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  1. Article ; Online: Letter from Italy.

    Sotgiu, Giovanni

    Respirology (Carlton, Vic.)

    2020  Volume 25, Issue 10, Page(s) 1099–1100

    Keywords covid19
    Language English
    Publishing date 2020-07-27
    Publishing country Australia
    Document type Letter
    ZDB-ID 1435849-9
    ISSN 1440-1843 ; 1323-7799
    ISSN (online) 1440-1843
    ISSN 1323-7799
    DOI 10.1111/resp.13919
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    Zs.A 4957: Show issues Location:
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    Jg. 1995 - 2021: Lesesall (2.OG)
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  2. Article ; Online: Optimizing the endoscopic diagnosis of mediastinal lymphadenopathy: a glimpse on cryobiopsy.

    Mondoni, Michele / Sotgiu, Giovanni

    BMC pulmonary medicine

    2022  Volume 22, Issue 1, Page(s) 355

    Abstract: Etiological diagnosis of mediastinal lymphadenopathy represents a daily challenge. Endosonography (transesophageal and transbronchial ultrasound-guided needle aspiration) is the recommended technique in the first diagnostic work-up and in the mediastinal ...

    Abstract Etiological diagnosis of mediastinal lymphadenopathy represents a daily challenge. Endosonography (transesophageal and transbronchial ultrasound-guided needle aspiration) is the recommended technique in the first diagnostic work-up and in the mediastinal staging of lung cancer. Despite a good sensitivity, limited amount of collected tissue may hamper molecular assessment in advanced lung cancer and in the diagnosis of lymphoproliferative disorders, fibrotic sarcoidosis, and mycobacterial lymphadenitis. Cryobiopsy, a bronchoscopic technique based on cooling, crystallization, and subsequent collection of tissue, has been successfully employed in the diagnosis of interstitial lung diseases. Cryoprobes provide larger amount of tissue than conventional bronchoscopic sampling tools and might potentially prevent the need for invasive surgical procedures. New applications of the technique (e.g., bronchoscopic diagnosis of peripheral pulmonary lesions and mediastinal lymph nodes) have been recently described in few reports. In a recent issue of the Journal, Genova et al. described five patients who underwent endobronchial ultrasound transbronchial needle aspiration (EBUS-TBNA) followed by ultrasound-guided transbronchial cryobiopsy of mediastinal lymphadenopathy for a suspected malignancy. The authors discussed about the potential added value of mediastinal cryobiopsy on a correct histopathological and molecular assessment in patients with malignancies. EBUS-cryobiopsy could be a promising technique in the diagnostic pathway of mediastinal lymphadenitis. However, cryobiopsy is now available only in few selected centres. The learning curve of the technique adapted to mediastinal ultrasound-guided sampling, the optimal sampling strategy, its true diagnostic accuracy in patients with malignant and benign diseases, as well as its safety, are still largely unclear. Mediastinal cryobiopsy could be complementary rather than alternative to conventional endosonography. Rapid on-site evaluation of EBUS-TBNA could guide subsequent sampling with cryoprobes in case of poor collection of biological material or in case of suspected lymphoproliferative disorders. Further studies should investigate its diagnostic yield, in comparison or in combination with conventional endosonography, in large cohorts of patients with malignant or benign mediastinal lymphadenopthies.
    MeSH term(s) Bronchoscopy/methods ; Humans ; Lung Neoplasms/pathology ; Lymphadenitis/pathology ; Lymphadenopathy/diagnosis ; Lymphadenopathy/pathology ; Mediastinum/pathology
    Language English
    Publishing date 2022-09-19
    Publishing country England
    Document type Letter
    ZDB-ID 2059871-3
    ISSN 1471-2466 ; 1471-2466
    ISSN (online) 1471-2466
    ISSN 1471-2466
    DOI 10.1186/s12890-022-02160-2
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  3. Article ; Online: TB/Covid-19: An Underestimated Risk?

    Sotgiu, Giovanni / Mondoni, Michele

    Archivos de bronconeumologia

    2022  Volume 58, Issue 11, Page(s) 742–743

    MeSH term(s) Humans ; COVID-19 ; Coinfection ; Tuberculosis
    Language Spanish
    Publishing date 2022-07-20
    Publishing country Spain
    Document type Editorial
    ZDB-ID 733126-5
    ISSN 1579-2129 ; 0300-2896
    ISSN (online) 1579-2129
    ISSN 0300-2896
    DOI 10.1016/j.arbres.2022.07.006
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  5. Article ; Online: People inflows as a pandemic trigger: Evidence from a quasi-experimental study.

    Caria, Andrea / Delogu, Marco / Meleddu, Marta / Sotgiu, Giovanni

    Economics and human biology

    2023  Volume 52, Page(s) 101341

    Abstract: Although it has been established that population density can contribute to the outbreak of the COVID-19 virus, there is no evidence to suggest that economic activities, which imply a significant change in mobility, played a causal role in the unfolding ... ...

    Abstract Although it has been established that population density can contribute to the outbreak of the COVID-19 virus, there is no evidence to suggest that economic activities, which imply a significant change in mobility, played a causal role in the unfolding of the pandemic. In this paper, we exploit the particular situation of Sardinia (Italy) in 2020 to examine how changes in mobility due to tourism inflows (a proxy of economic activities) influenced the development of the COVID-19 pandemic. Using a difference-in-differences approach, we identify a strong causal relationship between tourism flows and the emergence of COVID-19 cases in Sardinia. We estimate the elasticity of COVID-19 cases in relation to the share of tourists to be 4.1%, which increases to 5.1% when excluding local residents. Our analysis suggests that, in the absence of tools preventing the spread of infection, changes in population density due to economic activities trigger the pandemic spreading in previously unaffected locations. This work contributes to the debate on the complex relationship between COVID-19 and the characteristics of locations by providing helpful evidence for risk-prevention policies.
    MeSH term(s) Humans ; Pandemics ; COVID-19/epidemiology ; Disease Outbreaks ; Italy/epidemiology ; Policy
    Language English
    Publishing date 2023-12-15
    Publishing country Netherlands
    Document type Journal Article
    ZDB-ID 2099749-8
    ISSN 1873-6130 ; 1570-677X
    ISSN (online) 1873-6130
    ISSN 1570-677X
    DOI 10.1016/j.ehb.2023.101341
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  6. Article ; Online: Improving clinical management of COVID-19: the role of prediction models.

    Wynants, Laure / Sotgiu, Giovanni

    The Lancet. Respiratory medicine

    2021  Volume 9, Issue 4, Page(s) 320–321

    MeSH term(s) COVID-19 ; Humans ; Prognosis ; SARS-CoV-2
    Language English
    Publishing date 2021-01-11
    Publishing country England
    Document type Journal Article ; Comment
    ZDB-ID 2686754-0
    ISSN 2213-2619 ; 2213-2600
    ISSN (online) 2213-2619
    ISSN 2213-2600
    DOI 10.1016/S2213-2600(21)00006-0
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    Zs.A 7041: Show issues Location:
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  7. Article ; Online: Cost-Impact Analysis of a Novel Diagnostic Test to Assess Community-Acquired Pneumonia Etiology in the Emergency Department Setting: A Multi-Country European Study.

    Houshmand, Hirad / Porta, Camilla / Pradelli, Lorenzo / Pinciroli, Matteo / Sotgiu, Giovanni

    International journal of environmental research and public health

    2023  Volume 20, Issue 5

    Abstract: Background: We aimed to estimate the economic and clinical impacts of a novel diagnostic test called LIAISON: Methods: A cost-impact simulation model was developed to investigate the financial consequences of the introduction of LMMBV into the ... ...

    Abstract Background: We aimed to estimate the economic and clinical impacts of a novel diagnostic test called LIAISON
    Methods: A cost-impact simulation model was developed to investigate the financial consequences of the introduction of LMMBV into the standard of care (SOC) diagnostic process in Italy, Germany, and Spain. Clinical outcomes were expressed as antibiotic patients and days saved, reduced hospital admissions, and shortened hospital length of stay (LOS). Cost savings were evaluated from the perspectives of third-party payers and hospitals. A deterministic sensitivity analysis (DSA) was carried out.
    Results: LMMBV was associated with a reduction in antibiotic prescriptions, treatment duration, and LOS. Furthermore, the adoption of LMMBV would allow savings per patient up to EUR 364 and EUR 328 for hospitals and EUR 91 and EUR 59 for payers in Italy and Germany, respectively. In Spain, average savings per patient could reach up to EUR 165 for both payers and hospitals. Savings were most sensitive to test accuracy, with DSA confirming the robustness of the results.
    Conclusions: Combining LMMBV with the current SOC diagnostic process is expected to provide clinical and economic benefits in Italy, Germany, and Spain.
    MeSH term(s) Humans ; Anti-Bacterial Agents/therapeutic use ; Costs and Cost Analysis ; Pneumonia ; Hospitalization ; Community-Acquired Infections/drug therapy ; Diagnostic Tests, Routine
    Chemical Substances Anti-Bacterial Agents
    Language English
    Publishing date 2023-02-21
    Publishing country Switzerland
    Document type Journal Article ; Research Support, Non-U.S. Gov't
    ZDB-ID 2175195-X
    ISSN 1660-4601 ; 1661-7827
    ISSN (online) 1660-4601
    ISSN 1661-7827
    DOI 10.3390/ijerph20053853
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  8. Article ; Online: Synergistic properties of linezolid against Enterococcus spp. isolates: a systematic review from in vitro studies.

    Antonello, Roberta Maria / Riccardi, Niccolò / Saderi, Laura / Sotgiu, Giovanni

    European journal of clinical microbiology & infectious diseases : official publication of the European Society of Clinical Microbiology

    2023  Volume 43, Issue 1, Page(s) 17–31

    Abstract: Purpose: Vancomycin-resistant enterococci (VRE) are a leading cause of hospital-acquired infections with limited therapeutic options. Combination of at least two antimicrobials is a possible strategy to obtain rapid and sustained bactericidal effects ... ...

    Abstract Purpose: Vancomycin-resistant enterococci (VRE) are a leading cause of hospital-acquired infections with limited therapeutic options. Combination of at least two antimicrobials is a possible strategy to obtain rapid and sustained bactericidal effects and overcome the emergence of resistance. We revised the literature on linezolid synergistic properties from in vitro studies to assess its activity in combination with molecules belonging to other antibiotic classes against Enterococcus spp.
    Methods: We performed a systematic review of the literature from three peer-reviewed databases including papers evaluating linezolid synergistic properties in vitro against Enterococcus spp. isolates.
    Results: We included 206 Enterococcus spp. isolates (92 E. faecalis, 90 E. faecium, 2 E. gallinarum, 3 E. casseliflavus, 19 Enterococcus spp.) from 24 studies. When an isolate was tested with different combinations, each combination was considered independently for further analysis. The most frequent interaction was indifferent effect (247/343, 72% of total interactions). The highest synergism rates were observed when linezolid was tested in combination with rifampin (10/49, 20.4% of interactions) and fosfomycin (16/84, 19.0%, of interactions). Antagonistic effect accounted for 7/343 (2.0%) of total interactions.
    Conclusion: Our study reported overall limited synergistic in vitro properties of linezolid with other antibiotics when tested against Enterococcus spp. The clinical choice of linezolid in combination with other antibiotics should be guided by reasoned empiric therapy in the suspicion of a polymicrobial infection or targeted therapy on microbiological results, rather than on an intended synergistic effect of the linezolid-based combination.
    MeSH term(s) Humans ; Anti-Bacterial Agents/pharmacology ; Anti-Bacterial Agents/therapeutic use ; Enterococcus faecalis ; Enterococcus faecium ; Fosfomycin/pharmacology ; Fosfomycin/therapeutic use ; Gram-Positive Bacterial Infections/drug therapy ; Gram-Positive Bacterial Infections/microbiology ; Linezolid/pharmacology ; Linezolid/therapeutic use ; Microbial Sensitivity Tests ; Rifampin/pharmacology ; Rifampin/therapeutic use ; Vancomycin-Resistant Enterococci
    Chemical Substances Anti-Bacterial Agents ; Fosfomycin (2N81MY12TE) ; Linezolid (ISQ9I6J12J) ; Rifampin (VJT6J7R4TR)
    Language English
    Publishing date 2023-11-17
    Publishing country Germany
    Document type Systematic Review ; Journal Article ; Review
    ZDB-ID 603155-9
    ISSN 1435-4373 ; 0934-9723 ; 0722-2211
    ISSN (online) 1435-4373
    ISSN 0934-9723 ; 0722-2211
    DOI 10.1007/s10096-023-04704-8
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    In stock of ZB MED Cologne/Königswinter

    Zs.A 1732: Show issues Location:
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  9. Article ; Online: Do We Really Need to Treat Over-80-Year-Old Patients Affected by IPF? A Response.

    Mondoni, Michele / Alfano, Fausta / Varone, Francesco / Centanni, Stefano / Sotgiu, Giovanni

    Respiration; international review of thoracic diseases

    2023  Volume 102, Issue 7, Page(s) 526–527

    MeSH term(s) Humans ; Idiopathic Pulmonary Fibrosis/drug therapy ; Pyridones
    Chemical Substances Pyridones
    Language English
    Publishing date 2023-06-28
    Publishing country Switzerland
    Document type Case Reports ; Letter
    ZDB-ID 206674-9
    ISSN 1423-0356 ; 0025-7931
    ISSN (online) 1423-0356
    ISSN 0025-7931
    DOI 10.1159/000531025
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  10. Article: Sarcopenia and Risk of Pancreatic Fistula after Pancreatic Surgery: A Systematic Review.

    Perra, Teresa / Sotgiu, Giovanni / Porcu, Alberto

    Journal of clinical medicine

    2022  Volume 11, Issue 14

    Abstract: Postoperative pancreatic fistula (POPF) is one of the most critical complications after pancreatic surgery. The relationship between sarcopenia and outcomes following this type of surgery is debated. The aim of this review was to assess the impact of ... ...

    Abstract Postoperative pancreatic fistula (POPF) is one of the most critical complications after pancreatic surgery. The relationship between sarcopenia and outcomes following this type of surgery is debated. The aim of this review was to assess the impact of sarcopenia on the risk of POPF. A literature search was performed using the PubMed database and the reference lists of relevant articles to identify papers about the impact of sarcopenia on POPF in pancreatic surgery. Twenty-one studies published between 2016 and 2021 with a total of 4068 patients were included. Some studies observed a significant difference in the incidence of POPF between the sarcopenic and non-sarcopenic patients undergoing pancreatoduodenectomy. Interestingly, there was a trend of a lower POPF rate in sarcopenic patients than in non-sarcopenic patients. Only one study included patients undergoing distal pancreatectomy specifically. The role of sarcopenia in surgical outcomes is still unclear. A combination of objective CT measurements could be used to predict POPF. It could be assessed by routine preoperative staging CT and could improve preoperative risk stratification in patients undergoing pancreatic surgery.
    Language English
    Publishing date 2022-07-16
    Publishing country Switzerland
    Document type Journal Article ; Review
    ZDB-ID 2662592-1
    ISSN 2077-0383
    ISSN 2077-0383
    DOI 10.3390/jcm11144144
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