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Article ; Online: Anjou Vintage Bike (Anjou Vélo Vintage)

Sophie Lecomte / Océane Metais

Quality in Sport, Vol 4, Iss 1, Pp 54-

2018 Volume 65

Abstract: Purpose: To show that a local event can have an international reputation. Design / methodology / approach : We will see through the analysis of the routes, the organization of the event and the proposed animations how much Angers velo vintage can have at ...

Abstract	Purpose: To show that a local event can have an international reputation. Design / methodology / approach : We will see through the analysis of the routes, the organization of the event and the proposed animations how much Angers velo vintage can have at international and local level Research and practical limitations / implications : We will rely solely on published news articles and researches published.
Keywords	vélo ; course ; parcours ; vintage ; france ; international ; angers ; bike ; bicycle ; race ; competition ; Sports ; GV557-1198.995 ; Sports medicine ; RC1200-1245
Language	English
Publishing date	2018-06-01T00:00:00Z
Publisher	Nicolaus Copernicus University in Toruń
Document type	Article ; Online
Database	BASE - Bielefeld Academic Search Engine (life sciences selection)

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Article ; Online: A case of left foot drop as initial symptom of granulomatosis with polyangiitis

Marjolaine Weynand / Ioannis Raftakis / Mohammad Yassine Chérif / Sophie Lecomte / Valérie Badot

Clinical Case Reports, Vol 10, Iss 10, Pp n/a-n/a (2022)

Triggered by COVID‐19 disease?

2022

Abstract: Abstract In Granulomatosis with polyangiitis (GPA), involvement of the peripheral nervous system is frequent but its occurrence as an initial presentation is unusual. This case highlights the importance of this occurrence to permit an early diagnosis. ... ...

Abstract	Abstract In Granulomatosis with polyangiitis (GPA), involvement of the peripheral nervous system is frequent but its occurrence as an initial presentation is unusual. This case highlights the importance of this occurrence to permit an early diagnosis. Moreover, GPA started after a coronavirus disease 2019 infection and could have been induced by this.
Keywords	ear ; nose and throat ; neurology ; ophthalmology ; rheumatology ; Medicine ; R ; Medicine (General) ; R5-920
Language	English
Publishing date	2022-10-01T00:00:00Z
Publisher	Wiley
Document type	Article ; Online
Database	BASE - Bielefeld Academic Search Engine (life sciences selection)

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Article ; Online: Structural Dissection of the First Events Following Membrane Binding of the Islet Amyloid Polypeptide

Lucie Khemtemourian / Hebah Fatafta / Benoit Davion / Sophie Lecomte / Sabine Castano / Birgit Strodel

Frontiers in Molecular Biosciences, Vol

2022 Volume 9

Abstract: The islet amyloid polypeptide (IAPP) is the main constituent of the amyloid fibrils found in the pancreas of type 2 diabetes patients. The aggregation of IAPP is known to cause cell death, where the cell membrane plays a dual role: being a catalyst of ... ...

Abstract	The islet amyloid polypeptide (IAPP) is the main constituent of the amyloid fibrils found in the pancreas of type 2 diabetes patients. The aggregation of IAPP is known to cause cell death, where the cell membrane plays a dual role: being a catalyst of IAPP aggregation and being the target of IAPP toxicity. Using ATR-FTIR spectroscopy, transmission electron microscopy, and molecular dynamics simulations we investigate the very first molecular steps following IAPP binding to a lipid membrane. In particular, we assess the combined effects of the charge state of amino-acid residue 18 and the IAPP-membrane interactions on the structures of monomeric and aggregated IAPP. Distinct IAPP-membrane interaction modes for the various IAPP variants are revealed. Membrane binding causes IAPP to fold into an amphipathic α-helix, which in the case of H18K-, and H18R-IAPP readily moves beyond the headgroup region. For all IAPP variants but H18E-IAPP, the membrane-bound helix is an intermediate on the way to amyloid aggregation, while H18E-IAPP remains in a stable helical conformation. The fibrillar aggregates of wild-type IAPP and H18K-IAPP are dominated by an antiparallel β-sheet conformation, while H18R- and H18A-IAPP exhibit both antiparallel and parallel β-sheets as well as amorphous aggregates. Our results emphasize the decisive role of residue 18 for the structure and membrane interaction of IAPP. This residue is thus a good therapeutic target for destabilizing membrane-bound IAPP fibrils to inhibit their toxic actions.
Keywords	islet amyloid polypeptide ; type 2 diabetes mellitus ; amylin ; amyloid aggregation ; peptide-membrane interactions ; Biology (General) ; QH301-705.5
Subject code	612
Language	English
Publishing date	2022-03-01T00:00:00Z
Publisher	Frontiers Media S.A.
Document type	Article ; Online
Database	BASE - Bielefeld Academic Search Engine (life sciences selection)

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Article ; Online: Diffusion-Weighted MRI in the Evaluation of Early-Stage Breast Cancer Treated with a Short Preoperative Radiotherapy

Nathalie Hottat / Jacques Jani / Dominique Badr / Mark De Ridder / André Nazac / Katherina Vanden Houte / Sophie Lecomte / Mieke Cannie

Journal of the Belgian Society of Radiology, Vol 107, Iss

Preliminary Results

2023 Volume 1

Abstract: Objective: To assess tumor response with diffusion-weighted MRI (DW-MRI) after a short preoperative radiotherapy in early-stage breast cancer (BCa). Materials and Methods: This was a prospective, single-center pilot study. 3T-MRI were performed before ... ...

Abstract	Objective: To assess tumor response with diffusion-weighted MRI (DW-MRI) after a short preoperative radiotherapy in early-stage breast cancer (BCa). Materials and Methods: This was a prospective, single-center pilot study. 3T-MRI were performed before and after radiotherapy. The longest diameter (LD) and the apparent diffusion coefficient (ADC) value of a region of interest (ROI) of the tumors were recorded. Histopathology and immunohistochemistry, including the Ki-67 index of the core biopsy and of the surgical specimen, were the reference standards. Results: Nineteen patients with 22 early-stage BCa were included. The mean ROI ADC value was 1.093 ± 0.278 × 10-3 mm2/s before radiotherapy and 1.490 ± 0.429 × 10-3 mm2/s (p-value < 0.001) after radiotherapy. The Ki-67 index was 9.2 ± 9.1% at the percutaneous biopsy before radiotherapy and 4.9 ± 7.5% (p-value = 0.005) after radiotherapy at the surgical specimen. After neoadjuvant radiotherapy, a 4.7% decrease in LD and a 36.3% increase in ROI-ADC of the tumors were measured at MRI and a 46.7% decrease in Ki-67 index was observed at histology of the surgical specimen in comparison with the percutaneous core biopsy. Conclusion: In early-stage BCa, a significant increase in ROI-ADC at DWI and a significant decrease in Ki-67 index were observed after a short preoperative radiotherapy, suggesting early tumor response.
Keywords	apparent diffusion coefficient ; diffusion-weighted mri ; early-stage breast cancer ; ki-67 index ; neoadjuvant radiotherapy ; Medical physics. Medical radiology. Nuclear medicine ; R895-920
Subject code	610
Language	English
Publishing date	2023-02-01T00:00:00Z
Publisher	Ubiquity Press
Document type	Article ; Online
Database	BASE - Bielefeld Academic Search Engine (life sciences selection)

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Article ; Online: Structural polymorphism of the low-complexity C-terminal domain of TDP-43 amyloid aggregates revealed by solid-state NMR

Jayakrishna Shenoy / Alons Lends / Mélanie Berbon / Muhammed Bilal / Nadia El Mammeri / Mathilde Bertoni / Ahmad Saad / Estelle Morvan / Axelle Grélard / Sophie Lecomte / François-Xavier Theillet / Alexander K. Buell / Brice Kauffmann / Birgit Habenstein / Antoine Loquet

Frontiers in Molecular Biosciences, Vol

2023 Volume 10

Abstract: Aberrant aggregation of the transactive response DNA-binding protein (TDP-43) is associated with several lethal neurodegenerative diseases, including amyotrophic lateral sclerosis and frontotemporal dementia. Cytoplasmic neuronal inclusions of TDP-43 are ...

Abstract	Aberrant aggregation of the transactive response DNA-binding protein (TDP-43) is associated with several lethal neurodegenerative diseases, including amyotrophic lateral sclerosis and frontotemporal dementia. Cytoplasmic neuronal inclusions of TDP-43 are enriched in various fragments of the low-complexity C-terminal domain and are associated with different neurotoxicity. Here we dissect the structural basis of TDP-43 polymorphism using magic-angle spinning solid-state NMR spectroscopy in combination with electron microscopy and Fourier-transform infrared spectroscopy. We demonstrate that various low-complexity C-terminal fragments, namely TDP-13 (TDP-43300–414), TDP-11 (TDP-43300–399), and TDP-10 (TDP-43314–414), adopt distinct polymorphic structures in their amyloid fibrillar state. Our work demonstrates that the removal of less than 10% of the low-complexity sequence at N- and C-termini generates amyloid fibrils with comparable macroscopic features but different local structural arrangement. It highlights that the assembly mechanism of TDP-43, in addition to the aggregation of the hydrophobic region, is also driven by complex interactions involving low-complexity aggregation-prone segments that are a potential source of structural polymorphism.
Keywords	TDP-43 ; amyotrophic lateral sclerosis ; frontotemporal dementia ; amyloid ; polymorphism ; solid-state NMR ; Biology (General) ; QH301-705.5
Subject code	540
Language	English
Publishing date	2023-03-01T00:00:00Z
Publisher	Frontiers Media S.A.
Document type	Article ; Online
Database	BASE - Bielefeld Academic Search Engine (life sciences selection)

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Article ; Online: High Speed AFM and NanoInfrared Spectroscopy Investigation of Aβ1–42 Peptide Variants and Their Interaction With POPC/SM/Chol/GM1 Model Membranes

Cecile Feuillie / Eleonore Lambert / Maxime Ewald / Mehdi Azouz / Sarah Henry / Sophie Marsaudon / Christophe Cullin / Sophie Lecomte / Michael Molinari

Frontiers in Molecular Biosciences, Vol

2020 Volume 7

Abstract: Due to an aging population, neurodegenerative diseases such as Alzheimer’s disease (AD) have become a major health issue. In the case of AD, Aβ1–42 peptides have been identified as one of the markers of the disease with the formation of senile plaques ... ...

Abstract	Due to an aging population, neurodegenerative diseases such as Alzheimer’s disease (AD) have become a major health issue. In the case of AD, Aβ1–42 peptides have been identified as one of the markers of the disease with the formation of senile plaques via their aggregation, and could play a role in memory impairment and other tragic syndromes associated with the disease. Many studies have shown that not only the morphology and structure of Aβ1–42 peptide assembly are playing an important role in the formation of amyloid plaques, but also the interactions between Aβ1–42 and the cellular membrane are crucial regarding the aggregation processes and toxicity of the amyloid peptides. Despite the increasing amount of information on AD associated amyloids and their toxicity, the molecular mechanisms involved still remain unclear and require in-depth investigation at the local scale to clearly decipher the role of the sequence of the amyloid peptides, of their secondary structures, of their oligomeric states, and of their interactions with lipid membranes. In this original study, through the use of Atomic Force Microscopy (AFM) related-techniques, high-speed AFM and nanoInfrared AFM, we tried to unravel at the nanoscale the link between aggregation state, structure and interaction with membranes in the amyloid/membrane interaction. Using three mutants of Aβ peptides, L34T, oG37C, and WT Aβ1–42 peptides, with differences in morphology, structure and assembly process, as well as model lipidic membranes whose composition and structure allow interactions with the peptides, our AFM study coupling high spatial and temporal resolution and nanoscale structure information clearly evidences a local correlation between the secondary structure of the peptides, their fibrillization kinetics and their interactions with model membranes. Membrane disruption is associated to small transient oligomeric entities in the early stages of aggregation that strongly interact with the membrane, and present an antiparallel β-sheet secondary ...
Keywords	high speed atomic force microscopy ; nanoInfrared spectroscopy ; peptide Aβ ; model lipidic membranes ; Alzheimer’s disease ; Biology (General) ; QH301-705.5
Subject code	540
Language	English
Publishing date	2020-09-01T00:00:00Z
Publisher	Frontiers Media S.A.
Document type	Article ; Online
Database	BASE - Bielefeld Academic Search Engine (life sciences selection)

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Article: The effect of surfactant crystallization on partial coalescence in O/W emulsions

Goibier, Lucie / Chrystel Faure / Fernando Leal-Calderon / Sophie Lecomte

Journal of colloid and interface science. 2017 Aug. 15, v. 500

2017

Abstract: Partial coalescence is a ubiquitous instability in emulsions whose dispersed phase is partially crystallized. When emulsions are stabilized with proteins, interfacial stiffness and long-range repulsive surface forces hinder this type of instability. The ... ...

Abstract	Partial coalescence is a ubiquitous instability in emulsions whose dispersed phase is partially crystallized. When emulsions are stabilized with proteins, interfacial stiffness and long-range repulsive surface forces hinder this type of instability. The addition of low molecular weight surfactants modifies the interfacial properties and surface forces, generally promoting partial coalescence. In the present work, various surfactants (Tween® 80, palmitic acid and monoglycerides) differing in their crystallization temperature were probed for their ability to induce partial coalescence in model O/W emulsions stabilized by sodium caseinate. The initially fluid emulsions were submitted to a tempering cycle leading to the gelation of the system. The extent of partial coalescence was evaluated by measuring the bulk storage modulus. DSC was used to determine the melting range of the oil phase and surfactants, while polarized microscopy, Raman imaging, and surface rheology measurements were performed to characterize the oil/water interface. The experimental conditions in terms of droplet size, surfactant-to-protein molar ratio and tempering history favoring partial coalescence were first explored in presence of Tween® 80. We show that partial coalescence is rather marginal when crystallizable surfactants are added, and pronounced with liquid surfactants. The phenomena underlying this result, especially interfacial crystallization of surfactants, are evidenced and discussed.
Keywords	crystallization ; droplet size ; emulsions ; gelation ; liquids ; melting ; microscopy ; models ; molecular weight ; monoacylglycerols ; oils ; palmitic acid ; proteins ; Raman imaging ; rheology ; sodium caseinate ; storage modulus ; surfactants ; temperature ; tempering
Language	English
Dates of publication	2017-0815
Size	p. 304-314.
Publishing place	Elsevier Inc.
Document type	Article
ZDB-ID	241597-5
ISSN	1095-7103 ; 0021-9797
ISSN (online)	1095-7103
ISSN	0021-9797
DOI	10.1016/j.jcis.2017.04.021
Database	NAL-Catalogue (AGRICOLA)

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Article: Interfacial activity and emulsifying behaviour of inclusion complexes between helical polysaccharides and flavouring molecules resulting from non-covalent interactions

De Fenoyl, Louise / DÃ©borah Hirel / Emile Perez / Estelle Morvan / Mathieu Delample / Sophie Lecomte

Food research international. 2018 Mar., v. 105

2018

Abstract: This study deals with the fabrication of inclusion complexes starting from a cross coupling of seven helical polysaccharides (host) and six flavouring agents (guest). Neither of the substrates is considered as an emulsifier when studied alone. Due to a ... ...

Abstract	This study deals with the fabrication of inclusion complexes starting from a cross coupling of seven helical polysaccharides (host) and six flavouring agents (guest). Neither of the substrates is considered as an emulsifier when studied alone. Due to a complexation mechanism, the presence of intermolecular hydrogen bonds between substrates was highlighted by infra-red spectroscopy and Â¹Â³C NMR. In addition, depending on the polysaccharide used, the guest molecule could be preferentially located either inside or in the interstitial spaces of the helix. In a comparison between raw substrates, the inclusion complexes obtained presented the unique interfacial activity of decreasing surface tension values (Î³) and, in some cases, their behaviour in water was similar to that of regular emulsifiers due to the presence of a critical aggregation concentration (CAC). Substrate concentrations and the ratios between them were the main parameters investigated in this study, which focused on the two inclusion complexes: vanillin/amylose and vanillin/Î¹-carrageenan. The first decreased Î³ values by as much as 53mN/m with a double transition, whereas the second could cause Î³ fall to 36mN/m with a regular break. In addition, these systems were able to stabilize foams for up to 60min, which confirmed their unique emulsifying properties.
Keywords	amylose ; emulsifiers ; emulsifying ; emulsifying properties ; flavorings ; foams ; hydrogen bonding ; nuclear magnetic resonance spectroscopy ; surface tension ; vanillin
Language	English
Dates of publication	2018-03
Size	p. 801-811.
Publishing place	Elsevier Ltd
Document type	Article
ZDB-ID	1111695-x
ISSN	1873-7145 ; 0963-9969
ISSN (online)	1873-7145
ISSN	0963-9969
DOI	10.1016/j.foodres.2017.11.064
Database	NAL-Catalogue (AGRICOLA)

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Article: Hevea brasiliensis prohevein possesses a conserved C-terminal domain with amyloid-like properties in vitro

Berthelot, Karine / Ahmed Bentaleb / Bénédicte Coulary-Salin / Frédéric Peruch / Sophie Lecomte

Biochimica et biophysica acta. 2016 Apr., v. 1864, no. 4

2016

Abstract: Prohevein is a wound-induced protein and a main allergen from latex of Hevea brasiliensis (rubber tree). This 187 amino-acid protein is cleaved in two fragments: a N-terminal 43 amino-acids called hevein, a lectin bearing a chitin-binding motif with ... ...

Abstract	Prohevein is a wound-induced protein and a main allergen from latex of Hevea brasiliensis (rubber tree). This 187 amino-acid protein is cleaved in two fragments: a N-terminal 43 amino-acids called hevein, a lectin bearing a chitin-binding motif with antifungal properties and a C-terminal domain (C-ter) far less characterized. We provide here new insights on the characteristics of prohevein, hevein and C-terminal domain. Using complementary biochemical (ThT/CR/chitin binding, agglutination) and structural (modeling, ATR-FTIR, TEM, WAXS) approaches, we show that this domain clearly displays all the characteristics of an amyloid-like proteins in vitro, that could confer agglutination activity in synergy with its chitin-binding activity. Additionally, this C-ter domain is highly conserved and present in numerous plant prohevein-like proteins or pathogenesis-related (PR and WIN) proteins. This could be the hallmark of the eventual presence of proteins with amyloid properties in plants, that could potentially play a role in defense through aggregation properties.
Keywords	agglutination ; allergens ; amino acids ; amyloid ; antifungal properties ; chitin ; Fourier transform infrared spectroscopy ; Hevea brasiliensis ; hevein ; latex ; lectins ; models ; pathogenesis-related proteins ; transmission electron microscopy
Language	English
Dates of publication	2016-04
Size	p. 388-399.
Publishing place	Elsevier B.V.
Document type	Article
ZDB-ID	2918798-9
ISSN	1878-1454 ; 1570-9639
ISSN (online)	1878-1454
ISSN	1570-9639
DOI	10.1016/j.bbapap.2016.01.006
Database	NAL-Catalogue (AGRICOLA)

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Article: Stabilization of air bubbles in oil by surfactant crystals: A route to produce air-in-oil foams and air-in-oil-in-water emulsions

Brun, Mathieu / Mathieu Delample / Etienne Harte / Sophie Lecomte / Fernando Leal-Calderon

Food research international. 2015 Jan., v. 67

2015

Abstract: The incorporation of air in vegetable oils is highly sought after as it allows reducing the total fat content, while providing a light and pleasant texture. To meet consumers' requirements, nonaqueous foams must remain kinetically stable for several ... ...

Abstract	The incorporation of air in vegetable oils is highly sought after as it allows reducing the total fat content, while providing a light and pleasant texture. To meet consumers' requirements, nonaqueous foams must remain kinetically stable for several months and must withstand large deformations and flows. In this paper, we describe the fabrication of air-in-oil foams of outstanding stability, both at rest and under flow, based on the use of crystallizable surfactants (mixture of mono- and diglycerides). The air volume fraction is close to 55%, irrespective of the surfactant concentration. The air bubbles are protected against coalescence and Ostwald ripening by a dense layer of crystals. Moreover, the firmness of the surfactant crystal network formed in the oil bulk is large enough to hinder buoyancy driven phenomena. Finally, we demonstrate that the oil foams can be dispersed in an aqueous phase containing hydrocolloids to form a novel type of material: air-in-oil-in-water (A/O/W) emulsions.
Keywords	Ostwald ripening ; air ; bubbles ; crystals ; deformation ; diacylglycerols ; emulsions ; firmness ; foams ; hydrocolloids ; lipid content ; surfactants ; texture ; vegetable oil
Language	English
Dates of publication	2015-01
Size	p. 366-375.
Publishing place	Elsevier Ltd
Document type	Article
ZDB-ID	1111695-x
ISSN	1873-7145 ; 0963-9969
ISSN (online)	1873-7145
ISSN	0963-9969
DOI	10.1016/j.foodres.2014.11.044
Database	NAL-Catalogue (AGRICOLA)

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