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  1. AU="Song, Sin-Mao"
  2. AU="Yaxuan He"
  3. AU="Wu, Jiaojie"
  4. AU="Tze Kwun Ng"
  5. AU="Leonard L Yeo"

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  1. Article: Using Cu as a Spacer to Fabricate and Control the Porosity of Titanium Zirconium Based Bulk Metallic Glass Foams for Orthopedic Implant Applications.

    Wong, Pei-Chun / Song, Sin-Mao / Tsai, Pei-Hua / Maqnun, Muhammad Jauharul / Wang, Wei-Ru / Wu, Jia-Lin / Jang, Shian-Ching Jason

    Materials (Basel, Switzerland)

    2022  Volume 15, Issue 5

    Abstract: In this study, a porous titanium zirconium (TiZr)-based bulk metallic foam was successfully fabricated using the Cu spacer by employing the hot press method. TiZr-based bulk metallic foams with porosities ranging from 0% to 50% were fabricated and ... ...

    Abstract In this study, a porous titanium zirconium (TiZr)-based bulk metallic foam was successfully fabricated using the Cu spacer by employing the hot press method. TiZr-based bulk metallic foams with porosities ranging from 0% to 50% were fabricated and analyzed. The results indicate that thermal conductivity increased with the addition of Cu spacer; the increased thermal conductivity reduced the holding time in the hot press method. Moreover, the compressive strength decreased from 1261 to 76 MPa when the porosity of the TiZr-based bulk metallic foam increased to 50%, and the compressive strength was predictable. In addition, the foam demonstrated favorable biocompatibility in cell viability, cell migration capacity, and calcium deposition tests. Moreover, the pore size of the porous TiZr-based bulk metallic foam was around 120 µm. In conclusion, TiZr-based bulk metallic foam has favorable biocompatibility, mechanical property controllability, and porous structure for bone ingrowth and subsequent enhanced osteointegration. This porous TiZr-based bulk metallic foam has great potential as an orthopedic implant to enhance bone healing and decrease healing time.
    Language English
    Publishing date 2022-03-03
    Publishing country Switzerland
    Document type Journal Article
    ZDB-ID 2487261-1
    ISSN 1996-1944
    ISSN 1996-1944
    DOI 10.3390/ma15051887
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  2. Article: Relationship between the Surface Roughness of Biodegradable Mg-Based Bulk Metallic Glass and the Osteogenetic Ability of MG63 Osteoblast-Like Cells.

    Wong, Pei-Chun / Song, Sin-Mao / Tsai, Pei-Hua / Nien, Yi-Yuan / Jang, Jason Shian-Ching / Cheng, Cheng-Kung / Chen, Chih-Hwa

    Materials (Basel, Switzerland)

    2020  Volume 13, Issue 5

    Abstract: Mg-based bulk metallic glass materials have been investigated for their large potential for application in orthopedic implants due to their biocompatibility, low degradation rate, and osteogenetic ability. As an orthopedic implant, initial cell adhesion ... ...

    Abstract Mg-based bulk metallic glass materials have been investigated for their large potential for application in orthopedic implants due to their biocompatibility, low degradation rate, and osteogenetic ability. As an orthopedic implant, initial cell adhesion has been a critical issue for subsequent osteogenesis and bone formation because the first contact between cells and the implant occurs upon the implants surface. Here, we aimed to create Mg-based bulk metallic glass samples with three different surface roughness attributes in order to understand the degradation behavior of Mg-based bulk metallic glass and the adhesion ability and osteogenetic ability of the contact cells. It was found that the degradation behavior of Mg
    Language English
    Publishing date 2020-03-06
    Publishing country Switzerland
    Document type Journal Article
    ZDB-ID 2487261-1
    ISSN 1996-1944
    ISSN 1996-1944
    DOI 10.3390/ma13051188
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  3. Article ; Online: A bi-phase core-shell structure of Mg-based bulk metallic glass for application in orthopedic fixation implants.

    Song, Sin-Mao / Wong, Pei-Chun / Chiang, Chih-Wei / Tsai, Pei-Hua / Jang, J S C / Chen, Chih-Hwa

    Materials science & engineering. C, Materials for biological applications

    2020  Volume 111, Page(s) 110783

    Abstract: Mg-based bulk metallic glass (BMG) and its composites have been promising candidates for orthopedic fixation implants because of their biocompatibility, low degradation rate, and osteogenic potential. However, the amorphous state is affected by the ... ...

    Abstract Mg-based bulk metallic glass (BMG) and its composites have been promising candidates for orthopedic fixation implants because of their biocompatibility, low degradation rate, and osteogenic potential. However, the amorphous state is affected by the cooling rate during the casting process. Solid, unstable structures combined with amorphous and crystalline structures are generated when an insufficient cooling rate is used. Here, we aimed to design and synthesize a novel core-shell structure comprising an amorphous shell and a crystalline core in order to overcome the material size limit imposed by the cooling rate effects. Our results show that the core-shell structure of Mg-based BMG does have a lower degradation rate and can maintain a more amorphous structure after six weeks of degradation. Moreover, the biocompatibility and osteogenic effects were similar between the core-shell and solid structures of Mg-based BMG. In conclusion, the core-shell structure of Mg-based BMG exhibits a lower degradation rate while still enhancing osteogenic potential in vitro. This core-shell structure of Mg-based BMG overcomes the cooling rate effects and provides a new structure for manufacturing Mg-based BMG.
    MeSH term(s) Biocompatible Materials/chemistry ; Biocompatible Materials/pharmacology ; Cell Line ; Cell Survival/drug effects ; Compressive Strength ; Glass/chemistry ; Humans ; Magnesium/chemistry ; Orthopedic Fixation Devices ; Osteogenesis/drug effects ; Phase Transition ; Surface Properties ; Temperature ; Zirconium/chemistry
    Chemical Substances Biocompatible Materials ; Zirconium (C6V6S92N3C) ; Magnesium (I38ZP9992A)
    Language English
    Publishing date 2020-02-26
    Publishing country Netherlands
    Document type Journal Article
    ZDB-ID 2012160-X
    ISSN 1873-0191 ; 0928-4931
    ISSN (online) 1873-0191
    ISSN 0928-4931
    DOI 10.1016/j.msec.2020.110783
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  4. Article: Open-Cell Tizr-Based Bulk Metallic Glass Scaffolds with Excellent Biocompatibility and Suitable Mechanical Properties for Biomedical Application.

    Nguyen, Van Tai / Wong, Xavier Pei-Chun / Song, Sin-Mao / Tsai, Pei-Hua / Jang, Jason Shian-Ching / Tsao, I-Yu / Lin, Che-Hsin / Nguyen, Van Cuong

    Journal of functional biomaterials

    2020  Volume 11, Issue 2

    Abstract: A series of biocompatible high-porosity (up to 72.4%) TiZr-based porous bulk metallic glass (BMG) scaffolds were successfully fabricated by hot pressing a mixture of toxic element-free TiZr-based BMG powder and an Al particle space holder. The morphology ...

    Abstract A series of biocompatible high-porosity (up to 72.4%) TiZr-based porous bulk metallic glass (BMG) scaffolds were successfully fabricated by hot pressing a mixture of toxic element-free TiZr-based BMG powder and an Al particle space holder. The morphology of the fabricated scaffolds was similar to that of human bones, with pore sizes ranging from 75 to 250 μm. X-ray diffraction patterns and transmission electron microscopy images indicated that the amorphous structure of the TiZr-based BMG scaffolds remained in the amorphous state after hot pressing. Noncytotoxicity and extracellular calcium deposition of the TiZr-based BMG scaffolds at porosities of 32.8%, 48.8%, and 64.0% were examined by using the direct contact method. The results showed that the BMG scaffolds possess high cell viability and extracellular calcium deposition with average cell survival and deposition rates of approximately 170.1% and 130.9%, respectively. In addition, the resulting TiZr-based BMG scaffolds exhibited a considerable reduction in Young's moduli from 56.4 to 2.3 GPa, compressive strength from 979 to 19 MPa, and bending strength from 157 MPa to 49 MPa when the porosity was gradually increased from 2.0% to 72.4%. Based on the aforementioned specific characteristics, TiZr-based BMG scaffolds can be considered as potential candidates for biomedical applications in the human body.
    Language English
    Publishing date 2020-05-01
    Publishing country Switzerland
    Document type Journal Article
    ZDB-ID 2648525-4
    ISSN 2079-4983
    ISSN 2079-4983
    DOI 10.3390/jfb11020028
    Database MEDical Literature Analysis and Retrieval System OnLINE

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