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  1. Article ; Online: Positive, again! What to make of "re-positive" SARS-CoV-2 molecular test results.

    Simon, Viviana / van Bakel, Harm / Sordillo, Emilia Mia

    EBioMedicine

    2020  Volume 60, Page(s) 103011

    MeSH term(s) Betacoronavirus/genetics ; Betacoronavirus/isolation & purification ; COVID-19 ; Coronavirus Infections/diagnosis ; Coronavirus Infections/virology ; Humans ; Nucleic Acid Amplification Techniques ; Pandemics ; Pneumonia, Viral/diagnosis ; Pneumonia, Viral/virology ; RNA, Viral/genetics ; RNA, Viral/metabolism ; SARS-CoV-2
    Chemical Substances RNA, Viral
    Keywords covid19
    Language English
    Publishing date 2020-09-22
    Publishing country Netherlands
    Document type Journal Article
    ZDB-ID 2851331-9
    ISSN 2352-3964
    ISSN (online) 2352-3964
    DOI 10.1016/j.ebiom.2020.103011
    Database MEDical Literature Analysis and Retrieval System OnLINE

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    In stock of ZB MED Cologne/Königswinter

    Zs.A 7090: Show issues Location:
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  2. Article ; Online: The Rationale for Use of Amiodarone and its Derivatives for the Treatment of Chagas' Disease and Leishmaniasis.

    Benaim, Gustavo / Paniz-Mondolfi, Alberto E / Sordillo, Emilia Mia

    Current pharmaceutical design

    2020  Volume 27, Issue 15, Page(s) 1825–1833

    Abstract: The repurposing or repositioning of previously-approved drugs has become an accepted strategy for the expansion of the pharmacopeia for neglected diseases. Accordingly, amiodarone, an inexpensive and extensively- used class III antiarrhythmic has been ... ...

    Abstract The repurposing or repositioning of previously-approved drugs has become an accepted strategy for the expansion of the pharmacopeia for neglected diseases. Accordingly, amiodarone, an inexpensive and extensively- used class III antiarrhythmic has been proposed as a treatment for Chagas' disease and leishmaniasis. Amiodarone has a potent trypanocidal and leishmanicidal action, mainly acting through the disruption of parasite intracellular Ca
    MeSH term(s) Amiodarone/pharmacology ; Amiodarone/therapeutic use ; Animals ; Calcium ; Chagas Disease/drug therapy ; Dogs ; Leishmaniasis/drug therapy ; Trypanocidal Agents ; Trypanosoma cruzi
    Chemical Substances Trypanocidal Agents ; Amiodarone (N3RQ532IUT) ; Calcium (SY7Q814VUP)
    Language English
    Publishing date 2020-09-08
    Publishing country United Arab Emirates
    Document type Journal Article ; Research Support, Non-U.S. Gov't
    ZDB-ID 1304236-1
    ISSN 1873-4286 ; 1381-6128
    ISSN (online) 1873-4286
    ISSN 1381-6128
    DOI 10.2174/1381612826666200928161403
    Database MEDical Literature Analysis and Retrieval System OnLINE

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    In stock of ZB MED Cologne/Königswinter

    Zs.A 4714: Show issues Location:
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    Jg. 1995 - 2021: Lesesall (2.OG)
    ab Jg. 2022: Lesesaal (EG)

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  3. Article ; Online: SARS-CoV-2-infection- and vaccine-induced antibody responses are long lasting with an initial waning phase followed by a stabilization phase.

    Srivastava, Komal / Carreño, Juan Manuel / Gleason, Charles / Monahan, Brian / Singh, Gagandeep / Abbad, Anass / Tcheou, Johnstone / Raskin, Ariel / Kleiner, Giulio / van Bakel, Harm / Sordillo, Emilia Mia / Krammer, Florian / Simon, Viviana

    Immunity

    2024  Volume 57, Issue 3, Page(s) 587–599.e4

    Abstract: It is thought that mRNA-based vaccine-induced immunity to severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) wanes quickly, based mostly on short-term studies. Here, we analyzed the kinetics and durability of the humoral responses to SARS-CoV-2 ...

    Abstract It is thought that mRNA-based vaccine-induced immunity to severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) wanes quickly, based mostly on short-term studies. Here, we analyzed the kinetics and durability of the humoral responses to SARS-CoV-2 infection and vaccination using >8,000 longitudinal samples collected over a 3-year period in New York City. Upon primary immunization, participants with pre-existing immunity mounted higher antibody responses faster and achieved higher steady-state antibody titers than naive individuals. Antibody kinetics were characterized by two phases: an initial rapid decay, followed by a stabilization phase with very slow decay. Booster vaccination equalized the differences in antibody concentration between participants with and without hybrid immunity, but the peak antibody titers decreased with each successive antigen exposure. Breakthrough infections increased antibodies to similar titers as an additional vaccine dose in naive individuals. Our study provides strong evidence that SARS-CoV-2 antibody responses are long lasting, with initial waning followed by stabilization.
    MeSH term(s) Humans ; COVID-19 ; SARS-CoV-2 ; Antibody Formation ; Vaccines ; Vaccination ; Immunization, Secondary ; mRNA Vaccines ; Antibodies, Viral
    Chemical Substances Vaccines ; mRNA Vaccines ; Antibodies, Viral
    Language English
    Publishing date 2024-02-22
    Publishing country United States
    Document type Journal Article
    ZDB-ID 1217235-2
    ISSN 1097-4180 ; 1074-7613
    ISSN (online) 1097-4180
    ISSN 1074-7613
    DOI 10.1016/j.immuni.2024.01.017
    Database MEDical Literature Analysis and Retrieval System OnLINE

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    Zs.A 4227: Show issues Location:
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    Jg. 1995 - 2021: Lesesall (2.OG)
    ab Jg. 2022: Lesesaal (EG)
    Zs.MG 69: Show issues

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  4. Article ; Online: Editorial: Advances in the Molecular Biology of Trypanosomatid Pathogens: New Strategies Against Ancient Enemies.

    Benaim, Gustavo / Paniz-Mondolfi, Alberto E / Ramírez, Juan David / Sordillo, Emilia Mia

    Frontiers in cellular and infection microbiology

    2021  Volume 11, Page(s) 777008

    MeSH term(s) Chagas Disease ; Humans ; Leishmaniasis ; Molecular Biology ; Trypanosoma cruzi
    Language English
    Publishing date 2021-10-06
    Publishing country Switzerland
    Document type Editorial ; Research Support, Non-U.S. Gov't
    ZDB-ID 2619676-1
    ISSN 2235-2988 ; 2235-2988
    ISSN (online) 2235-2988
    ISSN 2235-2988
    DOI 10.3389/fcimb.2021.777008
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  5. Article ; Online: Murine Broadly Reactive Antineuraminidase Monoclonal Antibodies Protect Mice from Recent Influenza B Virus Isolates and Partially Inhibit Virus Transmission in the Guinea Pig Model.

    Tan, Jessica / Chromikova, Veronika / O'Dell, George / Sordillo, Emilia Mia / Simon, Viviana / van Bakel, Harm / Krammer, Florian / McMahon, Meagan

    mSphere

    2022  Volume 7, Issue 5, Page(s) e0092721

    Abstract: Current influenza virus vaccines and antivirals have limitations, some of which disproportionately affect their utilization against influenza B viruses. To inform ongoing efforts to address the considerable global burden of influenza B viruses, we ... ...

    Abstract Current influenza virus vaccines and antivirals have limitations, some of which disproportionately affect their utilization against influenza B viruses. To inform ongoing efforts to address the considerable global burden of influenza B viruses, we previously described five murine monoclonal antibodies that broadly bind conserved epitopes on the neuraminidase of influenza B viruses and protect against lethal challenge in a mouse model when delivered via intraperitoneal injection. Here, we validate the continued relevance of these antibodies by demonstrating that their protective effects extend to lethal challenge with mouse-adapted influenza B viruses recently isolated from humans. We also found that humanization of murine antibodies 1F2 and 4F11 resulted in molecules that retain the ability to protect mice from lethal challenge when administered prophylactically. Intranasal administration as an alternative route of 1F2 delivery revealed no differences in the mouse challenge model compared to intraperitoneal injection, supporting further assessment of this more targeted and convenient administration method. Lastly, we evaluated the potential for intranasal 1F2 administration initiated 1 day after infection to prevent transmission of an influenza B virus between cocaged guinea pigs. Here, we observed a 40% rate of transmission with the 1F2 antibody administered to the infected donor compared to 100% transmission with administration of an irrelevant control antibody. These data suggest that intranasal administration could be a viable route of administration for antibody therapeutics. Collectively, these findings demonstrate the potential of broad antineuraminidase antibodies as therapeutics to prevent and treat infections caused by influenza B viruses. IMPORTANCE The global health burden of influenza B viruses, especially in children, has long been underappreciated. Although two antigenically distinct influenza B virus lineages cocirculated before the coronavirus disease 2019 (COVID-19) pandemic, the commonly used trivalent seasonal vaccines contain antigens from only one influenza B virus, providing limited cross-protection against viruses of the other lineage. Additionally, studies have called into question the clinical effectiveness of the neuraminidase inhibitors that comprise the majority of available antivirals in treating influenza B virus infections. We previously described antibodies that bind broadly to neuraminidases of influenza B viruses across decades of antigenic evolution and potently protect mice against lethal challenge. Here we appraise additional factors to develop these antineuraminidase antibodies as antivirals to prevent and treat infections caused by an extensive range of influenza B viruses. In addition this work assesses recent clinical isolates belonging to the two influenza B virus lineages, finding evidence supporting the development of these antibodies for prophylactic and therapeutic use.
    MeSH term(s) Animals ; Guinea Pigs ; Humans ; Mice ; Antibodies, Monoclonal/therapeutic use ; Antibodies, Viral ; Antiviral Agents ; Disease Models, Animal ; Epitopes ; Influenza B virus ; Influenza Vaccines ; Neuraminidase ; Orthomyxoviridae Infections
    Chemical Substances Antibodies, Monoclonal ; Antibodies, Viral ; Antiviral Agents ; Epitopes ; Influenza Vaccines ; Neuraminidase (EC 3.2.1.18)
    Language English
    Publishing date 2022-09-07
    Publishing country United States
    Document type Journal Article ; Research Support, Non-U.S. Gov't ; Research Support, N.I.H., Extramural
    ISSN 2379-5042
    ISSN (online) 2379-5042
    DOI 10.1128/msphere.00927-21
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  7. Article ; Online: Positive, again! What to make of “re-positive” SARS-CoV-2 molecular test results

    Simon, Viviana / van Bakel, Harm / Sordillo, Emilia Mia

    EBioMedicine

    2020  Volume 60, Page(s) 103011

    Keywords covid19
    Language English
    Publisher Elsevier BV
    Publishing country us
    Document type Article ; Online
    ZDB-ID 2851331-9
    ISSN 2352-3964
    ISSN (online) 2352-3964
    DOI 10.1016/j.ebiom.2020.103011
    Database BASE - Bielefeld Academic Search Engine (life sciences selection)

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    In stock of ZB MED Cologne/Königswinter

    Zs.A 7090: Show issues Location:
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    bis Jg. 2021: Bestellungen von Artikeln über das Online-Bestellformular
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  8. Article ; Online: Disruption of Intracellular Calcium Homeostasis as a Therapeutic Target Against

    Benaim, Gustavo / Paniz-Mondolfi, Alberto E / Sordillo, Emilia Mia / Martinez-Sotillo, Nathalia

    Frontiers in cellular and infection microbiology

    2020  Volume 10, Page(s) 46

    Abstract: There is no effective cure for Chagas disease, which is caused by infection with the arthropod-borne parasite, ...

    Abstract There is no effective cure for Chagas disease, which is caused by infection with the arthropod-borne parasite,
    MeSH term(s) Amiodarone ; Calcium ; Chagas Disease/drug therapy ; Homeostasis ; Humans ; Trypanosoma cruzi
    Chemical Substances Amiodarone (N3RQ532IUT) ; Calcium (SY7Q814VUP)
    Language English
    Publishing date 2020-02-14
    Publishing country Switzerland
    Document type Journal Article ; Research Support, Non-U.S. Gov't ; Review
    ZDB-ID 2619676-1
    ISSN 2235-2988 ; 2235-2988
    ISSN (online) 2235-2988
    ISSN 2235-2988
    DOI 10.3389/fcimb.2020.00046
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  9. Article: Clinical performance of a quantitative pan-genus

    Ramírez, Juan David / Cao, Liyong / Castillo-Castañeda, Adriana C / Patino, Luz Helena / Ayala, Martha S / Cordon-Cardo, Carlos / Sordillo, Emilia Mia / Paniz-Mondolfi, Alberto

    Practical laboratory medicine

    2023  Volume 37, Page(s) e00341

    Abstract: Leishmaniasis is a complex vector-borne disease caused by ... ...

    Abstract Leishmaniasis is a complex vector-borne disease caused by various
    Language English
    Publishing date 2023-10-05
    Publishing country Netherlands
    Document type Journal Article
    ZDB-ID 2834973-8
    ISSN 2352-5517
    ISSN 2352-5517
    DOI 10.1016/j.plabm.2023.e00341
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  10. Article ; Online: Molecular Detection of

    Ramírez, Juan David / Wang, Chin Yi / Bolton, Deandra / Liggayu, Bernadette / Schaefer, Sarah / Patel, Gopi / Javaid, Waleed / Cordon-Cardo, Carlos / Firpo-Betancourt, Adolfo / Sordillo, Emilia Mia / Paniz-Mondolfi, Alberto

    Journal of fungi (Basel, Switzerland)

    2023  Volume 9, Issue 8

    Abstract: ... Candida ... ...

    Abstract Candida auris
    Language English
    Publishing date 2023-08-15
    Publishing country Switzerland
    Document type Journal Article
    ZDB-ID 2784229-0
    ISSN 2309-608X ; 2309-608X
    ISSN (online) 2309-608X
    ISSN 2309-608X
    DOI 10.3390/jof9080849
    Database MEDical Literature Analysis and Retrieval System OnLINE

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