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  1. Article ; Online: Construction of a Knowledge Map of Speech Emotion Features Based on Impulse-Coupled Neural Networks.

    Song, Yan

    Computational intelligence and neuroscience

    2022  Volume 2022, Page(s) 8766145

    Abstract: This paper constructs knowledge graphs of speech emotion feature to support the expression of rich semantic information due to their unique graphical structure and to provide new ideas for studying speech emotion recognition recommendations. Impulse- ... ...

    Abstract This paper constructs knowledge graphs of speech emotion feature to support the expression of rich semantic information due to their unique graphical structure and to provide new ideas for studying speech emotion recognition recommendations. Impulse-coupled neural networks, as a mathematical abstraction of the visual properties of the human eye, have been widely used in various fields of speech processing. In this paper, we take the classical impulse-coupled neural network model as the research object, aiming to explore, analyze, and study the method of constructing knowledge maps of speech emotion features based on the impulse-coupled neural network model, and propose several improved impulse-coupled neural network models, which are used in the fields of target detection, speech segmentation, and quantization compression. This paper further constructs various domain semantic concept maps and performs multidimensional semantic enhancement understanding of search text based on the concept maps and the constructed entity-relationship knowledge maps and proposes a knowledge-based interpretable recommendation method for cloud services and a generalized recommendation and sample enhancement method for cloud scenarios. The fusion algorithm based on multiscale analysis can decompose the source speech into subspeech at different scales and then fuse each subspeech separately, while typical objects in the real world are also composed of many components at different scales. Based on the factors of different degrees in the speech context, the imagery work ruler evaluation model is refined with the basic principles of risk perception and risk resolution in the context, and an exploratory design is carried out separately for the verbal description, graphics, text, color, animation, and sound signals in the audiovisual signal using the workshop format to obtain a large number of design samples and evaluate the important units in turn, finally integrating the context involved in the study. The perceptual design system is given as a specific contextual design method.
    MeSH term(s) Algorithms ; Emotions ; Humans ; Neural Networks, Computer ; Speech ; Speech Perception
    Language English
    Publishing date 2022-07-08
    Publishing country United States
    Document type Journal Article
    ZDB-ID 2388208-6
    ISSN 1687-5273 ; 1687-5273
    ISSN (online) 1687-5273
    ISSN 1687-5273
    DOI 10.1155/2022/8766145
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  2. Article ; Online: It takes two to tango: The dance of cell fate specification.

    Song, Yan

    Developmental biology

    2022  Volume 490, Page(s) 125

    Language English
    Publishing date 2022-08-06
    Publishing country United States
    Document type Editorial
    ZDB-ID 1114-9
    ISSN 1095-564X ; 0012-1606
    ISSN (online) 1095-564X
    ISSN 0012-1606
    DOI 10.1016/j.ydbio.2022.07.011
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  3. Article ; Online: Prognostic and immunological implications of paraptosis-related genes in lung adenocarcinoma: Comprehensive analysis and functional verification of hub gene.

    Zhuo, Ying / Song, Yan

    Environmental toxicology

    2024  

    Abstract: Background: Lung adenocarcinoma (LUAD) poses significant clinical challenges due to its inherent heterogeneity and variable response to treatment. Recent research has specifically focused on elucidating the role of Paraptosis-related genes (PRGs) in the ...

    Abstract Background: Lung adenocarcinoma (LUAD) poses significant clinical challenges due to its inherent heterogeneity and variable response to treatment. Recent research has specifically focused on elucidating the role of Paraptosis-related genes (PRGs) in the progression of cancer and the prognosis of patients.
    Methods: We conducted a comprehensive analysis of the differential expression of PRGs in LUAD. Additionally, univariate Cox regression analysis was utilized to determine the prognostic significance of these genes. Furthermore, consensus clustering was employed to differentiate molecular subtypes within LUAD, while immune heterogeneity was assessed. To evaluate treatment outcomes, the expression of immune checkpoint inhibitors was examined, and the sensitivity of LUAD patients to chemotherapy drugs was assessed. Moreover, machine learning algorithms were employed to construct a Paraptosis-related risk score with prognostic and immunological indicators. Finally, to validate the findings, in vitro experiments were performed to verify the regulatory effect of key PRGs on Paraptosis.
    Results: Our analysis identified 24 PRGs that exhibited differential expression, with CDKN3, TP53, and PHB emerging as the most prominently upregulated genes in tumor tissues. Among these genes, seven were identified as prognostic markers, with HSPB8 being the sole protective factor. Notably, our analysis also revealed the existence of two distinct molecular subtypes within LUAD, each characterized by unique prognoses and immune responses. Specifically, Subtype B displayed a poorer prognosis but demonstrated increased sensitivity to both chemotherapy and immunotherapy. In addition, our development of a Paraptosis-Associated Risk Score yielded a significant prognostic value in predicting patient outcomes. Furthermore, we found regulatory effect of CDKN3 on Paraptosis in two cell lines.
    Conclusions: Our study highlights the importance of PRGs in LUAD, particularly in prognosis and treatment response. The identified molecular subtypes and Paraptosis-Associated Risk Score offer valuable insights for personalized treatment strategies.
    Language English
    Publishing date 2024-03-06
    Publishing country United States
    Document type Journal Article
    ZDB-ID 1463449-1
    ISSN 1522-7278 ; 1520-4081
    ISSN (online) 1522-7278
    ISSN 1520-4081
    DOI 10.1002/tox.24185
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  4. Article ; Online: Revisiting the Modularity-Disease transmission Link: Uncovering the importance of intra-modular structure.

    Song, Yan / Yang, Qian

    Journal of theoretical biology

    2024  Volume 583, Page(s) 111772

    Abstract: Studies have shown that the internal structure of modules is hardly important for the spread of epidemics. However, most of these studies have assumed that intra-module connectivity and inter-module connectivity do not affect each other. In reality, ... ...

    Abstract Studies have shown that the internal structure of modules is hardly important for the spread of epidemics. However, most of these studies have assumed that intra-module connectivity and inter-module connectivity do not affect each other. In reality, changes in the internal structure of modules may affect inter-module links and thus change the modularity of the entire network. Therefore, we have developed a theoretical network model with adjustable modularity to investigate the impact of this situation on disease transmission. Our findings indicate that the intra-module structure plays a crucial role in disease outbreaks. Changes in intra-module structure lead to significant numerical changes in peak prevalence and duration of disease. This implies that the potential impact of changes in exposure patterns within modules should also be considered when investigating the exact impact of modular social networks on disease burden.
    MeSH term(s) Models, Theoretical ; Disease Outbreaks ; Epidemics ; Social Networking
    Language English
    Publishing date 2024-03-03
    Publishing country England
    Document type Journal Article
    ZDB-ID 2972-5
    ISSN 1095-8541 ; 0022-5193
    ISSN (online) 1095-8541
    ISSN 0022-5193
    DOI 10.1016/j.jtbi.2024.111772
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  5. Article ; Online: An Improved Non-Negative Latent Factor Model for Missing Data Estimation via Extragradient-Based Alternating Direction Method.

    Li, Ming / Song, Yan

    IEEE transactions on neural networks and learning systems

    2023  Volume 34, Issue 9, Page(s) 5640–5653

    Abstract: In this article, an improved double factorization-based symmetric and non-negative latent factor (Im-DF-SNLF) model is proposed to make the estimation for missing data in symmetric, high-dimensional, and sparse (SHiDS) matrices. The main idea of the Im- ... ...

    Abstract In this article, an improved double factorization-based symmetric and non-negative latent factor (Im-DF-SNLF) model is proposed to make the estimation for missing data in symmetric, high-dimensional, and sparse (SHiDS) matrices. The main idea of the Im-DF-SNLF model is fourfold: 1) considering the data variety in the practical engineering, non-negative latent factors (NLFs) in different cases are considered to better reflect the latent relationships between entries; 2) the l
    Language English
    Publishing date 2023-09-01
    Publishing country United States
    Document type Journal Article
    ISSN 2162-2388
    ISSN (online) 2162-2388
    DOI 10.1109/TNNLS.2021.3130289
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  6. Article ; Online: RBM15 m

    Song, Yan / Wu, Qiongwei

    Environmental toxicology

    2023  Volume 38, Issue 9, Page(s) 2155–2164

    Abstract: Cervical cancer (CC) is a deadly gynecological tumor worldwide. Otubain 2 (OTUB2) has been recently identified as an oncogene in human malignancies. However, its expression and function remain unclear. This work aims to explore the role of OTUB2 in CC ... ...

    Abstract Cervical cancer (CC) is a deadly gynecological tumor worldwide. Otubain 2 (OTUB2) has been recently identified as an oncogene in human malignancies. However, its expression and function remain unclear. This work aims to explore the role of OTUB2 in CC progression. Herein, The Cancer Genome Atlas data revealed that OTUB2 expression was significantly upregulated in cervical squamous cell carcinoma and endocervical adenocarcinoma (CESC) and gradually increased with CESC progression; moreover, OTUB2 expression predicted poor outcomes of CESC patients. Then, RT-qPCR and Western blotting were applied to determine mRNA and protein expression in CC and normal cells. Our results confirmed that OTUB2 was highly expressed in CC cell lines. As indicated by CCK-8, Transwell, and flow cytometry results, OTUB2 silencing attenuated proliferative and metastatic capacities of CC cells but promoted CC cell apoptosis. Then, RBM15, an N6-methyladenosine (m
    MeSH term(s) Female ; Humans ; Uterine Cervical Neoplasms/metabolism ; Proto-Oncogene Proteins c-akt/genetics ; Proto-Oncogene Proteins c-akt/metabolism ; Up-Regulation ; Cell Line, Tumor ; Signal Transduction ; TOR Serine-Threonine Kinases/genetics ; TOR Serine-Threonine Kinases/metabolism ; Cell Proliferation ; RNA-Binding Proteins/genetics ; RNA-Binding Proteins/metabolism ; Thiolester Hydrolases/genetics ; Thiolester Hydrolases/metabolism
    Chemical Substances Proto-Oncogene Proteins c-akt (EC 2.7.11.1) ; TOR Serine-Threonine Kinases (EC 2.7.11.1) ; RBM15 protein, human ; RNA-Binding Proteins ; OTUB2 protein, human (EC 3.1.2.-) ; Thiolester Hydrolases (EC 3.1.2.-)
    Language English
    Publishing date 2023-06-19
    Publishing country United States
    Document type Journal Article
    ZDB-ID 1463449-1
    ISSN 1522-7278 ; 1520-4081
    ISSN (online) 1522-7278
    ISSN 1520-4081
    DOI 10.1002/tox.23852
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  7. Article ; Online: An effective method in modulating thermally activated delayed fluorescence (TADF) emitters from green to blue emission: the role of the phenyl ring.

    Wang, Lijuan / Ge, Zhongqi / Xu, Lin / Song, Yan

    Physical chemistry chemical physics : PCCP

    2024  Volume 26, Issue 6, Page(s) 5597–5606

    Abstract: Developing efficient blue emitters with high performance and low cost is crucial for the further development of organic light-emitting diodes (OLEDs). Based on the two experimentally reported green thermally activated delayed fluorescence (TADF) emitters, ...

    Abstract Developing efficient blue emitters with high performance and low cost is crucial for the further development of organic light-emitting diodes (OLEDs). Based on the two experimentally reported green thermally activated delayed fluorescence (TADF) emitters, which are thioxanthone derivatives consisting of carbazole as an electron donor and 9
    Language English
    Publishing date 2024-02-07
    Publishing country England
    Document type Journal Article
    ZDB-ID 1476244-4
    ISSN 1463-9084 ; 1463-9076
    ISSN (online) 1463-9084
    ISSN 1463-9076
    DOI 10.1039/d3cp05632e
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  8. Article: Development and validation of a simple, fast and sensitive liquid chromatography-tandem mass spectrometry method to establish reference intervals for 24-h urinary free normetanephrine, metanephrine and methoxytyramine.

    Song, Yan / Xu, Runhao / Liu, Dan / Zhang, Jie

    Practical laboratory medicine

    2024  Volume 39, Page(s) e00358

    Abstract: Objective: To develop and validate a rapid liquid chromatography-tandem mass spectrometry (LC-MS/MS) method to detect urinary free metanephrines and methoxytyramine, establishing reference intervals.: Methods: Urine samples were diluted with isotope ... ...

    Abstract Objective: To develop and validate a rapid liquid chromatography-tandem mass spectrometry (LC-MS/MS) method to detect urinary free metanephrines and methoxytyramine, establishing reference intervals.
    Methods: Urine samples were diluted with isotope internal standard solution, then analyzed directly using tandem mass spectrometry with multiple reaction monitoring measurement and electrospray ionization source in positive ion mode. Analytical parameters including linearity, lower limit of quantitation, imprecision and accuracy of the method were evaluated. The reference intervals for urinary catecholamine metabolites were established by analyzing 24-h urine samples collected from 81 apparently healthy volunteers.
    Results: The analytical times for MN, NMN, and 3-MT were at 2.79, 2.80, and 2.74 min, respectively. The method displayed excellent linearity (r > 0.99) in the range of 1-1000 ng/mL, with lower limits of quantification (LLOQ) at 0.50 ng/mL for MN and NMN, and 0.25 ng/mL for 3-MT. The method's intra-day and inter-day imprecisions were less than 8 %. The method recovery ranged from 96.8% to 105.8 % for MN, 89.7%-106.4 % for NMN, and 93.5%-106.2 % for 3-MT. No carry-over was observed during the analysis of all analytes. The LC-MS/MS method was used to establish reference intervals in 24-h urine samples from 81 apparently healthy volunteers. There was no association of sex with urinary free metabolites.
    Conclusion: This study established a novel, fast and sensitive LC-MS/MS method for determining urinary free catecholamine metabolites, which could facilitate screening and diagnosis for catecholamine-related tumors more conveniently and quickly.
    Language English
    Publishing date 2024-01-23
    Publishing country Netherlands
    Document type Journal Article
    ZDB-ID 2834973-8
    ISSN 2352-5517
    ISSN 2352-5517
    DOI 10.1016/j.plabm.2024.e00358
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  9. Article ; Online: Validation of a LC-MS/MS method for establishing reference intervals and assessing diagnostic performance of urinary free cortisol and cortisone.

    Song, Yan / Zhao, Juan / Liu, Dan / Zhang, Jie

    Steroids

    2024  Volume 205, Page(s) 109378

    Abstract: Background: 24-h urinary free cortisol (UFF) is recommended for screening of Cushing's syndrome (CS), a rare disease characterized by apparent cortisol and cortisone excess. We aimed to validate a simple LC-MS/MS method for accurate measurement of UFF ... ...

    Abstract Background: 24-h urinary free cortisol (UFF) is recommended for screening of Cushing's syndrome (CS), a rare disease characterized by apparent cortisol and cortisone excess. We aimed to validate a simple LC-MS/MS method for accurate measurement of UFF and urinary free cortisone (UFE), establishment of reference ranges, and evaluation of performance for CS diagnosis.
    Methods: Urine samples were processed using solid-phase extraction cartridges, followed by elution with methanol and acetonitrile. Analysis was performed via tandem mass spectrometry, utilizing multiple reaction monitoring and electrospray ionization source in positive ion mode.
    Results: The assay displayed excellent linearity (r > 0.99) in the range of 0.05-100 ng/mL for cortisol and 0.25-500 ng/mL for cortisone, with lower limits of quantification (LLOQ) at 0.05 ng/mL for cortisol and 0.25 ng/mL for cortisone. The obtained results for intra-day and inter-day imprecision for both analytes were within the acceptable range of less than 10 %. The trueness values for both compounds were also within the acceptable limit of 15 %. No significant matrix effects or carry over observed in our method. The reference intervals of UFF, UFE and UFF:UFE ratio were 7.01-45.66 µg/24-h, 27.97-139.21 µg/24-h and 0.17-0.56, respectively. UFF > 56.75 µg/24-h showed 100 % specificity and 100 % sensitivity for CS diagnosis, which was superior to UFF:UFE ratio.
    Conclusions: We developed and validated a sensitive LC-MS/MS method to detect UFF and UFE. Our data indicate that UFF measured by the current LC-MS/MS assay exhibited high diagnostic performance for CS.
    MeSH term(s) Humans ; Cortisone ; Hydrocortisone/urine ; Tandem Mass Spectrometry ; Liquid Chromatography-Mass Spectrometry ; Chromatography, Liquid/methods ; Cushing Syndrome/urine
    Chemical Substances Cortisone (V27W9254FZ) ; Hydrocortisone (WI4X0X7BPJ)
    Language English
    Publishing date 2024-02-01
    Publishing country United States
    Document type Journal Article
    ZDB-ID 80312-1
    ISSN 1878-5867 ; 0039-128X
    ISSN (online) 1878-5867
    ISSN 0039-128X
    DOI 10.1016/j.steroids.2024.109378
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  10. Article ; Online: A review of the clinical characteristics and management of immunosuppressed patients living with HIV or solid organ transplants infected with SARS-CoV-2 omicron variants.

    Song, Yan / Lou, Lixin / Zhang, Kaiyu

    Frontiers in public health

    2024  Volume 12, Page(s) 1327093

    Abstract: The severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) omicron strain was first detected in South Africa in November 2021. Although clinical responses to SARS-CoV-2 depend on host immunity, it remains uncertain how immunosuppression affects ... ...

    Abstract The severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) omicron strain was first detected in South Africa in November 2021. Although clinical responses to SARS-CoV-2 depend on host immunity, it remains uncertain how immunosuppression affects subsequent coronavirus disease 2019-related (COVID-19-related) incidence, severity, and mortality, especially with respect to the omicron strain. Conversely, immunosuppressants are often thought to predispose to infection. To explore the associations between host immunity and infection with SARS-CoV-2 omicron variants, here we discuss two groups of immunosuppressed patients: organ transplant recipients, who generally receive exogenous immunosuppressants, and Human Immunodeficiency Virus (HIV)-infected patients, who often have disease-related immunosuppression. In summarizing the clinical features and prognoses of HIV-infected patients and human organ transplant recipients infected with SARS-CoV-2 omicron variants, we provide new insights into the pathogenesis of omicron SARS-CoV-2 and provide a framework for the management of these patients now and in the future.
    MeSH term(s) Humans ; SARS-CoV-2 ; COVID-19 ; Immunosuppressive Agents/therapeutic use ; Organ Transplantation ; HIV Infections
    Chemical Substances Immunosuppressive Agents
    Language English
    Publishing date 2024-02-22
    Publishing country Switzerland
    Document type Journal Article ; Review
    ZDB-ID 2711781-9
    ISSN 2296-2565 ; 2296-2565
    ISSN (online) 2296-2565
    ISSN 2296-2565
    DOI 10.3389/fpubh.2024.1327093
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