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Article ; Online: Retraction: He-Wei granules (HWKL) combat cisplatin-induced nephrotoxicity and myelosuppression in rats by inhibiting oxidative stress, inflammatory cytokines and apoptosis.

Song, Zehai / Chang, Hang / Han, Na / Liu, Zhihui / Liu, Ye / Wang, Hui / Shao, Jingxuan / Wang, Zhonglin / Gao, Hao / Yin, Jun

RSC advances

2023 Volume 13, Issue 18, Page(s) 12276

Abstract: This retracts the article DOI: 10.1039/C7RA02830J.]. ...

Abstract	[This retracts the article DOI: 10.1039/C7RA02830J.].
Language	English
Publishing date	2023-04-19
Publishing country	England
Document type	Retraction of Publication
ISSN	2046-2069
ISSN (online)	2046-2069
DOI	10.1039/d3ra90036c
Database	MEDical Literature Analysis and Retrieval System OnLINE

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Article ; Online: He-Wei Granule enhances anti-tumor activity of cyclophosphamide by changing tumor microenvironment.

Zhai, Jianxiu / Song, Zehai / Chang, Hang / Wang, Yuwei / Han, Na / Liu, Zhihui / Yin, Jun

Chinese herbal medicines

2021 Volume 14, Issue 1, Page(s) 79–89

Abstract: Objective: He-Wei Granule (HWKL) is a modern product derived from the modified formulation of traditional Chinese medicine Banxia Xiexin Decoction (BXD), which remarkedly enhanced the anti-proliferation activity of cyclophosphamide (CTX) on HepG2 and ... ...

Abstract	Objective: He-Wei Granule (HWKL) is a modern product derived from the modified formulation of traditional Chinese medicine Banxia Xiexin Decoction (BXD), which remarkedly enhanced the anti-proliferation activity of cyclophosphamide (CTX) on HepG2 and SGC-7901 cell lines Methods: The CTX-toxic-reducing efficacy of HWKL was evaluated by hematology indexes, organ indexes and marrow DNA detection. To investigate the underlying mechanisms, histopathology test, immunohistochemistry test and TUNEL staining were conducted. The efficacy of HWKL on the micro-vessel density (MVD) in tumor tissue was also evaluated by measuring CD34 level. Results: High dose HWKL (6.75 g/kg) markedly attenuated CTX-induced hepatotoxicity and myelosuppression while significantly enhanced CTX anticancer efficacy Conclusion: It can be concluded that high-dose HWKL enhanced CTX efficacy by promoting apoptosis, inhibiting autophagy and angiogenesis in tumor tissue while significantly alleviated CTX-induced toxicity, and could be applied along with CTX in clinical treatment as a supplement agent.
Language	English
Publishing date	2021-10-07
Publishing country	Singapore
Document type	Journal Article
ISSN	2589-3610
ISSN (online)	2589-3610
DOI	10.1016/j.chmed.2021.10.002
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Article: Zhixiong Capsule (ZXC), a traditional Chinese patent medicine, prevents atherosclerotic plaque formation in rabbit carotid artery and the related mechanism investigation based on network pharmacology and biological research

Zhai, Jianxiu / Song, Zehai / Wang, Yuwei / Han, Mingshu / Ren, Zhaohui / Han, Na / Liu, Zhihui / Yin, Jun

Phytomedicine. 2019 June, v. 59

2019

Abstract: Chinese patent medicine Zhixiong Capsule (ZXC) has been used in clinical treatment against blood stasis-induced dizziness and headache for many years in China.Recent clinical observations demonstrated a good efficacy of ZXC against atherosclerotic plaque ...

Abstract	Chinese patent medicine Zhixiong Capsule (ZXC) has been used in clinical treatment against blood stasis-induced dizziness and headache for many years in China.Recent clinical observations demonstrated a good efficacy of ZXC against atherosclerotic plaque formation in carotid arteries. The aims of this study were to verify the plaque-preventing efficacy of ZXC in animals and to investigate the underlying mechanisms.ZXC (185 mg/kg and 370 mg/kg) was administrated to rabbits which received collar implantation accompanied with high fat diet administration (12 days). The blood-dissolved components of ZXC were identified by an UPLC-QTOF-MS method. The key components and targets of ZXC were then predicted based on network pharmacology analysis and biological investigations.Compared with vehicle control group, ZXC administration (185 mg/kg) significantly prevented plaque formation and attenuated intima thickening in the collar-implanted carotid arteries, markedly decreased blood lipid level, and increased plasma IL-4 level in rabbits. A total of 23 blood-dissolved components were identified. Four ingredients (namely, kaempferol, daidzein, puerarin, miltirone) along with leech, and three targets (namely, JUN, FOS and TP53) were recognized to play important roles for ZXC bioactivity.It could be concluded that ZXC could be applied to prevent atherosclerotic plaque formation and intimal thickening in carotid arteries at the current clinical dose.
Keywords	blood ; blood lipids ; carotid arteries ; daidzein ; headache ; herbal medicines ; high fat diet ; ingredients ; interleukin-4 ; kaempferol ; pharmacology ; rabbits
Language	English
Dates of publication	2019-06
Publishing place	Elsevier GmbH
Document type	Article
ZDB-ID	1205240-1
ISSN	1618-095X ; 0944-7113
ISSN (online)	1618-095X
ISSN	0944-7113
DOI	10.1016/j.phymed.2018.11.036
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Article: He-Wei granules inhibit chemotherapy-induced vomiting (CINV) in rats by reducing oxidative stress and regulating 5-HT, substance P, ghrelin and obestatin

Song, Zehai / Chang, Hang / Han, Na / Liu, Zhihui / Wang, Zhonglin / Gao, Hao / Yin, Jun

RSC advances. 2017 Sept. 11, v. 7, no. 69

2017

Abstract: As a common side effect of a variety of chemotherapy drugs, CINV severely limits the clinical use of chemotherapy drugs. Reducing the CINV levels may be useful to improve patient life quality and enable effective use of chemotherapy drugs. In this study, ...

Abstract	As a common side effect of a variety of chemotherapy drugs, CINV severely limits the clinical use of chemotherapy drugs. Reducing the CINV levels may be useful to improve patient life quality and enable effective use of chemotherapy drugs. In this study, we investigated the protective effects of He-Wei granules (HWKL) against CINV using a cisplatin-induced (5 mg kg−1) pica model. HWKL consists of seven herbs: Pinellia ternata (Thunb.) Breit, Zingiber officinale Rosc, Panax ginseng C. A. Mey, Scutellaria baicalensis Georgi, Coptis chinensis Franch, Glycyrrhiza uralensis Fisch, and Ziziphus jujuba Mill. The CINV levels were measured based on the consumption of kaolin. Results showed that HWKL was able to reduce cisplatin-induced increase in kaolin consumption. Cisplatin-mediated increase in tryptophan hydroxylase1 (TPH1), TPH2, 5-hydroxytryptamine 3 receptors (5-HT3AR), neurokinin-1 receptors (NK-1R), 5-HT3AR mRNA, preprotachykinin A (PPTA) mRNA, and NK-1R mRNA was markedly suppressed by HWKL. In addition, cisplatin-induced inhibition of monoamine oxidase (MAOA) and serotonin reuptake transporter (SERT) mRNA was significantly increased after HWKL treatment. HWKL dramatically enhanced appetite by regulating obestatin (OB) and ghrelin (GH); this contributed to further inhibit CINV. The results obtained for G protein-coupled receptor (GPR39) mRNA also confirmed the abovementioned conclusion. HWKL also contributed towards an increase in epidermal growth factor receptor (EGFR) and phosphorylation of extracellular regulated protein kinases (p-ERK1/2) to help repair the damaged mucosa; this indicated that HWKL improved the gastrointestinal damage. Overall, our findings suggest that HWKL inhibit CINV by several mechanisms acting simultaneously and provide basic evidence to confirm that HWKL may be useful in clinical situations as a protective agent to prevent CINV. Moreover, 5-hydroxytryptamine (5-HT) and substance P (SP) result in inhibition of CINV.
Keywords	Coptis chinensis ; G-protein coupled receptors ; Glycyrrhiza uralensis ; Panax ginseng ; Pinellia ternata ; Scutellaria baicalensis ; Zingiber officinale ; Ziziphus jujuba ; adverse effects ; amine oxidase (flavin-containing) ; appetite ; drug therapy ; drugs ; epidermal growth factor receptors ; gastrointestinal system ; ghrelin ; granules ; herbs ; kaolin ; messenger RNA ; models ; mucosa ; oxidative stress ; patients ; phosphorylation ; protective effect ; quality of life ; rats ; serotonin ; substance P ; tryptophan ; vomiting
Language	English
Dates of publication	2017-0911
Size	p. 43866-43878.
Publishing place	The Royal Society of Chemistry
Document type	Article
ISSN	2046-2069
DOI	10.1039/c7ra06312a
Database	NAL-Catalogue (AGRICOLA)

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Article ; Online: Screening of the optimized prescription from Suqingwan in terms of its therapeutic effect on DSS-induced ulcerative colitis by its regulation of inflammatory and oxidative mediators.

Shao, Jingxuan / Liu, Zhihui / Wang, Lin / Song, Zehai / Chang, Hang / Han, Na / Yin, Jun

Journal of ethnopharmacology

2017 Volume 202, Page(s) 54–62

Abstract: Ethnopharmacological relevance: Suqingwan (SQW), a traditional Chinese medicine used for treating ulcerative colitis (UC), is composed of 13 kinds of Traditional Chinese medicines (TCMs). According to TCM theory, we investigated whether a simplified ... ...

Abstract	Ethnopharmacological relevance: Suqingwan (SQW), a traditional Chinese medicine used for treating ulcerative colitis (UC), is composed of 13 kinds of Traditional Chinese medicines (TCMs). According to TCM theory, we investigated whether a simplified prescription composed of the herbs with some functions, would have similar effects to SQW and examined its potential treatment mechanism of action. Materials and methods: We categorized the herbs in SQW into four groups according to their traditional functions and used an orthogonal experimental design to obtain nine separated prescriptions (SPs) of SQW. A dextran sulfate sodium (DSS)-induced UC mouse model was used to evaluate the anti-ulcer colitis effects of the nine SPs and the calculated prescription (CP) was obtained based on the orthogonal t values of the disease activity index (DAI) of the nine SPs. The effect of the CP and SP8 were verified in the DSS-induced UC model, and the DAI and histopathology of the UC mice were examined. Myeloperoxidase (MPO), malondialdehyde (MDA), tumor necrosis factor (TNF)-α, interleukin (IL)-1β, IL-6, IL-4 and IL-10 of the mice in SP8 were investigated to explore the mechanism of action of the optimized prescription with regard to anti-inflammatory and anti-oxidation effects. Results: Among the 9 SPs, separate prescription 6, 7 and 8 (SP6, SP7 and SP8) and the SQW formulation all significantly reduced the DAI of the UC mice and, in particular, SP8 had an effect similar to SQW, which consists of Sanguisorba officinalis L., Rehmannia glutinosa Libosch. and four other herbal medicines. In a further investigation, SP8 was found to improve the ulcerative colitis in mice in terms of both clinical symptoms and histopathology. The mortality of mice in the SP8 group was 33.3%, better than CP based on the orthogonal t values (83.3%). SP8 could also reduce the levels of TNF-α, IL-1β, IL-6, MPO and MDA and increase the levels of IL-4 and IL-10 in colon tissue of UC mice in comparison with those of the model group (p<0.05). Conclusions: An optimized prescription (SP8) from SQW was obtained based on an orthogonal experimental design, which involved 6 herbal medicines, with significantly fewer herbs than in the original prescription. SP8 displayed a similar anti-ulcerative colitis activity to SQW, and its in vivo mechanism of action is related to up-regulation of anti-inflammatory cytokines and down-regulation of pro-inflammatory and oxidative factors.
MeSH term(s)	Animals ; Biomarkers/analysis ; Colitis, Ulcerative/chemically induced ; Colitis, Ulcerative/drug therapy ; Colitis, Ulcerative/mortality ; Colon/pathology ; Dextran Sulfate ; Drug Compounding ; Drug Prescriptions/statistics & numerical data ; Drugs, Chinese Herbal/administration & dosage ; Drugs, Chinese Herbal/pharmacology ; Drugs, Chinese Herbal/therapeutic use ; Inflammation Mediators/metabolism ; Medicine, Chinese Traditional/methods ; Mice ; Oxidative Stress/drug effects ; Quality Control ; Spleen/pathology
Chemical Substances	Biomarkers ; Drugs, Chinese Herbal ; Inflammation Mediators ; suqingwan ; Dextran Sulfate (9042-14-2)
Language	English
Publishing date	2017-04-18
Publishing country	Ireland
Document type	Journal Article
ZDB-ID	134511-4
ISSN	1872-7573 ; 0378-8741
ISSN (online)	1872-7573
ISSN	0378-8741
DOI	10.1016/j.jep.2017.03.006
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Zs.A 1494: Show issues

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Article ; Online: Optimization and antioxidant activity of polysaccharides from Plantago depressa.

Han, Na / Wang, Lin / Song, Zehai / Lin, Junyu / Ye, Chun / Liu, Zhihui / Yin, Jun

International journal of biological macromolecules

2016 Volume 93, Issue Pt A, Page(s) 644–654

Abstract: Polysaccharide from the herb of Plantago depressa (PDP) was obtained through ethanol precipitation preceded by a water extraction step. The optimum extraction yield of 5.68±0.46% was obtained with the treatment of raw material in water (w/v, 1:25.34) at ... ...

Abstract	Polysaccharide from the herb of Plantago depressa (PDP) was obtained through ethanol precipitation preceded by a water extraction step. The optimum extraction yield of 5.68±0.46% was obtained with the treatment of raw material in water (w/v, 1:25.34) at 80.44°C during 1.97h, 3.28 times. Under these conditions, obtained yield value was in total agreement with value predicted by the model executed by Box-Behnken design (BBD). Following analysis by IR, HPLC-UV, MS and
MeSH term(s)	Animals ; Antioxidants/chemistry ; Antioxidants/isolation & purification ; Antioxidants/pharmacology ; Antioxidants/toxicity ; Linoleic Acid/chemistry ; Mice ; Monosaccharides/analysis ; Oxidation-Reduction/drug effects ; Plantago/chemistry ; Polysaccharides/chemistry ; Polysaccharides/isolation & purification ; Polysaccharides/pharmacology ; Polysaccharides/toxicity ; Temperature ; Time Factors ; beta Carotene/chemistry
Chemical Substances	Antioxidants ; Monosaccharides ; Polysaccharides ; beta Carotene (01YAE03M7J) ; Linoleic Acid (9KJL21T0QJ)
Language	English
Publishing date	2016-12
Publishing country	Netherlands
Document type	Journal Article
ZDB-ID	282732-3
ISSN	1879-0003 ; 0141-8130
ISSN (online)	1879-0003
ISSN	0141-8130
DOI	10.1016/j.ijbiomac.2016.09.028
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Zs.B 2374: Show issues

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Article ; Online: Zhixiong Capsule (ZXC), a traditional Chinese patent medicine, prevents atherosclerotic plaque formation in rabbit carotid artery and the related mechanism investigation based on network pharmacology and biological research.

Zhai, Jianxiu / Song, Zehai / Wang, Yuwei / Han, Mingshu / Ren, Zhaohui / Han, Na / Liu, Zhihui / Yin, Jun

Phytomedicine : international journal of phytotherapy and phytopharmacology

2018 Volume 59, Page(s) 152776

Abstract: Background and aims: Chinese patent medicine Zhixiong Capsule (ZXC) has been used in clinical treatment against blood stasis-induced dizziness and headache for many years in China.: Hypothesis/purpose: Recent clinical observations demonstrated a good ...

Abstract	Background and aims: Chinese patent medicine Zhixiong Capsule (ZXC) has been used in clinical treatment against blood stasis-induced dizziness and headache for many years in China. Hypothesis/purpose: Recent clinical observations demonstrated a good efficacy of ZXC against atherosclerotic plaque formation in carotid arteries. The aims of this study were to verify the plaque-preventing efficacy of ZXC in animals and to investigate the underlying mechanisms. Study design/methods: ZXC (185 mg/kg and 370 mg/kg) was administrated to rabbits which received collar implantation accompanied with high fat diet administration (12 days). The blood-dissolved components of ZXC were identified by an UPLC-QTOF-MS method. The key components and targets of ZXC were then predicted based on network pharmacology analysis and biological investigations. Results: Compared with vehicle control group, ZXC administration (185 mg/kg) significantly prevented plaque formation and attenuated intima thickening in the collar-implanted carotid arteries, markedly decreased blood lipid level, and increased plasma IL-4 level in rabbits. A total of 23 blood-dissolved components were identified. Four ingredients (namely, kaempferol, daidzein, puerarin, miltirone) along with leech, and three targets (namely, JUN, FOS and TP53) were recognized to play important roles for ZXC bioactivity. Conclusion: It could be concluded that ZXC could be applied to prevent atherosclerotic plaque formation and intimal thickening in carotid arteries at the current clinical dose.
MeSH term(s)	Animals ; Cardiovascular Agents/chemistry ; Cardiovascular Agents/pharmacology ; Carotid Arteries/drug effects ; Carotid Arteries/pathology ; Interleukin-4/blood ; Isoflavones/analysis ; Kaempferols/analysis ; Leeches ; Male ; Medicine, Chinese Traditional ; Plaque, Atherosclerotic/prevention & control ; Rabbits
Chemical Substances	Cardiovascular Agents ; Isoflavones ; Kaempferols ; Interleukin-4 (207137-56-2) ; daidzein (6287WC5J2L) ; puerarin (Z9W8997416)
Language	English
Publishing date	2018-12-07
Publishing country	Germany
Document type	Journal Article
ZDB-ID	1205240-1
ISSN	1618-095X ; 0944-7113
ISSN (online)	1618-095X
ISSN	0944-7113
DOI	10.1016/j.phymed.2018.11.036
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Zs.A 4115: Show issues

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Article ; Online: Evaluation of the antithrombotic activity of Zhi-Xiong Capsules, a Traditional Chinese Medicinal formula, via the pathway of anti-coagulation, anti-platelet activation and anti-fibrinolysis.

Zhou, Jingjing / Song, Zehai / Han, Mingshu / Yu, Baoxing / Lv, Guanghui / Han, Na / Liu, Zhihui / Yin, Jun

Biomedicine & pharmacotherapy = Biomedecine & pharmacotherapie

2017 Volume 97, Page(s) 1622–1631

Abstract: Zhi-Xiong Capsules (ZXC) involving Hirudo, Ligusticum chuanxiong, Salvia miltiorrhiza, Leonurus artemisia, and Pueraria lobata, is an empirical prescription used in Chinese clinics applied for treating cerebral arteriosclerosis and blood-stasis in clinic. ...

Abstract	Zhi-Xiong Capsules (ZXC) involving Hirudo, Ligusticum chuanxiong, Salvia miltiorrhiza, Leonurus artemisia, and Pueraria lobata, is an empirical prescription used in Chinese clinics applied for treating cerebral arteriosclerosis and blood-stasis in clinic. However, the mechanism of its antithrombotic activity has not been investigated until now. The present study was designed to investigate its antithrombotic effects, the mechanism of ZXC on anti-thrombus action and to identify the main chemical composition of ZXC using HPLC-DAD-ESI-IT-TOF-MS. Two animal models were used to evaluate the antithrombotic effect of ZXC, the arterial thrombosis model and a venous thrombosis model. ZXC prolonged the plasma recalcification time (PRT), the activated partial thromboplastin time (APTT), the thrombin time (TT) and the prothrombin time (PT) and clearly reduced the content of fibrinogen (FIB) obviously in the arterial thrombosis model. Furthermore, it markedly suppressed the level of TXB
MeSH term(s)	Acute Disease ; Animals ; Anticoagulants/pharmacology ; Anticoagulants/therapeutic use ; Antithrombins/pharmacology ; Antithrombins/therapeutic use ; Aspirin/pharmacology ; Blood Coagulation/drug effects ; Capsules ; Carotid Arteries/drug effects ; Carotid Arteries/pathology ; Chlorides ; Disease Models, Animal ; Drug Evaluation, Preclinical ; Drugs, Chinese Herbal/pharmacology ; Drugs, Chinese Herbal/therapeutic use ; Ferric Compounds ; Fibrinolysis/drug effects ; Heparin/pharmacology ; Lung/drug effects ; Lung/pathology ; Mice ; Platelet Activation/drug effects ; Platelet Aggregation/drug effects ; Prostaglandins F/blood ; Prostaglandins F/metabolism ; Pulmonary Embolism/blood ; Pulmonary Embolism/complications ; Pulmonary Embolism/drug therapy ; Rabbits ; Rats, Sprague-Dawley ; Thrombolytic Therapy ; Thrombosis/blood ; Thrombosis/complications ; Thrombosis/drug therapy ; Thromboxane B2/pharmacology
Chemical Substances	Anticoagulants ; Antithrombins ; Capsules ; Chlorides ; Drugs, Chinese Herbal ; Ferric Compounds ; Prostaglandins F ; Thromboxane B2 (54397-85-2) ; Heparin (9005-49-6) ; Aspirin (R16CO5Y76E) ; ferric chloride (U38V3ZVV3V) ; prostaglandin F1 (WJ72O6860W)
Language	English
Publishing date	2017-12-01
Publishing country	France
Document type	Journal Article
ZDB-ID	392415-4
ISSN	1950-6007 ; 0753-3322 ; 0300-0893
ISSN (online)	1950-6007
ISSN	0753-3322 ; 0300-0893
DOI	10.1016/j.biopha.2017.11.135
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Article ; Online: Lignans from the root of Wikstroemia indica and their cytotoxic activity against PANC-1 human pancreatic cancer cells.

Chang, Hang / Wang, Yuwei / Gao, Xue / Song, Zehai / Awale, Suresh / Han, Na / Liu, Zhihui / Yin, Jun

Fitoterapia

2017 Volume 121, Page(s) 31–37

Abstract: Six new compounds, wikstronin A (1), wikstronin B (2), wikstresinol (3), acetylwikstresinol (4), bis-5',5'-(+)-matairesinol (5), bis-5,5'-(+)-matairesinol (6), together with 20 known compounds (7-26) were isolated from the ... ...

Abstract	Six new compounds, wikstronin A (1), wikstronin B (2), wikstresinol (3), acetylwikstresinol (4), bis-5',5'-(+)-matairesinol (5), bis-5,5'-(+)-matairesinol (6), together with 20 known compounds (7-26) were isolated from the CH
MeSH term(s)	Antineoplastic Agents, Phytogenic/isolation & purification ; Antineoplastic Agents, Phytogenic/pharmacology ; Cell Line, Tumor ; Drug Screening Assays, Antitumor ; Humans ; Lignans/isolation & purification ; Lignans/pharmacology ; Molecular Structure ; Pancreatic Neoplasms/drug therapy ; Plant Roots/chemistry ; Wikstroemia/chemistry
Chemical Substances	Antineoplastic Agents, Phytogenic ; Lignans
Language	English
Publishing date	2017-09
Publishing country	Netherlands
Document type	Journal Article
ZDB-ID	412385-2
ISSN	1873-6971 ; 0367-326X
ISSN (online)	1873-6971
ISSN	0367-326X
DOI	10.1016/j.fitote.2017.06.012
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Zs.B 1873: Show issues

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Article: He-Wei granules (HWKL) combat cisplatin-induced nephrotoxicity and myelosuppression in rats by inhibiting oxidative stress, inflammatory cytokines and apoptosis

Song, Zehai / Chang, Hang / Han, Na / Liu, Zhihui / Liu, Ye / Wang, Hui / Shao, Jingxuan / Wang, Zhonglin / Gao, Hao / Yin, Jun

RSC advances. 2017 Apr. 04, v. 7, no. 32

2017

Abstract: As a highly effective antineoplastic chemotherapeutic drug, cisplatin is widely used clinically to treat a variety of human malignancies. However, its clinical use is severely limited by serious side-effects, of which nephrotoxicity and myelosuppression ... ...

Abstract	As a highly effective antineoplastic chemotherapeutic drug, cisplatin is widely used clinically to treat a variety of human malignancies. However, its clinical use is severely limited by serious side-effects, of which nephrotoxicity and myelosuppression are considered to be the most important because they significantly reduce patient life quality and hinder effective use. In this study, we investigated whether HWKL, a product obtained from modified Ban-xia xie-xin decoction first described 1700 years ago, exhibits protective effects against cisplatin-induced nephrotoxicity and myelosuppression. After intraperitoneal injection of 7 mg kg−1 cisplatin to Wistar rats, nephrotoxicity and myelosuppression were observed. HWKL reduced cisplatin-induced elevations in blood urea nitrogen (BUN) and serum creatinine (Scr) levels, increased water intake and improved renal tubular lesions. Cisplatin-induced increases in tumor necrosis alpha (TNF-α) protein, interleukin-1 beta (IL-1β) protein, cyclooxygenase-2 (COX-2) protein, extracellular signal-regulated kinase (ERK), TNF-α mRNA and IL-1β mRNA were significantly reduced by HWKL and cisplatin-induced oxidative stress was also inhibited by HWKL. Furthermore, HWKL contributed to increase immunological function to combat cisplatin-induced myelosuppression. Our findings indicate that HWKL inhibits cisplatin-induced nephrotoxicity and myelosuppression via several mechanisms which operate simultaneously and provide basic evidence to confirm that HWKL could be useful in clinical situations as a protective agent to prevent cisplatin-induced nephrotoxicity and myelosuppression.
Keywords	adverse effects ; apoptosis ; blood serum ; cisplatin ; creatinine ; drug therapy ; granules ; humans ; interleukin-1beta ; intraperitoneal injection ; laboratory animals ; messenger RNA ; mitogen-activated protein kinase ; necrosis ; neoplasms ; nephrotoxicity ; oxidative stress ; patients ; prostaglandin synthase ; protective effect ; quality of life ; rats ; tumor necrosis factor-alpha ; urea nitrogen
Language	English
Dates of publication	2017-0404
Size	p. 19794-19807.
Publishing place	The Royal Society of Chemistry
Document type	Article
ISSN	2046-2069
DOI	10.1039/c7ra02830j
Database	NAL-Catalogue (AGRICOLA)

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