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Article: Intervention et rôle du pédiatre en salle de naissance.

Sorèze, Yohan

2018 Volume 39, Issue 301, Page(s) 26–29

Abstract: Some newborns require the presence of a paediatrician in the delivery room, for emergency care. This generally leads to hospitalisation in neonatal intensive care or neonatology. Prematurity and respiratory distress are the main causes. These unexpected ... ...

Title translation	Intervention and role of the paediatrician in the delivery room.
Abstract	Some newborns require the presence of a paediatrician in the delivery room, for emergency care. This generally leads to hospitalisation in neonatal intensive care or neonatology. Prematurity and respiratory distress are the main causes. These unexpected situations are a source of anxiety for the parents. It is essential that the multidisciplinary team draws on both its technical and relational expertise, in order to provide optimal treatment to the infant while supporting the parents with the necessary empathy.
MeSH term(s)	Communication ; Delivery Rooms ; Female ; Hospitalization ; Humans ; Infant, Newborn ; Intensive Care Units, Neonatal ; Parents ; Pediatricians ; Physician-Patient Relations ; Pregnancy ; Respiratory Distress Syndrome, Newborn/therapy
Language	French
Publishing date	2018-03
Publishing country	France
Document type	Journal Article
ZDB-ID	1234484-9
ISSN	2214-9325 ; 1259-4792
ISSN (online)	2214-9325
ISSN	1259-4792
DOI	10.1016/j.spp.2018.01.008
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Article ; Online: Predictive value of microcirculation for pediatric extracorporeal membrane oxygenation weaning test: A monocentric prospective observational study.

Suc, Violette / Starck, Julie / Levy, Yael / Soreze, Yohan / Rambaud, Jerome / Léger, Pierre-Louis

Artificial organs

2024

Abstract: Background: Extracorporeal membrane oxygenation (ECMO) is widely used for children treated for refractory respiratory failures or refractory cardiogenic shock. Its duration depends on organ functions recovery. Weaning is decided using macro-circulatory ... ...

Abstract	Background: Extracorporeal membrane oxygenation (ECMO) is widely used for children treated for refractory respiratory failures or refractory cardiogenic shock. Its duration depends on organ functions recovery. Weaning is decided using macro-circulatory tools, but microcirculation is not well evaluated. Sidestream dark-field video imaging is used to assess the perfusion of the sublingual microvascular vessels. The aim of this study was to assess the predictive value of microcirculatory indices in ECMO weaning. Methods: This prospective monocentric study examined pediatric patients at Trousseau Hospital between March 2017 and December 2020. The study included all patients from 35 weeks of gestational age to 18 years old who were treated with ECMO. Children were divided into two groups: one with stability after weaning and the other with instability after weaning. We collected clinical and biological data, ventilation parameters, extracorporeal membrane oxygenation parameters, and drugs used at admission and after the weaning test. Microcirculations videos were taken after weaning trials with echocardiography and blood gas monitoring. Results: The study included 30 patients with a median age of 29 days (range: 1-770 days) at admission, including 18 patients who received venoarterial ECMO (60%). There were 19 children in the stability group and 11 in the instability group. Macrocirculatory and microcirculatory indices showed no differences between groups. The microvascular flow index was subnormal in both groups (2.3 (1.8-2.4) and 2.3 (2.3-2.6), respectively; p = 0.24). The microvascular indices were similar between cases of venovenous and venoarterial ECMO and between age groups. Conclusion: Microcirculation monitoring at the weaning phase did not predict the failure of ECMO weaning.
Language	English
Publishing date	2024-04-22
Publishing country	United States
Document type	Journal Article
ZDB-ID	441812-8
ISSN	1525-1594 ; 0160-564X
ISSN (online)	1525-1594
ISSN	0160-564X
DOI	10.1111/aor.14754
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Zs.A 1463: Show issues

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Article ; Online: Acinar Dysplasia in a Full-Term Newborn with a NKX2.1 Variant.

Soreze, Yohan / Nathan, Nadia / Jegard, Julien / Hervieux, Erik / Clermidi, Pauline / Sileo, Chiara / Louvrier, Camille / Legendre, Marie / Coulomb L'Herminé, Aurore

Neonatology

2023 Volume 121, Issue 1, Page(s) 133–136

Abstract: Acinar dysplasia (AcDys) is one of the three main diffuse developmental disorders of the lung. The transcription factor NK2 homeobox 1 (NKX2.1) partly controls the synthesis of surfactant proteins by type 2 alveolar epithelial cells (AEC2), and germline ... ...

Abstract	Acinar dysplasia (AcDys) is one of the three main diffuse developmental disorders of the lung. The transcription factor NK2 homeobox 1 (NKX2.1) partly controls the synthesis of surfactant proteins by type 2 alveolar epithelial cells (AEC2), and germline mutations are known to be associated with brain-lung thyroid syndrome. We report the case of a full-term neonate who developed refractory respiratory failure with pulmonary hypertension requiring venoarterial extracorporeal membrane oxygenation. Histological examination of the lung biopsy specimen was consistent with the diagnosis of AcDys. Molecular analyses led to the identification of the missense heterozygous variant in NKX2.1 (NM_001079668) c.731A>G p.(Tyr244Cys), which is predicted to be pathogenic. After 5 weeks, because AcDys is a fatal disorder and the patient's status worsened, life-sustaining therapies were withdrawn, and she died after a few hours. This study is the first to extend the phenotype of NKX2.1 pathogenic variant, to a fatal form of AcDys.
MeSH term(s)	Infant, Newborn ; Female ; Humans ; Mutation ; Lung/metabolism ; Transcription Factors/genetics ; Transcription Factors/metabolism ; Respiratory Insufficiency/genetics ; Respiratory Insufficiency/therapy ; Respiratory Distress Syndrome, Newborn/diagnosis ; Respiratory Distress Syndrome, Newborn/genetics
Chemical Substances	Transcription Factors
Language	English
Publishing date	2023-11-30
Publishing country	Switzerland
Document type	Case Reports
ZDB-ID	2266911-5
ISSN	1661-7819 ; 1661-7800
ISSN (online)	1661-7819
ISSN	1661-7800
DOI	10.1159/000534076
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Article ; Online: Hidden Harlequin syndrome in neonatal and pediatric VA-ECMO.

Levy, Yael / Starck, Julie / Mary, Anne-Lise / Soreze, Yohan / Jean, Sandrine / Kreitmann, Bernard / Léger, Pierre-Louis / Rambaud, Jerome

Critical care (London, England)

2022 Volume 26, Issue 1, Page(s) 146

MeSH term(s)	Autonomic Nervous System Diseases/therapy ; Child ; Extracorporeal Membrane Oxygenation ; Flushing ; Humans ; Hypohidrosis/diagnosis ; Hypohidrosis/etiology ; Infant, Newborn ; Retrospective Studies
Language	English
Publishing date	2022-05-20
Publishing country	England
Document type	Letter
ZDB-ID	2041406-7
ISSN	1466-609X ; 1364-8535
ISSN (online)	1466-609X
ISSN	1364-8535
DOI	10.1186/s13054-022-04017-w
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Article ; Online: Lung biopsies in infants and children in critical care situation.

Levy, Yaël / Bitton, Lauren / Sileo, Chiara / Rambaud, Jérôme / Soreze, Yohan / Louvrier, Camille / Ducou le Pointe, Hubert / Corvol, Harriet / Hervieux, Erik / Irtan, Sabine / Leger, Pierre-Louis / Prévost, Blandine / Coulomb L'Herminé, Aurore / Nathan, Nadia

Pediatric pulmonology

2024 Volume 59, Issue 4, Page(s) 907–914

Abstract: Introduction: Lung biopsy is considered as the last step investigation for diagnosing lung diseases; however, its indication must be carefully balanced with its invasiveness. The present study aims to evaluate the diagnostic yield of lung biopsy in ... ...

Abstract	Introduction: Lung biopsy is considered as the last step investigation for diagnosing lung diseases; however, its indication must be carefully balanced with its invasiveness. The present study aims to evaluate the diagnostic yield of lung biopsy in critically ill patients hospitalized in the pediatric intensive care unit (ICU). Material and methods: Children who underwent a lung biopsy in the ICU between 1995 and 2022 were included. Biopsies performed in the operating room and post-mortem biopsies were excluded. Results: Thirty-one patients were included, with a median age of 18 days (2 days to 10.8 years); 21 (67.7%) were newborns. All patients required invasive mechanical ventilation, 26 (89.7%) had a pulmonary hypertension, and 22 (70.9%) were placed under extracorporeal membrane oxygenation (ECMO). The lung biopsy led to a diagnosis in 81% of the patients. The diagnostic reliability seemed to decrease with age (95% in newborns, 71% in 1 month to 2 years and 0/3 patients aged over 2 years old). Diffuse developmental disorders of the lung accounted for 15 (49%) patients, primarily alveolar capillary dysplasia, followed by surfactant disorders in 5 (16%) patients. Complications occurred in 9/31 (29%) patients including eight under ECMO, with massive hemorrhages in seven cases. Discussion and conclusion: In critical situations, lung biopsy should be performed. Lung biopsy is a reliable diagnostic procedure for neonates in critical situation when a diffuse developmental disorder of the lung is suspected. The majority of lung biopsy complication was associated with the use of ECMO. The prospective evaluation of the complications of such procedure under ECMO, and particularly over 10 days of ECMO and in children over 2-year-old remains to be ascertained.
MeSH term(s)	Infant ; Child ; Infant, Newborn ; Humans ; Aged ; Child, Preschool ; Reproducibility of Results ; Lung/pathology ; Pulmonary Alveoli ; Critical Care ; Biopsy/adverse effects ; Biopsy/methods ; Retrospective Studies
Language	English
Publishing date	2024-01-02
Publishing country	United States
Document type	Journal Article
ZDB-ID	632784-9
ISSN	1099-0496 ; 8755-6863
ISSN (online)	1099-0496
ISSN	8755-6863
DOI	10.1002/ppul.26845
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Article: Sevoflurane Sedation with AnaConDa-S Device for a Child Undergoing Extracorporeal Membrane Oxygenation.

Soreze, Yohan / Piloquet, Jean-Eudes / Amblard, Alain / Constant, Isabelle / Rambaud, Jérôme / Leger, Pierre-Louis

Indian journal of critical care medicine : peer-reviewed, official publication of Indian Society of Critical Care Medicine

2020 Volume 24, Issue 7, Page(s) 596–598

Abstract: Background: Deep sedation in critically ill children undergoing extracorporeal membrane oxygenation (ECMO) can be challenging. Volatile anesthetics like sevoflurane can be a good alternative for patients hospitalized in pediatric intensive care units, ... ...

Abstract	Background: Deep sedation in critically ill children undergoing extracorporeal membrane oxygenation (ECMO) can be challenging. Volatile anesthetics like sevoflurane can be a good alternative for patients hospitalized in pediatric intensive care units, in whom adequate sedation is difficult to obtain. Case description: We report here the first pediatric case of a patient under extracorporeal membrane oxygenation receiving sedation by sevoflurane using the AnaConDa-S device. This 2-year-old girl, suffering from congenital diaphragmatic hernia, was put on extracorporeal membrane oxygenation due to a persistent pulmonary hypertension following metapneumovirus infection. Despite high doses of drugs, neither satisfactory sedation nor analgesia could be reached. Sevoflurane allowed her to be released and we were able to wean her from certain drugs. Her physiological parameters and the indicators of pain and sedation improved. Conclusion: Anesthesia using sevoflurane with the AnaConDa-S device is efficient for children under ECMO. Clinical significance: This is the first pediatric report on anesthesia with sevoflurane under ECMO. How to cite this article: Soreze Y, Piloquet J-E, Amblard A, Constan I, Rambaud J, Leger P-L. Sevoflurane Sedation with AnaConDa-S Device for a Child Undergoing Extracorporeal Membrane Oxygenation. Indian J Crit Care Med 2020;24(7):596-598.
Language	English
Publishing date	2020-09-18
Publishing country	India
Document type	Journal Article
ZDB-ID	2121263-6
ISSN	1998-359X ; 0972-5229
ISSN (online)	1998-359X
ISSN	0972-5229
DOI	10.5005/jp-journals-10071-23487
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Article: Small for Gestational Age Preterm Neonates Exhibit Defective GH/IGF1 Signaling Pathway.

Motte-Signoret, Emmanuelle / Shankar-Aguilera, Shivani / Brailly-Tabard, Sylvie / Soreze, Yohan / Dell Orto, Valentina / Ben Ammar, Rafik / De Luca, Daniele / Boileau, Pascal

Frontiers in pediatrics

2021 Volume 9, Page(s) 711400

Abstract: Objective: ...

Abstract	Objective:
Language	English
Publishing date	2021-08-10
Publishing country	Switzerland
Document type	Journal Article
ZDB-ID	2711999-3
ISSN	2296-2360
ISSN	2296-2360
DOI	10.3389/fped.2021.711400
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Article ; Online: Reduced Sufentanil Doses are Effective for Postoperative Analgesia After Ductal Closure in Extremely Premature Infants: A 10 Years Retrospective Cohort Study.

Soreze, Yohan / Audureau, Etienne / Decobert, Fabrice / Jaby, Olivier / Blary, Sabine / Danan, Claude / Durrmeyer, Xavier

The Clinical journal of pain

2017 Volume 33, Issue 12, Page(s) 1109–1116

Abstract: Objectives: The objective of the study was to assess the efficacy of reduced sufentanil doses for postoperative analgesia following surgical ductal closure in extremely premature infants.: Methods: This was a retrospective, single-center, cohort ... ...

Abstract	Objectives: The objective of the study was to assess the efficacy of reduced sufentanil doses for postoperative analgesia following surgical ductal closure in extremely premature infants. Methods: This was a retrospective, single-center, cohort study comparing 2 sufentanil dosing regimens used between 2001 and 2010 and included all infants born at <28 weeks of gestation with surgical ductal closure. Sufentanil doses were reduced in 2007 as a standard of care. Time was divided into 3 epochs to distinguish the effects of practice changes over time from the effects of sufentanil dose change: epoch 1 (2001 to 2004), epoch 2 (May 2005 to 2007), and epoch 3 (June 2007 to 2010). Results: A total of 109 of 114 eligible infants were analyzed (mean [±SD], gestational age: 25.1 [±1.1] wk; mean [±SD], birth weight: 756 [±144] g). Median sufentanil doses were significantly higher during epochs 1 and 2 (0.1 to 0.2 µg/kg/h) than during epoch 3 (0.03 to 0.04 µg/kg/h) (P<0.0001). EDIN (Echelle de Douleur et d'Inconfort du Nouveau-né) pain scores were mostly ≤4 throughout the study period and their changes over time were not contemporaneous with the reduction in sufentanil doses; they were lower during epoch 1 versus epochs 2 and 3 (P<0.0001) and comparable between epochs 2 and 3. Midazolam doses and paracetamol use were not higher during epoch 3 as compared with epochs 1 and 2. No difference in opioid-related adverse events was observed between the 3 epochs. Conclusion: Our study supports the use of low continuous intravenous sufentanil doses, consistent with morphine doses currently recommended in this population.
MeSH term(s)	Administration, Intravenous ; Analgesics, Opioid/administration & dosage ; Analgesics, Opioid/adverse effects ; Dose-Response Relationship, Drug ; Ductus Arteriosus, Patent/surgery ; Female ; Humans ; Infant, Extremely Premature ; Infant, Newborn ; Ligation ; Male ; Pain Measurement ; Pain, Postoperative/drug therapy ; Retrospective Studies ; Sufentanil/administration & dosage ; Sufentanil/adverse effects ; Time Factors ; Treatment Outcome
Chemical Substances	Analgesics, Opioid ; Sufentanil (AFE2YW0IIZ)
Language	English
Publishing date	2017-04-09
Publishing country	United States
Document type	Comparative Study ; Journal Article
ZDB-ID	632582-8
ISSN	1536-5409 ; 0749-8047
ISSN (online)	1536-5409
ISSN	0749-8047
DOI	10.1097/AJP.0000000000000487
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Article ; Online: Use of neurally adjusted ventilator assist in postsurgical hemidiaphragmatic paralysis.

Soreze, Yohan / Motte, Emmanuelle / Dell'Orto, Valentina / Yousef, Nadya / De Luca, Daniele

Archives of disease in childhood. Fetal and neonatal edition

2017 Volume 103, Issue 1, Page(s) F86–F87

MeSH term(s)	Cardiovascular Surgical Procedures/adverse effects ; Ductus Arteriosus, Patent/diagnostic imaging ; Ductus Arteriosus, Patent/surgery ; Female ; Humans ; Infant, Newborn ; Infant, Premature ; Intensive Care Units, Neonatal ; Interactive Ventilatory Support/methods ; Respiratory Paralysis/etiology ; Ventilators, Mechanical
Language	English
Publishing date	2017-11-01
Publishing country	England
Document type	Case Reports ; Journal Article
ZDB-ID	2007331-8
ISSN	1468-2052 ; 1359-2998
ISSN (online)	1468-2052
ISSN	1359-2998
DOI	10.1136/archdischild-2017-313570
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Article ; Online: Feasibility of open abdomen surgery treatment for near fatal necrotizing enterocolitis in preterm infants.

Irtan, Sabine / Reignier, Pierre-Louis / Durandy, Amélie / Hervieux, Erik / Constant, Isabelle / Lemale, Julie / Soreze, Yohan / Leger, Pierre-Louis / Audry, Georges / Rambaud, Jérôme / Guellec, Isabelle

Journal of pediatric surgery

2021 Volume 57, Issue 7, Page(s) 1336–1341

Abstract: Introduction: Necrotizing Enterocolitis (NEC) remained a dramatic complication leading to death or neonatal morbidities in preterms. For some, Intra-Abdominal Hypertension (IAH) and Abdominal Compartment Syndrome worsened the multi-organ failure. An ... ...

Abstract	Introduction: Necrotizing Enterocolitis (NEC) remained a dramatic complication leading to death or neonatal morbidities in preterms. For some, Intra-Abdominal Hypertension (IAH) and Abdominal Compartment Syndrome worsened the multi-organ failure. An open abdomen surgery could be an alternative to conventional surgical treatment to move beyond this stage. Objectives: To retrospectively describe the clinical course, pre- and post-operative features of preterms suffering from severe NEC with IAH treated by open abdomen surgery and referred to our center from October 2007 to September 2019. Our secondary objective is to identify various risk factors for mortality in this population. Methods: Data on neonatal, clinical, biological, pre and post-operative features and outcome were collected. Univariate analyses were performed to compare their pre and post-operative features stratifying on outcome. Results: Among 29 included patients, 14 (48%) survived to discharge without short bowel syndrome. Death was associated with an earlier postnatal age at NEC (16.3 ± 9.1 versus 31.3 ± 25.9 days; p = 0.004) and followed a withdrawal of treatment in 60% of cases. Surgery was associated with a significant improvement of respiratory and hemodynamic features (decrease of mean ventilator pressure from 13.1 ± 5.4 to 11.3 ± 4.0 cmH2O, p < 0.001), oxygen requirement (mean FiO2 decreased from 65.0% ± 31.2 to 49.0% ± 24.6, p < 0.001) and inotropic score (from 38.6 ± 70.1 to 29.9 ± 64.3, p < 0.001). In the survival group, pre and post-operative findings exhibited a significant increase of serum lactate concentrations from 2.7 ± 1.6 to 11.0 ± 20.3 mmol/L (p = 0.02) but a similar pH. Conclusion: Open abdomen surgery could be considered to rescue preterms with near fatal NEC. IAH and Abdominal Compartment Syndrome in these preterms should be investigated through further studies. Level of evidence: Level III.
MeSH term(s)	Abdomen ; Enterocolitis, Necrotizing ; Feasibility Studies ; Humans ; Infant ; Infant, Newborn ; Infant, Newborn, Diseases ; Infant, Premature ; Intra-Abdominal Hypertension/etiology ; Intra-Abdominal Hypertension/surgery ; Retrospective Studies
Language	English
Publishing date	2021-10-02
Publishing country	United States
Document type	Journal Article
ZDB-ID	80165-3
ISSN	1531-5037 ; 0022-3468
ISSN (online)	1531-5037
ISSN	0022-3468
DOI	10.1016/j.jpedsurg.2021.09.044
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