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  1. Article ; Online: Coxiella burnetii Femoro-Popliteal Bypass Infection

    Farah Azouzi / Louis Olagne / Sophie Edouard / Serge Cammilleri / Pierre-Edouard Magnan / Pierre-Edouard Fournier / Matthieu Million

    Microorganisms, Vol 11, Iss 2146, p

    A Case Report

    2023  Volume 2146

    Abstract: Cardiovascular infections are the most severe and potentially lethal among the persistent focalized Coxiella burnetii infections. While aortic infections on aneurysms or prostheses are well-known, with specific complications (risk of fatal rupture), new ... ...

    Abstract Cardiovascular infections are the most severe and potentially lethal among the persistent focalized Coxiella burnetii infections. While aortic infections on aneurysms or prostheses are well-known, with specific complications (risk of fatal rupture), new non-aortic vascular infections are increasingly being described thanks to the emerging use of 18-fluorodeoxyglucose positron emission tomography ( 18 F-FDG PET-scan). Here, we describe an infection of a femoro-popliteal bypass that would not have been diagnosed without the use of PET-scan. It is well-known that vascular prosthetic material is a site favorable for bacterial persistence, but the description of unusual anatomical sites, outside the heart or aorta, should raise the clinicians’ awareness and generalize the indications for PET-scan, with careful inclusion of the upper and lower limbs (not included in PET-scan for cancer), particularly in the presence of vascular prostheses. Future studies will be needed to precisely determine their optimal management.
    Keywords Q fever ; Coxiella burnetii ; PET-scan ; vascular graft infection ; Biology (General) ; QH301-705.5
    Subject code 333
    Language English
    Publishing date 2023-08-01T00:00:00Z
    Publisher MDPI AG
    Document type Article ; Online
    Database BASE - Bielefeld Academic Search Engine (life sciences selection)

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  2. Article ; Online: Contagion Management at the Méditerranée Infection University Hospital Institute

    Pierre-Edouard Fournier / Sophie Edouard / Nathalie Wurtz / Justine Raclot / Marion Bechet / Christine Zandotti / Véronique Filosa / Didier Raoult / Florence Fenollar

    Journal of Clinical Medicine, Vol 10, Iss 2627, p

    2021  Volume 2627

    Abstract: The Méditerranée Infection University Hospital Institute (IHU) is located in a recent building, which includes experts on a wide range of infectious disease. The IHU strategy is to develop innovative tools, including epidemiological monitoring, point-of- ... ...

    Abstract The Méditerranée Infection University Hospital Institute (IHU) is located in a recent building, which includes experts on a wide range of infectious disease. The IHU strategy is to develop innovative tools, including epidemiological monitoring, point-of-care laboratories, and the ability to mass screen the population. In this study, we review the strategy and guidelines proposed by the IHU and its application to the COVID-19 pandemic and summarise the various challenges it raises. Early diagnosis enables contagious patients to be isolated and treatment to be initiated at an early stage to reduce the microbial load and contagiousness. In the context of the COVID-19 pandemic, we had to deal with a shortage of personal protective equipment and reagents and a massive influx of patients. Between 27 January 2020 and 5 January 2021, 434,925 nasopharyngeal samples were tested for the presence of SARS-CoV-2. Of them, 12,055 patients with COVID-19 were followed up in our out-patient clinic, and 1888 patients were hospitalised in the Institute. By constantly adapting our strategy to the ongoing situation, the IHU has succeeded in expanding and upgrading its equipment and improving circuits and flows to better manage infected patients.
    Keywords contagion ; institut hospitalo-universitaire méditerranée infection ; SARS-CoV-2 ; COVID-19 ; diagnosis ; rapid diagnostic test ; Medicine ; R
    Language English
    Publishing date 2021-06-01T00:00:00Z
    Publisher MDPI AG
    Document type Article ; Online
    Database BASE - Bielefeld Academic Search Engine (life sciences selection)

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  3. Article ; Online: Sunbathing, a possible risk factor of murine typhus infection in Greece.

    Stavroula Labropoulou / Ekatherina Charvalos / Stylianos Chatzipanagiotou / Anastasios Ioannidis / Panagiotis Sylignakis / Styliani Τaka / Ioulia Karageorgou / Maria Linou / Giota Mpizta / Andreas Mentis / Sophie Edouard / Didier Raoult / Emmanouil Angelakis

    PLoS Neglected Tropical Diseases, Vol 15, Iss 3, p e

    2021  Volume 0009186

    Abstract: Background There are few studies about the presence of murine typhus in Greece. Our objective was to conduct a large scale retrospective investigation to determine the clinical and epidemiological features of patients diagnosed with murine typhus in ... ...

    Abstract Background There are few studies about the presence of murine typhus in Greece. Our objective was to conduct a large scale retrospective investigation to determine the clinical and epidemiological features of patients diagnosed with murine typhus in Greece. Methodology/principal findings From 2012 to 2019 serum samples from hospitalized patients and outpatients throughout Greece suspected for murine typhus infection were tested by immunofluorescence assay for Rickettsia typhi. Immunofluorescence positive samples obtained since 2016 were also tested by qPCR targeting R. typhi. Clinical and epidemiological data were retrospectively collected for the patients with confirmed murine typhus. Overall, we tested 5,365 different patients and, in total, 174 patients from all geographic regions of Greece were diagnosed with murine typhus. The most frequently reported sign or symptom was fever (89%), followed by headache (84%) and rash (81%). The classical triad of fever, headache, and rash was present in 72% of patients during their illness. Severe infections with complications including acute renal failure or septic shock were not recorded. The majority of cases (81%) occurred during May-October and peaked in June and September. Most of patients (81%) infected in Athens, recalled that their only activity the last weeks before symptoms onset was swimming on the beach and 59% of them also reported an insect bite while sunbathing. Conclusions/significance Our results may reflect the reemergence of murine typhus in Greece and we highlight the importance of awareness of this difficult-to-recognize undifferentiated febrile illness.
    Keywords Arctic medicine. Tropical medicine ; RC955-962 ; Public aspects of medicine ; RA1-1270
    Subject code 616
    Language English
    Publishing date 2021-03-01T00:00:00Z
    Publisher Public Library of Science (PLoS)
    Document type Article ; Online
    Database BASE - Bielefeld Academic Search Engine (life sciences selection)

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  4. Article ; Online: “Nigerium massiliense” gen. nov., sp. nov., a new bacterium isolated from the gut from a patient with acute malnutrition

    Sory Ibrahima Traore / Souleymane Brah / Jeremy Delerce / Pierre Edouard Fournier / Didier Raoult / Sophie Edouard

    Human Microbiome Journal, Vol 1, Iss , Pp 12-

    2016  Volume 13

    Abstract: We propose the main characteristics of a new bacterium named “Nigerium massiliense” strain SIT5 (CSURP1302) that was isolated from the stool of a 2-year-old Nigerian child suffering from kwashiorkor, a form of severe acute malnutrition. Keywords: ... ...

    Abstract We propose the main characteristics of a new bacterium named “Nigerium massiliense” strain SIT5 (CSURP1302) that was isolated from the stool of a 2-year-old Nigerian child suffering from kwashiorkor, a form of severe acute malnutrition. Keywords: Culturomics, Taxonomy, Genomics, Taxono-genomics, “Nigerium massiliense”
    Keywords Medicine (General) ; R5-920 ; Microbiology ; QR1-502
    Language English
    Publishing date 2016-09-01T00:00:00Z
    Publisher Elsevier
    Document type Article ; Online
    Database BASE - Bielefeld Academic Search Engine (life sciences selection)

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  5. Article ; Online: Capybara and Brush Cutter Involvement in Q Fever Outbreak in Remote Area of Amazon Rain Forest, French Guiana, 2014

    Jacques-Robert Christen / Sophie Edouard / Thierry Lamour / Enguerrane Martinez / Claire Rousseau / Franck de Laval / François Catzeflis / Félix Djossou / Didier Raoult / Vincent Pommier de Santi / Loïc Epelboin

    Emerging Infectious Diseases, Vol 26, Iss 5, Pp 993-

    2020  Volume 997

    Abstract: We investigated a Q fever outbreak that occurred in an isolated area of the Amazon Rain Forest in French Guiana in 2014. Capybara fecal samples were positive for Coxiella burnetii DNA. Being near brush cutters in use was associated with disease ... ...

    Abstract We investigated a Q fever outbreak that occurred in an isolated area of the Amazon Rain Forest in French Guiana in 2014. Capybara fecal samples were positive for Coxiella burnetii DNA. Being near brush cutters in use was associated with disease development. Capybaras are a putative reservoir for C. burnetii.
    Keywords Q fever ; Hydrochoerus hydrochaeris ; capybara ; infectious aerosol ; brush cutter ; weed whacker ; Medicine ; R ; Infectious and parasitic diseases ; RC109-216
    Language English
    Publishing date 2020-05-01T00:00:00Z
    Publisher Centers for Disease Control and Prevention
    Document type Article ; Online
    Database BASE - Bielefeld Academic Search Engine (life sciences selection)

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  6. Article: Molecular detection of Rickettsia conorii and other zoonotic spotted fever group rickettsiae in ticks, Romania

    Ionita, Mariana / Cornelia Silaghi / Ioan Liviu Mitrea / Kurt Pfister / Philippe Parola / Sophie Edouard

    Ticks and tick-borne diseases. 2016 Feb., v. 7, no. 1

    2016  

    Abstract: The diverse tick fauna as well as the abundance of tick populations in Romania represent potential risks for both human and animal health. Spotted fever group (SFG) rickettsiae are recognized as important agents of emerging human tick-borne diseases ... ...

    Abstract The diverse tick fauna as well as the abundance of tick populations in Romania represent potential risks for both human and animal health. Spotted fever group (SFG) rickettsiae are recognized as important agents of emerging human tick-borne diseases worldwide. However, the epidemiology of rickettsial diseases has been poorly investigated in Romania. In urban habitats, companion animals which are frequently exposed to tick infestation, play a role in maintenance of tick populations and as reservoirs of tick-borne pathogens. Therefore, the aim of the present study was to investigate the occurrence of SFG rickettsiae in ticks infesting dogs in a greater urban area in South-eastern Romania. Adult ixodid ticks (n=205), including Rhipicephalus sanguineus sensu lato (n=120), Dermacentor reticulatus (n=76) and Ixodes ricinus (n=9) were collected from naturally infested dogs and were screened for SFG rickettsiae using conventional PCR followed by sequencing. Additionally, ticks were screened for DNA of Babesia spp., Hepatozoon spp., Ehrlichia canis, and Anaplasma platys. Four zoonotic SFG rickettsiae were identified: Rickettsia raoultii (16%) and Rickettsia slovaca (3%) in D. reticulatus, Rickettsia monacensis (11%) in I. ricinus, and Rickettsia conorii (0.8%) in Rh. sanguineus s.l. Moreover, pathogens of veterinary importance, such as B. canis (21%) in D. reticulatus and E. canis (7.5%) in Rh. sanguineus s.l. were identified. The findings expand the knowledge on distribution of SFG rickettsiae as well as canine pathogens in Romania. Additionally, this is the first report describing the molecular detection of R. conorii in ticks from Romania.
    Keywords adults ; Anaplasma platys ; Babesia ; Dermacentor reticulatus ; DNA ; dog diseases ; dogs ; Ehrlichia canis ; fauna ; fever ; habitats ; Hepatozoon ; humans ; Ixodes ricinus ; pathogens ; pets ; polymerase chain reaction ; Rhipicephalus sanguineus ; Rickettsia conorii ; Rickettsia slovaca ; rickettsial diseases ; risk ; tick infestations ; tick-borne diseases ; ticks ; urban areas ; Romania
    Language English
    Dates of publication 2016-02
    Size p. 150-153.
    Publishing place Elsevier GmbH
    Document type Article
    ZDB-ID 2541872-5
    ISSN 1877-9603 ; 1877-959X
    ISSN (online) 1877-9603
    ISSN 1877-959X
    DOI 10.1016/j.ttbdis.2015.10.006
    Database NAL-Catalogue (AGRICOLA)

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  7. Article ; Online: Two Human Cases of Rickettsia felis Infection, Thailand

    Sophie Edouard / Saithip Bhengsri / Scott F. Dowell / George Watt / Philippe Parola / Didier Raoult

    Emerging Infectious Diseases, Vol 20, Iss 10, Pp 1780-

    2014  Volume 1781

    Keywords Rickettsia felis ; rickettsia ; bacteria ; human infections ; fever ; PCR ; Medicine ; R ; Infectious and parasitic diseases ; RC109-216
    Language English
    Publishing date 2014-10-01T00:00:00Z
    Publisher Centers for Disease Control and Prevention
    Document type Article ; Online
    Database BASE - Bielefeld Academic Search Engine (life sciences selection)

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  8. Article: Human leptospirosis: An emerging risk in Europe?

    Dupouey, Julien / Angeli Kodjo / Benoît Faucher / Bernard Davoust / Hervé Richet / Michel Drancourt / Sophie Edouard

    Comparative immunology, microbiology, and infectious diseases. 2014 Mar., v. 37, no. 2

    2014  

    Abstract: Leptospirosis has been reemerging in both developed and developing countries including Europe, where, this phenomenon has notably been associated with urban transmission. However, the comprehensive data that are needed to fully understand the ongoing ... ...

    Abstract Leptospirosis has been reemerging in both developed and developing countries including Europe, where, this phenomenon has notably been associated with urban transmission. However, the comprehensive data that are needed to fully understand the ongoing epidemiological trends are lacking. In this article, we report surveillance data from throughout Europe, especially in France, to have an overview of this neglected disease in temperate countries. Our results underline the important role of wild rodents as reservoir of leptospirosis, and highlight the potential danger of a reemergence of this under-reported infectious disease in European cities, associated with the important expansion of the rat population in urban areas.
    Keywords cities ; developing countries ; humans ; leptospirosis ; monitoring ; rats ; risk ; urban areas ; France
    Language English
    Dates of publication 2014-03
    Size p. 77-83.
    Publishing place Elsevier Ltd
    Document type Article
    ZDB-ID 436522-7
    ISSN 1878-1667 ; 0147-9571
    ISSN (online) 1878-1667
    ISSN 0147-9571
    DOI 10.1016/j.cimid.2013.12.002
    Database NAL-Catalogue (AGRICOLA)

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  9. Article ; Online: Clustered Cases of Rickettsia sibirica mongolitimonae Infection, France

    Sophie Edouard / Philippe Parola / Cristina Socolovschi / Bernard Davoust / Bernard La Scola / Didier Raoult

    Emerging Infectious Diseases, Vol 19, Iss 2, Pp 337-

    2013  Volume 338

    Keywords Rickettsia sibirica mongolitimonae ; Rhipicephalus pusillus ; clustered cases ; bacteria ; rickettsia ; ticks ; Medicine ; R ; Infectious and parasitic diseases ; RC109-216
    Language English
    Publishing date 2013-02-01T00:00:00Z
    Publisher Centers for Disease Control and Prevention
    Document type Article ; Online
    Database BASE - Bielefeld Academic Search Engine (life sciences selection)

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  10. Article: Loss of TSS1 in hypervirulent Coxiella burnetii 175, the causative agent of Q fever in French Guiana

    D’Amato, Felicetta / Carole Eldin / Didier Raoult / Jeremy Delerce / Kalliopi Georgiades / Noémie Labas / Sophie Edouard

    Comparative immunology, microbiology, and infectious diseases. 2015 Aug., v. 41

    2015  

    Abstract: In French Guiana, the unique Coxiella burnetii circulating genotype 17 causes 24% of community-acquired pneumonia, the highest prevalence ever described. To explain this unusual virulence, we performed a comparative genomic analysis of strain Cb175, ... ...

    Abstract In French Guiana, the unique Coxiella burnetii circulating genotype 17 causes 24% of community-acquired pneumonia, the highest prevalence ever described. To explain this unusual virulence, we performed a comparative genomic analysis of strain Cb175, which was isolated from a patient from French Guiana. Cb175 has a greater number of mutations in genes involved in metabolism compared with the Nine Mile I strain. We found a 6105bp fragment missing in Cb175, which corresponds to the Type 1 secretion systems (T1SS) hlyCABD operon region. This deletion was detected by a specific qPCR in the 8 other strains available from this territory an in none of 298C.burnetii strains from other areas and other genotypes (8/8 vs 0/298, Fisher's exact test, p<0.0000001). Loss of genes implicated in secretion systems has been observed in other epidemic bacterial strains. Thus, the virulence of Cb175 may be linked to this genome reduction.
    Keywords Coxiella burnetii ; genomics ; genotype ; metabolism ; mutation ; operon ; patients ; pneumonia ; Q fever ; quantitative polymerase chain reaction ; secretion ; virulence ; French Guiana
    Language English
    Dates of publication 2015-08
    Size p. 35-41.
    Publishing place Elsevier Ltd
    Document type Article
    ZDB-ID 436522-7
    ISSN 1878-1667 ; 0147-9571
    ISSN (online) 1878-1667
    ISSN 0147-9571
    DOI 10.1016/j.cimid.2015.04.003
    Database NAL-Catalogue (AGRICOLA)

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