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Article ; Online: Direct Air Capture of CO

Priyadarshini, Pranjali / Rim, Guanhe / Rosu, Cornelia / Song, MinGyu / Jones, Christopher W

ACS environmental Au

2023 Volume 3, Issue 5, Page(s) 295–307

Abstract: ... Rising ... ...

Abstract	Rising CO
Language	English
Publishing date	2023-06-29
Publishing country	United States
Document type	Journal Article
ISSN	2694-2518
ISSN (online)	2694-2518
DOI	10.1021/acsenvironau.3c00010
Database	MEDical Literature Analysis and Retrieval System OnLINE

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Article ; Online: USP18 Stabilized FTO Protein to Activate Mitophagy in Ischemic Stroke Through Repressing m6A Modification of SIRT6.

Song, Mingyu / Yi, Fang / Zeng, Feiyue / Zheng, Lan / Huang, Lei / Sun, Xinyu / Huang, Qianyi / Deng, Jun / Wang, Hong / Gu, Wenping

Molecular neurobiology

2024

Abstract: Ischemic stroke (IS) is a dangerous cerebrovascular disorder with a significant incidence and death rate. Ubiquitin-specific peptidase 18 (USP18) has been proven to mitigate ischemic brain damage; however, its potential regulatory mechanisms remain ... ...

Abstract	Ischemic stroke (IS) is a dangerous cerebrovascular disorder with a significant incidence and death rate. Ubiquitin-specific peptidase 18 (USP18) has been proven to mitigate ischemic brain damage; however, its potential regulatory mechanisms remain unclear. In vivo and in vitro models of IS were established by middle cerebral artery occlusion (MCAO) and oxygen-glucose deprivation/reoxygenation (OGD/R). Neurocyte injury was detected by MTT, LDH, ROS level, mitochondrial membrane potential (Δψm), and flow cytometry. Molecular expression was evaluated by qPCR, Western blotting, and immunofluorescence staining. Molecular mechanisms were determined by Co-IP, RIP, and MeRIP. IS injury was determined by neurological behavior score and TTC staining. Mitophagy was observed by TEM. USP18 and fat mass and obesity-associated protein (FTO) expression declined after OGD/R. Dysfunctional mitochondrial and apoptosis in OGD/R-stimulated neurocytes were eliminated by USP18/FTO overexpression via mitophagy activation. USP18-mediated de-ubiquitination was responsible for increasing FTO protein stability. Up-regulation of FTO protein restrained m6A modification of sirtuin6 (SIRT6) in a YTHDF2-dependent manner to enhance SIRT6 expression and subsequent activation of AMPK/PGC-1α/AKT signaling. FTO induced mitophagy to ameliorate nerve cell damage through SIRT6/AMPK/PGC-1α/AKT pathway. Finally, USP18/FTO overexpression relieved IS in rats via triggering SIRT6/AMPK/PGC-1α/AKT axis-mediated mitophagy. USP18 increased FTO protein stability to trigger SIRT6-induced mitophagy, thus mitigating IS. Our data unravel the novel neuroprotective mechanism of USP18 and suggest its potential as a promising treatment target for IS.
Language	English
Publishing date	2024-02-10
Publishing country	United States
Document type	Journal Article
ZDB-ID	645020-9
ISSN	1559-1182 ; 0893-7648
ISSN (online)	1559-1182
ISSN	0893-7648
DOI	10.1007/s12035-024-04001-1
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Article ; Online: Humans combine value learning and hypothesis testing strategically in multi-dimensional probabilistic reward learning.

Song, Mingyu / Baah, Persis A / Cai, Ming Bo / Niv, Yael

PLoS computational biology

2022 Volume 18, Issue 11, Page(s) e1010699

Abstract: Realistic and complex decision tasks often allow for many possible solutions. How do we find the correct one? Introspection suggests a process of trying out solutions one after the other until success. However, such methodical serial testing may be too ... ...

Abstract	Realistic and complex decision tasks often allow for many possible solutions. How do we find the correct one? Introspection suggests a process of trying out solutions one after the other until success. However, such methodical serial testing may be too slow, especially in environments with noisy feedback. Alternatively, the underlying learning process may involve implicit reinforcement learning that learns about many possibilities in parallel. Here we designed a multi-dimensional probabilistic active-learning task tailored to study how people learn to solve such complex problems. Participants configured three-dimensional stimuli by selecting features for each dimension and received probabilistic reward feedback. We manipulated task complexity by changing how many feature dimensions were relevant to maximizing reward, as well as whether this information was provided to the participants. To investigate how participants learn the task, we examined models of serial hypothesis testing, feature-based reinforcement learning, and combinations of the two strategies. Model comparison revealed evidence for hypothesis testing that relies on reinforcement-learning when selecting what hypothesis to test. The extent to which participants engaged in hypothesis testing depended on the instructed task complexity: people tended to serially test hypotheses when instructed that there were fewer relevant dimensions, and relied more on gradual and parallel learning of feature values when the task was more complex. This demonstrates a strategic use of task information to balance the costs and benefits of the two methods of learning.
MeSH term(s)	Humans ; Reward ; Learning ; Reinforcement, Psychology
Language	English
Publishing date	2022-11-23
Publishing country	United States
Document type	Journal Article
ZDB-ID	2193340-6
ISSN	1553-7358 ; 1553-734X
ISSN (online)	1553-7358
ISSN	1553-734X
DOI	10.1371/journal.pcbi.1010699
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Article ; Online: Cold Temperature Direct Air CO

Wang, Yuxiang / Rim, Guanhe / Song, MinGyu / Holmes, Hannah E / Jones, Christopher W / Lively, Ryan P

ACS applied materials & interfaces

2023 Volume 16, Issue 1, Page(s) 1404–1415

Abstract: Zeolites, silica-supported amines, and metal-organic frameworks (MOFs) have been demonstrated as promising adsorbents for direct air ... ...

Abstract	Zeolites, silica-supported amines, and metal-organic frameworks (MOFs) have been demonstrated as promising adsorbents for direct air CO
Language	English
Publishing date	2023-12-18
Publishing country	United States
Document type	Journal Article
ISSN	1944-8252
ISSN (online)	1944-8252
DOI	10.1021/acsami.3c13528
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Article ; Online: Quality characteristics and antioxidant activities of Korean traditional rice and quinoa‐based wine “Makgeolli”

Jeon, Eun Bi / Song, Min-gyu / Kim, So Hee / Choi, Jae‐Suk / Lee, Jung‐Suck / Park, Shin Young

Cereal Chemistry. 2023 Mar., v. 100, no. 2 p.473-483

2023

Abstract: BACKGROUND AND OBJECTIVES: Makgeolli is a traditional Korean rice wine that is brewed by fermenting a mixture of steamed rice and Nuruk. Quinoa products contain polyphenols, including phenolic acids, flavonoids, and tannins, which make up bioactive ... ...

Abstract	BACKGROUND AND OBJECTIVES: Makgeolli is a traditional Korean rice wine that is brewed by fermenting a mixture of steamed rice and Nuruk. Quinoa products contain polyphenols, including phenolic acids, flavonoids, and tannins, which make up bioactive secondary plant metabolites that contribute to diverse physiological properties, such as antimicrobial, antioxidant, and antitumor activities. The preparation of rice‐based Makgeolli (RM) and quinoa‐added Makgeolli (QM) were obtained by combining rice and quinoa in ratios 1:1 (RM; control: without supplement). This study sought to assess the physicochemical, microbiological, antioxidant, and taste tests of RM and QM during a 6‐day fermentation period. FINDING: The alcohol content increased steadily until Day 6 (10.7%–10.3%). From the start of fermentation to Day 2 of fermentation, the number of lactic acid bacteria (LAB) in RM and QM increased rapidly (p < .05), with no significant increase thereafter (p > .05). 1,1‐diphenyl‐2‐picrylhydrazyl (DPPH) and 2,2‐azino‐bis(3‐ethylbenzthiazoline‐6‐sulfonic acid) (ABTS) radical scavenging activities were significantly (p < .05) higher in QM (DPPH: 81.01%, ABTS: 91.46%) than in RM (DPPH: 43.65%, ABTS: 53.85%). The average result of iron(II) chelating activity for RM was 39.81%, while for QM was 47.09%. Moreover, superoxide dismutase scavenging activity of both RM and QM were 41.07% and 56.23%, respectively. There were no significant differences in color, smell, appearance, and overall acceptability between RM and QM (p > .05). However, taste values were significantly higher (p < .05) in QM than in RM (5.9 vs. 4.3). CONCLUSION: Makgeolli supplemented with quinoa owing to its good physicochemical and microbiological characteristics, including high antioxidant properties and good consumer acceptance.
Keywords	2,2-diphenyl-1-picrylhydrazyl ; antioxidants ; chemistry ; color ; consumer acceptance ; fermentation ; flavonoids ; iron ; lactic acid ; metabolites ; polyphenols ; rice ; rice wines ; smell ; superoxide dismutase ; taste
Language	English
Dates of publication	2023-03
Size	p. 473-483.
Publishing place	John Wiley & Sons, Ltd
Document type	Article ; Online
Note	JOURNAL ARTICLE
ZDB-ID	242360-1
ISSN	0009-0352
ISSN	0009-0352
DOI	10.1002/cche.10626
Database	NAL-Catalogue (AGRICOLA)

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Article: Ultrafast N-arylation of sulfoximines enabled by micellar catalysis in water

Song, Mingyu / Zhang, Lei / Wei, Diandian / He, Yu / Jia, Jiajia / Li, Heng / Yuan, Bingxin

Green chemistry. 2022 Aug. 15, v. 24, no. 16

2022

Abstract: A sustainable and ultrafast protocol was developed for the N-arylation of sulfoximines with aryl bromides in water. The protocol requires low catalyst loading and the synthesis period was shortened to several minutes. The strategy was compatible with ... ...

Abstract	A sustainable and ultrafast protocol was developed for the N-arylation of sulfoximines with aryl bromides in water. The protocol requires low catalyst loading and the synthesis period was shortened to several minutes. The strategy was compatible with diverse aryl bromides and sulfoximines, giving scaffolds in good to excellent yields.
Keywords	catalysts ; catalytic activity ; green chemistry
Language	English
Dates of publication	2022-0815
Size	p. 6119-6124.
Publishing place	The Royal Society of Chemistry
Document type	Article
ZDB-ID	2006274-6
ISSN	1463-9270 ; 1463-9262
ISSN (online)	1463-9270
ISSN	1463-9262
DOI	10.1039/d2gc01919a
Database	NAL-Catalogue (AGRICOLA)

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Article ; Online: Severity Evaluation of Regional Cerebrovascular Reactivity in Acute Stroke Patients Using SPECT.

Kang, Chang-Ki / Song, Min-Gyu / Yang, Jiwon / Lee, Haejun / Lee, Yeong-Bae

Current medical imaging

2022 Volume 18, Issue 8, Page(s) 837–844

Abstract: Background: Cerebrovascular Reactivity (CVR), as measured using perfusion Single Photon Emission Computed Tomography (SPECT), is an important indicator for the treatment and prognosis of cerebrovascular disease, but there are a few studies on acute ... ...

Abstract	Background: Cerebrovascular Reactivity (CVR), as measured using perfusion Single Photon Emission Computed Tomography (SPECT), is an important indicator for the treatment and prognosis of cerebrovascular disease, but there are a few studies on acute stroke or small vascular disease using SPECT. Objective: This study evaluated the regional severity with quantitatively determined CVR in patients with acute stroke. Methods: Fifty-eight patients who took brain SPECT images were selected to localize quantitative CVR values. The severity of the disease (Grade 1 to 4) was determined through image-based clinical assessment in the absence and presence of a CVR map, and their results were compared. Results: In 1st diagnosis without the map, the mean CVR values of Grades 2 and 3 were -6.07 % and -9.12 %, respectively (P=0.034), while they were -4.78 % and -12.34 % in 2nd diagnosis with the map, respectively (P<0.001), suggesting that the CVR difference with the map was much more pronounced than without the map. Furthermore, in the ROC analysis, the diagnostic sensitivity between Grades 2 and 3 in the 2nd diagnosis (AUC=0.899, P<0.001) was substantially greater than the 1st diagnosis (AUC=0.646, P=0.048). Conclusion: This study demonstrated that the quantitative CVR maps could reinforce the clinical evaluation of cerebral severity by showing that they can provide statistically significant results between severity and CVR. Furthermore, this study was the first to evaluate the effectiveness of quantitative CVR by examining the difference in the presence or absence of CVR in patients with acute stroke.
MeSH term(s)	Cerebrovascular Circulation ; Humans ; Stroke/diagnostic imaging ; Tomography, Emission-Computed, Single-Photon/methods
Language	English
Publishing date	2022-01-03
Publishing country	United Arab Emirates
Document type	Journal Article ; Research Support, Non-U.S. Gov't
ISSN	1573-4056
ISSN (online)	1573-4056
DOI	10.2174/1573405618666220103104726
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Article ; Online: Symptomatic plaque enhancement is associated with early-onset post-stroke depression.

Liu, Fan / Song, Mingyu / Huang, Xia / Yi, Hanxi / Chen, Hengshu / Tian, Fafa

Journal of affective disorders

2022 Volume 306, Page(s) 281–287

Abstract: Background: The association between imaging features closely associated with symptomatic intracranial atherosclerotic plaques and early-onset post-stroke depression (PSD) is currently unclear.: Materials and methods: 76 ischemic stroke patients who ... ...

Abstract	Background: The association between imaging features closely associated with symptomatic intracranial atherosclerotic plaques and early-onset post-stroke depression (PSD) is currently unclear. Materials and methods: 76 ischemic stroke patients who underwent high-resolution vessel wall magnetic resonance imaging (HR-VWI) were divided into PSD and non-PSD groups according to their DSM-V diagnoses and HAMD-17 scores at 14 days after onset. Clinical data and the imaging features associated with symptomatic plaques (including the enhancement index (EI), remodeling index, and plaque surface irregularity) were compared between groups. Multifactorial logistic regression analysis was used to find independent predictors of early-onset PSD. Spearman rank correlation analysis explores the association between clinical data, symptomatic plaque imaging features, and HAMD-17 in patients. Results: The sample comprised 36 patients with early-onset PSD. The symptomatic plaque EI and infarct volume were significantly higher in depressed patients than in patients without depression (P < 0.05). Multivariate logistic regression showed that symptomatic plaque EI could be used as an independent predictor of early-onset PSD after correcting for the confounding factor of infarct volume (OR = 1.034, 95% CI:1.014-1.055, P = 0.001). In the total sample, symptomatic plaque EI, infarct volume, and HAMD-17 had a significant positive correlation with each other (P < 0.05). Limitations: This study focused only on the patients' symptomatic plaques and did not monitor patients' systemic inflammation levels at the time of HR-VWI. Conclusions: The degree of symptomatic plaque enhancement is an independent predictive imaging marker of early-onset PSD and can be used the early diagnosis of early-onset PSD.
MeSH term(s)	Depression/diagnostic imaging ; Depression/etiology ; Humans ; Infarction/complications ; Intracranial Arteriosclerosis/complications ; Intracranial Arteriosclerosis/pathology ; Magnetic Resonance Imaging/methods ; Plaque, Atherosclerotic/complications ; Plaque, Atherosclerotic/diagnostic imaging ; Plaque, Atherosclerotic/pathology ; Stroke/complications ; Stroke/diagnostic imaging ; Stroke/pathology
Language	English
Publishing date	2022-03-23
Publishing country	Netherlands
Document type	Journal Article ; Research Support, Non-U.S. Gov't
ZDB-ID	135449-8
ISSN	1573-2517 ; 0165-0327
ISSN (online)	1573-2517
ISSN	0165-0327
DOI	10.1016/j.jad.2022.03.026
Database	MEDical Literature Analysis and Retrieval System OnLINE

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Zs.A 1485: Show issues

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ab Jg. 2022: Lesesaal (EG)

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Article ; Online: Support Pore Structure and Composition Strongly Influence the Direct Air Capture of CO

Rim, Guanhe / Priyadarshini, Pranjali / Song, MinGyu / Wang, Yuxiang / Bai, Andrew / Realff, Matthew J / Lively, Ryan P / Jones, Christopher W

Journal of the American Chemical Society

2023 Volume 145, Issue 13, Page(s) 7190–7204

Abstract: A variety of amine-impregnated porous solid sorbents for direct air capture (DAC) of ... ...

Abstract	A variety of amine-impregnated porous solid sorbents for direct air capture (DAC) of CO
Language	English
Publishing date	2023-03-27
Publishing country	United States
Document type	Journal Article
ZDB-ID	3155-0
ISSN	1520-5126 ; 0002-7863
ISSN (online)	1520-5126
ISSN	0002-7863
DOI	10.1021/jacs.2c12707
Database	MEDical Literature Analysis and Retrieval System OnLINE

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Article ; Online: BMSC-derived exosomal miR-148b-3p attenuates OGD/R-induced HMC3 cell activation by targeting DLL4 and Notch1.

Yi, Fang / Xiao, Hui / Song, Mingyu / Huang, Lei / Huang, Qianyi / Deng, Jun / Yang, Han / Zheng, Lan / Wang, Hong / Gu, Wenping

Neuroscience research

2023 Volume 199, Page(s) 36–47

Abstract: Bone mesenchymal stem cell (BMSC)-derived exosome (BMSC-Exo) could be a treatment method for ischemic injury. In ischemic cerebrovascular disease (IC), microglia is pivotal in neuronal damage and remodeling. This study explores the mechanisms of BMSC-Exo ...

Abstract	Bone mesenchymal stem cell (BMSC)-derived exosome (BMSC-Exo) could be a treatment method for ischemic injury. In ischemic cerebrovascular disease (IC), microglia is pivotal in neuronal damage and remodeling. This study explores the mechanisms of BMSC-Exo miR-148b-3p in regulating oxygen-glucose deprivation/reoxygenation (OGD/R)-induced human microglial clone 3 (HMC3) cell activation. Transmission electron microscopy (TEM) and qNano were used to assess BMSC-Exo features. The functions of BMSC-Exo miR-148 b-3p in OGD/R-induced HMC3 cell activation were explored via MTT assay, flow cytometry, scratch, transwell, and enzyme-linked immunosorbent assay (ELISA) assays. A dual-luciferase reporter assay was performed to determine the relationship between miR-148b-3p and Delta-like ligand 4(DDL4) or neurogenic locus notch homolog protein 1 (Notch1). OGD/R decreased miR-148b-3p expression in HMC3 cells. After BMSC-Exo treatment, miR-148b-3p expression was upregulated, cell viability and migration were inhibited, cell cycles remained in the G0/G1 phase, and proinflammatory cytokines were decreased in OGD/R-induced HMC3 cells. More importantly, BMSC-Exo miR-148b-3p could further strengthen BMSC-Exo effects. DDL4 and Notch1 are direct targets of miR-148b-3p, respectively. Moreover, the knockdown of DLL4 or Notch1 could inhibit OGD/R-induced HMC3 cell activation. BMSC-Exo miR-148b-3p inhibited OGD/R-induced HMC3 cell activation via inhibiting DLL4 and Notch1 expression, which provided a new strategy for treating cerebral ischemia.
MeSH term(s)	Humans ; MicroRNAs/metabolism ; Oxygen/pharmacology ; Glucose/pharmacology ; Mesenchymal Stem Cells/metabolism ; Clone Cells/metabolism ; Apoptosis ; Calcium-Binding Proteins/metabolism ; Adaptor Proteins, Signal Transducing/metabolism
Chemical Substances	MicroRNAs ; Oxygen (S88TT14065) ; Glucose (IY9XDZ35W2) ; DLL4 protein, human ; Calcium-Binding Proteins ; Adaptor Proteins, Signal Transducing
Language	English
Publishing date	2023-09-21
Publishing country	Ireland
Document type	Journal Article
ZDB-ID	605842-5
ISSN	1872-8111 ; 0168-0102 ; 0921-8696
ISSN (online)	1872-8111
ISSN	0168-0102 ; 0921-8696
DOI	10.1016/j.neures.2023.09.005
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