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  1. Article ; Online: Trigeminal trophic syndrome after ischaemic stroke.

    Moreiras Arias, Noelia / Sopeña, Bernardo / Sainz Gaspar, Laura

    Medicina clinica

    2021  Volume 158, Issue 1, Page(s) 38–39

    Title translation Síndrome trófico del trigémino tras ictus isquémico.
    MeSH term(s) Brain Ischemia/complications ; Humans ; Ischemic Stroke ; Skin Ulcer/etiology ; Stroke/complications
    Language Spanish
    Publishing date 2021-06-12
    Publishing country Spain
    Document type Letter
    ZDB-ID 411607-0
    ISSN 1578-8989 ; 0025-7753
    ISSN (online) 1578-8989
    ISSN 0025-7753
    DOI 10.1016/j.medcli.2021.03.016
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  2. Article ; Online: Efficacy of Canakinumab in a Patient With Adult-Onset Glucocorticoid-Resistant Periodic Fever, Aphthous Stomatitis, Pharyngitis and Cervical Adenitis (PFAPA) Syndrome.

    Sopeña, Bernardo / Araújo, Olga / Freire, Mayka / Barrera-López, Lucía / José, Hernández-Rodríguez

    Modern rheumatology case reports

    2022  

    Abstract: Periodic fever, aphthous stomatitis, pharyngitis and cervical adenitis (PFAPA) syndrome, a polygenic or multifactorial condition, is the most frequent autoinflammatory disease in children. There is increasing evidence that some patients may have a ... ...

    Abstract Periodic fever, aphthous stomatitis, pharyngitis and cervical adenitis (PFAPA) syndrome, a polygenic or multifactorial condition, is the most frequent autoinflammatory disease in children. There is increasing evidence that some patients may have a disease onset during adulthood. With regard to PFAPA syndrome treatment, single medium-to-high doses of glucocorticoids during flares constitute the therapy of choice in children and adults, colchicine may be useful in some patients and tonsillectomy has been reported of utility mainly in pediatric patients. Interleukin-1 (IL-1) blockers have been sporadically used with good response in glucocorticoid-resistant cases. We report a patient with an adult-onset of glucocorticoid-resistant PFAPA syndrome and inconsistent response to colchicine and anakinra, who later achieved a complete and sustained response to canakinumab. Although canakinumab seems to be a good therapeutic option in pediatric and adult patients with refractory PFAPA syndrome, the best anti-IL-1 agent and the sequence of administration have to be still determined in well-designed clinical trials.
    Language English
    Publishing date 2022-05-27
    Publishing country England
    Document type Journal Article
    ISSN 2472-5625
    ISSN (online) 2472-5625
    DOI 10.1093/mrcr/rxac043
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  3. Article ; Online: Guillain Barré syndrome associated with COVID-19- lessons learned about its pathogenesis during the first year of the pandemic, a systematic review.

    Freire, Mayka / Andrade, Ariadna / Sopeña, Bernardo / Lopez-Rodriguez, Maria / Varela, Pablo / Cacabelos, Purificación / Esteban, Helena / González-Quintela, Arturo

    Autoimmunity reviews

    2021  Volume 20, Issue 8, Page(s) 102875

    MeSH term(s) COVID-19 ; Guillain-Barre Syndrome/epidemiology ; Guillain-Barre Syndrome/etiology ; Humans ; Pandemics ; SARS-CoV-2
    Language English
    Publishing date 2021-06-10
    Publishing country Netherlands
    Document type Letter ; Systematic Review
    ZDB-ID 2144145-5
    ISSN 1873-0183 ; 1568-9972
    ISSN (online) 1873-0183
    ISSN 1568-9972
    DOI 10.1016/j.autrev.2021.102875
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    Zs.A 5913: Show issues Location:
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  4. Article ; Online: Factors associated with serum IgM concentrations: a general adult population study.

    Carballo, Iago / Alonso-Sampedro, Manuela / Escribano, Rosa-María / Fernandez-Merino, Carmen / Sopeña, Bernardo / Vidal, Carmen / Gude, Francisco / Gonzalez-Quintela, Arturo

    Scandinavian journal of clinical and laboratory investigation

    2021  Volume 81, Issue 6, Page(s) 454–460

    Abstract: Background and aim: To investigate the influence of common factors on serum immunoglobulin M (IgM) concentrations in adults, and clinical associations with high and low values.: Methods: We measured serum IgM levels using immunonephelometry in a ... ...

    Abstract Background and aim: To investigate the influence of common factors on serum immunoglobulin M (IgM) concentrations in adults, and clinical associations with high and low values.
    Methods: We measured serum IgM levels using immunonephelometry in a random sample of 1510 individuals (aged 18-91 years, 44.7% male). We obtained data defining metabolic syndrome from all participants, defined atopy by skin prick tests to aeroallergens, and assessed lifestyle factors by questionnaire.
    Results: Women showed higher IgM concentrations than men; 95 (6.3%, mostly male) individuals showed low (<0.40 g/L) IgM values, and 64 (4.2%, mostly female) showed high (>2.30 g/L) IgM values. Individuals with abnormal IgM concentrations had no history of opportunistic infections nor a different atopy prevalence. Serum IgM concentrations decreased with age, and obesity was negatively associated with IgM concentrations. Alcohol consumption, smoking, physical activity, and metabolic syndrome had no significant influence in the multivariate analyses.
    Conclusions: Many adults in the general population show abnormally high or low IgM concentrations with no evidence of immunodeficiency-associated diseases. Sex and age should be considered when defining reference IgM concentrations.
    MeSH term(s) Adolescent ; Adult ; Age Factors ; Aged ; Aged, 80 and over ; Female ; Humans ; Immunoglobulin M/blood ; Linear Models ; Male ; Middle Aged ; Multivariate Analysis ; Risk Factors ; Young Adult
    Chemical Substances Immunoglobulin M
    Language English
    Publishing date 2021-07-08
    Publishing country England
    Document type Journal Article
    ZDB-ID 3150-1
    ISSN 1502-7686 ; 0036-5513
    ISSN (online) 1502-7686
    ISSN 0036-5513
    DOI 10.1080/00365513.2021.1946843
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    Ud II Zs.150: Show issues Location:
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  5. Article ; Online: Limited diagnostic value of total serum IgG4 measurements in adult patients.

    Carballo, Iago / Sopeña, Bernardo / Freire, Mayka / Vidal, Carmen / Gonzalez-Quintela, Arturo

    Annals of allergy, asthma & immunology : official publication of the American College of Allergy, Asthma, & Immunology

    2019  Volume 124, Issue 2, Page(s) 202–203

    MeSH term(s) Biomarkers ; Humans ; Hypersensitivity/blood ; Hypersensitivity/diagnosis ; Hypersensitivity/immunology ; Immunoglobulin G/blood ; Immunoglobulin G/immunology ; Prognosis
    Chemical Substances Biomarkers ; Immunoglobulin G
    Language English
    Publishing date 2019-11-20
    Publishing country United States
    Document type Letter ; Research Support, Non-U.S. Gov't
    ZDB-ID 1228189-x
    ISSN 1534-4436 ; 0003-4738 ; 1081-1206
    ISSN (online) 1534-4436
    ISSN 0003-4738 ; 1081-1206
    DOI 10.1016/j.anai.2019.11.013
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    Uh III Zs.136: Show issues Location:
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  6. Article ; Online: C-Reactive Protein versus Erythrocyte Sedimentation Rate: Implications Among Patients with No Known Inflammatory Conditions.

    Alende-Castro, Vanessa / Alonso-Sampedro, Manuela / Fernández-Merino, Carmen / Sánchez-Castro, Juan / Sopeña, Bernardo / Gude, Francisco / Gonzalez-Quintela, Arturo

    Journal of the American Board of Family Medicine : JABFM

    2020  Volume 34, Issue 5, Page(s) 974–983

    Abstract: Background: Measurements of C-reactive protein (CRP) concentration and erythrocyte sedimentation rate (ESR) are frequently ordered jointly in clinical practice.: Aim: To investigate the factors associated with discordances between CRP concentration ... ...

    Abstract Background: Measurements of C-reactive protein (CRP) concentration and erythrocyte sedimentation rate (ESR) are frequently ordered jointly in clinical practice.
    Aim: To investigate the factors associated with discordances between CRP concentration and ESR in adults.
    Methods: We conducted a cross-sectional study of 1472 adults with no known inflammatory disorders (44.5% male; median age, 52 years; range, 18-91 years), randomly selected from a municipality in Spain. The participants underwent simultaneous measurements of ESR, serum CRP, and interleukin-6 concentrations. Alcohol consumption, smoking, and physical activity were evaluated by questionnaire. Body mass index (BMI) measurement and metabolic syndrome criteria were available for all participants.
    Results: Most (n = 1123, 74.9%) of the participants showed normal CRP and ESR values. Sixty-nine (4.6%) participants showed high CRP and ESR values. Seventy-two (4.8%) participants showed a discordant pattern of high ESR and normal CRP values, which was associated with age after adjusting for sex, alcohol consumption, physical activity, BMI, and the presence of metabolic syndrome (odds ratio [OR], 1.052; 95% CI, 1.034-1.071;
    Conclusion: In this general adult population with no overt inflammatory disease, the discordant pattern of high ESR and normal CRP was associated with greater age, whereas the pattern of high CRP and normal ESR was associated with higher BMI.
    MeSH term(s) Adolescent ; Adult ; Aged ; Aged, 80 and over ; Biomarkers ; Blood Sedimentation ; Body Mass Index ; C-Reactive Protein/analysis ; Cross-Sectional Studies ; Exercise ; Female ; Humans ; Male ; Middle Aged
    Chemical Substances Biomarkers ; C-Reactive Protein (9007-41-4)
    Language English
    Publishing date 2020-12-03
    Publishing country United States
    Document type Journal Article ; Research Support, Non-U.S. Gov't
    ZDB-ID 2239939-2
    ISSN 1558-7118 ; 1557-2625
    ISSN (online) 1558-7118
    ISSN 1557-2625
    DOI 10.3122/jabfm.2021.05.210072
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    Zs.A 2626: Show issues Location:
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  7. Article ; Online: Being an internist throughout the world - same name, different training curricula.

    Freire, Mayka / Sopeña, Bernardo / Carballo, Iago / Diaz-Peromingo, José A / Vazquez-Agra, Nestor / Gonzalez-Quintela, Arturo

    Internal medicine journal

    2020  Volume 50, Issue 2, Page(s) 235–238

    Abstract: In the 79 countries revised, two fundamental internal medicine (IM) training patterns were in evidence, first, only basic training needed, requiring a 3-4-year residency period for obtaining the diploma of internist; and advanced training needed, ... ...

    Abstract In the 79 countries revised, two fundamental internal medicine (IM) training patterns were in evidence, first, only basic training needed, requiring a 3-4-year residency period for obtaining the diploma of internist; and advanced training needed, requiring 5-7 years of study. Second, evaluation of common IM training for sub-specialists revealed the following three patterns: dual training; core training and separate training.
    MeSH term(s) Curriculum ; Humans ; Internal Medicine/education ; Internship and Residency/organization & administration ; Specialization
    Language English
    Publishing date 2020-04-13
    Publishing country Australia
    Document type Journal Article
    ZDB-ID 2045436-3
    ISSN 1445-5994 ; 1444-0903
    ISSN (online) 1445-5994
    ISSN 1444-0903
    DOI 10.1111/imj.14733
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    Zs.A 792: Show issues Location:
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    Zs.MO 424: Show issues

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  8. Article ; Online: Serum immunoglobulin-A (IgA) concentrations in a general adult population: association with demographics and prevalence of selective IgA deficiency.

    Dieguez-Alvarez, Mar / Carballo, Iago / Alonso-Sampedro, Manuela / Sopeña, Bernardo / Gude, Francisco / Gonzalez-Quintela, Arturo

    Clinical chemistry and laboratory medicine

    2019  Volume 58, Issue 4, Page(s) e109–e112

    MeSH term(s) Adolescent ; Adult ; Aged ; Aged, 80 and over ; Cross-Sectional Studies ; Female ; Genotype ; Humans ; IgA Deficiency/diagnosis ; IgA Deficiency/epidemiology ; IgA Deficiency/genetics ; Immunoglobulin A/blood ; Male ; Middle Aged ; Polymorphism, Single Nucleotide ; Prevalence ; Spain/epidemiology ; Young Adult
    Chemical Substances Immunoglobulin A
    Language English
    Publishing date 2019-11-01
    Publishing country Germany
    Document type Letter
    ZDB-ID 1418007-8
    ISSN 1437-4331 ; 1434-6621 ; 1437-8523
    ISSN (online) 1437-4331
    ISSN 1434-6621 ; 1437-8523
    DOI 10.1515/cclm-2019-0957
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    Zs.A 121: Show issues Location:
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  9. Article ; Online: Exposure to different occupational chemicals and clinical phenotype of a cohort of patients with systemic sclerosis.

    Freire, Mayka / Sopeña, Bernardo / González-Quintela, Arturo / Del Castillo, Alfredo Guillén / Moraga, Eduardo Callejas / Lledó-Ibañez, Gema M / Rubio-Rivas, Manuel / Trapiella, Luis / Argibay, Ana / Tolosa, Carles / Alfonso, Begoña Marí / Vargas-Hitos, Jose Antonio / Salas, Xavier Pla / González-Echávarri, Cristina / Chamorro, Antonio-J / Fraile, Isabel Perales / García, Andrés González / de la Red Bellvis, Gloria / Bello, David Bernal /
    Salomó, Antoni Castro / Jiménez Pérez de Heredia, Iratxe / Marín-Ballve, Adela / Rodríguez-Pintó, Ignasi / Saez-Comet, Luis / Ortego-Centeno, Norberto / Todolí-Parra, José Antonio / Fonollosa Pla, Vicent / Simeón-Aznar, Carmen Pilar

    Autoimmunity reviews

    2024  Volume 23, Issue 5, Page(s) 103542

    Language English
    Publishing date 2024-04-08
    Publishing country Netherlands
    Document type Letter
    ZDB-ID 2144145-5
    ISSN 1873-0183 ; 1568-9972
    ISSN (online) 1873-0183
    ISSN 1568-9972
    DOI 10.1016/j.autrev.2024.103542
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    Zs.A 5913: Show issues Location:
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  10. Article: Visible gallbladder: a variant of the Courvoisier sign.

    Sopena, Bernardo / Sousa, Josefa

    Mayo Clinic proceedings

    2007  Volume 82, Issue 7, Page(s) 791

    MeSH term(s) Aged, 80 and over ; Cholangiopancreatography, Magnetic Resonance ; Cholestasis/diagnostic imaging ; Cholestasis/physiopathology ; Cholestasis/therapy ; Humans ; Male ; Radiography ; Stents
    Language English
    Publishing date 2007-07
    Publishing country England
    Document type Case Reports ; Journal Article
    ZDB-ID 124027-4
    ISSN 1942-5546 ; 0025-6196
    ISSN (online) 1942-5546
    ISSN 0025-6196
    DOI 10.4065/82.7.791
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