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Article: Yinglu Guo: PSA screening test requires wider application in China.

Song, Xiaoping

2016 Volume 1, Issue 4, Page(s) 199–201

Language	English
Publishing date	2016-01-01
Publishing country	China
Document type	Journal Article
ZDB-ID	2851630-8
ISSN	2223-4691 ; 2223-4691 ; 2223-4683
ISSN (online)	2223-4691
ISSN	2223-4691 ; 2223-4683
DOI	10.3978/j.issn.2223-4683.2012.11.04
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Article ; Online: Synergistic anticancer effects of ginsenoside CK and gefitinib against gefitinib-resistant NSCLC by regulating the balance of angiogenic factors through HIF-1α/VEGF.

Song, Xiaoping / Wang, Lina / Cai, Panpan / Xu, Ying / Liu, Qingchao / Fan, Daidi

Toxicology and applied pharmacology

2024 Volume 486, Page(s) 116938

Abstract: Drug resistance is a serious problem for gefitinib in the treatment of lung cancer. Ginsenoside CK, a metabolite of diol ginsenosides, have many excellent pharmacological activities, but whether ginsenoside CK can overcome gefitinib resistance remains ... ...

Abstract	Drug resistance is a serious problem for gefitinib in the treatment of lung cancer. Ginsenoside CK, a metabolite of diol ginsenosides, have many excellent pharmacological activities, but whether ginsenoside CK can overcome gefitinib resistance remains unclear. In our study, the sensitizing activity of ginsenoside CK on gefitinib-resistant non-small cell lung cancer (NSCLC) in vitro and in vivo was investigated. Ginsenoside CK was confirmed to enhance the anti-proliferation, pro-apoptotic and anti-migration effects of gefitinib in primary and acquired resistant NSCLC. Furthermore, the combined administration of CK and gefitinib effectively promoted the sensitivity of lung cancer xenograft to gefitinib in vivo, and the tumor inhibition rate reached 70.97% (vs. gefitinib monotherapy 32.65%). Subsequently, tubule formation experiment and western blot results showed that co-treatment of ginsenoside CK inhibited the angiogenesis ability of HUVEC cells, and inhibited the expression of HIF-1α, VEGF, FGF and MMP2/9. More interestingly, ginsenoside CK co-treatment enhanced the expression of anti-angiogenic factor PF4, increased pericellular envelope, and promoted the normalization of vascular structure. In conclusion, ginsenoside CK improved the resistance of gefitinib by regulating the balance of angiogenic factors through down-regulating the HIF-1α/VEGF signaling pathway, providing a theoretical basis for improving the clinical efficacy of gefitinib and applying combined strategies to overcome drug resistance.
Language	English
Publishing date	2024-04-19
Publishing country	United States
Document type	Journal Article
ZDB-ID	204477-8
ISSN	1096-0333 ; 0041-008X
ISSN (online)	1096-0333
ISSN	0041-008X
DOI	10.1016/j.taap.2024.116938
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Zs.B 14: Show issues

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Article: Chlorogenic acid: a review on its mechanisms of anti-inflammation, disease treatment, and related delivery systems.

Huang, Jianhuan / Xie, Mingxiang / He, Liang / Song, Xiaoping / Cao, Tianze

Frontiers in pharmacology

2023 Volume 14, Page(s) 1218015

Abstract: Chlorogenic acid is a bioactive compound ubiquitously present in the natural realm, lauded for its salient anti-inflammatory and antioxidant attributes. It executes its anti-inflammatory function by moderating the synthesis and secretion of inflammatory ... ...

Abstract	Chlorogenic acid is a bioactive compound ubiquitously present in the natural realm, lauded for its salient anti-inflammatory and antioxidant attributes. It executes its anti-inflammatory function by moderating the synthesis and secretion of inflammatory mediators, namely, TNF-α, IL-1β, IL-6, IL-8, NO, and PGE2. Concurrently, it modulates key signaling pathways and associated factors, including NF-κB, MAPK, Nrf2, and others, bestowing protection upon cells and tissues against afflictions such as cardio-cerebrovascular and diabetes mellitus. Nevertheless, the inherent low bioavailability of chlorogenic acid poses challenges in practical deployments. To surmount this limitation, sophisticated delivery systems, encompassing liposomes, micelles, and nanoparticles, have been devised, accentuating their stability, release mechanisms, and bioactivity. Given its innate anti-inflammatory prowess and safety profile, chlorogenic acid stands as a promising contender for advanced biomedical investigations and translational clinical endeavors.
Language	English
Publishing date	2023-09-13
Publishing country	Switzerland
Document type	Journal Article ; Review
ZDB-ID	2587355-6
ISSN	1663-9812
ISSN	1663-9812
DOI	10.3389/fphar.2023.1218015
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Article ; Online: Insights into Recent Studies on Biotransformation and Pharmacological Activities of Ginsenoside Rd.

Song, Xiaoping / Wang, Lina / Fan, Daidi

Biomolecules

2022 Volume 12, Issue 4

Abstract: It is well known that ginsenosides-major bioactive constituents of Panax ginseng-are attracting more attention due to their beneficial pharmacological activities. Ginsenoside Rd, belonging to protopanaxadiol (PPD)-type ginsenosides, exhibits diverse and ... ...

Abstract	It is well known that ginsenosides-major bioactive constituents of Panax ginseng-are attracting more attention due to their beneficial pharmacological activities. Ginsenoside Rd, belonging to protopanaxadiol (PPD)-type ginsenosides, exhibits diverse and powerful pharmacological activities. In recent decades, nearly 300 studies on the pharmacological activities of Rd-as a potential treatment for a variety of diseases-have been published. However, no specific, comprehensive reviews have been documented to date. The present review not only summarizes the in vitro and in vivo studies on the health benefits of Rd, including anti-cancer, anti-diabetic, anti-inflammatory, neuroprotective, cardioprotective, ischemic stroke, immunoregulation, and other pharmacological effects, it also delves into the inclusion of potential molecular mechanisms, providing an overview of future prospects for the use of Rd in the treatment of chronic metabolic diseases and neurodegenerative disorders. Although biotransformation, pharmacokinetics, and clinical studies of Rd have also been reviewed, clinical trial data of Rd are limited; the only data available are for its treatment of acute ischemic stroke. Therefore, clinical evidence of Rd should be considered in future studies.
MeSH term(s)	Biotransformation ; Ginsenosides/metabolism ; Ginsenosides/pharmacology ; Ginsenosides/therapeutic use ; Humans ; Ischemic Stroke ; Panax/metabolism
Chemical Substances	Ginsenosides ; ginsenoside Rd (WB232T95AV)
Language	English
Publishing date	2022-03-28
Publishing country	Switzerland
Document type	Journal Article ; Review ; Research Support, Non-U.S. Gov't
ZDB-ID	2701262-1
ISSN	2218-273X ; 2218-273X
ISSN (online)	2218-273X
ISSN	2218-273X
DOI	10.3390/biom12040512
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Article: Oil extraction following digestion to separate microplastics from mussels

Song, Xiaowei / Wu, Xiaofeng / Song, Xiaoping / Zhang, Zhengdong

Chemosphere. 2022 Feb., v. 289

2022

Abstract: Mussels are often used as biological indicators for monitoring marine microplastic pollution. The crucial procedure during monitoring is the separation of microplastics from mussel samples. We investigated the separation efficiencies of six combinations ... ...

Abstract	Mussels are often used as biological indicators for monitoring marine microplastic pollution. The crucial procedure during monitoring is the separation of microplastics from mussel samples. We investigated the separation efficiencies of six combinations of two digestion solutions (10% KOH and 30% H₂O₂) and three extraction solutions (NaCl, oil in H₂O, and oil in NaCl) for mussels with low- and high-density microplastics. After KOH digestion, no polyethylene terephthalate (PET) could be extracted using the three extraction solutions, which might be due to the degradation of PET. After H₂O₂ digestion, the total extraction recovery rates of polypropylene, polyvinyl chloride, and PET for oil in H₂O and oil in NaCl solution ranged from 95.6% ± 5.09%–100%, which were higher than those of the saturated NaCl solution (51.1% ± 17.1%–67.8% ± 13.9%). The first extraction recovery rates of oil in NaCl solution for PP, PET, and PVC were higher than those of oil in H₂O. In this study, extraction by oil in NaCl solution after 30% H₂O₂ digestion was suggested to separate microplastics from mussels. This method is conducive to promoting the standardization of microplastic monitoring in mussels and might be suitable for large-scale monitoring of marine microplastic pollution.
Keywords	digestion ; microplastics ; mussels ; oils ; pollution ; poly(vinyl chloride) ; polyethylene terephthalates ; polypropylenes
Language	English
Dates of publication	2022-02
Publishing place	Elsevier Ltd
Document type	Article
ZDB-ID	120089-6
ISSN	1879-1298 ; 0045-6535 ; 0366-7111
ISSN (online)	1879-1298
ISSN	0045-6535 ; 0366-7111
DOI	10.1016/j.chemosphere.2021.133187
Database	NAL-Catalogue (AGRICOLA)

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Zs.A 2540: Show issues

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Article ; Online: Improved impurity determination of pure organic substances by differential scanning calorimetry with a dynamic method.

Wang, Yanhong / Wang, Haifeng / Song, Xiaoping / Li, Jia / Sun, Guohua

Analytical sciences : the international journal of the Japan Society for Analytical Chemistry

2022

Abstract: Differential scanning calorimetry can be used to measure the impurity contents of pure organic substances on the principle of freezing-point depression. Impurity determination by differential scanning calorimetry with a dynamic method, which has the ... ...

Abstract	Differential scanning calorimetry can be used to measure the impurity contents of pure organic substances on the principle of freezing-point depression. Impurity determination by differential scanning calorimetry with a dynamic method, which has the advantages of speediness and convenience, remains to be explored. Here, a series of acetanilide and dibenzothiophene samples with various purities was prepared through zone melting, and the samples were then analyzed by gas chromatography-mass spectrometry. A modified dynamic method, including encapsulating the analyte in a volatile pan through cold welding, remelting the analyte with a low heating rate, calculating the melted fraction considering the area of the tailing under the heat-flow curve, and reducing the error from solid-solution formation, is proposed. Encapsulating with a volatile pan using a proper torque gave an accurate result. Remelting gave a lower impurity content and a more narrow and sooth peak of heat-flow compared with the first melting. The impurity-content results calculated by the modified method were usually higher than those calculated by the ASTM standard method. For acetanilide and dibenzothiophene with impurity contents of less than 0.30%, the modified dynamic method showed good accuracy. The proposed method is applicable to determination of reference materials of organic substances with high purity owing to its accuracy and convenience.
Language	English
Publishing date	2022-10-21
Publishing country	Switzerland
Document type	Journal Article
ZDB-ID	1483376-1
ISSN	1348-2246 ; 1348-2246
ISSN (online)	1348-2246
ISSN	1348-2246
DOI	10.1007/s44211-022-00205-4
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Article ; Online: Insight on structural modification, biological activity, structure-activity relationship of PPD-type ginsenoside derivatives.

Tong, Yangliu / Song, Xiaoping / Zhang, Yanxin / Xu, Ying / Liu, Qingchao

Fitoterapia

2022 Volume 158, Page(s) 105135

Abstract: Ginsenosides, characterized by triterpenoid, are one of the active components of ginseng. Among them, PPD-type ginsenosides have potent and diverse pharmacological activities, while the effective applications and clinical studies are limited by the poor ... ...

Abstract	Ginsenosides, characterized by triterpenoid, are one of the active components of ginseng. Among them, PPD-type ginsenosides have potent and diverse pharmacological activities, while the effective applications and clinical studies are limited by the poor stability, water solubility and oral bioavailability. In this review, we have attempted to demonstrate the structural-activity relationship of chemical modifications on the dammarane-type skeleton and the C-17 side chain, noting that certain structurally modified derivatives exhibit satisfactory pharmacological activity. This review will provide ideas for the design and synthesis of novel PPD derivatives, and valuable help for the further study of PPD derivatives to make it realize clinical application.
MeSH term(s)	Ginsenosides/pharmacology ; Molecular Structure ; Panax/chemistry ; Structure-Activity Relationship
Chemical Substances	Ginsenosides
Language	English
Publishing date	2022-01-31
Publishing country	Netherlands
Document type	Journal Article ; Review
ZDB-ID	412385-2
ISSN	1873-6971 ; 0367-326X
ISSN (online)	1873-6971
ISSN	0367-326X
DOI	10.1016/j.fitote.2022.105135
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Zs.B 1873: Show issues

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Article ; Online: Accurate identification of methanol and ethanol gasoline types and rapid detection of the alcohol content using effective chemical information.

Li, Ke / Ding, Chaomin / Zhang, Jin / Du, Biao / Song, Xiaoping / Wang, Guixuan / Li, Qi / Zhang, Yinglan / Zhang, Zhengdong

Talanta

2024 Volume 274, Page(s) 125961

Abstract: Methanol and ethanol gasoline are two emerging clean energy sources with different characteristics. To achieve the qualitative identification and quantitative analysis of the alcohols present in methanol and ethanol gasoline, effective chemical ... ...

Abstract	Methanol and ethanol gasoline are two emerging clean energy sources with different characteristics. To achieve the qualitative identification and quantitative analysis of the alcohols present in methanol and ethanol gasoline, effective chemical information (ECI) models based on the characteristic spectral bands of the near-infrared (NIR) spectra of the methanol and ethanol molecules were developed using the partial least squares discriminant analysis (PLS-DA) and partial least squares (PLS) algorithms. The ECI model was further compared with models built from the full wavenumber (Full) spectra, variable importance in projection (VIP) spectra, and Monte Carlo uninformative variable elimination (MC-UVE) spectra to determine the predictive performance of ECI model. Among the various qualitative identification models, it was found that the ECI-PLS-DA model, which is built using the differences in molecular chemical information between methanol and ethanol, exhibited sensitivity, specificity and accuracy values of 100%. The ECI-PLS-DA model accurately identified methanol gasoline and ethanol gasoline with different contents. In the quantitative analysis model for methanol gasoline, the methanol gasoline and ethanol gasoline ECI-PLS models exhibited the smallest root mean squared error of predictions (RMSEP) of 0.18 and 0.21% (v/v), respectively, compared to the other models. Meanwhile, the F-test and T-test results revealed that the NIR method employing the ECI-PLS model showed no significant difference compared to the standard method. Compared with other spectral models examined herein, the ECI model demonstrated the highest recognition success and determination accuracy. This study therefore established a highly accurate and rapid determination model for the qualitative identification and quantitative analysis based on chemical structures. It is expected that this model could be extended to the NIR analysis of other physicochemical properties of fuel.
Language	English
Publishing date	2024-03-27
Publishing country	Netherlands
Document type	Journal Article
ZDB-ID	1500969-5
ISSN	1873-3573 ; 0039-9140
ISSN (online)	1873-3573
ISSN	0039-9140
DOI	10.1016/j.talanta.2024.125961
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Article ; Online: Mussel shell-derived pro-regenerative scaffold with conductive porous multi-scale-patterned microenvironment for spinal cord injury repair.

Yin, Wenming / Yang, Chang / Liu, Dan / Cha, Shuhan / Cai, Liu / Ye, Genlan / Song, Xiaoping / Zhang, Jifeng / Qiu, Xiaozhong

Biomedical materials (Bristol, England)

2024 Volume 19, Issue 3

Abstract: It is well-established that multi-scale porous scaffolds can guide axonal growth and facilitate functional restoration after spinal cord injury (SCI). In this study, we developed a novel mussel shell-inspired conductive scaffold for SCI repair with ease ... ...

Abstract	It is well-established that multi-scale porous scaffolds can guide axonal growth and facilitate functional restoration after spinal cord injury (SCI). In this study, we developed a novel mussel shell-inspired conductive scaffold for SCI repair with ease of production, multi-scale porous structure, high flexibility, and excellent biocompatibility. By utilizing the reducing properties of polydopamine, non-conductive graphene oxide (GO) was converted into conductive reduced graphene oxide (rGO) and crosslinked
MeSH term(s)	Animals ; Spinal Cord Injuries/therapy ; Tissue Scaffolds/chemistry ; Porosity ; Graphite/chemistry ; Bivalvia ; Nerve Regeneration ; Polymers/chemistry ; Biocompatible Materials/chemistry ; Indoles/chemistry ; Animal Shells/chemistry ; Cell Differentiation ; Electric Conductivity ; Neurons ; Rats ; Rats, Sprague-Dawley ; Cell Adhesion ; Neurogenesis ; Tissue Engineering/methods ; Nerve Growth Factor/metabolism ; Nerve Growth Factor/chemistry ; Hippocampus
Chemical Substances	Graphite (7782-42-5) ; graphene oxide ; Polymers ; Biocompatible Materials ; polydopamine ; Indoles ; Nerve Growth Factor (9061-61-4)
Language	English
Publishing date	2024-04-30
Publishing country	England
Document type	Journal Article ; Research Support, Non-U.S. Gov't
ZDB-ID	2265222-X
ISSN	1748-605X ; 1748-6041
ISSN (online)	1748-605X
ISSN	1748-6041
DOI	10.1088/1748-605X/ad3f63
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Zs.A 6626: Show issues

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Article ; Online: Simultaneous Rapid Detection of Multiple Physicochemical Properties of Jet Fuel Using Near-Infrared Spectroscopy.

Li, Ke / Zhang, Xin / Zhang, Jing / Du, Biao / Song, Xiaoping / Wang, Guixuan / Li, Qi / Zhang, Yinglan / Liu, Fan / Zhang, Zhengdong

ACS omega

2024 Volume 9, Issue 14, Page(s) 16138–16146

Abstract: Jet fuel is the primary fuel used in the aviation industry, and its quality has a direct impact on the safety and operational efficiency of aircraft. The accurate quantitative detection and analysis of various physicochemical property indicators are ... ...

Abstract	Jet fuel is the primary fuel used in the aviation industry, and its quality has a direct impact on the safety and operational efficiency of aircraft. The accurate quantitative detection and analysis of various physicochemical property indicators are important for improving and ensuring the quality of jet fuel in the domestic market. This study used near-infrared (NIR) spectroscopy to establish a suitable model for the simultaneous and rapid detection of multiple physicochemical properties in jet fuel. Using more than 40 different sources of jet fuel, a rapid detection model was established by optimizing the spectral processing methods. The measurement models were separately built using the partial least-squares (PLS) and orthogonal PLS algorithms, and the model parameters were optimized. The results show that after the Savitzky-Golay second derivative preprocessing, the PLS model built using the feature spectra selected by the uninformative variable elimination wavelength algorithm achieved the best measurement performance. Compared with the PLS model without preprocessing, the range of the resulting accuracy improvement was at least 15.01%. Under the optimal model parameters, the calibration set regression coefficient (
Language	English
Publishing date	2024-03-28
Publishing country	United States
Document type	Journal Article
ISSN	2470-1343
ISSN (online)	2470-1343
DOI	10.1021/acsomega.3c09994
Database	MEDical Literature Analysis and Retrieval System OnLINE

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