Article ; Online: A case-control study of the clinical and economic impact of infections caused by Carbapenemase-producing Enterobacterales (CPE).
2024
Abstract: Purpose: The aim was to analyse the clinical and economic impact of carbapenemase-producing Enterobacterales (CPE) infections.: Methods: Case-control study. Adult patients with CPE infections were considered cases, while those with non-CPE infections ...
| Abstract | Purpose: The aim was to analyse the clinical and economic impact of carbapenemase-producing Enterobacterales (CPE) infections. Methods: Case-control study. Adult patients with CPE infections were considered cases, while those with non-CPE infections were controls. Matching criteria were age (± 5 years), sex, source of infection and microorganism (ratio 1:2). Primary outcome was 30-day mortality. Secondary outcomes were 90-day mortality, clinical failure, hospitalisation costs and resource consumption. Results: 246 patients (82 cases and 164 controls) were included. Klebsiella pneumoniae OXA-48 was the most common microorganism causing CPE infections. CPE cases had more prior comorbidities (p = 0.007), septic shock (p = 0.003), and were more likely to receive inappropriate empirical and definitive antibiotic treatment (both p < 0.001). Multivariate analysis identified septic shock and inappropriate empirical treatment as independent predictors for 7-day and end-of-treatment clinical failure, whereas Charlson Index and septic shock were associated with 30- and 90-day mortality. CPE infection was independently associated with early clinical failure (OR 2.18, 95% CI, 1.03-4.59), but not with end-of-treatment clinical failure or 30- or 90-day mortality. In terms of resource consumption, hospitalisation costs for CPE were double those of the non-CPE group. CPE cases had longer hospital stay (p < 0.001), required more long-term care facilities (p < 0.001) and outpatient parenteral antibiotic therapy (p = 0.007). Conclusions: The CPE group was associated with worse clinical outcomes, but this was mainly due to a higher comorbidity burden, more severe illness, and more frequent inappropriate antibiotic treatment rather than resistance patterns as such. However, the CPE group consumed more healthcare resources and incurred higher costs. |
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| Language | English |
| Publishing date | 2024-05-03 |
| Publishing country | Germany |
| Document type | Journal Article |
| ZDB-ID | 185104-4 |
| ISSN | 1439-0973 ; 0300-8126 ; 0173-2129 |
| ISSN (online) | 1439-0973 |
| ISSN | 0300-8126 ; 0173-2129 |
| DOI | 10.1007/s15010-024-02268-z |
| Database | MEDical Literature Analysis and Retrieval System OnLINE |
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