LIVIVO - Search results -

Search results

Result 1 - 10 of total 167

Search options

Article ; Online: Glucosylated Hybrid TiO

Zlotver, Ivan / Sosnik, Alejandro

Small (Weinheim an der Bergstrasse, Germany)

2023 Volume 20, Issue 4, Page(s) e2305475

Abstract: Sonodynamic therapy (SDT) is an anti-cancer therapeutic strategy based on the generation of reactive oxygen species (ROS) upon local ultrasound (US) irradiation of sono-responsive molecules or nanomaterials that accumulate in the tumor. In this work, the ...

Abstract	Sonodynamic therapy (SDT) is an anti-cancer therapeutic strategy based on the generation of reactive oxygen species (ROS) upon local ultrasound (US) irradiation of sono-responsive molecules or nanomaterials that accumulate in the tumor. In this work, the sonodynamic efficiency of sono-responsive hybrid nanomaterials composed of amorphous titanium dioxide and an amphiphilic poly(ethylene oxide)-b-poly(propylene oxide) block copolymer is synthesized, fully characterized, and investigated both in vitro and in vivo. The modular and versatile synthetic pathway enables the control of the nanoparticle size between 30 and 300 nm (dynamic light scattering) and glucosylation of the surface for active targeting of tumors overexpressing glucose transporters. Studies on 2D and 3D rhabdomyosarcoma cell cultures reveal a statistically significant increase in the sonodynamic efficiency of glucosylated hybrid nanoparticles with respect to unmodified ones. Using a xenograft rhabdomyosarcoma murine model, it is demonstrated that by tuning the nanoparticle size and surface features, the tumor accumulation is increased by ten times compared to main off-target clearance organs such as the liver. Finally, the SDT of rhabdomyosarcoma-bearing mice is investigated with 50-nm glucosylated nanoparticles. Findings evidence a dramatic prolongation of the animal survival and tumor volumes 100 times smaller than those treated only with ultrasound or nanoparticles.
MeSH term(s)	Humans ; Animals ; Mice ; Ultrasonography ; Ultrasonic Therapy/methods ; Nanoparticles/therapeutic use ; Reactive Oxygen Species/metabolism ; Polymers ; Rhabdomyosarcoma ; Cell Line, Tumor
Chemical Substances	Reactive Oxygen Species ; Polymers
Language	English
Publishing date	2023-09-15
Publishing country	Germany
Document type	Journal Article
ZDB-ID	2168935-0
ISSN	1613-6829 ; 1613-6810
ISSN (online)	1613-6829
ISSN	1613-6810
DOI	10.1002/smll.202305475
Database	MEDical Literature Analysis and Retrieval System OnLINE

Order via subito

This service is chargeable due to the Delivery terms set by subito. Orders including an article and supplementary material will be classified as separate orders. In these cases, fees will be demanded for each order.

Article ; Online: Mucus-Mimicking Mucin-Based Hydrogels by Tandem Chemical and Physical Crosslinking.

Porfiryeva, Natalia N / Zlotver, Ivan / Davidovich-Pinhas, Maya / Sosnik, Alejandro

Macromolecular bioscience

2024 , Page(s) e2400028

Abstract: Mucosal tissues represent a major interface between the body and the external environment and are covered by a highly hydrated mucins gel called mucus. Mucus lubricates, protects and modulates the moisture levels of the tissue and is capitalized in ... ...

Abstract	Mucosal tissues represent a major interface between the body and the external environment and are covered by a highly hydrated mucins gel called mucus. Mucus lubricates, protects and modulates the moisture levels of the tissue and is capitalized in transmucosal drug delivery. Pharmaceutical researchers often use freshly excised animal mucosal membranes to assess mucoadhesion and muco-penetration of pharmaceutical formulations which may struggle with limited accessibility, reproducibility, and ethical questions. Aiming to develop a platform for the rationale study of the interaction of drugs and delivery systems with mucosal tissues, in this work mucus-mimicking mucin-based hydrogels are synthesized by the tandem chemical and physical crosslinking of mucin aqueous solutions. Chemical crosslinking is achieved with glutaraldehyde (0.3% and 0.75% w/v), while physical crosslinking by one or two freeze-thawing cycles. Hydrogels after one freeze-thawing cycle show water content of 97.6-98.1%, density of 0.0529-0.0648 g cm⁻
Language	English
Publishing date	2024-03-21
Publishing country	Germany
Document type	Journal Article
ZDB-ID	2039130-4
ISSN	1616-5195 ; 1616-5187
ISSN (online)	1616-5195
ISSN	1616-5187
DOI	10.1002/mabi.202400028
Database	MEDical Literature Analysis and Retrieval System OnLINE

Order via subito

Book ; Online: Biomateriais aplicados ao desenvolvimento de sistemas terapêuticos avançados

Sousa, Hermínio C. de / Braga, Mara E. M. / Sosnik, Alejandro

2015

Abstract: Esta obra apresenta contribuições que cobrem o estado-da-arte de vários tópicos científicos e técnicos e que foram desenvolvidos no âmbito das actividades científicas e de formação de um projecto-em-rede CYTED, intitulado RIMADEL - Rede Ibero-Americana ... ...

Abstract	Esta obra apresenta contribuições que cobrem o estado-da-arte de vários tópicos científicos e técnicos e que foram desenvolvidos no âmbito das actividades científicas e de formação de um projecto-em-rede CYTED, intitulado RIMADEL - Rede Ibero-Americana de Nuevos Materiales para el Diseño de Sistemas Avanzados de Liberación de Fármacos en Enfermidades de Alto Impacto Socioeconómico. Este projecto pretendeu criar uma plataforma Ibero-Americana de intercâmbio de investigadores, de conhecimento e de recursos científicos e tecnológicos, orientada para o desenvolvimento de novos biomateriais com aplicações em sistemas avançados de libertação de agentes terapêuticos, e em suportes para dispositivos biomédicos e engenharia de tecidos/medicina regenerativa. Apresentam-se perspectivas abrangentes, embora muito actuais, e para que este livro possa servir também como uma obra de referência para estudantes de graduação e de pós-graduação de países falantes da Língua Portuguesa ou Castelhana, em áreas como a Engenharia (Engenharia Química, Engenharia de Materiais, Engenharia Biomédica, Engenharia Biológica), Ciências Farmacêuticas, Química, Química Medicinal, Química Biológica, Bioquímica, e Biologia
Keywords	Science (General)
Size	1 electronic resource (770 p.)
Publisher	Coimbra University Press
Publishing place	Verlagsort nicht ermittelbar
Document type	Book ; Online
Note	Portuguese ; Open Access
HBZ-ID	HT020195345
ISBN	9789892608808 ; 9892608801
Database	ZB MED Catalogue: Medicine, Health, Nutrition, Environment, Agriculture

Order via subito

Inter-library loan at ZB MED

Your chosen title can be delivered directly to ZB MED Cologne location if you are registered as a user at ZB MED Cologne.

Article ; Online: Galactomannan-

Sosnik, Alejandro / Zlotver, Ivan / Peled, Ella

Journal of materials chemistry. B

2023 Volume 11, Issue 35, Page(s) 8471–8483

Abstract: Macrophages are immune cells that can be activated into either pro-inflammatory M1 or anti-inflammatory M2 phenotypes. Attempts to modulate macrophage phenotype using drugs have been limited by targeting issues and systemic toxicity. This study ... ...

Abstract	Macrophages are immune cells that can be activated into either pro-inflammatory M1 or anti-inflammatory M2 phenotypes. Attempts to modulate macrophage phenotype using drugs have been limited by targeting issues and systemic toxicity. This study investigates the effect of drug-free self-assembled hydrolyzed galactomannan-poly(methyl methacrylate) (hGM-
MeSH term(s)	Humans ; Polymethyl Methacrylate/pharmacology ; Anti-Inflammatory Agents/pharmacology ; Cytokines ; Macrophages ; Nanoparticles ; Phenotype
Chemical Substances	Polymethyl Methacrylate (9011-14-7) ; gentamicin-polymethylmethacrylate bead ; galactomannan (11078-30-1) ; Anti-Inflammatory Agents ; Cytokines
Language	English
Publishing date	2023-09-13
Publishing country	England
Document type	Journal Article ; Research Support, Non-U.S. Gov't
ZDB-ID	2702241-9
ISSN	2050-7518 ; 2050-750X
ISSN (online)	2050-7518
ISSN	2050-750X
DOI	10.1039/d3tb01397a
Database	MEDical Literature Analysis and Retrieval System OnLINE

Order via subito

Article ; Online: Pulmonary arterial hypertension nanotherapeutics: New pharmacological targets and drug delivery strategies.

Boucetta, Hamza / Zhang, Lei / Sosnik, Alejandro / He, Wei

Journal of controlled release : official journal of the Controlled Release Society

2023 Volume 365, Page(s) 236–258

Abstract: Pulmonary arterial hypertension (PAH) is a rare, serious, and incurable disease characterized by high lung pressure. PAH-approved drugs based on conventional pathways are still not exhibiting favorable therapeutic outcomes. Drawbacks like short half- ... ...

Abstract	Pulmonary arterial hypertension (PAH) is a rare, serious, and incurable disease characterized by high lung pressure. PAH-approved drugs based on conventional pathways are still not exhibiting favorable therapeutic outcomes. Drawbacks like short half-lives, toxicity, and teratogenicity hamper effectiveness, clinical conventionality, and long-term safety. Hence, approaches like repurposing drugs targeting various and new pharmacological cascades and/or loaded in non-toxic/efficient nanocarrier systems are being investigated lately. This review summarizes the status of conventional, repurposed, either in vitro, in vivo, and/or in clinical trials of PAH treatment. In-depth description, discussion, and classification of the new pharmacological targets and nanomedicine strategies with a description of all the nanocarriers that showed promising efficiency in delivering drugs are discussed. Ultimately, an illustration of the different nucleic acids tailored and nanoencapsulated within different types of nanocarriers to restore the pathways affected by this disease is presented.
MeSH term(s)	Humans ; Pulmonary Arterial Hypertension/drug therapy ; Drug Delivery Systems ; Familial Primary Pulmonary Hypertension/drug therapy ; Nanomedicine
Language	English
Publishing date	2023-11-24
Publishing country	Netherlands
Document type	Journal Article ; Review
ZDB-ID	632533-6
ISSN	1873-4995 ; 0168-3659
ISSN (online)	1873-4995
ISSN	0168-3659
DOI	10.1016/j.jconrel.2023.11.012
Database	MEDical Literature Analysis and Retrieval System OnLINE

In stock of ZB MED Cologne/Königswinter

Zs.A 2055: Show issues

Location:
Je nach Verfügbarkeit (siehe Angabe bei Bestand)
bis Jg. 1994: Bestellungen von Artikeln über das Online-Bestellformular
Jg. 1995 - 2021: Lesesall (1.OG)
ab Jg. 2022: Lesesaal (EG)

Order via subito

Details ▾
- See ZB MED holdings
- Order with fees

Article: Editorial of Special Column on Delivery Nanotechnologies to Modulate the Immune System and Combat Inflammation and Infection.

He, Wei / Sosnik, Alejandro / Xu, Chenjie

Acta pharmaceutica Sinica. B

2023 Volume 13, Issue 6, Page(s) 2296–2297

Language	English
Publishing date	2023-06-28
Publishing country	Netherlands
Document type	Editorial
ISSN	2211-3835
ISSN	2211-3835
DOI	10.1016/j.apsb.2023.05.027
Database	MEDical Literature Analysis and Retrieval System OnLINE

Order via subito

Inter-library loan at ZB MED

Your chosen title can be delivered directly to ZB MED Cologne location if you are registered as a user at ZB MED Cologne.

Article: Solid-State Dewetting of Thin Au Films for Surface Functionalization of Biomedical Implants.

Sharipova, Aliya / Zlotver, Ivan / Sosnik, Alejandro / Rabkin, Eugen

Materials (Basel, Switzerland)

2023 Volume 16, Issue 24

Abstract: Biomaterial-centered infections of orthopedic implants remain a significant burden in the healthcare system due to sedentary lifestyles and an aging population. One approach to combat infections and improve implant osteointegration is functionalizing the ...

Abstract	Biomaterial-centered infections of orthopedic implants remain a significant burden in the healthcare system due to sedentary lifestyles and an aging population. One approach to combat infections and improve implant osteointegration is functionalizing the implant surface with anti-infective and osteoinductive agents. In this framework, Au nanoparticles are produced on the surface of Ti-6Al-4V medical alloy by solid-state dewetting of 5 nm Au film and used as the substrate for the conjugation of a model antibiotic vancomycin via a mono-thiolated poly(ethylene glycol) linker. Produced Au nanoparticles on Ti-6Al-4V surface are equiaxed with a mean diameter 19.8 ± 7.2 nm, which is shown by high-resolution scanning electron microscopy and atomic force microscopy. The conjugation of the antibiotic vancomycin, 18.8 ± 1.3 nm-thick film, is confirmed by high resolution-scanning transmission electron microscopy and X-ray photoelectron spectroscopy. Overall, showing a link between the solid-state dewetting process and surface functionalization, we demonstrate a novel, simple, and versatile method for functionalization of implant surfaces.
Language	English
Publishing date	2023-12-06
Publishing country	Switzerland
Document type	Journal Article
ZDB-ID	2487261-1
ISSN	1996-1944
ISSN	1996-1944
DOI	10.3390/ma16247524
Database	MEDical Literature Analysis and Retrieval System OnLINE

Order via subito

Article ; Online: Enhanced photoluminescence of boron nitride quantum dots by encapsulation within polymeric nanoparticles.

Abu Saleh, Doaa / Sosnik, Alejandro

Nanotechnology

2021 Volume 32, Issue 19, Page(s) 195104

Abstract: Boron nitride quantum dots (BNQDs) have been proposed as probes for bioimaging owing their to outstanding photoluminescent properties, although their hydrophobic nature and strong aggregation tendency in aqueous media limit their application in the ... ...

Abstract	Boron nitride quantum dots (BNQDs) have been proposed as probes for bioimaging owing their to outstanding photoluminescent properties, although their hydrophobic nature and strong aggregation tendency in aqueous media limit their application in the biomedical field. In this work, we synthesize BNQDs by a liquid exfoliation-solvothermal process under pressure from boron nitride nanoparticles in N,N-dimethylformamide. The BNQDs display an average size of 3.3 ± 0.6 nm, as measured by transmission electron microscopy, and a (100) crystalline structure. In addition, a quantum yield of 21.75 ± 0.20% was achieved. To ensure complete dispersibility in water and prevent possible elimination by renal filtration upon injection, the BNQDs (20% w/w) are encapsulated within poly(ethylene glycol)-b-poly(epsilon-caprolactone) nanoparticles by a simple and scalable nanoprecipitation method, and hybrid nanocomposite particles with significantly stronger photoluminescence than their free counterparts are produced. Finally, their optimal cell compatibility and bioimaging features are demonstrated in vitro in murine macrophage and human rhabdomyosarcoma cell lines.
Language	English
Publishing date	2021-01-29
Publishing country	England
Document type	Journal Article
ZDB-ID	1362365-5
ISSN	1361-6528 ; 0957-4484
ISSN (online)	1361-6528
ISSN	0957-4484
DOI	10.1088/1361-6528/abe155
Database	MEDical Literature Analysis and Retrieval System OnLINE

Order via subito

Article ; Online: Heterocellular spheroids of the neurovascular blood-brain barrier as a platform for personalized nanoneuromedicine.

Kumarasamy, Murali / Sosnik, Alejandro

iScience

2021 Volume 24, Issue 3, Page(s) 102183

Abstract: Nanoneuromedicine investigates nanotechnology to target the brain and treat neurological diseases. In this work, we biofabricated heterocellular spheroids comprising human brain microvascular endothelial cells, brain vascular pericytes and astrocytes ... ...

Abstract	Nanoneuromedicine investigates nanotechnology to target the brain and treat neurological diseases. In this work, we biofabricated heterocellular spheroids comprising human brain microvascular endothelial cells, brain vascular pericytes and astrocytes combined with primary cortical neurons and microglia isolated from neonate rats. The structure and function are characterized by confocal laser scanning and light sheet fluorescence microscopy, electron microscopy, western blotting, and RNA sequencing. The spheroid bulk is formed by neural cells and microglia and the surface by endothelial cells and they upregulate key structural and functional proteins of the blood-brain barrier. These cellular constructs are utilized to preliminary screen the permeability of polymeric, metallic, and ceramic nanoparticles (NPs). Findings reveal that penetration and distribution patterns depend on the NP type and that microglia would play a key role in this pathway, highlighting the promise of this platform to investigate the interaction of different nanomaterials with the central nervous system in nanomedicine, nanosafety and nanotoxicology.
Language	English
Publishing date	2021-02-12
Publishing country	United States
Document type	Journal Article
ISSN	2589-0042
ISSN (online)	2589-0042
DOI	10.1016/j.isci.2021.102183
Database	MEDical Literature Analysis and Retrieval System OnLINE

Order via subito

Inter-library loan at ZB MED

Your chosen title can be delivered directly to ZB MED Cologne location if you are registered as a user at ZB MED Cologne.

Article ; Online: Amphiphilic galactomannan nanoparticles trigger the alternative activation of murine macrophages.

Peled, Ella / Sosnik, Alejandro

Journal of controlled release : official journal of the Controlled Release Society

2021 Volume 339, Page(s) 473–483

Abstract: Macrophages are highly plastic phagocytic cells that can exist in distinct phenotypes and play key roles in physiological and pathological pathways. They can be classically activated to the pro-inflammatory M1 phenotype or alternatively activated to an ... ...

Abstract	Macrophages are highly plastic phagocytic cells that can exist in distinct phenotypes and play key roles in physiological and pathological pathways. They can be classically activated to the pro-inflammatory M1 phenotype or alternatively activated to an M2 anti-inflammatory one by various stimuli in the biological milieu. Different biomaterials polarize macrophages to M1 or M2 phenotypes and emerged as a very promising strategy to modulate their activation and performance. In this work, we investigate the ability of drug-free amphiphilic nanoparticles (hydrodynamic diameter of ~130 nm) produced by the self-assembly of a graft copolymer of hydrolyzed galactomannan, a natural polysaccharide of galactose and mannose, that was hydrophobized in the side-chain with poly(methyl methacrylate) blocks and that can encapsulate hydrophobic drugs, to trigger macrophage polarization. The compatibility and uptake of the nanoparticles are demonstrated in the murine macrophage cell line RAW264.7 by a metabolic assay, confocal laser scanning fluorescence microscopy (CLSFM) and imaging flow cytometry in the absence and the presence of endocytosis inhibitors. Results indicate that they are internalized by both clathrin- and caveolin-mediated endocytosis. The ability of these drug-free nanoparticles to polarize these cells to the M2-like phenotype and to switch an M1 to an M2 phenotype is confirmed by the downregulation of the M1 marker cluster of differentiation 80 (CD80), and upregulation of M2 markers CD163 and CD206, as measured by flow cytometry and CLSFM. In addition, we preliminarily assess the effect of the nanoparticles on wound healing by tracking the closure of an artificial wound of RAW264.7 macrophages in a scratch assay. Findings indicate a faster closure of the wound in the presence of the nanoparticles with respect to untreated cells. Finally, a migration assay utilizing a macrophage/fibroblast co-culture model in vitro demonstrates that M2 polarization increases fibroblast migration by 24-fold with respect to untreated cells. These findings demonstrate the ability of this nanotechnology platform to interfere and change the macrophages phenotype in vitro and represent robust evidence for the investigation of their therapeutic performance alone or in combination with an encapsulated hydrophobic drug in wound models in vivo.
MeSH term(s)	Animals ; Cytokines ; Galactose/analogs & derivatives ; Macrophages ; Mannans ; Mice ; Nanoparticles
Chemical Substances	Cytokines ; Mannans ; galactomannan (11078-30-1) ; Galactose (X2RN3Q8DNE)
Language	English
Publishing date	2021-10-16
Publishing country	Netherlands
Document type	Journal Article ; Research Support, Non-U.S. Gov't
ZDB-ID	632533-6
ISSN	1873-4995 ; 0168-3659
ISSN (online)	1873-4995
ISSN	0168-3659
DOI	10.1016/j.jconrel.2021.10.017
Database	MEDical Literature Analysis and Retrieval System OnLINE

In stock of ZB MED Cologne/Königswinter

Zs.A 2055: Show issues

Location:
Je nach Verfügbarkeit (siehe Angabe bei Bestand)
bis Jg. 1994: Bestellungen von Artikeln über das Online-Bestellformular
Jg. 1995 - 2021: Lesesall (1.OG)
ab Jg. 2022: Lesesaal (EG)

Order via subito

Details ▾
- See ZB MED holdings
- Order with fees

To top

More links

Kategorien

Order via subito

More links

Kategorien

Order via subito

More links

Kategorien

Order via subito

Inter-library loan at ZB MED

More links

Kategorien

Order via subito

More links

Kategorien

In stock of ZB MED Cologne/Königswinter

Order via subito

More links

Kategorien

Order via subito

Inter-library loan at ZB MED

More links

Kategorien

Order via subito

More links

Kategorien

Order via subito

More links

Kategorien

Order via subito

Inter-library loan at ZB MED

More links

Kategorien

In stock of ZB MED Cologne/Königswinter

Order via subito