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  1. Article: GC-MS Profile of Hua-Feng-Dan and RNA-Seq Analysis of Induced Adaptive Responses in the Liver.

    Liu, Jia-Jia / Liang, Yan / Zhang, Ya / Wu, Rui-Xia / Song, Ying-Lian / Zhang, Feng / Shi, Jing-Shan / Liu, Jie / Xu, Shang-Fu / Wang, Zhang

    Frontiers in pharmacology

    2022  Volume 13, Page(s) 730318

    Abstract: Background: ...

    Abstract Background:
    Language English
    Publishing date 2022-03-08
    Publishing country Switzerland
    Document type Journal Article
    ZDB-ID 2587355-6
    ISSN 1663-9812
    ISSN 1663-9812
    DOI 10.3389/fphar.2022.730318
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  2. Article ; Online: Discovery of Epipodophyllotoxin-Derived B

    Song, Ying-Lian / Liu, Shuai-Shuai / Yang, Jie / Xie, Jiao / Zhou, Xiang / Wu, Zhi-Bing / Liu, Li-Wei / Wang, Pei-Yi / Yang, Song

    International journal of molecular sciences

    2022  Volume 23, Issue 16

    Abstract: The emergence of phytopathogenic bacteria resistant to antibacterial agents has rendered previously manageable plant diseases intractable, highlighting the need for safe and environmentally responsible agrochemicals. Inhibition of bacterial cell division ...

    Abstract The emergence of phytopathogenic bacteria resistant to antibacterial agents has rendered previously manageable plant diseases intractable, highlighting the need for safe and environmentally responsible agrochemicals. Inhibition of bacterial cell division by targeting bacterial cell division protein FtsZ has been proposed as a promising strategy for developing novel antibacterial agents. We previously identified 4'-demethylepipodophyllotoxin (DMEP), a naturally occurring substance isolated from the barberry species
    MeSH term(s) Anti-Bacterial Agents/chemistry ; Bacterial Proteins/metabolism ; Cell Division ; Oryza ; Plant Diseases/microbiology ; Plant Diseases/prevention & control ; Podophyllotoxin/metabolism ; Podophyllotoxin/pharmacology ; Structure-Activity Relationship ; Xanthomonas
    Chemical Substances Anti-Bacterial Agents ; Bacterial Proteins ; Podophyllotoxin (L36H50F353)
    Language English
    Publishing date 2022-08-14
    Publishing country Switzerland
    Document type Journal Article
    ZDB-ID 2019364-6
    ISSN 1422-0067 ; 1422-0067 ; 1661-6596
    ISSN (online) 1422-0067
    ISSN 1422-0067 ; 1661-6596
    DOI 10.3390/ijms23169119
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  3. Article ; Online: Synthesis of novel 18β-glycyrrhetinic piperazine amides displaying significant in vitro and in vivo antibacterial activities against intractable plant bacterial diseases.

    Xiang, Meng / Song, Ying-Lian / Ji, Jin / Zhou, Xiang / Liu, Li-Wei / Wang, Pei-Yi / Wu, Zhi-Bing / Li, Zhong / Yang, Song

    Pest management science

    2020  Volume 76, Issue 9, Page(s) 2959–2971

    Abstract: Background: The limited amount of agrochemicals targeting plant bacterial diseases has motivated us to study innovative antibacterial surrogates with fresh modes of action. Notably, fabrication of violent apoptosis inducers to control the reproduction ... ...

    Abstract Background: The limited amount of agrochemicals targeting plant bacterial diseases has motivated us to study innovative antibacterial surrogates with fresh modes of action. Notably, fabrication of violent apoptosis inducers to control the reproduction of pathogenic bacteria should be a feasible way to control plant bacterial diseases. To achieve this aim, we constructed a series of novel 18β-glycyrrhetinic piperazine amides based on the natural bioactive ingredient 18β-glycyrrhetinic acid to evaluate the in vitro and in vivo antibacterial activity and induced apoptosis behaviors on tested pathogens.
    Results: Screening results suggested that these designed compounds were extremely bioactive against two notorious pathogens, Xanthomonas oryzae pv. oryzae and X. axonopodis pv. citri. This conclusion was highlighted by the biological effects of compounds A
    Conclusion: Given these features, we anticipate that these novel piperazine-tailored 18β-glycyrrhetinic hybrids can provide an perceptible insight for fighting bacterial infections by activation of the apoptosis mechanism. Novel 18β-glycyrrhetinic piperazine amides were reported to have excellent antibacterial efficacy toward phytopathogens Xanthomonas oryzae pv. oryzae and X. axonopodis pv. citri. A possible apoptosis mechanism was proposed from the remarkable apoptotic behaviors triggered by target compounds. © 2020 Society of Chemical Industry.
    MeSH term(s) Amides ; Anti-Bacterial Agents/pharmacology ; Bacterial Infections ; Humans ; Microbial Sensitivity Tests ; Oryza ; Piperazine ; Plant Diseases ; Prospective Studies ; Xanthomonas
    Chemical Substances Amides ; Anti-Bacterial Agents ; Piperazine (1RTM4PAL0V)
    Language English
    Publishing date 2020-04-27
    Publishing country England
    Document type Journal Article
    ZDB-ID 2001705-4
    ISSN 1526-4998 ; 1526-498X
    ISSN (online) 1526-4998
    ISSN 1526-498X
    DOI 10.1002/ps.5841
    Database MEDical Literature Analysis and Retrieval System OnLINE

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