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Article ; Online: People's attitudes toward others' positive self-presentations and demotivation self-presentations on SNS.

Bai, Jing / Song, Xiaoqing / Song, Jingjing

2024 Volume 243, Page(s) 104160

Abstract: People tend to make positive self-presentations on social networking sites (SNS). We aim to compare people's attitudes toward others' positive self-presentations on SNS and its mechanism. The sample in Experimental 1 included 71 Chinese college students. ...

Abstract	People tend to make positive self-presentations on social networking sites (SNS). We aim to compare people's attitudes toward others' positive self-presentations on SNS and its mechanism. The sample in Experimental 1 included 71 Chinese college students. We measured participants' attitudes to others' positive self-presentation, life details self-presentation, and demotivation self-presentation on SNS. Results from Experiment 1 showed that participants preferred others' life details self-presentations over positive self-presentations, and mostly disliked demotivation self-presentations. In Experiment 2, with another sample, we tested idealization, perceived interpersonal distance, stress, anxiety, and depression as mediators of participants' attitudes toward others' positive self-presentation. The results suggested that feelings of depression and interpersonal distance play a mediating role in the relationship between the self-presentation types and people's likability of these posts. The results have implications for understanding why people dislike positive self-presentations on SNS. Positive self-presentations lead people to feel more depressed and far interpersonally distanced from the sharer, and thus they are less likely to like positive self-presentation.
MeSH term(s)	Humans ; Attitude ; Emotions ; Anxiety Disorders ; Anxiety ; Social Media ; Social Networking
Language	English
Publishing date	2024-01-28
Publishing country	Netherlands
Document type	Journal Article
ZDB-ID	1480049-4
ISSN	1873-6297 ; 0001-6918
ISSN (online)	1873-6297
ISSN	0001-6918
DOI	10.1016/j.actpsy.2024.104160
Database	MEDical Literature Analysis and Retrieval System OnLINE

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Article ; Online: Regional intensity of biological disasters in farmland: quantitative assessment and spatiotemporal analysis.

Shen, Yajing / Wang, Xiong / Song, Xiaoqing / Xu, Huixiao

Environmental science and pollution research international

2022 Volume 29, Issue 44, Page(s) 67402–67417

Abstract: Biological disasters in farmland have become a serious threat to global sustainability. Quantitative studies on spatiotemporal change in regional intensity of biological disasters in farmland (RIBDF) are crucial for promoting sustainable intensification ... ...

Abstract	Biological disasters in farmland have become a serious threat to global sustainability. Quantitative studies on spatiotemporal change in regional intensity of biological disasters in farmland (RIBDF) are crucial for promoting sustainable intensification of farmland use and global food security. Many studies have revealed the impacts of natural environment on biological disasters in farmland. However, research on the impacts of farmers' activities on biological disasters remains very limited from the perspective of induced substitution in agricultural production. Based on the principle of induced substitution in agricultural production, a theoretical framework for the impacts of farmland use intensity (FUI), the occurrence intensity of biological disasters (OIBD), the natural loss intensity resulting from biological disasters (NLIBD), and the actual loss intensity controlled by human activities (ALIBD) on change in RIBDF was presented, and we therefore established an assessment model integrating these four key indices in this study. Taking Guangdong Province in China as the study area, this study analyzed the spatiotemporal changes in RIBDF from 1996 to 2017 and found that RIBDF increased overall with three change stages of slow growth, rapid growth, and decline at the provincial and regional levels. Moreover, the gravity center of RIBDF appeared to shift towards the coastal region in southwestern Guangdong at a speed of 18.20 km per year. The results reveal that the spatiotemporal change in RIBDF is determined by the key influencing factors including the substitution of chemical fertilizers for farmland and crop substitution. These findings suggest that it is necessary to expand the scale of farmland management and to encourage farmers to implement diversified cropping as well as chemical fertilizers reduction. The foremost contribution of this study is its exploration of an understanding of the linkage between farmland use activities characterized as induced substitution in agricultural production and biological disasters. Moreover, policy implications for sustainable intensification of farmland use were discussed based on these findings.
MeSH term(s)	Agriculture/methods ; Disasters ; Farms ; Fertilizers/analysis ; Humans ; Spatio-Temporal Analysis
Chemical Substances	Fertilizers
Language	English
Publishing date	2022-05-06
Publishing country	Germany
Document type	Journal Article
ZDB-ID	1178791-0
ISSN	1614-7499 ; 0944-1344
ISSN (online)	1614-7499
ISSN	0944-1344
DOI	10.1007/s11356-022-20497-3
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Article ; Online: Regional intensity of biological disasters in farmland: quantitative assessment and spatiotemporal analysis

Shen, Yajing / Wang, Xiong / Song, Xiaoqing / Xu, Huixiao

Environ Sci Pollut Res. 2022 Sept., v. 29, no. 44 p.67402-67417

2022

Abstract	Biological disasters in farmland have become a serious threat to global sustainability. Quantitative studies on spatiotemporal change in regional intensity of biological disasters in farmland (RIBDF) are crucial for promoting sustainable intensification of farmland use and global food security. Many studies have revealed the impacts of natural environment on biological disasters in farmland. However, research on the impacts of farmers’ activities on biological disasters remains very limited from the perspective of induced substitution in agricultural production. Based on the principle of induced substitution in agricultural production, a theoretical framework for the impacts of farmland use intensity (FUI), the occurrence intensity of biological disasters (OIBD), the natural loss intensity resulting from biological disasters (NLIBD), and the actual loss intensity controlled by human activities (ALIBD) on change in RIBDF was presented, and we therefore established an assessment model integrating these four key indices in this study. Taking Guangdong Province in China as the study area, this study analyzed the spatiotemporal changes in RIBDF from 1996 to 2017 and found that RIBDF increased overall with three change stages of slow growth, rapid growth, and decline at the provincial and regional levels. Moreover, the gravity center of RIBDF appeared to shift towards the coastal region in southwestern Guangdong at a speed of 18.20 km per year. The results reveal that the spatiotemporal change in RIBDF is determined by the key influencing factors including the substitution of chemical fertilizers for farmland and crop substitution. These findings suggest that it is necessary to expand the scale of farmland management and to encourage farmers to implement diversified cropping as well as chemical fertilizers reduction. The foremost contribution of this study is its exploration of an understanding of the linkage between farmland use activities characterized as induced substitution in agricultural production and biological disasters. Moreover, policy implications for sustainable intensification of farmland use were discussed based on these findings.
Keywords	agricultural land ; coasts ; food security ; gravity ; humans ; issues and policy ; models ; China
Language	English
Dates of publication	2022-09
Size	p. 67402-67417.
Publishing place	Springer Berlin Heidelberg
Document type	Article ; Online
ZDB-ID	1178791-0
ISSN	1614-7499 ; 0944-1344
ISSN (online)	1614-7499
ISSN	0944-1344
DOI	10.1007/s11356-022-20497-3
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Article ; Online: TMT-based proteomic analysis of liquorice root in response to drought stress.

Zhang, Dong / Yang, Zhongren / Song, Xiaoqing / Zhang, Fenglan / Liu, Yan

BMC genomics

2022 Volume 23, Issue 1, Page(s) 524

Abstract: Background: Drought stress is a serious threat to land use efficiency and crop yields worldwide. Understanding the mechanisms that plants use to withstand drought stress will help breeders to develop drought-tolerant medicinal crops. Liquorice ( ... ...

Abstract	Background: Drought stress is a serious threat to land use efficiency and crop yields worldwide. Understanding the mechanisms that plants use to withstand drought stress will help breeders to develop drought-tolerant medicinal crops. Liquorice (Glycyrrhiza uralensis Fisch.) is an important medicinal crop in the legume family and is currently grown mostly in northwest China, it is highly tolerant to drought. Given this, it is considered an ideal crop to study plant stress tolerance and can be used to identify drought-resistant proteins. Therefore, to understand the effects of drought stress on protein levels of liquorice, we undertook a comparative proteomic analysis of liquorice seedlings grown for 10 days in soil with different relative water content (SRWC of 80%, 65%, 50% and 35%, respectively). We used an integrated approach of Tandem Mass Tag labeling in conjunction with LC-MS/MS. Results: A total of 7409 proteins were identified in this study, of which 7305 total proteins could be quantified. There were 837 differentially expressed proteins (DEPs) identified after different drought stresses. Compared with CK, 123 DEPs (80 up-regulated and 43 down-regulated) were found in LS; 353 DEPs (254 up-regulated and 99 down-regulated) in MS; and 564 DEPs (312 up-regulated and 252 down-regulated) in SS.The number of differentially expressed proteins increased with increasing water stress, and the number of up-regulated proteins was higher than that of down-regulated proteins in the different drought stress treatments compared with the CK. Used systematic bioinformatics analysis of these data to identify informative proteins we showed that osmolytes such as cottonseed sugars and proline accumulated under light drought stress and improved resistance. Under moderate and severe drought stress, oxidation of unsaturated fatty acids and accumulation of glucose and galactose increased in response to drought stress. Under moderate and severe drought stress synthesis of the terpene precursors, pentacene 2,3-epoxide and β-coumarin, was inhibited and accumulation of triterpenoids (glycyrrhetinic acid) was also affected. Conclusions: These data provide a baseline reference for further study of the downstream liquorice proteome in response to drought stress. Our data show that liquorice roots exhibit specific response mechanisms to different drought stresses.
MeSH term(s)	Chromatography, Liquid ; Droughts ; Gene Expression Regulation, Plant ; Glycyrrhiza/metabolism ; Plant Proteins/genetics ; Plant Proteins/metabolism ; Proteomics ; Stress, Physiological ; Tandem Mass Spectrometry
Chemical Substances	Plant Proteins
Language	English
Publishing date	2022-07-19
Publishing country	England
Document type	Journal Article
ZDB-ID	2041499-7
ISSN	1471-2164 ; 1471-2164
ISSN (online)	1471-2164
ISSN	1471-2164
DOI	10.1186/s12864-022-08733-z
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Article ; Online: Protective effect of hydroxysafflor yellow A on MSCs against senescence induced by

Song, Xiaoqing / Wang, Jinying / Zhang, Yu / Du, Xinqian / Qian, Qibing

Chinese herbal medicines

2022 Volume 15, Issue 1, Page(s) 86–93

Abstract: Objective: To examine the protective effects of hydroxysafflor yellow A (HSYA) against the senescence of mesenchymal stem cells (MSCs) induced by : Methods: Grouping experiment, Normal control (NC) group: conventional culture with complete medium; ... ...

Abstract	Objective: To examine the protective effects of hydroxysafflor yellow A (HSYA) against the senescence of mesenchymal stem cells (MSCs) induced by Methods: Grouping experiment, Normal control (NC) group: conventional culture with complete medium; Senescence group: MSCs were cultured for 48 h with complete medium containing 10 g/L Results: As compared with Senescence group, treatment with HSYA (120 mg/L) effectively ameliorated the adverse situation of MSCs. Oxidation stress and inflammation along with Conclusion: HSYA (120 mg/L) significantly delayed the
Language	English
Publishing date	2022-12-16
Publishing country	Singapore
Document type	Journal Article
ISSN	2589-3610
ISSN (online)	2589-3610
DOI	10.1016/j.chmed.2022.06.011
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Article ; Online: Mapping the Tumor Microenvironment in TNBC and Deep Exploration for M1 Macrophages-Associated Prognostic Genes.

Xu, Baojin / Sun, Hefen / Song, Xiaoqing / Liu, Qiqi / Jin, Wei

Frontiers in immunology

2022 Volume 13, Page(s) 923481

Abstract: Triple negative breast cancer (TNBC) remains the worst molecular subtype due to high heterogeneity and lack of effective therapeutic targets. Here we investigated the tumor and immune microenvironment heterogeneity of TNBC using scRNA-seq and bulk RNA- ... ...

Abstract	Triple negative breast cancer (TNBC) remains the worst molecular subtype due to high heterogeneity and lack of effective therapeutic targets. Here we investigated the tumor and immune microenvironment heterogeneity of TNBC using scRNA-seq and bulk RNA-seq data from public databases and our cohort. Macrophage subpopulations accounted for a high proportion of tumor immune microenvironment (TIME), and M1 macrophages were associated with better clinical outcomes. Furthermore, three maker genes including IFI35, PSMB9, and SAMD9L showed a close connection with M1 macrophages. Specifically, IFI35 was positively associated with macrophage activation, chemotaxis, and migration. Also, patients with high IFI35 expression had a better prognosis.
MeSH term(s)	Humans ; Macrophage Activation/genetics ; Macrophages ; Prognosis ; Triple Negative Breast Neoplasms/metabolism ; Tumor Microenvironment/genetics
Language	English
Publishing date	2022-06-30
Publishing country	Switzerland
Document type	Journal Article ; Research Support, Non-U.S. Gov't
ZDB-ID	2606827-8
ISSN	1664-3224 ; 1664-3224
ISSN (online)	1664-3224
ISSN	1664-3224
DOI	10.3389/fimmu.2022.923481
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Article: Protein supersaturation powers innate immune signaling.

Gama, Alejandro Rodriguez / Miller, Tayla / Venkatesan, Shriram / Lange, Jeffrey J / Wu, Jianzheng / Song, Xiaoqing / Bradford, Dan / Unruh, Jay R / Halfmann, Randal

bioRxiv : the preprint server for biology

2024

Abstract: Innate immunity protects us in youth but turns against us as we age. The reason for this tradeoff is unclear. Seeking a thermodynamic basis, we focused on death fold domains (DFDs), whose ordered polymerization has been stoichiometrically linked to ... ...

Abstract	Innate immunity protects us in youth but turns against us as we age. The reason for this tradeoff is unclear. Seeking a thermodynamic basis, we focused on death fold domains (DFDs), whose ordered polymerization has been stoichiometrically linked to innate immune signal amplification. We hypothesized that soluble ensembles of DFDs function as phase change batteries that store energy via supersaturation and subsequently release it through nucleated polymerization. Using imaging and FRET-based cytometry to characterize the phase behaviors of all 109 human DFDs, we found that the hubs of innate immune signaling networks encode large nucleation barriers that are intrinsically insulated from cross-pathway activation. We showed via optogenetics that supersaturation drives signal amplification and that the inflammasome is constitutively supersaturated
Language	English
Publishing date	2024-03-03
Publishing country	United States
Document type	Preprint
DOI	10.1101/2023.03.20.533581
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Article ; Online: IFI35 limits antitumor immunity in triple-negative breast cancer via CCL2 secretion.

Xu, Baojin / Sun, Hefen / Liu, Simeng / Liao, Li / Song, Xiaoqing / Wu, Yi / Hou, Yifeng / Jin, Wei

Oncogene

2024 Volume 43, Issue 10, Page(s) 693–702

Abstract: Triple-negative breast cancer (TNBC) is the most aggressive subtype of breast cancer with poor prognosis due to the lack of therapeutic targets. Although immunotherapy brings survival benefits to patients diagnosed with TNBC, it remains limited and ... ...

Abstract	Triple-negative breast cancer (TNBC) is the most aggressive subtype of breast cancer with poor prognosis due to the lack of therapeutic targets. Although immunotherapy brings survival benefits to patients diagnosed with TNBC, it remains limited and treatment resistance is widespread. Here we demonstrate that IFI35 is highly expressed in tumor tissues and can be induced by Interferon-γ in a time-dependent and concentration-dependent manner in breast cancer cells. In xenograft models, we reveal that IFI35 dramatically increases myeloid-derived suppressor cells infiltration in tumors, along with depletion and anergy of CD8
MeSH term(s)	Animals ; Humans ; Mice ; Breast ; CD8-Positive T-Lymphocytes ; Chemokine CCL2 ; Disease Models, Animal ; Immunotherapy ; Triple Negative Breast Neoplasms/genetics ; Triple Negative Breast Neoplasms/immunology ; Tumor Microenvironment ; Intracellular Signaling Peptides and Proteins/genetics ; Intracellular Signaling Peptides and Proteins/metabolism
Chemical Substances	CCL2 protein, human ; Chemokine CCL2 ; IFI35 protein, human ; Intracellular Signaling Peptides and Proteins
Language	English
Publishing date	2024-01-12
Publishing country	England
Document type	Journal Article
ZDB-ID	639046-8
ISSN	1476-5594 ; 0950-9232
ISSN (online)	1476-5594
ISSN	0950-9232
DOI	10.1038/s41388-023-02934-w
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Article: Exploring the therapeutic effect of Pen Yan Kang Fu Decoction on SPID rats based on LIF/JAK2/STAT3 signaling pathway.

Ji, Xiaoli / Hu, Quan / Yang, Chengcheng / Huang, Li / Huang, Yefang / Deng, Linwen / Song, Xiaoqing / Zhang, Yongqing / Wang, Yan

3 Biotech

2024 Volume 14, Issue 5, Page(s) 134

Abstract: Tubal inflammation, endometritis, and uterine adhesions due to post-pelvic inflammatory disease (SPID) are important causes of infertility. Chronic endometritis (CE) belongs to SPID, which seriously affects women's reproductive health, quality of life, ... ...

Abstract	Tubal inflammation, endometritis, and uterine adhesions due to post-pelvic inflammatory disease (SPID) are important causes of infertility. Chronic endometritis (CE) belongs to SPID, which seriously affects women's reproductive health, quality of life, and family harmony, and is a hot and difficult problem in clinical research. The efficacy of Pen Yan Kang Fu Decoction (PYKFD) has been verified in long-term clinical practice for chronic endometritis infertility caused by the SPID. Numerous studies have confirmed that the LIF/JAK2/STAT3 signaling pathway is important in embryo implantation and development, and endometritis infertility is close to LIF/JAK2/STAT3. In vivo results showed that PYKFD increased endometrial receptivity, repaired uterine tissue damage, and regulates the expression of endometrial receptivity-related factors ER (estrogen receptor), PR (progesterone receptor), CD31, and integrin αvβ3, and induced the transduction of LIF/JAK2/STAT3 signaling pathway. PYKFD can also regulate the expression of IL-6. The results of in vitro experiments showed that PYKFD regulates the behavior of rat endometrial epithelial cells (REECs) involving LIF. In conclusion, PYKFD can improve endometrial receptivity and promote endometrial repair by LIF/JAK2/STAT3 signaling pathway. Supplementary information: The online version contains supplementary material available at 10.1007/s13205-024-03981-0.
Language	English
Publishing date	2024-04-23
Publishing country	Germany
Document type	Journal Article
ZDB-ID	2600522-0
ISSN	2190-5738 ; 2190-572X
ISSN (online)	2190-5738
ISSN	2190-572X
DOI	10.1007/s13205-024-03981-0
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Article ; Online: Niche Tet maintains germline stem cells independently of dioxygenase activity.

Tu, Renjun / Ping, Zhaohua / Liu, Jian / Tsoi, Man Lung / Song, Xiaoqing / Liu, Wei / Xie, Ting

The EMBO journal

2024 Volume 43, Issue 8, Page(s) 1570–1590

Abstract: Ten-eleven translocation (TET) proteins are dioxygenases that convert 5-methylcytosine (5mC) into 5-hydroxylmethylcytosine (5hmC) in DNA and RNA. However, their involvement in adult stem cell regulation remains unclear. Here, we identify a novel ... ...

Abstract	Ten-eleven translocation (TET) proteins are dioxygenases that convert 5-methylcytosine (5mC) into 5-hydroxylmethylcytosine (5hmC) in DNA and RNA. However, their involvement in adult stem cell regulation remains unclear. Here, we identify a novel enzymatic activity-independent function of Tet in the Drosophila germline stem cell (GSC) niche. Tet activates the expression of Dpp, the fly homologue of BMP, in the ovary stem cell niche, thereby controlling GSC self-renewal. Depletion of Tet disrupts Dpp production, leading to premature GSC loss. Strikingly, both wild-type and enzyme-dead mutant Tet proteins rescue defective BMP signaling and GSC loss when expressed in the niche. Mechanistically, Tet interacts directly with Bap55 and Stat92E, facilitating recruitment of the Polybromo Brahma associated protein (PBAP) complex to the dpp enhancer and activating Dpp expression. Furthermore, human TET3 can effectively substitute for Drosophila Tet in the niche to support BMP signaling and GSC self-renewal. Our findings highlight a conserved novel catalytic activity-independent role of Tet as a scaffold protein in supporting niche signaling for adult stem cell self-renewal.
MeSH term(s)	Animals ; Female ; Humans ; Cell Differentiation/genetics ; Drosophila/genetics ; Drosophila melanogaster/genetics ; Drosophila Proteins/genetics ; Drosophila Proteins/metabolism ; Germ Cells/metabolism ; Stem Cell Niche/physiology ; Stem Cells/metabolism ; Dioxygenases/metabolism
Chemical Substances	dpp protein, Drosophila ; Drosophila Proteins ; Dioxygenases (EC 1.13.11.-)
Language	English
Publishing date	2024-03-18
Publishing country	England
Document type	Journal Article
ZDB-ID	586044-1
ISSN	1460-2075 ; 0261-4189
ISSN (online)	1460-2075
ISSN	0261-4189
DOI	10.1038/s44318-024-00074-9
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