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  1. Article ; Online: Synergistic effects of L-theanine and epigallocatechin gallate in alleviating ovalbumin allergy by regulating intestinal immunity through inhibition of mast cell degranulation.

    Xu, Wei / Song, Xianying / Qu, Qingyun / Gong, Zhihua / Xiao, Wenjun

    Food & function

    2023  Volume 14, Issue 4, Page(s) 2059–2073

    Abstract: Ovalbumin (OVA), a commonly consumed food protein, can cause severe allergies and intestinal immune disorders. L-Theanine (LTA) and epigallocatechin gallate (EGCG) regulate intestinal immunity. However, it is unclear whether an LTA and EGCG combined ... ...

    Abstract Ovalbumin (OVA), a commonly consumed food protein, can cause severe allergies and intestinal immune disorders. L-Theanine (LTA) and epigallocatechin gallate (EGCG) regulate intestinal immunity. However, it is unclear whether an LTA and EGCG combined intervention can alleviate OVA allergy (OVA-A) by modulating intestinal-specific immunity, and it is unknown whether there is a synergistic effect between LTA and EGCG. Therefore, we treated BALB/c OVA-sensitized mice with LTA, EGCG, or a combination of both (LTA + EGCG) to investigate the effects of LTA and EGCG on intestinal-specific immunity regulation and underlying mechanisms. Female mice were intraperitoneally injected with OVA to establish OVA-sensitive mouse models. MLEO LTA + EGCG (20 mg kg
    MeSH term(s) Female ; Mice ; Animals ; Ovalbumin ; Mast Cells ; Cell Degranulation ; Interleukin-4/metabolism ; Interleukin-13/metabolism ; Phosphatidylinositol 3-Kinases/metabolism ; Hypersensitivity/metabolism ; Cytokines/metabolism ; Mice, Inbred BALB C ; Disease Models, Animal
    Chemical Substances Ovalbumin (9006-59-1) ; theanine (8021PR16QO) ; Interleukin-4 (207137-56-2) ; Interleukin-13 ; epigallocatechin gallate (BQM438CTEL) ; Phosphatidylinositol 3-Kinases (EC 2.7.1.-) ; Cytokines
    Language English
    Publishing date 2023-02-21
    Publishing country England
    Document type Journal Article
    ZDB-ID 2612033-1
    ISSN 2042-650X ; 2042-6496
    ISSN (online) 2042-650X
    ISSN 2042-6496
    DOI 10.1039/d2fo03404b
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  2. Article ; Online: L-Theanine Modulates Intestine-Specific Immunity by Regulating the Differentiation of CD4+ T Cells in Ovalbumin-Sensitized Mice.

    Qu, Qing-Yun / Song, Xian-Ying / Lin, Ling / Gong, Zhi-Hua / Xu, Wei / Xiao, Wen-Jun

    Journal of agricultural and food chemistry

    2022  Volume 70, Issue 47, Page(s) 14851–14863

    Abstract: Ovalbumin (OVA), a common food protein, can cause deadly allergies with intestine-specific immune reactions. L-Theanine (LTA) shows great potential for regulating intestinal immunity. To investigate the regulatory effect of LTA intervention on intestine- ... ...

    Abstract Ovalbumin (OVA), a common food protein, can cause deadly allergies with intestine-specific immune reactions. L-Theanine (LTA) shows great potential for regulating intestinal immunity. To investigate the regulatory effect of LTA intervention on intestine-specific immunity, a 41 day experiment was performed on BALB/c OVA-sensitized mice. The results show that injecting female mice intraperitoneally with 50 μg of OVA and administering 30 mg of OVA 4 times can successfully establish an OVA-sensitized mouse model. LTA intervention significantly increased weight gain and thymus index (
    MeSH term(s) Female ; Mice ; Animals ; Ovalbumin ; CD4-Positive T-Lymphocytes ; Intestines ; Hypersensitivity
    Chemical Substances Ovalbumin (9006-59-1) ; theanine (8021PR16QO)
    Language English
    Publishing date 2022-11-17
    Publishing country United States
    Document type Journal Article
    ZDB-ID 241619-0
    ISSN 1520-5118 ; 0021-8561
    ISSN (online) 1520-5118
    ISSN 0021-8561
    DOI 10.1021/acs.jafc.2c06171
    Database MEDical Literature Analysis and Retrieval System OnLINE

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    In stock of ZB MED Cologne/Königswinter

    Zs.A 1172: Show issues Location:
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    Jg. 1995 - 2021: Lesesall (1.OG)
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  3. Article ; Online: Influences of fusion neutrons on Compton suppressed γ-spectrum analyses at the HL-2A tokamak.

    Zhang, Jie / Zhang, Yipo / Yang, Jinwei / Yuan, Guoliang / Li, Gang / Song, Xianying / Li, Xu / Shi, Zhongbing / Liu, Yi

    Applied radiation and isotopes : including data, instrumentation and methods for use in agriculture, industry and medicine

    2020  Volume 166, Page(s) 109387

    Abstract: The newly-built Compton suppression system at the HL-2A tokamak works in a harsh fusion neutron field especially when the second neutral beam injection system is put into application. The present paper performed Geant4 simulations to study the influences ...

    Abstract The newly-built Compton suppression system at the HL-2A tokamak works in a harsh fusion neutron field especially when the second neutral beam injection system is put into application. The present paper performed Geant4 simulations to study the influences of fusion neutrons on Compton suppressed γ-spectrum analyses. The simulation data show that the influence of fusion neutrons on suppressed γ-spectrum shape is limited, while the influence on detection efficiencies is considerable. Consequently, the changes of detection efficiencies caused by the coexisting neutrons must be taken into account in the subsequent γ-spectrum analyses. Hence, the empirical formulas of γ-ray detection efficiencies of the Compton suppression system, which had considered the influences of fusion neutrons, were put forward and then applied to unfold the experimental γ-spectra. This work lays a superior foundation for the further analyses of the Compton suppressed γ-spectra at the HL-2A tokamak.
    Language English
    Publishing date 2020-08-19
    Publishing country England
    Document type Journal Article
    ZDB-ID 1142596-9
    ISSN 1872-9800 ; 0883-2889 ; 0969-8043
    ISSN (online) 1872-9800
    ISSN 0883-2889 ; 0969-8043
    DOI 10.1016/j.apradiso.2020.109387
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  4. Article ; Online: Geant4 simulation study on detection efficiencies of the Compton suppression system at the HL-2A tokamak.

    Zhang, Jie / Zhang, Pengfei / Zhang, Yipo / Yang, Jinwei / Yuan, Guoliang / Song, Xianying / Li, Xu / Zhou, Yan

    Applied radiation and isotopes : including data, instrumentation and methods for use in agriculture, industry and medicine

    2019  Volume 150, Page(s) 63–69

    Abstract: A Compton suppression system (CSS), which plays an important role in γ-ray diagnostics, has been developed to acquire the γ-ray emission spectra generated in the HL-2A tokamak plasma. It takes advantages of the anti-coincidence method of two branches of ... ...

    Abstract A Compton suppression system (CSS), which plays an important role in γ-ray diagnostics, has been developed to acquire the γ-ray emission spectra generated in the HL-2A tokamak plasma. It takes advantages of the anti-coincidence method of two branches of γ-ray signals, one is from a high purity germanium (HPGe) detector, and the other from several bismuth germinate (BGO) detectors, to output the suppressed spectra. In the present paper, a Geant4 simulation, together with its subsequent data processing which took accidental coincidences into account, was performed to study the detection efficiencies of the CSS for γ-rays with energies between 0.2 and 13 MeV. Calculation results showed that there were small detection efficiency differences between the unsuppressed and suppressed spectra when HPGe count rates were smaller than 10
    Language English
    Publishing date 2019-05-15
    Publishing country England
    Document type Journal Article
    ZDB-ID 1142596-9
    ISSN 1872-9800 ; 0883-2889 ; 0969-8043
    ISSN (online) 1872-9800
    ISSN 0883-2889 ; 0969-8043
    DOI 10.1016/j.apradiso.2019.05.016
    Database MEDical Literature Analysis and Retrieval System OnLINE

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    In stock of ZB MED Cologne/Königswinter

    Ue I Zs.279: Show issues Location:
    Je nach Verfügbarkeit (siehe Angabe bei Bestand)
    bis Jg. 2021: Bestellungen von Artikeln über das Online-Bestellformular
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