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Artikel ; Online: Pharmacokinetics/pharmacodynamics and therapeutic drug monitoring of ceftazidime/avibactam administered by continuous infusion in patients with MDR Gram-negative bacterial infections-authors' response.

Fresán, Daniel / Luque, Sonia / Sorlí, Luisa / Grau, Santiago

The Journal of antimicrobial chemotherapy

2023 Band 78, Heft 9, Seite(n) 2385–2386

Mesh-Begriff(e)	Humans ; Ceftazidime/pharmacology ; Drug Monitoring ; Anti-Bacterial Agents/pharmacology ; Azabicyclo Compounds/pharmacology ; Gram-Negative Bacterial Infections/drug therapy ; Drug Combinations
Chemische Substanzen	Ceftazidime (9M416Z9QNR) ; avibactam (7352665165) ; Anti-Bacterial Agents ; Azabicyclo Compounds ; Drug Combinations
Sprache	Englisch
Erscheinungsdatum	2023-07-21
Erscheinungsland	England
Dokumenttyp	Letter ; Research Support, Non-U.S. Gov't ; Comment
ZDB-ID	191709-2
ISSN	1460-2091 ; 0305-7453
ISSN (online)	1460-2091
ISSN	0305-7453
DOI	10.1093/jac/dkad217
Datenquelle	MEDical Literature Analysis and Retrieval System OnLINE

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Artikel ; Online: Therapeutic drug monitoring of colistin in plasma and cerebrospinal fluid in meningoventriculitis caused by a carbapenem-resistant Enterobacter cloacae.

Acín, Pablo / Luque, Sonia / Sorli, Luisa / Grau, Santiago

Enfermedades infecciosas y microbiologia clinica (English ed.)

2022 Band 40, Heft 5, Seite(n) 277–278

Mesh-Begriff(e)	Carbapenem-Resistant Enterobacteriaceae ; Carbapenems/pharmacology ; Carbapenems/therapeutic use ; Colistin/therapeutic use ; Drug Monitoring ; Enterobacter cloacae
Chemische Substanzen	Carbapenems ; Colistin (Z67X93HJG1)
Sprache	Englisch
Erscheinungsdatum	2022-05-14
Erscheinungsland	Spain
Dokumenttyp	Case Reports
ISSN	2529-993X
ISSN (online)	2529-993X
DOI	10.1016/j.eimce.2021.02.011
Datenquelle	MEDical Literature Analysis and Retrieval System OnLINE

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Artikel ; Online: Therapeutic drug monitoring of colistin in plasma and cerebrospinal fluid in meningoventriculitis caused by a carbapenem-resistant Enterobacter cloacae.

Acín, Pablo / Luque, Sonia / Sorli, Luisa / Grau, Santiago

Enfermedades infecciosas y microbiologia clinica (English ed.)

2021

Sprache	Spanisch
Erscheinungsdatum	2021-04-15
Erscheinungsland	Spain
Dokumenttyp	Case Reports
ISSN	2529-993X
ISSN (online)	2529-993X
DOI	10.1016/j.eimc.2021.02.011
Datenquelle	MEDical Literature Analysis and Retrieval System OnLINE

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Artikel ; Online: Therapeutic Drug Monitoring and Prolonged Infusions of Ceftolozane/Tazobactam for MDR/XDR Pseudomonas aeruginosa Infections: An Observational Study.

Navarrete-Rouco, María Eugenia / Luque, Sònia / Sorlí, Luisa / Benítez-Cano, Adela / Roberts, Jason A / Grau, Santiago

European journal of drug metabolism and pharmacokinetics

2022 Band 47, Heft 4, Seite(n) 561–566

Abstract: Background and objective: Prolonged infusion of ceftolozane/tazobactam (C/T) is a strategy used to increase achievement of pharmacokinetic/pharmacodynamic targets for the treatment of multi- or extensively drug-resistant MDR/XDR Gram-negative ... ...

Abstract	Background and objective: Prolonged infusion of ceftolozane/tazobactam (C/T) is a strategy used to increase achievement of pharmacokinetic/pharmacodynamic targets for the treatment of multi- or extensively drug-resistant MDR/XDR Gram-negative microorganisms. The objective of this study was to describe our therapeutic drug monitoring (TDM) experience of C/T administered by prolonged infusion or intermittent infusion to patients with MDR/XDR Pseudomonas aeruginosa infections. Our outcomes of interest were pharmacokinetic/pharmacodynamic target achievement and clinical cure. Methods: Patients with MDR/XDR P. aeruginosa infections treated with C/T were enrolled between February 2018 and February 2020. Blood samples were obtained as part of a TDM program. The pharmacokinetic/pharmacodynamic therapeutic target of C/T was defined as 100% of the duration of the dosing interval that free concentrations are above the minimum inhibitory concentration (MIC) (100 %ƒT ≥ MIC) of the causative pathogen. Dose changes were performed according to TDM results. Results: Forty patients were included: 13 (32.5%) with a proven MDR and 27 (67.5%) with a XDR P. aeruginosa infection. C/T was administered by prolonged infusion in 32 (80%) patients and by intermittent infusion in 8 (20%) patients. Lower doses were administered in the prolonged infusion compared to the intermittent infusion group [3 (9.4%) vs. 5 (62.5%] patients received a dose of 9 g/day (ceftolozane 2 g + tazobactam 1 g, every 8 h; p = 0.004). All patients achieved the pharmacokinetic/pharmacodynamic target and C/T concentrations exceeded 10 × MIC in > 50% of patients in both groups. TDM-recommended dose reductions occurred in 19 (47.5%) patients, being 16 (84.2%) in the prolonged infusion group. A high proportion of patients achieved clinical cure (82.5%). Conclusions: The administration of C/T by prolonged infusion with TDM-guided dosing allowed the achievement of a pharmacokinetic/pharmacodynamic target even at lower doses. C/T showed a high efficacy for treating MDR/XDR P. aeruginosa infections.
Mesh-Begriff(e)	Anti-Bacterial Agents/pharmacology ; Anti-Bacterial Agents/therapeutic use ; Cephalosporins ; Drug Monitoring ; Humans ; Microbial Sensitivity Tests ; Pseudomonas Infections/drug therapy ; Pseudomonas aeruginosa ; Tazobactam/pharmacology ; Tazobactam/therapeutic use
Chemische Substanzen	Anti-Bacterial Agents ; Cephalosporins ; ceftolozane (37A4IES95Q) ; Tazobactam (SE10G96M8W)
Sprache	Englisch
Erscheinungsdatum	2022-06-03
Erscheinungsland	France
Dokumenttyp	Journal Article ; Observational Study
ZDB-ID	196729-0
ISSN	2107-0180 ; 0398-7639 ; 0378-7966
ISSN (online)	2107-0180
ISSN	0398-7639 ; 0378-7966
DOI	10.1007/s13318-022-00772-x
Datenquelle	MEDical Literature Analysis and Retrieval System OnLINE

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Artikel ; Online: Colistin plasma concentrations are not associated with better clinical outcomes in patients with pneumonia caused by extremely drug-resistant

Sorlí, Luisa / Luque, Sonia / Li, Jian / Benítez-Cano, Adela / Fernández, Xenia / Prim, Nuria / Vega, Victoria / Gómez-Junyent, Joan / López-Montesinos, Inmaculada / Gómez-Zorrilla, Silvia / Montero, M Milagro / Grau, Santiago / Horcajada, Juan Pablo

Microbiology spectrum

2023 Band 11, Heft 6, Seite(n) e0296723

Abstract: Importance: In some cases, colistin is the only treatment option for infections caused by the very drug- ... ...

Abstract	Importance: In some cases, colistin is the only treatment option for infections caused by the very drug-resistant
Mesh-Begriff(e)	Humans ; Colistin/therapeutic use ; Anti-Bacterial Agents/pharmacology ; Pseudomonas aeruginosa ; Drug Resistance, Multiple, Bacterial ; Pneumonia/drug therapy ; Pseudomonas Infections/drug therapy ; Microbial Sensitivity Tests
Chemische Substanzen	Colistin (Z67X93HJG1) ; Anti-Bacterial Agents
Sprache	Englisch
Erscheinungsdatum	2023-11-09
Erscheinungsland	United States
Dokumenttyp	Journal Article
ZDB-ID	2807133-5
ISSN	2165-0497 ; 2165-0497
ISSN (online)	2165-0497
ISSN	2165-0497
DOI	10.1128/spectrum.02967-23
Datenquelle	MEDical Literature Analysis and Retrieval System OnLINE

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Artikel ; Online: Therapeutic Drug Monitoring of Vancomycin Concentrations for the Management of Bone and Joint Infections: An Urgent Need.

Rio-No, Laura / Sorli, Luisa / Arderiu-Formenti, Alba / De Antonio, Marta / Martorell, Lucas / Subirana, Isaac / Puig, Lluis / Alier, Albert / Gómez-Junyent, Joan / Pérez-Prieto, Daniel / Luque, Sonia

Tropical medicine and infectious disease

2023 Band 8, Heft 2

Abstract: Vancomycin is used for the treatment of bone and joint infections (BJI), but scarce information is available about its pharmacokinetic/pharmacodynamic (PK/PD) characteristics. We aimed to identify the risk factors associated with the non-achievement of ... ...

Abstract	Vancomycin is used for the treatment of bone and joint infections (BJI), but scarce information is available about its pharmacokinetic/pharmacodynamic (PK/PD) characteristics. We aimed to identify the risk factors associated with the non-achievement of an optimal PK/PD target in the first therapeutic drug monitoring (TDM). Methods: A retrospective study was conducted in a tertiary hospital from January 2020 to January 2022. Patients with BJI and TDM of vancomycin on day 2 of treatment were included. Initial vancomycin fixed doses (1 g every 8 h or 12 h) was decided by the responsible doctors. According to TDM results, dosage adjustments were performed. An AUC
Sprache	Englisch
Erscheinungsdatum	2023-02-13
Erscheinungsland	Switzerland
Dokumenttyp	Journal Article
ISSN	2414-6366
ISSN (online)	2414-6366
DOI	10.3390/tropicalmed8020113
Datenquelle	MEDical Literature Analysis and Retrieval System OnLINE

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Artikel: Clinical, Microbiological and Treatment Characteristics of Severe Postoperative Respiratory Infections: An Observational Cohort Study.

Benítez-Cano, Adela / Bermejo, Silvia / Luque, Sonia / Sorlí, Luisa / Carazo, Jesús / Zaragoza, Irene / Ramos, Isabel / Vallès, Jordi / Horcajada, Juan P / Adalia, Ramón

Journal of personalized medicine

2023 Band 13, Heft 10

Abstract: Respiratory infections are frequent and life-threatening complications of surgery. This study aimed to evaluate the clinical, microbiological and treatment characteristics of severe postoperative pneumonia (POP) and tracheobronchitis (POT) in a large ... ...

Abstract	Respiratory infections are frequent and life-threatening complications of surgery. This study aimed to evaluate the clinical, microbiological and treatment characteristics of severe postoperative pneumonia (POP) and tracheobronchitis (POT) in a large series of patients. This single-center, prospective observational cohort study included patients with POP or POT requiring intensive care unit admission in the past 10 years. We recorded demographic, clinical, microbiological and therapeutic data. A total of 207 patients were included, and 152 (73%) were men. The mean (SD) age was 70 (13) years and the mean (SD) ARISCAT score was 46 (19). Ventilator-associated pneumonia was reported in 21 patients (10%), hospital-acquired pneumonia was reported in 132 (64%) and tracheobronchitis was reported in 54 (26%). The mean (SD) number of days from surgery to POP/POT diagnosis was 6 (4). The mean (SD) SOFA score was 5 (3). Respiratory microbiological sampling was performed in 201 patients (97%). A total of 177 organisms were cultured in 130 (63%) patients, with a high proportion of Gram-negative and multi-drug resistant (MDR) bacteria (20%). The most common empirical antibiotic therapy was a triple-drug regimen covering MDR Gram-negative bacteria and MRSA. In conclusion, surgical patients are a high-risk population with a high proportion of early onset severe POP/POT and nosocomial bacteria isolation.
Sprache	Englisch
Erscheinungsdatum	2023-10-11
Erscheinungsland	Switzerland
Dokumenttyp	Journal Article
ZDB-ID	2662248-8
ISSN	2075-4426
ISSN	2075-4426
DOI	10.3390/jpm13101482
Datenquelle	MEDical Literature Analysis and Retrieval System OnLINE

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Artikel ; Online: High-dose daptomycin together with rifampin as salvage therapy for prosthetic joint infections.

Herrera, Sabina / Sorlí, Luisa / Horcajada, Juan Pablo

Medicina clinica

2017 Band 149, Heft 5, Seite(n) 223–224

Titelübersetzung	Daptomicina a dosis elevadas y rifampicina como tratamiento de rescate para infecciones protésicas.
Mesh-Begriff(e)	Aged ; Aged, 80 and over ; Anti-Bacterial Agents/administration & dosage ; Anti-Bacterial Agents/therapeutic use ; Daptomycin/administration & dosage ; Daptomycin/therapeutic use ; Dose-Response Relationship, Drug ; Drug Administration Schedule ; Drug Therapy, Combination ; Female ; Humans ; Joint Prosthesis/adverse effects ; Male ; Middle Aged ; Prosthesis-Related Infections/drug therapy ; Retrospective Studies ; Rifampin/administration & dosage ; Rifampin/therapeutic use ; Salvage Therapy/methods ; Staphylococcal Infections/drug therapy ; Treatment Outcome
Chemische Substanzen	Anti-Bacterial Agents ; Daptomycin (NWQ5N31VKK) ; Rifampin (VJT6J7R4TR)
Sprache	Spanisch
Erscheinungsdatum	2017-06-08
Erscheinungsland	Spain
Dokumenttyp	Letter ; Observational Study
ZDB-ID	411607-0
ISSN	1578-8989 ; 0025-7753
ISSN (online)	1578-8989
ISSN	0025-7753
DOI	10.1016/j.medcli.2017.04.031
Datenquelle	MEDical Literature Analysis and Retrieval System OnLINE

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Artikel ; Online: Ampicillin-resistant and vancomycin-susceptible

Echeverria-Esnal, Daniel / Sorli, Luisa / Navarrete-Rouco, María Eugenia / Prim, Nuria / Barcelo-Vidal, Jaime / Conde-Estévez, David / Montero, María Milagro / Martin-Ontiyuelo, Clara / Horcajada, Juan Pablo / Grau, Santiago

Expert review of anti-infective therapy

2023 Band 21, Heft 7, Seite(n) 759–775

Abstract: Introduction: Enterococcus faecium: Areas covered: This article mostly reviews the relevant aspects of EfARSV bacteremia: microbiology, gastrointestinal tract colonization and invasion, antibiotic resistance, epidemiology, risk factors, mortality, ... ...

Abstract	Introduction: Enterococcus faecium Areas covered: This article mostly reviews the relevant aspects of EfARSV bacteremia: microbiology, gastrointestinal tract colonization and invasion, antibiotic resistance, epidemiology, risk factors, mortality, and treatment, including pharmacologic components of employed agents and related clinical evidence. A literature search was conducted on PubMed on 31 July 2022, which was updated on 15 November 2022. Expert opinion: EfARSV bacteremia presents high mortality. However, it is uncertain whether mortality is attributable to or a marker of severity/comorbidities. Considering its antibiotic resistance pattern, EfARSV is considered a difficult-to-treat microorganism. Glycopeptides have been used to treat EfARSV, with linezolid and daptomycin serving as potential alternative agents. Yet, the use of daptomycin is controversial due to a higher risk of treatment failures. Clinical evidence on this issue is scarce, unfortunately, and subject to many limitations. Despite increased incidence and mortality, EfARSV bacteremia presents multiple aspects to be addressed in well-conducted studies.
Mesh-Begriff(e)	Humans ; Anti-Bacterial Agents/adverse effects ; Vancomycin/pharmacology ; Vancomycin/therapeutic use ; Daptomycin/adverse effects ; Enterococcus faecium ; Treatment Outcome ; Bacteremia/drug therapy ; Bacteremia/epidemiology ; Ampicillin/pharmacology ; Ampicillin/therapeutic use ; Gram-Positive Bacterial Infections/drug therapy ; Gram-Positive Bacterial Infections/epidemiology
Chemische Substanzen	Anti-Bacterial Agents ; Vancomycin (6Q205EH1VU) ; Daptomycin (NWQ5N31VKK) ; Ampicillin (7C782967RD)
Sprache	Englisch
Erscheinungsdatum	2023-06-14
Erscheinungsland	England
Dokumenttyp	Journal Article ; Review
ZDB-ID	2181279-2
ISSN	1744-8336 ; 1478-7210
ISSN (online)	1744-8336
ISSN	1478-7210
DOI	10.1080/14787210.2023.2223977
Datenquelle	MEDical Literature Analysis and Retrieval System OnLINE

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Artikel ; Online: Real-world experience of therapeutic drug monitoring and PK/PD achievement of ceftaroline administered by different infusion regimens in patients with confirmed infections caused by Gram-positive bacteria.

Fresán, Daniel / Luque, Sonia / Benítez-Cano, Adela / Sorlí, Luisa / Montero, María Milagro / De-Antonio, Marta / Vega, Victoria / Roberts, Jason A / Horcajada, Juan P / Grau, Santiago

The Journal of antimicrobial chemotherapy

2023 Band 78, Heft 12, Seite(n) 2810–2815

Abstract: Background: Ceftaroline is a novel cephalosporin active against MDR Gram-positive (GP) bacteria. For β-lactam antibiotics, such as ceftaroline, prolonged infusions and therapeutic drug monitoring (TDM) are used for dosage optimization based on their ... ...

Abstract	Background: Ceftaroline is a novel cephalosporin active against MDR Gram-positive (GP) bacteria. For β-lactam antibiotics, such as ceftaroline, prolonged infusions and therapeutic drug monitoring (TDM) are used for dosage optimization based on their pharmacokinetics/pharmacodynamics (PK/PD). Objectives: To describe our experience with TDM and PK/PD target attainment of ceftaroline administered by intermittent and prolonged infusion in a cohort of patients with MDR-GP bacterial infections. Methods: Patients treated with ceftaroline administered by continuous (24 h), extended (3 h/6 h) and intermittent infusion (1 h) and undergoing TDM of plasma concentrations were included. A 100%fT>4×MIC was the pre-specified PK/PD target and 100%fT>10×MIC was considered overexposure. Dose recommendations were made based on TDM results and each patient's clinical condition. Results: Twelve patients [83.3% male, median age of 73 (38-83) years] were included. Nine patients (75%) achieved 100%fT>4×MIC, all under prolonged infusions. In one patient, the 100%fT was >10×MIC but no toxicity was observed. Based on TDM results, initial doses were recommended to be maintained in eight patients, decreased in three and increased in one. Conclusions: The administration of ceftaroline by prolonged infusion together with TDM may be a useful strategy for achieving the desired PK/PD target in these patients. However, more studies evaluating the relationship between PK/PD attainment and clinical outcomes are needed.
Mesh-Begriff(e)	Humans ; Male ; Aged ; Aged, 80 and over ; Female ; Anti-Bacterial Agents/adverse effects ; Drug Monitoring/methods ; Cephalosporins/adverse effects ; Infusions, Parenteral ; Monobactams ; Ceftaroline
Chemische Substanzen	Anti-Bacterial Agents ; Cephalosporins ; Monobactams
Sprache	Englisch
Erscheinungsdatum	2023-10-11
Erscheinungsland	England
Dokumenttyp	Journal Article ; Research Support, Non-U.S. Gov't
ZDB-ID	191709-2
ISSN	1460-2091 ; 0305-7453
ISSN (online)	1460-2091
ISSN	0305-7453
DOI	10.1093/jac/dkad296
Datenquelle	MEDical Literature Analysis and Retrieval System OnLINE

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