, Lac, and ET levels in the serum of children with severe pneumonia complicated by sepsis.
    Design: The research team performed retrospective study.
    Setting: The study took place at Nantong First People's Hospital in Nantong, Jiangsu, China.
    Participants: Participants were 90 children with severe pneumonia complicated by sepsis and 30 children with severe pneumonia only, all of whom had received treatment in the pediatric intensive care unit of the hospital between January 2018 and May 2020.
    Groups: At baseline, the research team divided the participants into three groups based on their pediatric clinical illness score (PCIS) at 24 h after admission: (1) the extremely critical group-0-70 points (n = 29), (2) the critical group-71-80 points (n = 31), and (3) the noncritical group->80 points (n = 30). The 30 children who had received treatment but who had severe pneumonia only became the control group.
    Outcome measures: The research team: (1) measured the serum PCT, Lac, and ET levels for the four groups at baseline, (2) compared those levels by group, (3) compared those levels by clinical outcome, (4) determined the correlation of the three indicators to the PCIS scores, and (5) identified the predictive value of the three indicators. To compare the levels by clinical outcome and to determine the indicators' predictive values, the team divided participants into two groups according to their clinical outcomes on day 28 of the study: (1) 40 children who died became the death group, and (2) 50 children who survived became the survival group.
    Results: The serum PCT, Lac, and ET levels in the extremely critical group were the highest, followed by the critical group, the noncritical group, and the control group. The serum PCT, Lac, and ET levels had a significant negative correlation with participants' PCIS scores (r = -0.8203 (PCT), -0.6384 (Lac), -0.6412 (ET), P < .05).The area under the curve (AUC) for the PCT level was 0.7732 (95% CI = 0.6214 to 0.9249, P = .0015), for the Lac level was 0.9533 (95% CI = 0.9036 to 1.000, P < .0001), and for the ET level was 0.8694 (95% CI = 0.7622 to 0.9765, P < .0001). These values indicate that all three indicators were significantly predictive regarding participants' prognoses.
    Conclusions: The serum PCT, Lac, and ET in children with severe pneumonia complicated by sepsis were abnormally high, and the levels of these indicators were significantly negatively correlated with the PCIS scores. PCT, Lac, and ET may be potential indicators for the diagnosis and prognosis assessment of children with severe pneumonia complicated by sepsis.
    MeSH term(s) Humans ; Child ; Procalcitonin ; Lactic Acid ; Retrospective Studies ; Clinical Relevance ; ROC Curve ; Sepsis/complications ; Sepsis/diagnosis ; Pneumonia/diagnosis ; Endotoxins
    Chemical Substances Procalcitonin ; Lactic Acid (33X04XA5AT) ; Endotoxins
    Language English
    Publishing date 2023-03-28
    Publishing country United States
    Document type Journal Article
    ZDB-ID 1225073-9
    ISSN 1078-6791
    ISSN 1078-6791
    Database MEDical Literature Analysis and Retrieval System OnLINE

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    Zs.A 4504: Show issues Location:
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  6. Article ; Online: Primary minimally invasive adenocarcinoma and inflammatory myofibroblastic tumor of the lungs in a 9-year-old child.

    Wen, Gang / Shou, Tiejun / Chen, Junxian / Song, Lei

    Asian journal of surgery

    2024  

    Language English
    Publishing date 2024-02-19
    Publishing country Netherlands
    Document type Letter
    ZDB-ID 1068461-x
    ISSN 0219-3108 ; 1015-9584
    ISSN (online) 0219-3108
    ISSN 1015-9584
    DOI 10.1016/j.asjsur.2024.02.040
    Database MEDical Literature Analysis and Retrieval System OnLINE

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    Zs.B 2831: Show issues Location:
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  7. Article: Encapsulation of Benzaldehyde Produced by the Eco-Friendly Degradation of Amygdalin in the Apricot Kernel Debitterizing Wastewater.

    Song, Lei / García Martín, Juan Francisco / Zhang, Qing-An

    Foods (Basel, Switzerland)

    2024  Volume 13, Issue 3

    Abstract: In order to fully utilize the by-products of apricot kernel-debitterizing and address the chemical instability of benzaldehyde in the food industry, benzaldehyde was first prepared by adding the apricot kernel powder to degrade the amygdalin present in ... ...

    Abstract In order to fully utilize the by-products of apricot kernel-debitterizing and address the chemical instability of benzaldehyde in the food industry, benzaldehyde was first prepared by adding the apricot kernel powder to degrade the amygdalin present in the apricot kernel-debitterizing water. Subsequently, β-cyclodextrin was employed to encapsulate the benzaldehyde, and its encapsulation efficacy was evaluated through various techniques including Fourier transform infrared spectroscopy, thermogravimetric analysis, release kinetics fitting inhibitory effect and the effect on
    Language English
    Publishing date 2024-01-29
    Publishing country Switzerland
    Document type Journal Article
    ZDB-ID 2704223-6
    ISSN 2304-8158
    ISSN 2304-8158
    DOI 10.3390/foods13030437
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  8. Article ; Online: Laparoscopic surgery of the pancreas for the high-grade blunt pancreatic injuries in children.

    Wen, Gang / Shou, Tiejun / Zhang, Pengjie / Song, Lei

    Asian journal of surgery

    2024  

    Language English
    Publishing date 2024-03-02
    Publishing country Netherlands
    Document type Letter
    ZDB-ID 1068461-x
    ISSN 0219-3108 ; 1015-9584
    ISSN (online) 0219-3108
    ISSN 1015-9584
    DOI 10.1016/j.asjsur.2024.02.128
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  9. Article ; Online: A dynamic panel threshold model analysis on heterogeneous environmental regulation, R&D investment, and enterprise green total factor productivity.

    Liu, Lu / Ren, Rong / Cui, Kaiyuan / Song, Lei

    Scientific reports

    2024  Volume 14, Issue 1, Page(s) 5208

    Abstract: Environmental regulations are important means to influence manufacturing enterprise green development. However, there are two completely different conclusions both in theoretical and in empirical research, namely the "Follow Cost" theory and the "Porter ... ...

    Abstract Environmental regulations are important means to influence manufacturing enterprise green development. However, there are two completely different conclusions both in theoretical and in empirical research, namely the "Follow Cost" theory and the "Porter Hypothesis". The nonlinear mechanism needs to be considered. Therefore, this study aims to explain the threshold impact of heterogeneous environmental regulations on enterprise green total factor productivity. Environmental regulations are divided into different sub-categories, then based on the panel data of 1220 Chinese manufacturing listed companies from 2011 to 2020, this paper uses threshold regression model to examine the impact of heterogeneous environmental regulations on Chinese manufacturing enterprise Green Total Factor Productivity. The empirical results show that: (1) Command-controlled, market-incentive and voluntary-agreement environmental regulation all have a significant nonlinear impact on enterprise Green Total Factor Productivity. (2) Enterprise R&D investment plays a threshold role in the impact. (3) There are industry and equity type differences in the impact process. This study focuses on the micro level of enterprises and tests the threshold mechanism, which make some theoretical complement to previous researches. The research results are not only beneficial for the government to propose appropriate environmental regulatory policies, but also for enterprises to achieve green growth through heterogeneous R&D investment.
    Language English
    Publishing date 2024-03-03
    Publishing country England
    Document type Journal Article
    ZDB-ID 2615211-3
    ISSN 2045-2322 ; 2045-2322
    ISSN (online) 2045-2322
    ISSN 2045-2322
    DOI 10.1038/s41598-024-55970-1
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  10. Article ; Online: Editorial: Innate immunity against intracellular bacteria: mechanisms and strategies.

    Tian, Jingfei / Liu, Han / Che, Jingai / Song, Lei

    Frontiers in immunology

    2024  Volume 15, Page(s) 1396114

    MeSH term(s) Immunity, Innate ; Inflammasomes ; Bacteria
    Chemical Substances Inflammasomes
    Language English
    Publishing date 2024-03-20
    Publishing country Switzerland
    Document type Editorial ; Research Support, Non-U.S. Gov't
    ZDB-ID 2606827-8
    ISSN 1664-3224 ; 1664-3224
    ISSN (online) 1664-3224
    ISSN 1664-3224
    DOI 10.3389/fimmu.2024.1396114
    Database MEDical Literature Analysis and Retrieval System OnLINE

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