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  1. AU="Songül KARAKAYA"
  2. AU="Bang, Sunghee"
  3. AU="Stasiak, Andrzej"
  4. AU="Ward, B.F.L."
  5. AU="Wu, Sizhu"
  6. AU="Maria-Magdalena Titirici"
  7. AU="Papapoulos, Socrates"
  8. AU="Valdivia, Anddre Osmar"
  9. AU="Graham, Miranda"
  10. AU="Lisitsyn, Nikolai A"

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  1. Artikel ; Online: Anatomical and Phytochemical Characteristics of Different Parts of Hypericum scabrum L. Extracts, Essential Oils, and Their Antimicrobial Potential

    Kubra Nalkiran Ergin / Songul Karakaya / Gamze Göger / Oksana Sytar / Betul Demirci / Hayri Duman

    Molecules, Vol 27, Iss 1228, p

    2022  Band 1228

    Abstract: Hypericum (Hypericaceae) is a genus that comprises a high number of species around the world. In this study, the roots, aerial parts, flowers, fruits, and aerial parts with flowers from Hypericum scabrum were macerated separately by methanol and water ... ...

    Abstract Hypericum (Hypericaceae) is a genus that comprises a high number of species around the world. In this study, the roots, aerial parts, flowers, fruits, and aerial parts with flowers from Hypericum scabrum were macerated separately by methanol and water and then fractionated by different solvents of, such as ethyl acetate, n -hexane, butanol, dichloromethane, aqueous residue sub-extracts, and ethnobotanical use. All the extracts, sub-extracts and essential oils of H. scabrum were investigated for the first time in detail for their antimicrobial, total phenolics, and antioxidant activities. Anatomical structures of the root, stem, leaf, upper and lower leaf surface, stamen, sepal, and petal of H. scabrum were examined. The biochemical layout of essential oils was determined by GC and GC/MS. The antioxidant activity was determined by free radical scavenging activity (by DPPH). Antimicrobial activity was applied against Candida albicans ATCC 10231, Escherichia coli ATCC 8739, Staphylococcus aureus ATCC 6538, Bacillus subtilis ATCC 19659, and C. tropicalis ATCC 750 using microdilution methods. The essentials of the aerial parts, flower, and fruit are characterized by the presence of monoterpene hydrocarbons, whereas roots oil include alkanes. The GC-FID and GC-MS analysis showed that major components of roots, aerial parts, flowers, and fruits oils were undecane (66.1%); α-pinene (17.5%), γ-terpinene (17.4%), and α-thujene (16.9%); α-pinene (55.6%), α-thujene (10.9%), and γ-terpinene (7.7%); α-pinene (85.2%), respectively. The aerial part sub-extracts indicated a greater level of total phenolics and antioxidant potential. The n -hexane sub-extracts (from aerial part, flower, and aerial part with flower) showed the best activity against B. subtilis , with 39.06 µg/mL MIC value. The presented research work indicates that H. scabrum can be a novel promising resource of natural antioxidant and antimicrobial compounds.
    Schlagwörter antioxidant ; antimicrobial ; essential oil ; Hypericum scabrum ; a-pinene ; secretory canals ; Organic chemistry ; QD241-441
    Thema/Rubrik (Code) 571
    Sprache Englisch
    Erscheinungsdatum 2022-02-01T00:00:00Z
    Verlag MDPI AG
    Dokumenttyp Artikel ; Online
    Datenquelle BASE - Bielefeld Academic Search Engine (Lebenswissenschaftliche Auswahl)

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  2. Artikel ; Online: Carbonic Anhydrase Isoenzymes I and II Inhibition Potentials of Leiotulus dasyanthus (K. Koch) Pimenov&Ostr. and Ferulago pauciradiata Boiss.&Heldr. (Apiaceae)

    Songül KARAKAYA / Zeynebe BİNGÖL / İlhami GÜLÇİN / Fatmagül DELİMUSTAFAOĞLU / Hayri DUMAN / Ceyda Sibel KILIÇ

    Bezmiâlem Science, Vol 9, Iss 2, Pp 153-

    2021  Band 157

    Abstract: Objective:Members of the Apiaceae family have many biological and pharmacological effects like anticancer, antidiabetic, antioxidant, anti-inflammatory, anti-hypertensive, anticoagulant, antimicrobial, and anticholinesterase. Also, some of them are ... ...

    Abstract Objective:Members of the Apiaceae family have many biological and pharmacological effects like anticancer, antidiabetic, antioxidant, anti-inflammatory, anti-hypertensive, anticoagulant, antimicrobial, and anticholinesterase. Also, some of them are consumed as vegetables, pickles, and spices. Carbonic anhydrase has a remarkable role in diseases like osteoporosis, glaucoma, edema, cancer, epilepsy, and obesity. The inhibition effects of methanol extracts and subextracts (n-hexane, dichloromethane, ethyl acetate, n-butanol, and aqueous residue) of Leiotulus dasyanthus and Ferulago pauciradiata roots on carbonic anhydrase I and II isoenzymes were investigated in this research.Methods:Leiotulus dasyanthus and Ferulago pauciradiata were collected in 2017 from Erzurum and in 2013 from Nevşehir (Turkey), respectively. The roots of L. dasyanthus and F. pauciradiata were macerated with methanol, dispersed with methanol: distilled water (1:9), and fractionated with n-hexane, dichloromethane, ethyl acetate, and n-butanol, in turn. The hCA I and II isoenzymes were isolated from erythrocytes of fresh human blood via Sepharose-4BL- Tyrosine-sulfanilamide affinity chromatography. The analysis of hCA I and II isoenzymes was actualized by the Verpoorte method.Results:The hCA I and II were influentially inhibited by the dichloromethane and ethyl acetate sub-extracts of F. pauciradiata root with IC50 values of 1.694 μg/mL towards hCA I and 1.677 μg/ mL towards hCA II, respectively. Whereas dichloromethane subextract and methanol extract of L. dasyanthus root inhibited hCA I and II isoenzymes with IC50 values of 1.828 μg/mL towards hCA I and 1.852 μg/mL towards hCA II, respectively.Conclusion:The hCA I and II were influentially inhibited by the dichloromethane and ethyl acetate sub-extracts of Ferulago pauciradiata root
    Schlagwörter apiaceae ; carbonic anhydrase ; ferulago ; leiotulus ; hca i ; hca ii ; Medicine (General) ; R5-920
    Sprache Englisch
    Erscheinungsdatum 2021-04-01T00:00:00Z
    Verlag Galenos Publishing House
    Dokumenttyp Artikel ; Online
    Datenquelle BASE - Bielefeld Academic Search Engine (Lebenswissenschaftliche Auswahl)

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  3. Artikel ; Online: Does Umbelliferone Protect Primary Cortical Neuron Cells Against Glutamate Excitotoxicity?

    Alper Kürşat DEMİRKAYA / Gülşah GÜNDOĞDU / Songül KARAKAYA / Şeymanur YILMAZ TAŞCI / Kemal Alp NALCI / Ahmet HACIMÜFTÜOĞLU

    Kafkas Universitesi Veteriner Fakultesi Dergisi, Vol 27, Iss 3, Pp 339-

    2021  Band 346

    Abstract: Glutamate is the major excitatory neurotransmitter in the central nervous system. Excessive glutamate is known to cause excitotoxicity. Umbelliferone is a coumarin derivative compound and has antioxidant, anti-inflammatory, and neuroprotective effects. ... ...

    Abstract Glutamate is the major excitatory neurotransmitter in the central nervous system. Excessive glutamate is known to cause excitotoxicity. Umbelliferone is a coumarin derivative compound and has antioxidant, anti-inflammatory, and neuroprotective effects. Also, umbelliferone can show neuroprotective eff ect by crossing the blood-brain barrier. In our study, it was aimed to investigate the neuroprotective effect of umbelliferone on primary cortical neuron (PCN) culture. Umbelliferone was isolated from the roots of Ferulago cassia dichloromethane sub-extract. The cerebral cortex of newborn Sprague Dawley rats was used to obtain PCNs. To stimulate glutamate excitotoxicity, cells were exposed to 6x10-5M glutamate. Then different concentrations (10-1000 μM) of umbelliferone were added into the medium and allowed to incubate for 24 and 72 h. MTT assay was used to measure cell viability. Total Antioxidant Status (TAS) and Total Oxidant Status (TOS) analyzes were used to evaluate reactive oxygen species. MTT results showed that cell viability was decreased with glutamate application. 25-250 µM umbelliferone had a significant protective eff ect against glutamate excitotoxicity at 72 h (P<0.05). Consistent with MTT results, TAS analysis results showed 50-250 µM umbelliferone increase the level of antioxidants in cells, which can help protect neurons against glutamate-induced excitotoxicity. In this study, umbelliferone showed a neuroprotective effect in PCN against glutamate excitotoxicity. These results suggest that umbelliferone may be used as therapeutic agent against glutamate excitotoxicity.
    Schlagwörter glutamate ; ferulago ; primary cortical neuron culture ; umbelliferone ; Veterinary medicine ; SF600-1100
    Sprache Englisch
    Erscheinungsdatum 2021-05-01T00:00:00Z
    Verlag University of Kafkas
    Dokumenttyp Artikel ; Online
    Datenquelle BASE - Bielefeld Academic Search Engine (Lebenswissenschaftliche Auswahl)

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  4. Artikel ; Online: Molecular Docking Studies of Coumarins Isolated from Extracts and Essential Oils of Zosima absinthifolia Link as Potential Inhibitors for Alzheimer’s Disease

    Songul Karakaya / Mehmet Koca / Serdar Volkan Yılmaz / Kadir Yıldırım / Nur Münevver Pınar / Betül Demirci / Marian Brestic / Oksana Sytar

    Molecules, Vol 24, Iss 4, p

    2019  Band 722

    Abstract: Coumarins and essential oils are the major components of the Apiaceae family and the Zosima genus. The present study reports anticholinesterase and antioxidant activities of extracts and essential oils from aerial parts, roots, flowers, fruits and ... ...

    Abstract Coumarins and essential oils are the major components of the Apiaceae family and the Zosima genus. The present study reports anticholinesterase and antioxidant activities of extracts and essential oils from aerial parts, roots, flowers, fruits and coumarins—bergapten ( 1 ); imperatorin ( 2 ), pimpinellin ( 3 ) and umbelliferone ( 4 )—isolated of the roots from Zosima absinthifolia . The investigation by light and scanning electron microscopy of the structures of secretory canals found different chemical compositions in the various types of secretory canals which present in the aerial parts, fruits and flowers. The canals, present in the aerial parts, are characterized by terpene hydrocarbons, while the secretory canals of roots, flowers and fruits include esters. Novel data of a comparative study on essential oils constituents of aerial parts, roots, flowers and fruits of Z. absinthfolia has been presented. The roots and fruits extract showed a high content of total phenolics and antioxidant activity. The GC-FID and GC-MS analysis revealed that the main components of the aerial parts, roots, flowers and fruits extracts were octanol (8.8%), octyl octanoate (7.6%), octyl acetate (7.3%); trans -pinocarvyl acetate (26.7%), β-pinene (8.9%); octyl acetate (19.9%), trans-p -menth-2-en-1-ol (4.6%); octyl acetate (81.6%), and ( Z )-4-octenyl acetate (5.1%). The dichloromethane fraction of fruit and flower essential oil was characterized by the highest phenolics level and antioxidant activity. The dichloromethane fraction of fruit had the best inhibition against butyrylcholinesterase enzyme (82.27 ± 1.97%) which was higher then acetylcholinesterase inhibition (61.09 ± 4.46%) of umbelliferone. This study shows that the flowers and fruit of Z. absinthifolia can be a new potential resource of natural antioxidant and anticholinesterase compounds.
    Schlagwörter Apiaceae ; antioxidant ; anticholinesterase ; essential oil ; secretory canals ; Zosima absinthifolia ; Organic chemistry ; QD241-441
    Thema/Rubrik (Code) 571
    Sprache Englisch
    Erscheinungsdatum 2019-02-01T00:00:00Z
    Verlag MDPI AG
    Dokumenttyp Artikel ; Online
    Datenquelle BASE - Bielefeld Academic Search Engine (Lebenswissenschaftliche Auswahl)

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