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  1. AU="Soniwala, Sarah"
  2. AU=Stahlberg Anders
  3. AU="Stewart, Tracy Murray"
  4. AU="Kong, Tsz-Ho"
  5. AU="Rennie, Sarah C"
  6. AU="Haider, Nafees"
  7. AU="Austin, Eric D"
  8. AU="Czechowicz, Agnieszka D"
  9. AU="Nume, Cosimo"
  10. AU=Cianferoni Antonella
  11. AU="Fernandez, Sarai Quirós"
  12. AU="Hajiabadi, Fatemeh"
  13. AU="Aslam, Muhammad M"
  14. AU="Wang, Xiangpei"
  15. AU="Stacey, Jemaine E"
  16. AU="Yu, Young Suk"
  17. AU=Agius R M AU=Agius R M
  18. AU="Hammer, Rachel A"
  19. AU="Dreyfuss, Jonathan M"
  20. AU="Eleanor Turner-Moss"

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  1. Artikel ; Online: The gut microbiome-joint connection: implications in osteoarthritis.

    Favazzo, Lacey J / Hendesi, Honey / Villani, David A / Soniwala, Sarah / Dar, Qurratul-Ain / Schott, Eric M / Gill, Steven R / Zuscik, Michael J

    Current opinion in rheumatology

    2019  Band 32, Heft 1, Seite(n) 92–101

    Abstract: Purpose of review: Osteoarthritis is a debilitating disease leading to joint degeneration, inflammation, pain, and disability. Despite efforts to develop a disease modifying treatment, the only accepted and available clinical approaches involve ... ...

    Abstract Purpose of review: Osteoarthritis is a debilitating disease leading to joint degeneration, inflammation, pain, and disability. Despite efforts to develop a disease modifying treatment, the only accepted and available clinical approaches involve palliation. Although many factors contribute to the development of osteoarthritis, the gut microbiome has recently emerged as an important pathogenic factor in osteoarthritis initiation and progression. This review examines the literature to date regarding the link between the gut microbiome and osteoarthritis.
    Recent findings: Studies showing correlations between serum levels of bacterial metabolites and joint degeneration were the first links connecting a dysbiosis of the gut microbiome with osteoarthritis. Further investigations have demonstrated that microbial community shifts induced by antibiotics, a germ-free environment or high-fat are important underlying factors in joint homeostasis and osteoarthritis. It follows that strategies to manipulate the microbiome have demonstrated efficacy in mitigating joint degeneration in osteoarthritis. Moreover, we have observed that dietary supplementation with nutraceuticals that are joint protective may exert their influence via shifts in the gut microbiome.
    Summary: Although role of the microbiome in osteoarthritis is an area of intense study, no clear mechanism of action has been determined. Increased understanding of how the two factors interact may provide mechanistic insight into osteoarthritis and lead to disease modifying treatments.
    Mesh-Begriff(e) Dysbiosis/complications ; Dysbiosis/metabolism ; Dysbiosis/microbiology ; Gastrointestinal Microbiome/physiology ; Humans ; Inflammation/metabolism ; Inflammation/microbiology ; Osteoarthritis/metabolism ; Osteoarthritis/microbiology
    Sprache Englisch
    Erscheinungsdatum 2019-11-14
    Erscheinungsland United States
    Dokumenttyp Journal Article ; Research Support, N.I.H., Extramural ; Research Support, U.S. Gov't, Non-P.H.S. ; Review
    ZDB-ID 1045317-9
    ISSN 1531-6963 ; 1040-8711
    ISSN (online) 1531-6963
    ISSN 1040-8711
    DOI 10.1097/BOR.0000000000000681
    Datenquelle MEDical Literature Analysis and Retrieval System OnLINE

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  2. Artikel ; Online: Targeting the gut microbiome to treat the osteoarthritis of obesity.

    Schott, Eric M / Farnsworth, Christopher W / Grier, Alex / Lillis, Jacquelyn A / Soniwala, Sarah / Dadourian, Gregory H / Bell, Richard D / Doolittle, Madison L / Villani, David A / Awad, Hani / Ketz, John P / Kamal, Fadia / Ackert-Bicknell, Cheryl / Ashton, John M / Gill, Steven R / Mooney, Robert A / Zuscik, Michael J

    JCI insight

    2018  Band 3, Heft 8

    Abstract: Obesity is a risk factor for osteoarthritis (OA), the greatest cause of disability in the US. The impact of obesity on OA is driven by systemic inflammation, and increased systemic inflammation is now understood to be caused by gut microbiome dysbiosis. ... ...

    Abstract Obesity is a risk factor for osteoarthritis (OA), the greatest cause of disability in the US. The impact of obesity on OA is driven by systemic inflammation, and increased systemic inflammation is now understood to be caused by gut microbiome dysbiosis. Oligofructose, a nondigestible prebiotic fiber, can restore a lean gut microbial community profile in the context of obesity, suggesting a potentially novel approach to treat the OA of obesity. Here, we report that - compared with the lean murine gut - obesity is associated with loss of beneficial Bifidobacteria, while key proinflammatory species gain in abundance. A downstream systemic inflammatory signature culminates with macrophage migration to the synovium and accelerated knee OA. Oligofructose supplementation restores the lean gut microbiome in obese mice, in part, by supporting key commensal microflora, particularly Bifidobacterium pseudolongum. This is associated with reduced inflammation in the colon, circulation, and knee and protection from OA. This observation of a gut microbiome-OA connection sets the stage for discovery of potentially new OA therapeutics involving strategic manipulation of specific microbial species inhabiting the intestinal space.
    Mesh-Begriff(e) Animals ; Bifidobacterium longum/immunology ; Bifidobacterium longum/metabolism ; Dysbiosis/microbiology ; Gastrointestinal Microbiome/physiology ; Humans ; Inflammation/metabolism ; Inflammation/microbiology ; Macrophages/metabolism ; Macrophages/pathology ; Mice ; Mice, Inbred C57BL ; Obesity/complications ; Obesity/metabolism ; Obesity/microbiology ; Obesity/pathology ; Oligosaccharides/metabolism ; Osteoarthritis/etiology ; Osteoarthritis/metabolism ; Osteoarthritis/microbiology ; Osteoarthritis/pathology ; Transcriptome/genetics
    Chemische Substanzen Oligosaccharides ; oligofructose
    Sprache Englisch
    Erscheinungsdatum 2018-04-19
    Erscheinungsland United States
    Dokumenttyp Comparative Study ; Journal Article ; Research Support, N.I.H., Extramural
    ISSN 2379-3708
    ISSN (online) 2379-3708
    DOI 10.1172/jci.insight.95997
    Datenquelle MEDical Literature Analysis and Retrieval System OnLINE

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