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Article ; Online: Two-meshes approach in posterior component separation with transversus abdominis release: the IMPACT study (Italian Multicentric Posterior-separation Abdominal Complex hernia Transversus-release).

Pizza, F / Maida, P / Bertoglio, C / Antinori, A / Mongardini, F M / Cerbara, L / Sordelli, I / Alampi, B D / Marte, G / Morini, L / Grimaldi, S / Gili, S / Docimo, L / Gambardella, C

Hernia : the journal of hernias and abdominal wall surgery

2024

Abstract: Background: Surgical management of large ventral hernias (VH) has remained a challenge. Various techniques like anterior component separation and posterior component separation (PCS) with transversus abdominis release (TAR) have been employed. Despite ... ...

Abstract	Background: Surgical management of large ventral hernias (VH) has remained a challenge. Various techniques like anterior component separation and posterior component separation (PCS) with transversus abdominis release (TAR) have been employed. Despite the initial success, the long-term efficacy of TAR is not yet comprehensively studied. Authors aimed to investigate the early-, medium-, and long-term outcomes and health-related quality of life (QoL) in patients treated with PCS and TAR. Methods: This multicenter retrospective study analyzed data of 308 patients who underwent open PCS with TAR for primary or recurrent complex abdominal hernias between 2015 and 2020. The primary endpoint was the rate of hernia recurrence (HR) and mesh bulging (MB) at 3, 6, 12, 24, and 36 months. Secondary outcomes included surgical site events and QoL, assessed using EuraHS-QoL score. Results: The average follow-up was 38.3 ± 12.7 months. The overall HR rate was 3.5% and the MB rate was 4.7%. Most of the recurrences were detected by clinical and ultrasound examination. QoL metrics showed improvement post-surgery. Conclusions: This study supports the long-term efficacy of PCS with TAR in the treatment of large and complex VH, with a low recurrence rate and an improvement in QoL. Further research is needed for a more in-depth understanding of these outcomes and the factors affecting them.
Language	English
Publishing date	2024-04-03
Publishing country	France
Document type	Journal Article
ZDB-ID	1388125-5
ISSN	1248-9204 ; 1265-4906
ISSN (online)	1248-9204
ISSN	1265-4906
DOI	10.1007/s10029-024-03001-3
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Zs.A 5390: Show issues

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Article ; Online: Posterior component separation with TAR: lessons learned from our first consecutive 52 cases.

Marte, Gianpaolo / Tufo, A / Ferronetti, A / Di Maio, V / Russo, R / Sordelli, I F / De Stefano, G / Maida, P

Updates in surgery

2022 Volume 75, Issue 3, Page(s) 723–733

Abstract: Patients with complex incisional hernia (IH) is a growing and challenging category that surgeons are facing in daily practice and represent indeed a technical challenge for most of them. The posterior component separation with TAR (PCS-TAR) has become ... ...

Abstract	Patients with complex incisional hernia (IH) is a growing and challenging category that surgeons are facing in daily practice and represent indeed a technical challenge for most of them. The posterior component separation with TAR (PCS-TAR) has become the procedure of choice to repair most complex abdominal wall defects, including those with loss of domain, subxiphoid, subcostal, parastomal or after trauma and sepsis treated initially with "open abdomen" and in those scenarios in which the fascia closure was not performed to avoid an abdominal compartment syndrome. Most recent studies showed that the PCS-TAR represents a valid procedure in recurrent IH. The purpose of our study is to evaluate the reproducibility of the PCS-TAR, describing our experience, our surgical technique and the rate of postoperative complications and recurrences in a cohort of consecutive patients. 52 consecutive patients with complex IH, who underwent PCS-TAR at "Betania Hospital and Ospedale del Mare Hospital" in Naples between May 2014 and November 2019 were identified from a prospectively maintained database and reviewed retrospectively. There were 36 males (69%) and 16 females (31%) with a mean age of 57.88 (range 39-76) and Body mass index (BMI kg/m
MeSH term(s)	Male ; Humans ; Female ; Animals ; Horses ; Middle Aged ; Abdominal Muscles ; Hernia, Ventral/surgery ; Hernia, Ventral/etiology ; Retrospective Studies ; Reproducibility of Results ; Treatment Outcome ; Incisional Hernia/surgery ; Herniorrhaphy/methods ; Surgical Mesh ; Recurrence ; Abdominal Wall/surgery
Language	English
Publishing date	2022-11-10
Publishing country	Italy
Document type	Journal Article
ZDB-ID	2572692-4
ISSN	2038-3312 ; 2038-131X
ISSN (online)	2038-3312
ISSN	2038-131X
DOI	10.1007/s13304-022-01418-y
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Article ; Conference proceedings: Small hypoechoic nodules in cirrhotic patients with previously treated HCC: analysis of non-enhancing nodules at contrast-enhanced-US

Tarantino, L / Sordelli, I / Francica, G

Ultraschall in der Medizin - European Journal of Ultrasound

2008

Abstract: Objective: To analyze new small hypoechoic nodules (SHN) showing absence of enhancement at Contrast-enhanced sonography (CEUS), in cirrhotic patients previously treated for Hepatocellular Carcinoma (HCC).: Subjects and methods: 215 cirrhotic patients ...

Event/congress	Euroson 2008, Timişoara, Romania, 2008
Abstract	Objective: To analyze new small hypoechoic nodules (SHN) showing absence of enhancement at Contrast-enhanced sonography (CEUS), in cirrhotic patients previously treated for Hepatocellular Carcinoma (HCC). Subjects and methods: 215 cirrhotic patients with HCC previously treated with surgery (19) and/or Percutaneous ablation (192) and/or Chemoembolization (44) were prospectively studied with US every two months (follow-up range: 10–32 months; median: 20 months) in order to early detect new hepatic nodules. All detected SHN were studied with CEUS. Nodules showing early arterial enhancement at CEUS were considered recurrent HCCs and treated with thermal ablation. Non-enhancing nodules in arterial phase underwent fine needle biopsy, and the cases with positive hystology for HCC underwent thermal ablation. HCC-hystologically negative nodules were followed-up with US every two months. Increasing in size at follow-up was considered specific for recurrent HCC. Follow-up results were compared to FNB results. Results: 78 SHNs (size range: 7–20mm; mean: 16mm) were detected at US in 65 patients within 4–24 months (mean: 12 months) after previous HCC treatment. CEUS showed early arterial enhancement in 52/78 (67%) nodules (diameter range 9–20mm; mean 16mm). 26 non-enhancing nodules (diameter range:7–13mm) underwent FNB. 11/26 (42%) cases showing HCC at hystology underwent thermal ablation. 15/26 cases (58%) of „cirrhosis“ at hystology were followed-up (4–24 months; mean: 12 months). 4/15 (27%) nodules increased in size within 4–8 months and underwent thermal ablation. 5/15 (33%) did not change at follow-up controls and are still on follow-up. 3/15 (20%) nodules fainted or completely disappeared at US examination. All non-enhancing nodules were <13mm in size. Conclusions: Over 2/3 of small hypoechoic relapsing nodules in the clinical setting of cirrhotic patient with previously treated HCC show early arterial enhancement at CEUS. 66% of non-enhancing nodules in arterial phase could not be malignant, and even disappear at follow-up control.
Language	English
Publishing date	2008-05-15
Publishing place	Stuttgart ; New York
Document type	Article ; Conference proceedings
ZDB-ID	801064-x
ISSN	1438-8782 ; 0172-4614 ; 1439-0914 ; 1431-4894
ISSN (online)	1438-8782
ISSN	0172-4614 ; 1439-0914 ; 1431-4894
DOI	10.1055/s-2008-1079827
Database	Thieme publisher's database

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Zs.A 1572: Show issues

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Article: Ablation of large HCCs using a new saline-enhanced expandable radiofrequency device().

Tarantino, L / Sordelli, I / Nocera, V / Piscopo, A / Ripa, C / Parmeggiani, D / Sperlongano, P

Journal of ultrasound

2009 Volume 12, Issue 2, Page(s) 69–74

Abstract: Purpose: Evaluation of a new device designed to achieve large volumes of necrosis in hepatocellular carcinoma (HCC) nodules by application of radiofrequency ablation (RFA).: Materials and methods: 29 consecutive patients with 31 HCC nodules ≥3 cm in ... ...

Abstract	Purpose: Evaluation of a new device designed to achieve large volumes of necrosis in hepatocellular carcinoma (HCC) nodules by application of radiofrequency ablation (RFA). Materials and methods: 29 consecutive patients with 31 HCC nodules ≥3 cm in diameter (range 3-7.5 cm; mean diameter 5.5 cm) underwent ultrasound (US) guided percutaneous RFA using an expandable electrode with 7 active arrays and saline injection designed to create tissue ablation in areas of up to 7 cm (Starburst XLi-enhanced RFA device). Treatment was performed in general anesthesia (6 patients) or deep sedation (23 patients). Treatment efficacy was assessed by three-phase contrast-enhanced computed tomography (CT) and bimonthly US follow-up. Results: One to three electrode insertions (mean number 1.6) were performed in each patient. CT showed complete necrosis in 23/31 HCC nodules (74%) in 22 patients. Follow-up of these 22 patients ranged from 2 to 15 months (mean time 8.3 months). In 6/22 patients (28%) intrahepatic recurrence occurred within 5-10 months (mean time 8.3 months). Major complications were post-ablation syndrome in 7/29 (24%), peritoneal effusion in 4/29 (14%), pleural effusion in 2/29 (7%) and transient obstructive jaundice in 1/29 (3.4%) patients. One patient died 6 months after treatment because of tumor progression. Conclusions: In the treatment of large HCC nodules, Starburst XLi-enhanced is an effective and safe device.
Language	English
Publishing date	2009-04-02
Publishing country	Italy
Document type	Journal Article
ZDB-ID	2365426-0
ISSN	1876-7931 ; 1971-3495
ISSN (online)	1876-7931
ISSN	1971-3495
DOI	10.1016/j.jus.2009.02.002
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Article ; Conference proceedings: ACUTE CARDIAC TAMPONADE IN HYPOTHYROIDISM: ROLE OF INTERVENTIONAL ULTRASOUND IN THE DIAGNOSIS AND TREATMENT

Tarantino, L / Nocera, V / Sordelli, I / Porzio, G / Piscopo, A

Ultraschall in der Medizin - European Journal of Ultrasound

2005

Abstract: Purpose: We present a rare case of acute cardiac tamponade in a Hypothyroid patient treated with percutaneous drainage under US guidance. We report the Rx and US findings and stress the role of interventional US as fundamental tool in emergency.: ... ...

Event/congress	EUROSON 2005 - XVII European Congress of Ultrasound in Medicine and Biology / S 1, Geneva, Switzerland, 2005
Abstract	Purpose: We present a rare case of acute cardiac tamponade in a Hypothyroid patient treated with percutaneous drainage under US guidance. We report the Rx and US findings and stress the role of interventional US as fundamental tool in emergency. Methods and Materials: Case report: female, 58 years with Down syndrome, presented at the emergency Department of our Institution with severe dyspnea, shock, abdominal pain. Chest X-ray showed cardiac enlargement and pleural effusion. Abdominal ultrasound (US) examination showed mild ascites, normal abdominal organs, bilateral pleural effusion and a “small“ heart in a massive pericardial effusion. The patient underwent pericardial drainage in general anesthesia with 8 French pig-tail catheter positioned with Seldinger technique under US guidance. Results: 480ml of clear watery fluid was drained and immediately afterwards the patient recovered. The catheter was left in situ for 6 days and withdrawn when the daily drained fluid was <10ml. Examination of pericardial fluid did not show inflammation. Except for mild increase of serum creatinine levels, routine laboratory tests were within normal ranges. Serological tests for many of the common viral infections were all negative. Thyroid hormones dosage showed severe hypothyroidism (TSH=175 mlU/L). L-Tiroxine therapy determined a fast and progressive improvement of patient's conditions. No relapse have been observed during a 6 months follow-up. Conclusions: emergency Interventional US is a fast and decisive tool for the diagnosis and treatment of acute cardiac tamponade. The diagnosis of hypothyroidism should be considered in patients presenting with unexplained pericardial effusion tamponade
Language	English
Publishing date	2005-09-14
Publishing place	Stuttgart ; New York
Document type	Article ; Conference proceedings
ZDB-ID	801064-x
ISSN	1438-8782 ; 0172-4614 ; 1439-0914 ; 1431-4894
ISSN (online)	1438-8782
ISSN	0172-4614 ; 1439-0914 ; 1431-4894
DOI	10.1055/s-2005-917494
Database	Thieme publisher's database

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Article: Prognosis of patients with spontaneous rupture of hepatocellular carcinoma in cirrhosis.

Tarantino, Luciano / Sordelli, Ignazio / Calise, Fulvio / Ripa, Carmine / Perrotta, Michele / Sperlongano, Pasquale

Updates in surgery

2011 Volume 63, Issue 1, Page(s) 25–30

Abstract: The treatment of cirrhotic patients with spontaneous rupture of hepatocellular carcinoma (HCC) is controversial and largely dependent on general conditions of the patients and compensation of the underlying cirrhosis. We retrospectively reviewed clinical, ...

Abstract	The treatment of cirrhotic patients with spontaneous rupture of hepatocellular carcinoma (HCC) is controversial and largely dependent on general conditions of the patients and compensation of the underlying cirrhosis. We retrospectively reviewed clinical, imaging and surgical records of 24 consecutive cirrhotic patients (17 males, 7 females; age range 52-88 years) with hemoperitoneum from spontaneous rupture of HCC observed from June 2004 to January 2010 at our Institution. When indicated, patients were referred to surgery or trans-arterial embolization (TAE). Advanced decompensated patients were conservatively treated and clinically followed up. Spontaneous rupture of HCC was assessed by aspiration of bloody ascites at paracentesis in all cases. The presence of large blood-clots over HCC and liver surface at US and/or CT was considered a specific sign of ruptured HCC in 14 cases. In two out of four patients who underwent TAE active bleeding from tumor surface could be demonstrated. In 2 cases, the active hemorrhage from the HCC surface could be assessed by contrast-enhanced ultrasonography. Four out of 24 patients underwent surgery. Three out of four of these patients died within 2 weeks, 8 months, and 20 months after operation, respectively. The remaining patient is still alive at 52 months follow-up. Four patients underwent TAE and died at 1, 2, 6 and 10 months after treatment, because of recurrent peritoneal bleeding and/or liver failure. Sixteen patients with ruptured HCC in the advanced Child C cirrhosis were treated conservatively with blood derivative transfusion and with procoagulant drugs. All patients, but one died within 2-18 days. One patient survived the acute hemorrhage from ruptured HCC and died of liver failure after 3 months. We concluded that spontaneous rupture of HCC is usually a fatal event in patients with poor liver function, even after successful TAE. In compensated patients, timely surgical treatment can result in long term and even tumor-free survival of the patient.
MeSH term(s)	Aged ; Aged, 80 and over ; Anticoagulants/therapeutic use ; Blood Transfusion ; Carcinoma, Hepatocellular/complications ; Carcinoma, Hepatocellular/mortality ; Carcinoma, Hepatocellular/therapy ; Embolization, Therapeutic ; Female ; Hemoperitoneum/etiology ; Hemoperitoneum/mortality ; Hemoperitoneum/therapy ; Humans ; Liver Cirrhosis/complications ; Liver Cirrhosis/mortality ; Liver Cirrhosis/therapy ; Liver Neoplasms/complications ; Liver Neoplasms/mortality ; Liver Neoplasms/therapy ; Male ; Middle Aged ; Prognosis ; Proportional Hazards Models ; Retrospective Studies ; Rupture, Spontaneous ; Treatment Outcome
Chemical Substances	Anticoagulants
Language	English
Publishing date	2011-01-22
Publishing country	Italy
Document type	Journal Article
ZDB-ID	2572692-4
ISSN	2038-3312 ; 2038-131X
ISSN (online)	2038-3312
ISSN	2038-131X
DOI	10.1007/s13304-010-0041-8
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Zs.B 101: Show issues

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Article ; Online: BRAF and PIK3CA genes are somatically mutated in hepatocellular carcinoma among patients from South Italy.

Colombino, M / Sperlongano, P / Izzo, F / Tatangelo, F / Botti, G / Lombardi, A / Accardo, M / Tarantino, L / Sordelli, I / Agresti, M / Abbruzzese, A / Caraglia, M / Palmieri, G

Cell death & disease

2012 Volume 3, Page(s) e259

Abstract: Poor data have been previously reported about the mutation rates in K-RAS, BRAF, and PIK3CA genes among patients with hepatocellular carcinoma (HCC). Here we further elucidated the role of these genes in pathogenesis of primary hepatic malignancies. ... ...

Abstract	Poor data have been previously reported about the mutation rates in K-RAS, BRAF, and PIK3CA genes among patients with hepatocellular carcinoma (HCC). Here we further elucidated the role of these genes in pathogenesis of primary hepatic malignancies. Archival tumour tissue from 65 HCC patients originating from South Italy were screened for mutations in these candidate genes by direct sequencing. Overall, oncogenic mutations were detected in 15 (23%) patients for BRAF gene, 18 (28%) for PIK3CA gene, and 1 (2%) for K-RAS gene. Using statistical analysis, BRAF mutations were significantly correlated with the presence of either multiple HCC nodules (P=0.021) or higher proliferation rates (P=0.034). Although further extensive screenings are awaited in HCC patients among different populations, our findings clearly indicated that mutational activation of both BRAF and PIK3CA genes does contribute to hepatocellular tumorigenesis at somatic level in Southern Italian population.
MeSH term(s)	Aged ; Aged, 80 and over ; Base Sequence ; Carcinoma, Hepatocellular/genetics ; Carcinoma, Hepatocellular/pathology ; DNA Mutational Analysis ; Female ; Humans ; Italy ; Liver Neoplasms/genetics ; Liver Neoplasms/pathology ; Male ; Middle Aged ; Molecular Sequence Data ; Mutation Rate ; Neoplasm Grading ; Phosphatidylinositol 3-Kinases/genetics ; Proto-Oncogene Proteins B-raf/genetics ; ras Proteins/genetics
Chemical Substances	Phosphatidylinositol 3-Kinases (EC 2.7.1.-) ; BRAF protein, human (EC 2.7.11.1) ; Proto-Oncogene Proteins B-raf (EC 2.7.11.1) ; ras Proteins (EC 3.6.5.2)
Language	English
Publishing date	2012-01-19
Publishing country	England
Document type	Journal Article ; Research Support, Non-U.S. Gov't
ZDB-ID	2541626-1
ISSN	2041-4889 ; 2041-4889
ISSN (online)	2041-4889
ISSN	2041-4889
DOI	10.1038/cddis.2011.136
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Article ; Conference proceedings: Large HCC ablation by a new saline-enhanced expandable radiofrequency device

Tarantino, L / Sordelli, I / Nocera, V / Piscopo, A / Ripa, C / Parmeggiani, D / Sperlongano, P

Ultraschall in der Medizin - European Journal of Ultrasound

2008

Abstract: Purpose: Evaluation of a new device designed for large volumes of necrosis by radiofrequency ablation (RFA) of hepatocellular carcinoma (HCC).: Methods and materials: Twenty-nine consecutive patients with 31 HCC >3cm in size (range 3–7.5cm, mean 5 ... ...

Event/congress	Euroson 2008, Timişoara, Romania, 2008
Abstract	Purpose: Evaluation of a new device designed for large volumes of necrosis by radiofrequency ablation (RFA) of hepatocellular carcinoma (HCC). Methods and materials: Twenty-nine consecutive patients with 31 HCC >3cm in size (range 3–7.5cm, mean 5.5cm) underwent US-guided-percutaneous-RFA using an expandable electrode with seven active arrays and saline injection, designed to create tissue ablation up to 7cm (StarBurst-XLienhanced, RITA Medical Systems. CA, USA). Treatments were performed in general anesthesia (6 patients) or deep sedation (23 patients). Treatment efficacy was assessed by three-phase-enhanced-CT and bimonthly US follow-up. Results: One to 5 electrodes insertions (mean 2.6) were performed per patient. Complete necrosis at CT was achieved in 23/31 HCC nodules (74%) in 22 patients. Follow-up of these 22 patients ranged from 2 to 15 months (mean 8.3 months). 6/22 (28%) patients showed new intrahepatic recurrences within 5–10 months (mean 8.3 months). Major complications were: post-ablation syndrome in 7/29 (24%), peritoneal effusion in 4/29 (14%), pleural effusion in 2/29 (7%) and transient obstructive jaundice in 1/29 (3.4%) patients. One patient died 6 months after treatment because of the tumor. Conclusion: StarBurst-XLi-enhanced is an effective and safe device for the treatment of large HCC.
Language	English
Publishing date	2008-05-15
Publishing place	Stuttgart ; New York
Document type	Article ; Conference proceedings
ZDB-ID	801064-x
ISSN	1438-8782 ; 0172-4614 ; 1439-0914 ; 1431-4894
ISSN (online)	1438-8782
ISSN	0172-4614 ; 1439-0914 ; 1431-4894
DOI	10.1055/s-2008-1079913
Database	Thieme publisher's database

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Article: Laserterapia interstiziale del piccolo epatocarcinoma su cirrosi senza alcuna anestesia: studio di fattibilità.

Tarantino, L / Sordelli, I / Parmeggiani, D / Pisaniello, D / Marzullo, E / Di Marzo, M / Santoriello, A / Sperlongano, P

I supplementi di Tumori : official journal of Societa italiana di cancerologia ... [et al.

2005 Volume 4, Issue 3, Page(s) S53

Abstract: Objective: We evaluated if interstitial laser photocoagulation (ILP) under ultrasound (US) guidance of intraparenchymal small HCC (<2 cm) in cirrhosis can be safely and effectively performed without any anesthesia.: Patients and methods: Twelve ... ...

Title translation	Interstitial laser treatment of small hepatocarcinoma on cirrhosis without anesthesia: feasibility study.
Abstract	Objective: We evaluated if interstitial laser photocoagulation (ILP) under ultrasound (US) guidance of intraparenchymal small HCC (<2 cm) in cirrhosis can be safely and effectively performed without any anesthesia. Patients and methods: Twelve cirrhotic patients with 14 nodules of HCC (diameter 1.2-2.0 cm; mean: 1.7) underwent ILP. All procedures were performed without local or general anesthesia. Necrosis of the nodules was evaluated with triphasic contrast-enhanced CT. Results: Post-treatment CT showed complete necrosis in all cases. Pain occurred in 5 patients during the treatment was treated with iv pain-killer and only in 1 case the procedure was stopped before the scheduled time. No major complication occurred. Conclusions: ILP under US guidance is feasible without any anesthesia in patients with small intraparenchymal HCC.
MeSH term(s)	Aged ; Anesthesia ; Carcinoma, Hepatocellular/complications ; Carcinoma, Hepatocellular/pathology ; Carcinoma, Hepatocellular/surgery ; Feasibility Studies ; Female ; Humans ; Liver Cirrhosis/complications ; Liver Neoplasms/complications ; Liver Neoplasms/pathology ; Liver Neoplasms/surgery ; Male ; Middle Aged
Language	Italian
Publishing date	2005-05
Publishing country	Italy
Document type	English Abstract ; Journal Article
ISSN	2283-5423
ISSN	2283-5423
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Article: Gastrointestinal tumours in elderly.

Sperlongano, P / Pisaniello, D / Parmeggiani, D / Piatto, A / De Falco, M / Di Marzo, M / Sordelli, I / Parmeggiani, U

Acta bio-medica : Atenei Parmensis

2005 Volume 76 Suppl 1, Page(s) 56–58

Abstract: The Authors report their experience concerning 129 cases of gastrointestinal neoplasms (gastric, colonic, anorectal), recorded during the last years among patients aged between 70 and 81 years, who underwent radical surgery. The main issues evaluated ... ...

Abstract	The Authors report their experience concerning 129 cases of gastrointestinal neoplasms (gastric, colonic, anorectal), recorded during the last years among patients aged between 70 and 81 years, who underwent radical surgery. The main issues evaluated were: anaesthesiological risk, stage, post-operative mortality and morbidity. Elderly seems not to be a contraindication, nor a limit for surgery if the patient is correctly and strictly managed pre and post-operatively.
MeSH term(s)	Aged ; Aged, 80 and over ; Gastrointestinal Neoplasms/surgery ; Humans
Language	English
Publishing date	2005
Publishing country	Italy
Document type	Journal Article
ZDB-ID	2114240-3
ISSN	0392-4203
ISSN	0392-4203
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