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Article ; Online: Ocular inflammatory events following COVID-19 vaccination: reporting of suspected adverse drug reactions to regulatory authorities in the UK.

Testi, Ilaria / Soomro, Taha / Pavesio, Carlos / Solebo, Ameenat Lola

2024

Abstract: Background/aims: The UK Medicines and Healthcare products Regulatory Agency (MHRA) has published suspected adverse drug reactions to vaccines against COVID-19. Ocular inflammatory events following COVID-19 vaccination have been reported worldwide.: ... ...

Abstract	Background/aims: The UK Medicines and Healthcare products Regulatory Agency (MHRA) has published suspected adverse drug reactions to vaccines against COVID-19. Ocular inflammatory events following COVID-19 vaccination have been reported worldwide. Methods: We analysed MHRA data on spontaneous reports of suspected ocular inflammatory events following COVID-19 vaccination between January 2021 and September 2022. Results: The MHRA received 300 UK spontaneous suspected reports of ocular inflammatory events following COVID-19 vaccination, with a calculated prevalence of 6.6 events per 1 000 000 vaccinated individuals. Anterior uveitis was the most common phenotype (58.3%), followed by optic neuritis in 39.3%. Median number of days between vaccination and onset was 8 days. Resolution of the event was seen in 52.3%. Conclusion: Ocular inflammatory events following COVID-19 vaccination have a very rare prevalence in the UK. There is no increase in the reporting rate of uveitis, optic neuritis and scleritis following COVID-19 vaccination when compared with the range of incidence in the UK population. The Yellow Card System represents a vital instrument within the domain of pharmacovigilance, empowering patients and healthcare professionals to contribute to the ongoing monitoring of medication safety.
Language	English
Publishing date	2024-01-22
Publishing country	England
Document type	Journal Article
ZDB-ID	80078-8
ISSN	1468-2079 ; 0007-1161
ISSN (online)	1468-2079
ISSN	0007-1161
DOI	10.1136/bjo-2023-324503
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Article ; Online: Safety, structure and function five years after hESC-RPE patch transplantation in acute neovascular AMD with submacular haemorrhage.

Soomro, Taha / Georgiadis, Odysseus / Coffey, Peter J / da Cruz, Lyndon

Graefe's archive for clinical and experimental ophthalmology = Albrecht von Graefes Archiv fur klinische und experimentelle Ophthalmologie

2024

Language	English
Publishing date	2024-04-05
Publishing country	Germany
Document type	Journal Article
ZDB-ID	8435-9
ISSN	1435-702X ; 0721-832X
ISSN (online)	1435-702X
ISSN	0721-832X
DOI	10.1007/s00417-024-06463-4
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Article ; Online: Recent advances in imaging technologies for assessment of retinal diseases.

Soomro, Taha / Shah, Neil / Niestrata-Ortiz, Magdalena / Yap, Timothy / Normando, Eduardo M / Cordeiro, M Francesca

Expert review of medical devices

2020 Volume 17, Issue 10, Page(s) 1095–1108

Abstract: Introduction: Retinal imaging is a key investigation in ophthalmology. New devices continue to be created to keep up with the demand for better imaging modalities in this field. This review looks to highlight current trends and the future of retinal ... ...

Abstract	Introduction: Retinal imaging is a key investigation in ophthalmology. New devices continue to be created to keep up with the demand for better imaging modalities in this field. This review looks to highlight current trends and the future of retinal imaging. Areas covered: This review looks at the advances in topographical imaging, photoacoustic microscopy, optical coherence tomography and molecular imaging. There is future scoping on further advances in retinal imaging. Expert opinion: Retinal imaging continues to develop at a rapid pace to improve diagnosis and management of patients. We will see the development of big data to gain powerful insights and new technologies such as teleophthalmology mature in the future.
MeSH term(s)	Angiography ; Fundus Oculi ; Humans ; Imaging, Three-Dimensional/trends ; Ophthalmoscopy ; Retinal Diseases/diagnostic imaging ; Tomography, Optical Coherence
Language	English
Publishing date	2020-09-15
Publishing country	England
Document type	Journal Article ; Review
ZDB-ID	2250857-0
ISSN	1745-2422 ; 1743-4440
ISSN (online)	1745-2422
ISSN	1743-4440
DOI	10.1080/17434440.2020.1816167
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Article ; Online: Acute Macular Neuroretinopathy Associated with Acute Influenza Virus Infection.

Ashfaq, Imran / Vrahimi, Maria / Waugh, Sheila / Soomro, Taha / Grinton, Michael E / Browning, Andrew C

Ocular immunology and inflammation

2019 Volume 29, Issue 2, Page(s) 333–339

Abstract: ... ...

Abstract	Purpose
MeSH term(s)	Adolescent ; Adult ; DNA, Viral/analysis ; Eye Infections, Viral/complications ; Eye Infections, Viral/diagnosis ; Eye Infections, Viral/virology ; Female ; Fluorescein Angiography/methods ; Fundus Oculi ; Humans ; Influenza A virus/genetics ; Influenza, Human/complications ; Influenza, Human/diagnosis ; Influenza, Human/virology ; Macula Lutea/diagnostic imaging ; Prospective Studies ; Tomography, Optical Coherence/methods ; Visual Acuity ; White Dot Syndromes/diagnosis ; White Dot Syndromes/etiology ; Young Adult
Chemical Substances	DNA, Viral
Language	English
Publishing date	2019-11-07
Publishing country	England
Document type	Journal Article ; Observational Study
ZDB-ID	1193873-0
ISSN	1744-5078 ; 0927-3948
ISSN (online)	1744-5078
ISSN	0927-3948
DOI	10.1080/09273948.2019.1681470
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Article ; Online: The Role of New Imaging Methods in Managing Age-Related Macular Degeneration.

Talks, Stephen James / Aftab, Akhunzada Muhammad / Ashfaq, Imran / Soomro, Taha

Asia-Pacific journal of ophthalmology (Philadelphia, Pa.)

2017 Volume 6, Issue 6, Page(s) 498–507

Abstract: The use of imaging for age-related macular degeneration (AMD) depends on how it benefits clinical management and on reimbursement. The latter should relate to the former. This review assesses how different forms of AMD can be imaged and what information ... ...

Abstract	The use of imaging for age-related macular degeneration (AMD) depends on how it benefits clinical management and on reimbursement. The latter should relate to the former. This review assesses how different forms of AMD can be imaged and what information this provides. For nonneovascular AMD high-resolution optical coherence tomography (OCT), autofluorescence, and near infrared imaging can identify the type of drusen, such as reticular pseudodrusen, which influences prognosis, and the amount of atrophy, for which phase 3 trials are underway. Clarifying the correct diagnosis for late-onset Stargardt and macular telangiectasia, if treatment becomes available, will be especially important. Choroidal thickness can be measured and changes with anti‒vascular endothelial growth factor treatment, but how this influences management is less clear. The finding of a thick choroid may alter the diagnosis to pachychoroid neovasculopathy, which may have a different treatment response. Peripheral retinal changes are commonly found on ultrawide-field imaging but their importance is not yet determined. The mainstay of imaging is OCT, which can detect neovascular AMD by detecting thickening and be used for follow-up, as the presence or absence of thickening is the main determinant of treatment. Higher resolution systems and now OCT angiography are able to distinguish neovascular type, especially type 2 choroidal neovascularization but also polypoidal choroidal vasculopathy and retinal angiomatous proliferation. Fundus fluorescein and indocyanine green angiographies still have a role, although that partly depends on whether photodynamic therapy is being considered. Automated image analysis and machine learning will be increasingly important in supporting clinician decisions.
MeSH term(s)	Choroidal Neovascularization/diagnostic imaging ; Diagnostic Techniques, Ophthalmological ; Fluorescein Angiography ; Geographic Atrophy/diagnostic imaging ; Humans ; Macular Degeneration/diagnostic imaging ; Tomography, Optical Coherence/methods
Language	English
Publishing date	2017-09-14
Publishing country	United States
Document type	Journal Article ; Review
ZDB-ID	2756329-7
ISSN	2162-0989 ; 2162-0989
ISSN (online)	2162-0989
ISSN	2162-0989
DOI	10.22608/APO.2017305
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Article ; Online: Three-year real-world outcomes of intravitreal anti-VEGF therapies in patients affected by myopic choroidal neovascularization.

Corazza, Paolo / Kabbani, Jamil / Soomro, Taha / Alam, Mostafa Mohamed Ragheb / D'Alterio, Francesco Maria / Younis, Saad

European journal of ophthalmology

2020 Volume 31, Issue 5, Page(s) 2481–2487

Abstract: Purpose: To describe real world data in patients affected by myopic choroidal neovascularization (CNV) treated with anti-vascular endothelial growth factors (VEGFs) and to compare our results with previous studies and clinical trials.: Methods: This ... ...

Abstract	Purpose: To describe real world data in patients affected by myopic choroidal neovascularization (CNV) treated with anti-vascular endothelial growth factors (VEGFs) and to compare our results with previous studies and clinical trials. Methods: This retrospective monocentric cohort study analyzed 96 eyes of 96 myopic-CNV patients treated with an anti-VEGF pro-re-nata regimen over a 3-year-long follow up period. Aflibercept and Ranibizumab were considered as first-line agents whereas Bevacizumab was reserved on a compassionate basis in patients outside the criteria for treatment. All patients underwent a best-corrected visual acuity (BCVA) recording at each follow up visit. Results: Our data showed that all three molecules produced significant improvements in BCVA at year 1, with no significant differences between the three drugs. Moreover, during the second year of treatment, Ranibizumab and Bevacizumab showed a significant improvement in the visual function. However, at year 3 of treatment, the data available indicated the BCVA improvement was not significant with Ranibizumab and Bevacizumab. In addition, no significant difference in the average number of injections between the three groups was detected over the follow up period. No serious adverse events were recorded, but five minor adverse events documented. Conclusion: Our study correlates with previous studies showing significant BCVA gains with the use of these molecules. Similarly, all three molecules seem to provide a similar duration of effects as previous studies have shown, with a low ocular adverse event rate.
MeSH term(s)	Angiogenesis Inhibitors/therapeutic use ; Bevacizumab/therapeutic use ; Choroidal Neovascularization/drug therapy ; Cohort Studies ; Follow-Up Studies ; Humans ; Intravitreal Injections ; Ranibizumab/therapeutic use ; Retrospective Studies ; Vascular Endothelial Growth Factor A ; Vascular Endothelial Growth Factors/therapeutic use ; Visual Acuity
Chemical Substances	Angiogenesis Inhibitors ; Vascular Endothelial Growth Factor A ; Vascular Endothelial Growth Factors ; Bevacizumab (2S9ZZM9Q9V) ; Ranibizumab (ZL1R02VT79)
Language	English
Publishing date	2020-11-02
Publishing country	United States
Document type	Journal Article
ZDB-ID	1089461-5
ISSN	1724-6016 ; 1120-6721
ISSN (online)	1724-6016
ISSN	1120-6721
DOI	10.1177/1120672120963455
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Article ; Online: Endothelial Insulin Receptors Promote VEGF-A Signaling via ERK1/2 and Sprouting Angiogenesis.

Walker, Andrew M N / Warmke, Nele / Mercer, Ben / Watt, Nicole T / Mughal, Romana / Smith, Jessica / Galloway, Stacey / Haywood, Natalie J / Soomro, Taha / Griffin, Kathryn J / Wheatcroft, Stephen B / Yuldasheva, Nadira Y / Beech, David J / Carmeliet, Peter / Kearney, Mark T / Cubbon, Richard M

Endocrinology

2021 Volume 162, Issue 8

Abstract: Endothelial insulin receptors (Insr) promote sprouting angiogenesis, although the underpinning cellular and molecular mechanisms are unknown. Comparing mice with whole-body insulin receptor haploinsufficiency (Insr+/-) against littermate controls, we ... ...

Abstract	Endothelial insulin receptors (Insr) promote sprouting angiogenesis, although the underpinning cellular and molecular mechanisms are unknown. Comparing mice with whole-body insulin receptor haploinsufficiency (Insr+/-) against littermate controls, we found impaired limb perfusion and muscle capillary density after inducing hind-limb ischemia; this was in spite of increased expression of the proangiogenic growth factor Vegfa. Insr+/- neonatal retinas exhibited reduced tip cell number and branching complexity during developmental angiogenesis, which was also found in separate studies of mice with endothelium-restricted Insr haploinsufficiency. Functional responses to vascular endothelial growth factor A (VEGF-A), including in vitro angiogenesis, were also impaired in aortic rings and pulmonary endothelial cells from Insr+/- mice. Human umbilical vein endothelial cells with shRNA-mediated knockdown of Insr also demonstrated impaired functional angiogenic responses to VEGF-A. VEGF-A signaling to Akt and endothelial nitric oxide synthase was intact, but downstream signaling to extracellular signal-reduced kinase 1/2 (ERK1/2) was impaired, as was VEGF receptor-2 (VEGFR-2) internalization, which is required specifically for signaling to ERK1/2. Hence, endothelial insulin receptors facilitate the functional response to VEGF-A during angiogenic sprouting and are required for appropriate signal transduction from VEGFR-2 to ERK1/2.
MeSH term(s)	Animals ; Endothelium, Vascular/metabolism ; Human Umbilical Vein Endothelial Cells ; Humans ; MAP Kinase Signaling System ; Male ; Mice, Inbred C57BL ; Mice, Knockout ; Neovascularization, Pathologic ; Neovascularization, Physiologic ; Receptor, Insulin/metabolism ; Vascular Endothelial Growth Factor A/metabolism ; Vascular Endothelial Growth Factor Receptor-2/metabolism ; Mice
Chemical Substances	Vascular Endothelial Growth Factor A ; Kdr protein, mouse (EC 2.7.10.1) ; Receptor, Insulin (EC 2.7.10.1) ; Vascular Endothelial Growth Factor Receptor-2 (EC 2.7.10.1)
Language	English
Publishing date	2021-05-26
Publishing country	United States
Document type	Journal Article ; Research Support, Non-U.S. Gov't
ZDB-ID	427856-2
ISSN	1945-7170 ; 0013-7227
ISSN (online)	1945-7170
ISSN	0013-7227
DOI	10.1210/endocr/bqab104
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Article ; Online: Longitudinal Examination of Fellow-Eye Vascular Anomalies in Coats' Disease With Widefield Fluorescein Angiography: A Multicenter Study.

Jeng-Miller, Karen W / Soomro, Taha / Scott, Nathan L / Rao, Prethy / Marlow, Elizabeth / Chang, Emmanuel Y / Ells, Anna / Chau, Felix / Nudleman, Eric / Calvo, Charles M / Patel, Nish / Schwartz, Roy / Cernichiaro-Espinosa, Linda A / Montoya, Alexandrea Gabrielle / Goldstein, Jessica / Harper, C Armitage / Baumal, Caroline R / Hartnett, Mary Elizabeth / Harbour, J William /

Besirli, Cagri G / Gupta, Mrinali P / Chan, R V Paul / Drenser, Kimberly A / Capone, Antonio / Murray, Timothy G / Mukai, Shizuo / Trese, Michael T / Berrocal, Audina M / Wong, Sui Chien / Yonekawa, Yoshihiro

Ophthalmic surgery, lasers & imaging retina

2019 Volume 50, Issue 4, Page(s) 221–227

Abstract: Background and objective: Retinovascular anomalies in the fellow eyes of patients with Coats' disease have been described, but the clinical significance is unknown, as well as whether these lesions progress over time.: Patients and methods: This is ... ...

Abstract	Background and objective: Retinovascular anomalies in the fellow eyes of patients with Coats' disease have been described, but the clinical significance is unknown, as well as whether these lesions progress over time. Patients and methods: This is an international, multicenter, retrospective, observational cohort study of fellow-eye abnormalities on widefield fluorescein angiography in patients with Coats' disease. Results: Three hundred fifty eyes of 175 patients with Coats' disease were analyzed. A total of 33 patients (18.8%) demonstrated abnormal fellow-eye findings: 14 (42.4%) telangiectasias, 18 (54.5%) aneurysms, six (18.2%) segmental non-perfusion, six (18.2%) leakage, and two (6.0%) vascular tortuosity. All eyes were asymptomatic, and none of the lesions progressed over time. There was no association between fellow-eye findings with severity of Coats' disease (P = .16), patient age (P = .16), or presence of systemic vascular disease (P = .16). Conclusions: The vascular abnormalities in fellow eyes of patients with Coats' disease did not progress over time. Observation is a reasonable initial management strategy. [Ophthalmic Surg Lasers Imaging Retina. 2019;50:221-227.].
MeSH term(s)	Child ; Eye Abnormalities/complications ; Eye Abnormalities/diagnosis ; Female ; Fluorescein Angiography/methods ; Follow-Up Studies ; Fundus Oculi ; Humans ; Male ; Retinal Telangiectasis/complications ; Retinal Telangiectasis/diagnosis ; Retinal Vessels/abnormalities ; Retinal Vessels/diagnostic imaging ; Retrospective Studies ; Time Factors ; Tomography, Optical Coherence/methods ; Visual Acuity
Language	English
Publishing date	2019-04-17
Publishing country	United States
Document type	Journal Article ; Multicenter Study ; Observational Study ; Research Support, N.I.H., Extramural ; Research Support, Non-U.S. Gov't
ZDB-ID	2701167-7
ISSN	2325-8179 ; 2325-8160
ISSN (online)	2325-8179
ISSN	2325-8160
DOI	10.3928/23258160-20190401-04
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