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  1. Article ; Online: Invited Perspective: Closing the Loop of Nonmonotonicity-from Natural Hormones in Experimental Endocrinology to Endocrine Disruptors in Epidemiology.

    Soto, Ana M / Sonnenschein, Carlos

    Environmental health perspectives

    2024  Volume 132, Issue 2, Page(s) 21304

    MeSH term(s) Endocrine Disruptors ; Hormones ; Endocrinology
    Chemical Substances Endocrine Disruptors ; Hormones
    Language English
    Publishing date 2024-02-28
    Publishing country United States
    Document type Journal Article
    ZDB-ID 195189-0
    ISSN 1552-9924 ; 0091-6765 ; 1078-0475
    ISSN (online) 1552-9924
    ISSN 0091-6765 ; 1078-0475
    DOI 10.1289/EHP14499
    Database MEDical Literature Analysis and Retrieval System OnLINE

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    In stock of ZB MED Cologne/Königswinter

    Zs.B 1360: Show issues Location:
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    Zs.MO 379: Show issues

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  2. Article ; Online: From Evidence of Harm to Public Health Policy: Is There Light at the End of the Tunnel? Response to: "Update on the Health Effects of bisphenol A: Overwhelming Evidence of Harm".

    Soto, Ana M / Sonnenschein, Carlos

    Endocrinology

    2021  Volume 162, Issue 3

    MeSH term(s) Benzhydryl Compounds/toxicity ; Health Policy ; Phenols/toxicity ; Public Policy
    Chemical Substances Benzhydryl Compounds ; Phenols ; bisphenol A (MLT3645I99)
    Language English
    Publishing date 2021-01-30
    Publishing country United States
    Document type Journal Article ; Research Support, N.I.H., Extramural ; Comment
    ZDB-ID 427856-2
    ISSN 1945-7170 ; 0013-7227
    ISSN (online) 1945-7170
    ISSN 0013-7227
    DOI 10.1210/endocr/bqaa203
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  3. Article ; Online: The cancer puzzle: Welcome to organicism.

    Soto, Ana M / Sonnenschein, Carlos

    Progress in biophysics and molecular biology

    2021  Volume 165, Page(s) 114–119

    Abstract: During the fifty years since President Nixon declared the "War on Cancer", those inside and outside the cancer community have witnessed the systematic moving of the goalposts attitude to accommodate evidence into an inadequate theory, that is, the ... ...

    Abstract During the fifty years since President Nixon declared the "War on Cancer", those inside and outside the cancer community have witnessed the systematic moving of the goalposts attitude to accommodate evidence into an inadequate theory, that is, the Somatic Mutation Theory (SMT). This sorry state promoted a renewable yearly promise that at the end of the next 10-year period the promises uttered in 1971 would become reality. Each failure triggered calls to do more of the same research under the same theory, routinely using more and more sophisticated technology. Meanwhile, in the last few years, an unambiguous general consensus has emerged acknowledging that this overall long, intensive effort has failed, and that it is likely that the solution to the cancer problem resides elsewhere, namely, in alternative theoretical principles of biology. In this essay we concentrate, first, on the big picture, from the philosophical stance (reductionism versus organicism) to the need to adopt rigorous theories. From this novel perspective we conceptualize cancer as a disease of tissue organization akin to development gone awry. Finally, having identified both a promising stance and a useful theory, i.e., the tissue organization field theory (TOFT), we call for abandoning the SMT and for adopting the more promising TOFT.
    MeSH term(s) Carcinogenesis ; Humans ; Neoplasms
    Language English
    Publishing date 2021-07-14
    Publishing country England
    Document type Journal Article ; Research Support, N.I.H., Extramural
    ZDB-ID 209302-9
    ISSN 1873-1732 ; 0079-6107
    ISSN (online) 1873-1732
    ISSN 0079-6107
    DOI 10.1016/j.pbiomolbio.2021.07.001
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  4. Article ; Online: Modeling Mammary Organogenesis from Biological First Principles: A Systems Biology Approach.

    Schaeberle, Cheryl M / Bouffard, Victoria A / Sonnenschein, Carlos / Soto, Ana M

    Methods in molecular biology (Clifton, N.J.)

    2023  Volume 2745, Page(s) 177–188

    Abstract: Stromal-epithelial interactions mediate mammary gland development and the formation and progression of breast cancer. To study these interactions in vitro, 3D models are essential. We have successfully developed novel 3D in vitro models that allow the ... ...

    Abstract Stromal-epithelial interactions mediate mammary gland development and the formation and progression of breast cancer. To study these interactions in vitro, 3D models are essential. We have successfully developed novel 3D in vitro models that allow the formation of mammary gland structures closely resembling those found in vivo and that respond to the hormonal cues that regulate mammary gland morphogenesis and function. Due to their simplicity when compared to in vivo studies, and to their accessibility to visualization in real time, these models are well suited to conceptual and mathematical modeling.
    MeSH term(s) Humans ; Animals ; Female ; Breast ; Organogenesis/physiology ; Breast Neoplasms ; Mammary Glands, Animal ; Morphogenesis/physiology ; Epithelial Cells
    Language English
    Publishing date 2023-12-07
    Publishing country United States
    Document type Journal Article
    ISSN 1940-6029
    ISSN (online) 1940-6029
    DOI 10.1007/978-1-0716-3577-3_11
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  5. Article ; Online: Over a century of cancer research: Inconvenient truths and promising leads.

    Sonnenschein, Carlos / Soto, Ana M

    PLoS biology

    2020  Volume 18, Issue 4, Page(s) e3000670

    Abstract: Despite over a century of intensive efforts, the great gains promised by the War on Cancer nearly 50 years ago have not materialized. Since 1999, we have analyzed the lack of progress in explaining and "curing" cancer by examining the merits of the ... ...

    Abstract Despite over a century of intensive efforts, the great gains promised by the War on Cancer nearly 50 years ago have not materialized. Since 1999, we have analyzed the lack of progress in explaining and "curing" cancer by examining the merits of the premises that determine how cancer is understood and treated. Our ongoing critical analyses have aimed at clarifying the sources of misunderstandings at the root of the cancer puzzle while providing a plausible and comprehensive biomedical perspective as well as a new theory of carcinogenesis that is compatible with evolutionary theory. In this essay, we explain how this new theory, the tissue organization field theory (TOFT), can help chart a path to progress for cancer researchers by explaining features of cancer that remain unexplainable from the perspective of the still hegemonic somatic mutation theory (SMT) and its variants. Of equal significance, the premises underlying the TOFT offer new perspectives on basic biological phenomena.
    MeSH term(s) Biomedical Research/methods ; Biomedical Research/trends ; Carcinogenesis/genetics ; Carcinogenesis/pathology ; Cell Proliferation ; Humans ; Mutation ; Neoplasms/etiology ; Neoplasms/genetics
    Language English
    Publishing date 2020-04-01
    Publishing country United States
    Document type Journal Article ; Research Support, N.I.H., Extramural
    ZDB-ID 2126776-5
    ISSN 1545-7885 ; 1544-9173
    ISSN (online) 1545-7885
    ISSN 1544-9173
    DOI 10.1371/journal.pbio.3000670
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    Zs.A 6193: Show issues Location:
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  6. Article: Information, programme, signal: dead metaphors that negate the agency of organisms.

    Soto, Ana M / Sonnenschein, Carlos

    Interdisciplinary science reviews : ISR

    2020  Volume 45, Issue 3, Page(s) 331–343

    Abstract: The metaphorical adoption of the concepts of information, program and signal introduced into biology the logic and implicit causal structure of the mathematical theories of information; this is inimical to biology. In turn, those metaphors have hindered ... ...

    Abstract The metaphorical adoption of the concepts of information, program and signal introduced into biology the logic and implicit causal structure of the mathematical theories of information; this is inimical to biology. In turn, those metaphors have hindered the development of a theory of organisms by transferring the agency of organisms to natural selection and to DNA. Moreover, those metaphors introduced into biology the dualism software-hardware and a Laplacian causal structure. Instead, we propose to uphold the agency of the living by adopting three foundational principles for a theory of organisms: namely, 1) the principle of biological inertia (i.e., the default state of cells is proliferation and motility), 2) the principle of variation, and 3) the principle of organization.
    Language English
    Publishing date 2020-10-01
    Publishing country England
    Document type Journal Article
    ZDB-ID 195350-3
    ISSN 0308-0188
    ISSN 0308-0188
    DOI 10.1080/03080188.2020.1794389
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    In stock of ZB MED Bonn / Germany

    Z 80/730: Show issues

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  7. Article ; Online: From Wingspread to CLARITY: a personal trajectory.

    Soto, Ana M / Schaeberle, Cheryl M / Sonnenschein, Carlos

    Nature reviews. Endocrinology

    2021  Volume 17, Issue 4, Page(s) 247–256

    Abstract: In the three decades since endocrine disruption was conceptualized at the Wingspread Conference, we have witnessed the growth of this multidisciplinary field and the accumulation of evidence showing the deleterious health effects of endocrine-disrupting ... ...

    Abstract In the three decades since endocrine disruption was conceptualized at the Wingspread Conference, we have witnessed the growth of this multidisciplinary field and the accumulation of evidence showing the deleterious health effects of endocrine-disrupting chemicals. It is only within the past decade that, albeit slowly, some changes regarding regulatory measures have taken place. In this Perspective, we address some historical points regarding the advent of the endocrine disruption field and the conceptual changes that endocrine disruption brought about. We also provide our personal recollection of the events triggered by our serendipitous discovery of oestrogenic activity in plastic, a founder event in the field of endocrine disruption. This recollection ends with the CLARITY study as an example of a discordance between 'science for its own sake' and 'regulatory science' and leads us to offer a perspective that could be summarized by the motto attributed to Ludwig Boltzmann: "Nothing is more practical than a good theory".
    MeSH term(s) Animals ; Endocrine Disruptors/toxicity ; Endocrine System/drug effects ; Environmental Exposure/adverse effects ; Fetal Development/drug effects ; Government Regulation ; Humans
    Chemical Substances Endocrine Disruptors
    Language English
    Publishing date 2021-01-29
    Publishing country England
    Document type Journal Article ; Research Support, N.I.H., Extramural ; Review
    ZDB-ID 2489381-X
    ISSN 1759-5037 ; 1759-5029
    ISSN (online) 1759-5037
    ISSN 1759-5029
    DOI 10.1038/s41574-020-00460-3
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    In stock of ZB MED Cologne/Königswinter

    Zs.A 6336: Show issues Location:
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    Zs.MG 93: Show issues

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  8. Article ; Online: Corrigendum to "Effects of perinatal exposure to bisphenol A on induction of prostate cancer in Sprague Dawley rats by MNU and testosterone" [Toxicology 484 (2023) 153394].

    Bosland, Maarten C / Schlicht, Michael J / Acevedo, Nicole / Soto, Ana M / Prins, Gail

    Toxicology

    2023  Volume 486, Page(s) 153445

    Language English
    Publishing date 2023-01-25
    Publishing country Ireland
    Document type Published Erratum
    ZDB-ID 184557-3
    ISSN 1879-3185 ; 0300-483X
    ISSN (online) 1879-3185
    ISSN 0300-483X
    DOI 10.1016/j.tox.2023.153445
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    Zs.A 888: Show issues Location:
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    Jg. 1995 - 2021: Lesesall (1.OG)
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  9. Book: The society of cells

    Sonnenschein, Carlos / Soto, Ana M.

    cancer and control of cell proliferation

    1999  

    Author's details C. Sonnenschein and A. M. Soto
    Keywords Proliferation ; Carcinogenese
    Subject Krebs ; Krebsentstehung ; Karzinogenese ; Kanzerogenese ; Onkogenese ; Zellproliferation
    Language English
    Size XIV, 154 S.
    Publisher BIOS Scientific Publ
    Publishing place Oxford
    Publishing country Great Britain
    Document type Book
    HBZ-ID HT009966264
    ISBN 1-85996-276-9 ; 978-1-85996-276-3
    Database Catalogue ZB MED Medicine, Health

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    Shelf markLoan statusLocation
    1999 A 1176 order for loan Magazin

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  10. Article ; Online: Reductionism, Organicism, and Causality in the Biomedical Sciences: A Critique.

    Soto, Ana M / Sonnenschein, Carlos

    Perspectives in biology and medicine

    2018  Volume 61, Issue 4, Page(s) 489–502

    Abstract: Biology is undergoing a crisis whereby technical innovations designed to overcome the difficulties encountered in explaining complex biological phenomena have not delivered the expected results. To overcome this problem, mainstream biomedical researchers ...

    Abstract Biology is undergoing a crisis whereby technical innovations designed to overcome the difficulties encountered in explaining complex biological phenomena have not delivered the expected results. To overcome this problem, mainstream biomedical researchers favor adopting new technological wonders without considering that what hinders their research could be due to their philosophical stance, theoretical frame, or looking into the wrong level of biological organization. We address the conceptual problems underlying the scientific crisis by examining the philosophical stances that have illuminated biological thought for the last 200 years and their evolution into the conceptual frames now known as reductionism and organicism. We also analyze how these stances seek to establish causality. The reductionist fixation on bottom-up causation is based on physicalism, a stance that does not allow for emergent phenomena. Organicism, by contrast, allows for emergence and asserts that biological entities are defined by the relation between what they are and what they do; thus, they generate novel qualities and structures. Also, only organisms experience illness and health. Organicism recognizes the role of agency and normativity in determining biological phenomena. Based on these premises, we favor adopting organicism to resolve the current crisis in the biomedical sciences.
    MeSH term(s) Animals ; Biology/history ; Biomedical Research/methods ; Embryonic Development ; History, 18th Century ; History, 19th Century ; Humans ; Information Science ; Philosophy
    Language English
    Publishing date 2018-10-26
    Publishing country United States
    Document type Historical Article ; Journal Article
    ZDB-ID 80373-x
    ISSN 1529-8795 ; 0031-5982
    ISSN (online) 1529-8795
    ISSN 0031-5982
    DOI 10.1353/pbm.2018.0059
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