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  1. Book ; Thesis: Modeling biological-physical feedback mechanisms in marine systems

    Sonntag, Sebastian

    2013  

    Author's details vorgelegt von Sebastian Sonntag
    Language English
    Size IV, 163 S, graph. Darst.
    Document type Book ; Thesis
    Thesis / German Habilitation thesis Univ., FB Geowiss., Diss. 2013--Hamburg, 2013
    Note Zsfassung in engl. Sprache
    Database Former special subject collection: coastal and deep sea fishing

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  2. Book ; Online ; Thesis: Modeling biological-physical feedback mechanisms in marine systems

    Sonntag, Sebastian / Hense, Inga

    2013  

    Title variant Modellierung biologisch-physikalischer Rückkopplungsmechanismen in marinen Systemen
    Author's details Sebastian Sonntag. Betreuer: Inga Hense
    Language English
    Size Online-Ressource
    Publisher Staats- und Universitätsbibliothek Hamburg
    Publishing place Hamburg
    Document type Book ; Online ; Thesis
    Thesis / German Habilitation thesis Univ. Hamburg, FB Geowiss., Diss.--Hamburg, 2013
    Database Former special subject collection: coastal and deep sea fishing

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  3. Book ; Online ; Thesis: Modeling biological-physical feedback mechanisms in marine systems

    Sonntag, Sebastian / Hense, Inga

    2013  

    Title variant Modellierung biologisch-physikalischer Rückkopplungsmechanismen in marinen Systemen
    Author's details Sebastian Sonntag. Betreuer: Inga Hense
    Language English
    Size Online-Ressource
    Publisher Staats- und Universitätsbibliothek Hamburg
    Publishing place Hamburg
    Document type Book ; Online ; Thesis
    Thesis / German Habilitation thesis Univ. Hamburg, FB Geowiss., Diss.--Hamburg, 2013
    Database Library catalogue of the German National Library of Science and Technology (TIB), Hannover

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  4. Article: Evaluation of the Effects of Harmine on β-cell Function and Proliferation in Standardized Human Islets Using 3D High-Content Confocal Imaging and Automated Analysis.

    Title, Alexandra C / Karsai, Maria / Mir-Coll, Joan / Grining, Özlem Yavas / Rufer, Chantal / Sonntag, Sebastian / Forschler, Felix / Jawurek, Sayro / Klein, Thomas / Yesildag, Burcak

    Frontiers in endocrinology

    2022  Volume 13, Page(s) 854094

    Abstract: Restoration of β-cell mass through the induction of proliferation represents an attractive therapeutic approach for the treatment of diabetes. However, intact and dispersed primary islets suffer from rapidly deteriorating viability and ... ...

    Abstract Restoration of β-cell mass through the induction of proliferation represents an attractive therapeutic approach for the treatment of diabetes. However, intact and dispersed primary islets suffer from rapidly deteriorating viability and function
    MeSH term(s) Cell Proliferation ; Harmine/metabolism ; Harmine/pharmacology ; Humans ; Insulin/metabolism ; Insulin/pharmacology ; Insulin Secretion ; Insulin-Secreting Cells/metabolism
    Chemical Substances Insulin ; Harmine (4FHH5G48T7)
    Language English
    Publishing date 2022-07-04
    Publishing country Switzerland
    Document type Journal Article ; Review ; Research Support, Non-U.S. Gov't
    ZDB-ID 2592084-4
    ISSN 1664-2392
    ISSN 1664-2392
    DOI 10.3389/fendo.2022.854094
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  5. Book ; Online: Ideas and perspectives

    Hense, Inga / Stemmler, Irene / Sonntag, Sebastian

    eISSN: 1726-4189

    climate-relevant marine biologically driven mechanisms in Earth system models

    2017  

    Abstract: The current generation of marine biogeochemical modules in Earth system models (ESMs) considers mainly the effect of marine biota on the carbon cycle. We propose to also implement other biologically driven mechanisms in ESMs so that more climate-relevant ...

    Abstract The current generation of marine biogeochemical modules in Earth system models (ESMs) considers mainly the effect of marine biota on the carbon cycle. We propose to also implement other biologically driven mechanisms in ESMs so that more climate-relevant feedbacks are captured. We classify these mechanisms in three categories according to their functional role in the Earth system: (1) <q>biogeochemical pumps</q>, which affect the carbon cycling; (2) <q>biological gas and particle shuttles</q>, which affect the atmospheric composition; and (3) <q>biogeophysical mechanisms</q>, which affect the thermal, optical, and mechanical properties of the ocean. To resolve mechanisms from all three classes, we find it sufficient to include five functional groups: bulk phyto- and zooplankton, calcifiers, and coastal gas and surface mat producers. We strongly suggest to account for a larger mechanism diversity in ESMs in the future to improve the quality of climate projections.
    Subject code 333
    Language English
    Publishing date 2017-01-26
    Publishing country de
    Document type Book ; Online
    Database BASE - Bielefeld Academic Search Engine (life sciences selection)

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  6. Article ; Online: Ideas and perspectives

    Hense, Inga / Stemmler, Irene / Sonntag, Sebastian

    climate-relevant marine biologically driven mechanisms in Earth system models

    2017  

    Abstract: The current generation of marine biogeochemical modules in Earth system models (ESMs) considers mainly the effect of marine biota on the carbon cycle. We propose to also implement other biologically driven mechanisms in ESMs so that more climate-relevant ...

    Abstract The current generation of marine biogeochemical modules in Earth system models (ESMs) considers mainly the effect of marine biota on the carbon cycle. We propose to also implement other biologically driven mechanisms in ESMs so that more climate-relevant feedbacks are captured. We classify these mechanisms in three categories according to their functional role in the Earth system: (1) "biogeochemical pumps", which affect the carbon cycling; (2) "biological gas and particle shuttles", which affect the atmospheric composition; and (3) "biogeophysical mechanisms", which affect the thermal, optical, and mechanical properties of the ocean. To resolve mechanisms from all three classes, we find it sufficient to include five functional groups: bulk phyto- and zooplankton, calcifiers, and coastal gas and surface mat producers. We strongly suggest to account for a larger mechanism diversity in ESMs in the future to improve the quality of climate projections.
    Subject code 333
    Language English
    Publisher Copernicus
    Publishing country de
    Document type Article ; Online
    Database BASE - Bielefeld Academic Search Engine (life sciences selection)

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  7. Article ; Online: Insight into nuclear body formation of phytochromes through stochastic modelling and experiment.

    Grima, Ramon / Sonntag, Sebastian / Venezia, Filippo / Kircher, Stefan / Smith, Robert W / Fleck, Christian

    Physical biology

    2018  Volume 15, Issue 5, Page(s) 56003

    Abstract: Spatial relocalization of proteins is crucial for the correct functioning of living cells. An interesting example of spatial ordering is the light-induced clustering of plant photoreceptor proteins. Upon irradiation by white or red light, the red light- ... ...

    Abstract Spatial relocalization of proteins is crucial for the correct functioning of living cells. An interesting example of spatial ordering is the light-induced clustering of plant photoreceptor proteins. Upon irradiation by white or red light, the red light-active phytochrome, phytochrome B, enters the nucleus and accumulates in large nuclear bodies (NBs). The underlying physical process of nuclear body formation remains unclear, but phytochrome B is thought to coagulate via a simple protein-protein binding process. We measure, for the first time, the distribution of the number of phytochrome B-containing NBs as well as their volume distribution. We show that the experimental data cannot be explained by a stochastic model of nuclear body formation via simple protein-protein binding processes using physically meaningful parameter values. Rather modelling suggests that the data is consistent with a two step process: a fast nucleation step leading to macroparticles followed by a subsequent slow step in which the macroparticles bind to form the nuclear body. An alternative explanation for the observed nuclear body distribution is that the phytochromes bind to a so far unknown molecular structure. We believe it is likely this result holds more generally for other nuclear body-forming plant photoreceptors and proteins.
    MeSH term(s) Active Transport, Cell Nucleus/radiation effects ; Arabidopsis/cytology ; Arabidopsis/metabolism ; Arabidopsis/radiation effects ; Arabidopsis Proteins/analysis ; Arabidopsis Proteins/metabolism ; Cell Nucleus/metabolism ; Cell Nucleus/radiation effects ; Computer Simulation ; Light ; Models, Biological ; Phytochrome B/analysis ; Phytochrome B/metabolism ; Protein Binding/radiation effects ; Stochastic Processes
    Chemical Substances Arabidopsis Proteins ; Phytochrome B (136250-22-1)
    Language English
    Publishing date 2018-05-18
    Publishing country England
    Document type Journal Article ; Research Support, Non-U.S. Gov't
    ZDB-ID 2133216-2
    ISSN 1478-3975 ; 1478-3967
    ISSN (online) 1478-3975
    ISSN 1478-3967
    DOI 10.1088/1478-3975/aac193
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  8. Article: Projected climate change impact on Baltic Sea cyanobacteria : Climate change impact on cyanobacteria

    Hense, Inga / Meier, H. E. Markus / Sonntag, Sebastian

    Climatic change. 2013 July, v. 119, no. 2

    2013  

    Abstract: Compared to other phytoplankton groups, nitrogen-fixing cyanobacteria generally prefer high water temperatures for growth and are therefore expected to benefit from global warming. We use a coupled biological-physical model with an advanced cyanobacteria ...

    Abstract Compared to other phytoplankton groups, nitrogen-fixing cyanobacteria generally prefer high water temperatures for growth and are therefore expected to benefit from global warming. We use a coupled biological-physical model with an advanced cyanobacteria life cycle model to compare the abundance of cyanobacteria in the Baltic Sea during two different time periods (1969–1998; 2069–2098). For the latter, we find prolonged growth and a more than twofold increase in the climatologically (30 years) averaged cyanobacteria biomass and nitrogen fixation. Additional sensitivity experiments indicate that the biological-physical feedback mechanism through light absorption becomes more important with global warming. In general, we find a nonlinear response of cyanobacteria to changes in the atmospheric forcing fields as a result of life-cycle related feedback mechanisms. Overall, the sensitivity of the cyanobacteria-driven system suggests that biological-physical and life-cycle related feedback mechanisms are important and must therefore be included in future projection studies.
    Keywords Cyanobacteria ; absorption ; biomass ; global warming ; models ; nitrogen fixation ; nitrogen-fixing cyanobacteria ; water temperature ; Baltic Sea
    Language English
    Dates of publication 2013-07
    Size p. 391-406.
    Publishing place Springer-Verlag
    Document type Article
    ZDB-ID 751086-x
    ISSN 0165-0009
    ISSN 0165-0009
    DOI 10.1007/s10584-013-0702-y
    Database NAL-Catalogue (AGRICOLA)

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    In stock of ZB MED Bonn / Germany

    Einzelsign.: Show issues
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  9. Article ; Online: Interferons are key cytokines acting on pancreatic islets in type 1 diabetes.

    Coomans de Brachène, Alexandra / Alvelos, Maria Ines / Szymczak, Florian / Zimath, Priscila L / Castela, Angela / Marmontel de Souza, Bianca / Roca Rivada, Arturo / Marín-Cañas, Sandra / Yi, Xiaoyan / Op de Beeck, Anne / Morgan, Noel G / Sonntag, Sebastian / Jawurek, Sayro / Title, Alexandra C / Yesildag, Burcak / Pattou, François / Kerr-Conte, Julie / Montanya, Eduard / Nacher, Montserrat /
    Marselli, Lorella / Marchetti, Piero / Richardson, Sarah J / Eizirik, Decio L

    Diabetologia

    2024  Volume 67, Issue 5, Page(s) 908–927

    Abstract: Aims/hypothesis: The proinflammatory cytokines IFN-α, IFN-γ, IL-1β and TNF-α may contribute to innate and adaptive immune responses during insulitis in type 1 diabetes and therefore represent attractive therapeutic targets to protect beta cells. However, ...

    Abstract Aims/hypothesis: The proinflammatory cytokines IFN-α, IFN-γ, IL-1β and TNF-α may contribute to innate and adaptive immune responses during insulitis in type 1 diabetes and therefore represent attractive therapeutic targets to protect beta cells. However, the specific role of each of these cytokines individually on pancreatic beta cells remains unknown.
    Methods: We used deep RNA-seq analysis, followed by extensive confirmation experiments based on reverse transcription-quantitative PCR (RT-qPCR), western blot, histology and use of siRNAs, to characterise the response of human pancreatic beta cells to each cytokine individually and compared the signatures obtained with those present in islets of individuals affected by type 1 diabetes.
    Results: IFN-α and IFN-γ had a greater impact on the beta cell transcriptome when compared with IL-1β and TNF-α. The IFN-induced gene signatures have a strong correlation with those observed in beta cells from individuals with type 1 diabetes, and the level of expression of specific IFN-stimulated genes is positively correlated with proteins present in islets of these individuals, regulating beta cell responses to 'danger signals' such as viral infections. Zinc finger NFX1-type containing 1 (ZNFX1), a double-stranded RNA sensor, was identified as highly induced by IFNs and shown to play a key role in the antiviral response in beta cells.
    Conclusions/interpretation: These data suggest that IFN-α and IFN-γ are key cytokines at the islet level in human type 1 diabetes, contributing to the triggering and amplification of autoimmunity.
    MeSH term(s) Humans ; Cytokines/metabolism ; Diabetes Mellitus, Type 1/metabolism ; Interferons/metabolism ; Tumor Necrosis Factor-alpha/metabolism ; Interferon-gamma/metabolism ; Islets of Langerhans/metabolism
    Chemical Substances Cytokines ; Interferons (9008-11-1) ; Tumor Necrosis Factor-alpha ; Interferon-gamma (82115-62-6)
    Language English
    Publishing date 2024-02-26
    Publishing country Germany
    Document type Journal Article
    ZDB-ID 1694-9
    ISSN 1432-0428 ; 0012-186X
    ISSN (online) 1432-0428
    ISSN 0012-186X
    DOI 10.1007/s00125-024-06106-7
    Database MEDical Literature Analysis and Retrieval System OnLINE

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    In stock of ZB MED Cologne/Königswinter

    Zs.A 279: Show issues Location:
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    bis Jg. 1994: Bestellungen von Artikeln über das Online-Bestellformular
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  10. Article ; Online: Insight into nuclear body formation of phytochromes through stochastic modelling and experiment

    Grima, Ramon / Sonntag, Sebastian / Venezia, Filippo / Kircher, Stefan / Smith, Robert W. / Fleck, Christian

    Physical Biology

    2018  Volume 15, Issue 5

    Abstract: Spatial relocalization of proteins is crucial for the correct functioning of living cells. An interesting example of spatial ordering is the light-induced clustering of plant photoreceptor proteins. Upon irradiation by white or red light, the red light- ... ...

    Abstract Spatial relocalization of proteins is crucial for the correct functioning of living cells. An interesting example of spatial ordering is the light-induced clustering of plant photoreceptor proteins. Upon irradiation by white or red light, the red light-active phytochrome, phytochrome B, enters the nucleus and accumulates in large nuclear bodies (NBs). The underlying physical process of nuclear body formation remains unclear, but phytochrome B is thought to coagulate via a simple protein-protein binding process. We measure, for the first time, the distribution of the number of phytochrome B-containing NBs as well as their volume distribution. We show that the experimental data cannot be explained by a stochastic model of nuclear body formation via simple protein-protein binding processes using physically meaningful parameter values. Rather modelling suggests that the data is consistent with a two step process: a fast nucleation step leading to macroparticles followed by a subsequent slow step in which the macroparticles bind to form the nuclear body. An alternative explanation for the observed nuclear body distribution is that the phytochromes bind to a so far unknown molecular structure. We believe it is likely this result holds more generally for other nuclear body-forming plant photoreceptors and proteins.
    Keywords biological physics ; nuclear bodies ; phytochrome signaling ; plant biology ; stochastic modelling
    Subject code 612
    Language English
    Publishing country nl
    Document type Article ; Online
    ZDB-ID 2133216-2
    ISSN 1478-3975 ; 1478-3967
    ISSN (online) 1478-3975
    ISSN 1478-3967
    Database BASE - Bielefeld Academic Search Engine (life sciences selection)

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