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  1. AU="Song, Mengwei"
  2. AU="Yimin Geng"
  3. AU="Wang, Chang-Sheng"
  4. AU="Doyle, Andrew D"
  5. AU="Redpath, Sophie H A"
  6. AU="Hopman, Maria Te"
  7. AU="Pomputius, William"
  8. AU="Agrawal, Sonali"
  9. AU="Martinez, Luis R"
  10. AU="Passoni, Lorena"
  11. AU="Slimani, Wafa"
  12. AU="Jin, J"
  13. AU="Xia, Hongmin"
  14. AU="Akdemir, İrem"
  15. AU=Ciccone Giovannino

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  1. Artikel ; Online: Study of Township Construction Land Carrying Capacity and Spatial Pattern Matching in Loess Plateau Hilly and Gully Region: A Case of Xifeng in China.

    Zhao, Yirui / Li, Tongsheng / Li, Julin / Song, Mengwei

    International journal of environmental research and public health

    2022  Band 19, Heft 23

    Abstract: With the acceleration of urbanization, the construction land scale of urban and rural areas is constantly expanding, which leads to contradiction and conflict between territorial development and ecological protection becoming more and more serious. ... ...

    Abstract With the acceleration of urbanization, the construction land scale of urban and rural areas is constantly expanding, which leads to contradiction and conflict between territorial development and ecological protection becoming more and more serious. Therefore, as an important unit of county (district), and even urban and rural, development, the study on land resource carrying capacity and the rationality of the development can provide some basis for developing the optimal strategies of differential territorial space. Taking Xifeng, Gansu Province, China as the research area, this study constructs the evaluation index system of township construction land carrying capacity from the three dimensions of ecological protection, natural environment, and social economy. It evaluates the suitability of township construction land by the means of a comprehensive scoring method and discusses the carrying capacity and spatial pattern matching of township construction land based on the suitability evaluation results. The results showed that: (1) the spatial difference of suitability of construction land is obvious, which is higher in the city center than in the surrounding areas; (2) the comprehensive carrying capacity of township construction land is 52.62%, and different townships range from 3.78% to 13.15%. It is different between towns; (3) on the whole, the condition of township construction land is well-developed, and the main distribution forms are flaky, banded, and dotted. (4) There is a positive correlation between spatial matching and carrying capacity. The carrying capacity should be considered in regional development to avoid overdevelopment. It can provide a basis for optimizing the territorial spatial layout, strengthening the coordinated development among townships, and improving the comprehensive township carrying capacity in the Loess Plateau hilly and gully region.
    Sprache Englisch
    Erscheinungsdatum 2022-12-06
    Erscheinungsland Switzerland
    Dokumenttyp Journal Article
    ZDB-ID 2175195-X
    ISSN 1660-4601 ; 1661-7827
    ISSN (online) 1660-4601
    ISSN 1661-7827
    DOI 10.3390/ijerph192316316
    Datenquelle MEDical Literature Analysis and Retrieval System OnLINE

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  2. Artikel ; Online: CXXC5 drove inflammation and ovarian cancer proliferation via transcriptional activation of ZNF143 and EGR1.

    Geng, Ting / Sun, Qigang / He, Jingliang / Chen, Yulu / Cheng, Wenhao / Shen, Jing / Liu, Bin / Zhang, Meiqi / Wang, Sen / Asan, Kadirya / Song, Mengwei / Gao, Qi / Song, Yizhuo / Liu, Ruotong / Liu, Xing / Ding, Yuanyuan / Jing, Aixin / Ye, Xiaoqing / Ren, Hongyu /
    Zeng, Kaile / Zhou, Ying / Zhang, Boyu / Ma, Shaojie / Liu, Wei / Liu, Shunfang / Ji, Jing

    Cellular signalling

    2024  Band 119, Seite(n) 111180

    Abstract: CXXC5, a zinc-finger protein, is known for its role in epigenetic regulation via binding to unmethylated CpG islands in gene promoters. As a transcription factor and epigenetic regulator, CXXC5 modulates various signaling processes and acts as a key ... ...

    Abstract CXXC5, a zinc-finger protein, is known for its role in epigenetic regulation via binding to unmethylated CpG islands in gene promoters. As a transcription factor and epigenetic regulator, CXXC5 modulates various signaling processes and acts as a key coordinator. Altered expression or activity of CXXC5 has been linked to various pathological conditions, including tumorigenesis. Despite its known role in cancer, CXXC5's function and mechanism in ovarian cancer are unclear. We analyzed multiple public databases and found that CXXC5 is highly expressed in ovarian cancer, with high expression correlating with poor patient prognosis. We show that CXXC5 expression is regulated by oxygen concentration and is a direct target of HIF1A. CXXC5 is critical for maintaining the proliferative potential of ovarian cancer cells, with knockdown decreasing and overexpression increasing cell proliferation. Loss of CXXC5 led to inactivation of multiple inflammatory signaling pathways, while overexpression activated these pathways. Through in vitro and in vivo experiments, we confirmed ZNF143 and EGR1 as downstream transcription factors of CXXC5, mediating its proliferative potential in ovarian cancer. Our findings suggest that the CXXC5-ZNF143/EGR1 axis forms a network driving ovarian cell proliferation and tumorigenesis, and highlight CXXC5 as a potential therapeutic target for ovarian cancer treatment.
    Mesh-Begriff(e) Humans ; Female ; Ovarian Neoplasms/genetics ; Ovarian Neoplasms/metabolism ; Ovarian Neoplasms/pathology ; Early Growth Response Protein 1/metabolism ; Early Growth Response Protein 1/genetics ; Cell Proliferation ; Cell Line, Tumor ; Trans-Activators/metabolism ; DNA-Binding Proteins/metabolism ; DNA-Binding Proteins/genetics ; Gene Expression Regulation, Neoplastic ; Animals ; Transcriptional Activation ; Inflammation/genetics ; Inflammation/metabolism ; Inflammation/pathology ; Hypoxia-Inducible Factor 1, alpha Subunit/metabolism ; Hypoxia-Inducible Factor 1, alpha Subunit/genetics ; Transcription Factors/metabolism ; Transcription Factors/genetics ; Mice, Nude ; Signal Transduction ; Mice
    Chemische Substanzen Early Growth Response Protein 1 ; EGR1 protein, human ; CXXC5 protein, human ; Trans-Activators ; ZNF143 protein, human ; DNA-Binding Proteins ; Hypoxia-Inducible Factor 1, alpha Subunit ; Transcription Factors ; HIF1A protein, human
    Sprache Englisch
    Erscheinungsdatum 2024-04-19
    Erscheinungsland England
    Dokumenttyp Journal Article ; Research Support, Non-U.S. Gov't
    ZDB-ID 1002702-6
    ISSN 1873-3913 ; 0898-6568
    ISSN (online) 1873-3913
    ISSN 0898-6568
    DOI 10.1016/j.cellsig.2024.111180
    Datenquelle MEDical Literature Analysis and Retrieval System OnLINE

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  3. Artikel ; Online: Caffeic acid dimethyl ether alleviates alcohol-induced hepatic steatosis via microRNA-378b-mediated CaMKK2-AMPK pathway.

    Lu, Jun / Zhang, Yan / Wang, Ying-Zhao / Li, Yuan-Yuan / Wang, Rui / Zhong, Yu-Juan / Chen, Li / Song, Meng-Wei / Shi, Lin / Li, Li / Li, Yong-Wen

    Bioengineered

    2022  Band 13, Heft 4, Seite(n) 11122–11136

    Abstract: Alcoholic liver disease (ALD), with its increasing morbidity and mortality, has seriously and extensively affected the health of people worldwide. Caffeic Acid Dimethyl Ether (CADE) significantly inhibits alcohol-induced hepatic ... ...

    Abstract Alcoholic liver disease (ALD), with its increasing morbidity and mortality, has seriously and extensively affected the health of people worldwide. Caffeic Acid Dimethyl Ether (CADE) significantly inhibits alcohol-induced hepatic steatosis
    Mesh-Begriff(e) AMP-Activated Protein Kinases/genetics ; Animals ; Caffeic Acids ; Calcium-Calmodulin-Dependent Protein Kinase Kinase/genetics ; Ethanol/toxicity ; Humans ; Lipids ; Methyl Ethers ; Mice ; Mice, Inbred C57BL ; MicroRNAs/genetics ; MicroRNAs/metabolism
    Chemische Substanzen Caffeic Acids ; Lipids ; Methyl Ethers ; MicroRNAs ; Ethanol (3K9958V90M) ; dimethyl ether (AM13FS69BX) ; CAMKK2 protein, human (EC 2.7.11.17) ; Calcium-Calmodulin-Dependent Protein Kinase Kinase (EC 2.7.11.17) ; Camkk2 protein, mouse (EC 2.7.11.17) ; AMP-Activated Protein Kinases (EC 2.7.11.31) ; caffeic acid (U2S3A33KVM)
    Sprache Englisch
    Erscheinungsdatum 2022-04-26
    Erscheinungsland United States
    Dokumenttyp Journal Article
    ZDB-ID 2737830-5
    ISSN 2165-5987 ; 2165-5979
    ISSN (online) 2165-5987
    ISSN 2165-5979
    DOI 10.1080/21655979.2022.2060586
    Datenquelle MEDical Literature Analysis and Retrieval System OnLINE

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  4. Artikel: [Community structure and difference of endophtic bacteria in Aquilaria sinensis with and without agarwood].

    Huang, Ya-Li / Kuang, Zao-Yuan / Song, Meng-Wei / Zhang, Ren

    Zhongguo Zhong yao za zhi = Zhongguo zhongyao zazhi = China journal of Chinese materia medica

    2015  Band 40, Heft 1, Seite(n) 63–67

    Abstract: Aquilaria sinensis can generate agarwood, which is closely related with endophyte. Up to now, studies mainly focused on the effects of endophytic fungi on agarwood formation, but studies about endophytic bacteria are rarely reported. In our research, the ...

    Abstract Aquilaria sinensis can generate agarwood, which is closely related with endophyte. Up to now, studies mainly focused on the effects of endophytic fungi on agarwood formation, but studies about endophytic bacteria are rarely reported. In our research, the T-RFs and Shannon index of endophytic bacteria in samples of agarwood increase. The number of distinctive T-RFs fragments of corresponding samples in the same group accounted for more than 60% the number of total T-RFs fragments. In samples of no-agarwood, the dominant bacterial population are Anoxybacillus, Clostridium, Candidatus endobugula, Lysinibacillus. In samples of agarwood, the dominant bacterial population are Clostridium, Lysinibacillus, Luteimonas, phytoplasma. Besides, there are. specific T-RFs fragment in samples of agarwood and no-agarwood respectively. When we perform cluster analysis, we found samples of agarwood highly gather together and samples of no-agarwood highly gather together. This means community of endophytic bacteria emerge significant and regular changes during agarwood formation, which may be result of agarwood production, or maybe it is important reason of agarwood production. In this paper, we obtain more comprehensive and accurate community of endophytic bacteria in Aquilaria sinensis and it's variation during agarwood formation using T-RFLP, which is first study of effects of endophytic bacteria on agarwood formation, and will help to exploit resource of endophytic bacteria more reasonably.
    Mesh-Begriff(e) Bacteria/classification ; Bacteria/genetics ; Bacteria/isolation & purification ; Biodiversity ; Endophytes/classification ; Endophytes/genetics ; Endophytes/isolation & purification ; Thymelaeaceae/microbiology ; Wood/microbiology
    Sprache Chinesisch
    Erscheinungsdatum 2015-01
    Erscheinungsland China
    Dokumenttyp Comparative Study ; English Abstract ; Journal Article
    ZDB-ID 1004649-5
    ISSN 1001-5302 ; 0254-0029
    ISSN 1001-5302 ; 0254-0029
    Datenquelle MEDical Literature Analysis and Retrieval System OnLINE

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  5. Artikel ; Online: Biochanin A Provides Neuroprotection Against Cerebral Ischemia/Reperfusion Injury by Nrf2-Mediated Inhibition of Oxidative Stress and Inflammation Signaling Pathway in Rats.

    Guo, Minmin / Lu, Huiling / Qin, Jian / Qu, Shengbiao / Wang, Wenbo / Guo, Yanhong / Liao, Weiyong / Song, Mengwei / Chen, Jian / Wang, Yong

    Medical science monitor : international medical journal of experimental and clinical research

    2019  Band 25, Seite(n) 8975–8983

    Abstract: BACKGROUND Oxidative stress and neuroinflammation are 2 pivotal mechanisms in the progression of cerebral ischemia/reperfusion injury. Biochanin A, a natural phytoestrogen, has been reported to protect against ischemic brain injury in animal experiments, ...

    Abstract BACKGROUND Oxidative stress and neuroinflammation are 2 pivotal mechanisms in the progression of cerebral ischemia/reperfusion injury. Biochanin A, a natural phytoestrogen, has been reported to protect against ischemic brain injury in animal experiments, but the possible pharmacological mechanisms of its neuroprotection remain elusive. In this research, we sought to investigate the neuroprotective effects of biochanin A in experimental stroke rats and the probable mechanisms underlying oxidative stress and inflammation signaling pathways. MATERIAL AND METHODS An ischemic stroke model was induced by inserting thread into the middle cerebral artery. Rats were pre-administered intraperitoneally with a vehicle solution or biochanin A (10, 20, or 40 mg·kg·d--⁻¹) for 14 days prior to ischemic stroke. Neurological score, infarct volume, and cerebral edema were assessed after 2 h of ischemia and 24 h of reperfusion. The activities of SOD and GSH-Px and MDA content were measured. The expressions of Nrf2, HO-1, and NF-kappaB and the activity of phosphor-IkappaBalpha were detected by Western blotting. RESULTS Biochanin A pretreatment significantly improved neurological deficit and decreased infarct size and brain edema. Biochanin A also enhanced SOD and GSH-Px activities and suppressed the production of MDA. Additionally, biochanin A promoted Nrf2 nuclear translocation, promoted the expression of HO-1, and inhibited NF-kappaB activation in ischemic brain injury. CONCLUSIONS The results indicated that biochanin A protected the brain against ischemic injury in rats by anti-oxidative and anti-inflammatory actions. The activation of the Nrf2 pathway and the inhibition of the NF-kappaB pathway may contribute to the neuroprotective effects of biochanin A.
    Mesh-Begriff(e) Animals ; Antioxidants/pharmacology ; Brain/metabolism ; Brain Edema/drug therapy ; Brain Ischemia/drug therapy ; Gene Expression Regulation/drug effects ; Genistein/metabolism ; Genistein/pharmacology ; Infarction, Middle Cerebral Artery/metabolism ; Inflammation/metabolism ; Male ; NF-E2-Related Factor 2/metabolism ; NF-E2-Related Factor 2/physiology ; NF-kappa B/metabolism ; Neuroprotection/drug effects ; Neuroprotective Agents/pharmacology ; Oxidative Stress/drug effects ; Oxidative Stress/physiology ; Rats ; Rats, Sprague-Dawley ; Reperfusion Injury/drug therapy ; Signal Transduction/drug effects ; Stroke/metabolism
    Chemische Substanzen Antioxidants ; NF-E2-Related Factor 2 ; NF-kappa B ; Neuroprotective Agents ; Nfe2l2 protein, rat ; Genistein (DH2M523P0H) ; biochanin A (U13J6U390T)
    Sprache Englisch
    Erscheinungsdatum 2019-11-26
    Erscheinungsland United States
    Dokumenttyp Journal Article
    ZDB-ID 1439041-3
    ISSN 1643-3750 ; 1234-1010
    ISSN (online) 1643-3750
    ISSN 1234-1010
    DOI 10.12659/MSM.918665
    Datenquelle MEDical Literature Analysis and Retrieval System OnLINE

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  6. Artikel ; Online: microRNA-378b regulates ethanol-induced hepatic steatosis by targeting CaMKK2 to mediate lipid metabolism.

    Wang, Ying-Zhao / Lu, Jun / Li, Yuan-Yuan / Zhong, Yu-Juan / Yang, Cheng-Fang / Zhang, Yan / Huang, Li-Hua / Huang, Su-Mei / Li, Qi-Ran / Wu, Dan / Song, Meng-Wei / Shi, Lin / Li, Li / Li, Yong-Wen

    Bioengineered

    2022  Band 12, Heft 2, Seite(n) 12659–12676

    Abstract: Alcoholic liver disease (ALD) has seriously harmed the health of people worldwide, but its underlying mechanisms remain unclear. This study aims to clarify the biological function of microRNA-378b (miR-378b) in ethanol (EtOH)-induced hepatic lipid ... ...

    Abstract Alcoholic liver disease (ALD) has seriously harmed the health of people worldwide, but its underlying mechanisms remain unclear. This study aims to clarify the biological function of microRNA-378b (miR-378b) in ethanol (EtOH)-induced hepatic lipid accumulation. Here, we report miR-378b is over-expressed in EtOH-induced cells and EtOH-fed mice and finally accelerates lipid accumulation. MiR-378b directly targets Ca
    Mesh-Begriff(e) Animals ; Base Sequence ; Calcium-Calmodulin-Dependent Protein Kinase Kinase/metabolism ; Ethanol ; Fatty Liver/etiology ; Fatty Liver/genetics ; Fatty Liver/metabolism ; Lipid Metabolism/genetics ; Male ; Mice, Inbred C57BL ; MicroRNAs/genetics ; MicroRNAs/metabolism ; Up-Regulation/genetics ; Mice
    Chemische Substanzen MIRN378 microRNA, mouse ; MicroRNAs ; Ethanol (3K9958V90M) ; Calcium-Calmodulin-Dependent Protein Kinase Kinase (EC 2.7.11.17)
    Sprache Englisch
    Erscheinungsdatum 2022-01-10
    Erscheinungsland United States
    Dokumenttyp Journal Article ; Research Support, Non-U.S. Gov't
    ZDB-ID 2737830-5
    ISSN 2165-5987 ; 2165-5979
    ISSN (online) 2165-5987
    ISSN 2165-5979
    DOI 10.1080/21655979.2021.2003677
    Datenquelle MEDical Literature Analysis and Retrieval System OnLINE

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  7. Artikel ; Online: Methyl ferulic acid ameliorates alcohol-induced hepatic insulin resistance via miR-378b-mediated activation of PI3K-AKT pathway.

    Zhang, Yan / Lu, Jun / Zhong, Yu-Juan / Yang, Cheng-Fang / Chen, Li / Wu, Dan / Song, Meng-Wei / Shi, Lin / Ma, Zu-Heng / Li, Li / Li, Yong-Wen

    Biomedicine & pharmacotherapy = Biomedecine & pharmacotherapie

    2021  Band 145, Seite(n) 112462

    Abstract: A previous study indicated that microRNA-378b (miR-378b) plays a critical role in controlling hepatic insulin resistance by targeting insulin receptor (IR) and p110α in alcoholic liver disease (ALD). Methyl ferulic acid (MFA), a bioactive ingredient in ... ...

    Abstract A previous study indicated that microRNA-378b (miR-378b) plays a critical role in controlling hepatic insulin resistance by targeting insulin receptor (IR) and p110α in alcoholic liver disease (ALD). Methyl ferulic acid (MFA), a bioactive ingredient in Securidaca inappendiculata Hassk rhizomes, exhibits multiple pharmacological activities. It has been reported that MFA ameliorates insulin resistance in ALD, whereas the underlying molecular mechanism remains unclear. The objective of study was to evaluate the influence of MFA on insulin sensitivity in ethanol-induced L-02 cells as well as alcohol-fed mice and illuminate the function of miR-378b-mediated phosphoinositide 3-kinase (PI3K)/protein kinase B (AKT) pathway in system. MFA was found to remarkably down-regulate miR-378b level and increase IR and p110α expressions. Furthermore, the effect of MFA on modulating miR-378b/PI3K-AKT pathway to enhance insulin sensitivity was corroborated by overexpressing and inhibiting miR-378b. Taken together, MFA exhibited a positive effect against ALD by attenuating the inhibition of miR-378b on IR/p110α and partly activating the insulin signaling to alleviate alcohol-induced hepatic insulin resistance.
    Mesh-Begriff(e) Animals ; Caffeic Acids/pharmacology ; Class I Phosphatidylinositol 3-Kinases/metabolism ; Gene Expression Regulation/drug effects ; Insulin Resistance/physiology ; Liver Diseases, Alcoholic/drug therapy ; Liver Diseases, Alcoholic/metabolism ; Mice ; MicroRNAs/metabolism ; Phosphatidylinositol 3-Kinase/metabolism ; Phytochemicals ; Proto-Oncogene Proteins c-akt/metabolism ; Receptor, Insulin/metabolism ; Securidaca ; Signal Transduction/drug effects ; Up-Regulation
    Chemische Substanzen Caffeic Acids ; MIRN378 microRNA, mouse ; MicroRNAs ; Phytochemicals ; 1-phosphatidylinositol 3-kinase p110 subunit, mouse (EC 2.7.1.137) ; Class I Phosphatidylinositol 3-Kinases (EC 2.7.1.137) ; Phosphatidylinositol 3-Kinase (EC 2.7.1.137) ; Receptor, Insulin (EC 2.7.10.1) ; Proto-Oncogene Proteins c-akt (EC 2.7.11.1) ; methyl ferulate (Y98BUA66RX)
    Sprache Englisch
    Erscheinungsdatum 2021-11-26
    Erscheinungsland France
    Dokumenttyp Journal Article
    ZDB-ID 392415-4
    ISSN 1950-6007 ; 0753-3322 ; 0300-0893
    ISSN (online) 1950-6007
    ISSN 0753-3322 ; 0300-0893
    DOI 10.1016/j.biopha.2021.112462
    Datenquelle MEDical Literature Analysis and Retrieval System OnLINE

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