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Article ; Online: Tacrolimus impairs airway mucociliary clearance of rats.

Prado E Silva, Maristela / de Fátima Soto, Sônia / de Almeida, Francine Maria / Correia, Aristides Tadeu / Pêgo-Fernandes, Paulo Manuel / Pazetti, Rogerio

Transplant immunology

2024 Volume 82, Page(s) 101990

Abstract: Objectives: Tacrolimus (TAC) is the most widely used immunosuppressive agent after lung transplantation. Considering that the ciliary beat frequency (CBF) mainly depends on the cytoplasmic calcium concentration and that TAC can affect this due to its ... ...

Abstract	Objectives: Tacrolimus (TAC) is the most widely used immunosuppressive agent after lung transplantation. Considering that the ciliary beat frequency (CBF) mainly depends on the cytoplasmic calcium concentration and that TAC can affect this due to its binding with the intracellular immunophilin FKBP12, we hypothesized that TAC could also impair the airway mucociliary clearance of rats. Methods: Sixty rats were divided into two groups (n = 30 each): Control = water; TAC = tacrolimus. After 7, 15 or 30 days of treatment, ten animals from each group were euthanized and the following parameters were studied: mucus transportability, CBF, mucociliary transport velocity (MCTV), and neutral and acid mucus production. Results: There was a significant decrease in CBF (Control vs TAC: 7 days, p = 0.008; 15 days, p = 0.007; 30 days, p = 0.001) and MCTV (Control vs TAC: 7 days, p = 0.004; 15 days, p < 0.001; 30 days, p < 0.001) in all immunosuppressed animals. TAC therapy also caused an increase in acid mucus production at all treatment times (Control vs TAC: 7 days, p = 0.001; 15 days, p = 0.043; 30 days, p = 0.001). Conclusions: TAC impairs airway mucociliary clearance of rats.
MeSH term(s)	Rats ; Animals ; Tacrolimus/therapeutic use ; Mucociliary Clearance ; Rats, Wistar ; Immunosuppressive Agents/therapeutic use ; Lung Transplantation
Chemical Substances	Tacrolimus (WM0HAQ4WNM) ; Immunosuppressive Agents
Language	English
Publishing date	2024-01-09
Publishing country	Netherlands
Document type	Journal Article
ZDB-ID	1160846-8
ISSN	1878-5492 ; 0966-3274
ISSN (online)	1878-5492
ISSN	0966-3274
DOI	10.1016/j.trim.2024.101990
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Article: Differences in Colorectal Cancer Survival Based on Primary Tumor Location: Retrospective Study from a Single Institution.

Diez-Alonso, Manuel / Mendoza-Moreno, Fernando / Ortega, Miguel A / Aguado, Hector / Matías, Belen / Vera, Cristina / Soto, Sonia / Quiroga, Ana / Blazquez, Silvestra Barrena / de Mon, Melchor Alvarez / Gutierrez-Calvo, Alberto

Journal of Cancer

2023 Volume 14, Issue 13, Page(s) 2444–2454

Abstract: Objective: ...

Abstract	Objective:
Language	English
Publishing date	2023-08-06
Publishing country	Australia
Document type	Journal Article
ZDB-ID	2573318-7
ISSN	1837-9664
ISSN	1837-9664
DOI	10.7150/jca.85695
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Article: Challenges to carbonate-evaporite peritidal facies models and cycles: Insights from Lower Cretaceous stromatolite-bearing deposits (Oncala Group, N Spain)

Quijada, I. Emma / Benito, M. Isabel / Suarez-Gonzalez, Pablo / Rodríguez-Martínez, Marta / Campos-Soto, Sonia

Sedimentary geology. 2020 Oct., v. 408

2020

Abstract: Peritidal carbonate-evaporite successions, since they are developed in the transition between continental and marine realms, provide essential keys for palaeobathymetric and palaeoclimatic interpretations. As a result, several facies models have been ... ...

Abstract	Peritidal carbonate-evaporite successions, since they are developed in the transition between continental and marine realms, provide essential keys for palaeobathymetric and palaeoclimatic interpretations. As a result, several facies models have been proposed to assist on the interpretation of ancient tidal flat deposits, and peritidal successions have been extensively used for cyclicity analyses. In this study, well-exposed, Lower Cretaceous peritidal deposits (Oncala Group, Cameros Basin, N Spain) are analysed and compared with the most commonly-used present-day analogues (from Shark Bay, the Arabian Gulf and the Bahamas) and with ancient peritidal successions, providing their palaeoenvironmental and palaeoclimatic interpretation, assessing the usefulness and limitations of the facies models, and evaluating the suitability of these deposits for analysis of decimetre to metre-scale cycles.The studied peritidal deposits consist of thinly-bedded to laminated dolostones, dolomitic stromatolites, stromatolite breccias, flat-pebble and edgewise breccias, and calcite and quartz pseudomorphs after anhydrite nodules. Abundant resemblances of the peritidal deposits of the Oncala Group with those of Shark Bay, including that they are largely composed of microbialites and intraclasts, makes the peritidal deposits of the Oncala Group one of the best fossil analogues of this present-day setting. However, the presence of anhydrite nodules indicates pervasive evaporite precipitation in the supratidal zone, which is a feature that does not occur in supratidal flats of Shark Bay, but is characteristic of arid sabkhas of the Arabian Gulf. Nevertheless, the fact that carbonate-evaporite tidal flats of the Oncala Group were laterally related with siliciclastic tidal flats with large freshwater input and broadly inhabited by dinosaurs, suggests that anhydrites precipitated under less arid climates than those of the Arabian Gulf nowadays, pointing to semiarid climatic conditions during deposition. Moreover, the fact that peritidal deposits with anhydrite nodules were exclusively formed in a low-subsidence area of the Cameros Basin suggests that the rate of accommodation space creation also played an important role in their development. Regarding the comparison with other fossil peritidal sediments, the studied deposits show more abundant similarities with Proterozoic and Cambrian successions, composed mainly of stromatolites, microbial laminites, and intraclasts, than with other Mesozoic peritidal deposits, in which bioclasts and burrowing are usually more abundant. This highlights the difficulties for assigning specific features to certain geological ages. Finally, peritidal facies of the Oncala Group may change laterally and vertically to any other facies, showing a patchy lateral distribution of facies and an unsystematic vertical stacking pattern. The sedimentary features of the stromatolite, breccia and thinly-bedded to laminated dolostone facies do not allow their assignment to a unique tidal zone. Moreover, sedimentary features indicative of subaerial exposure, such as anhydrite nodules formed in the capillary zone, occur within any of the carbonate facies and show limited lateral extent. This results in a succession that cannot be clearly subdivided into subsequent shallowing-upward cycles not even by using erosive surfaces or the anhydrite nodule layers as marker horizons of the upper part of the cycles, because their limited lateral extent prevents reliable correlations. Similar composite lateral and vertical facies relationships have been documented both in the present-day analogues and in ancient successions, which suggests that this kind of facies relationships may be common in peritidal successions and highlights the caution that must be taken when trying to perform cyclicity analysis on them.
Keywords	Cambrian period ; Cretaceous period ; Proterozoic eon ; anhydrite ; basins ; burrowing ; calcite ; carbonates ; climatic factors ; dinosaurs ; dolomitic limestone ; fossils ; freshwater ; models ; paleoclimatology ; paleoecology ; periodicity ; quartz ; sediments ; Bahamas ; Persian Gulf ; Spain
Language	English
Dates of publication	2020-10
Publishing place	Elsevier B.V.
Document type	Article
ZDB-ID	216739-6
ISSN	0037-0738
ISSN	0037-0738
DOI	10.1016/j.sedgeo.2020.105752
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Article: Evaluation of the Urine Protein/Creatinine Ratio Measured with the Dipsticks Clinitek Atlas PRO 12.

Hermida, Fernando J / Soto, Sonia / Benitez, Alfonso J

Clinical laboratory

2016 Volume 62, Issue 4, Page(s) 735–738

Abstract: Background: Screening for urine proteins is recommended for the detection of albuminuria in high risk groups. The aim of this study was to compare the Clinitek Atlas PRO12 reagent urine strip with quantitative methods for the determination of protein/ ... ...

Abstract	Background: Screening for urine proteins is recommended for the detection of albuminuria in high risk groups. The aim of this study was to compare the Clinitek Atlas PRO12 reagent urine strip with quantitative methods for the determination of protein/creatinine ratio and to evaluate the usefulness of the semi-quantitative Clinitek Atlas PRO12 reagent urine strip as a tool in the early detection of albuminuria among the general population. Methods: Six hundred first morning urine specimens were collected from outpatients with various clinical conditions. Results: The results showed that the test data for the urine dipstick Clinitek Atlas PRO12 show good agreement with the quantitative measurement of protein, creatinine and protein/creatinine ratio. In addition, this study shows that 97.2% of the samples which gave "normal" protein/creatinine ratios by the semi-quantitative method, showed albumin/creatinine ratio < 30 mg/g by the quantitative methods. Conclusions: Our results show that Clinitek Atlas PRO12 reagent strips can be used for the purposes of albuminuria screening in the general population.
MeSH term(s)	Albuminuria/diagnosis ; Creatinine/urine ; Female ; Humans ; Male ; Reagent Strips
Chemical Substances	Reagent Strips ; Creatinine (AYI8EX34EU)
Language	English
Publishing date	2016-05-23
Publishing country	Germany
Document type	Journal Article
ZDB-ID	1307629-2
ISSN	1433-6510 ; 0941-2131
ISSN	1433-6510 ; 0941-2131
DOI	10.7754/clin.lab.2015.150727
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Article ; Online: Validation of the "Vacutainer® urinalysis preservative plus urine tube" for the determination of albumin and protein.

Lojo, Santiago A / Soto, Sonia / Lojo-Luaces, Natalia

Clinical chemistry and laboratory medicine

2016 Volume 54, Issue 9, Page(s) e253–4

MeSH term(s)	Albumins/analysis ; Humans ; Linear Models ; Nephelometry and Turbidimetry ; Proteins/analysis ; Urinalysis/instrumentation ; Urinalysis/methods ; Urine/chemistry
Chemical Substances	Albumins ; Proteins
Language	English
Publishing date	2016-09-01
Publishing country	Germany
Document type	Journal Article ; Validation Studies
ZDB-ID	1418007-8
ISSN	1437-4331 ; 1434-6621 ; 1437-8523
ISSN (online)	1437-4331
ISSN	1434-6621 ; 1437-8523
DOI	10.1515/cclm-2015-1033
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Article ; Online: Random clinical trial to evaluate the effect of a multimodal intervention in hand hygiene in primary care in Madrid

Cañada A / Martín Carmen / Soto Sonia / Abánades Juan / Salinero Miguel

BMC Proceedings, Vol 5, Iss Suppl 6, p P

2011 Volume 257

Keywords	Medicine ; R ; Science ; Q
Language	English
Publishing date	2011-06-01T00:00:00Z
Publisher	BMC
Document type	Article ; Online
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Article: Registro de pacientes con hepatitis C en las Unidades Centinela para hepatitis virales en Argentina, 2007 - 2014. Distribución por año de nacimiento.

Vladimirsky, Sara Noemí / Munné, Maria Silvina / Otegui, Lucio Oscar / Altabert, Nancy Roxana / Soto, Sonia Soledad / Brajterman, Leonardo / González, Jorge Enrique

Acta gastroenterologica Latinoamericana

2015 Volume 45, Issue 2, Page(s) 110–116

Abstract: Recommendations for Hepatitis C screening based on risk factorsfor transmission proved to be ineffcient. Accordingly, the CDC recommended to screen all American individuals born between 1945-1965, based on data from population prevalence of infection. ... ...

Title translation	Hepatitis C patients' record in the Sentinel Units for viral Hepatitis in Argentina 2007- 2014. Distribution by year of birth.
Abstract	Recommendations for Hepatitis C screening based on risk factorsfor transmission proved to be ineffcient. Accordingly, the CDC recommended to screen all American individuals born between 1945-1965, based on data from population prevalence of infection. The effectiveness of implementing these recommendations in other contexts and/or populations can be estimated, in principle, knowing the age distribution of infected individuals. There is no data on population prevalence in our country. Yet we can know the age distribution of cases of Hepatitis C who accessed the health system. The aim of this paper is to analyze the distribution by birth cohort ofcases registered as "Hepatitis C" in the Sentinel Units for Viral Hepatitis in the 2007-2014 period. This will contribute to the identification, if any, ofa cohort in which case the recommendation of screening could be addressed, based on risk factors inherent to our country and our epidemiological reality. The age distribution of our cases was wider and younger than those of the population supporting the recommendation of the CDC and this suggests -beyond the difference in the populations being compared- is due to a range of risk factors and age at different infection between USA and Argentina. Thus, based on these results, the recommendation of the Argentine Consensus for Hepatitis C in 2013 to screen all individuals once in life is supported.
MeSH term(s)	Adolescent ; Adult ; Age Distribution ; Aged ; Aged, 80 and over ; Argentina/epidemiology ; Child ; Female ; Hepatitis C/epidemiology ; Humans ; Male ; Middle Aged ; Prevalence ; Risk Factors ; Sentinel Surveillance ; Young Adult
Language	Spanish
Publishing date	2015-06
Publishing country	Argentina
Document type	English Abstract ; Journal Article
ZDB-ID	730001-3
ISSN	0300-9033
ISSN	0300-9033
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Article ; Online: Development and content validation of the Multifactoral assessment of perceived social support (MAPSS), a brief, patient-reported measure of social support for use in HIV care.

Fredericksen, Rob J / Fitzsimmons, Emma / Gibbons, Laura E / Dougherty, Sarah / Loo, Stephanie / Shurbaji, Sally / Batey, David S / Avendano-Soto, Sonia / Mathews, William C / Christopoulos, Katerina / Mayer, Kenneth H / Mugavero, Michael J / Crane, Paul K / Crane, Heidi M

AIDS care

2019 Volume 31, Issue sup1, Page(s) 1–9

Abstract: Low perceived social support (SS) negatively impacts health outcomes. We developed a measure of perceived SS for use in HIV care. We sought and categorized legacy items, selecting strongest items within categories. We elicited SS concepts from patients ... ...

Abstract	Low perceived social support (SS) negatively impacts health outcomes. We developed a measure of perceived SS for use in HIV care. We sought and categorized legacy items, selecting strongest items within categories. We elicited SS concepts from patients in English/Spanish, coded transcripts to match item pool content, and developed new items for salient unrepresented content. In focus groups, patients prioritized highly-matched items. We conducted cognitive interviews on high-priority items, and validity testing on final items against two legacy measures. From interviews (
MeSH term(s)	Adult ; Female ; Focus Groups ; HIV Infections/diagnosis ; HIV Infections/psychology ; Health Status ; Humans ; Interpersonal Relations ; Male ; Middle Aged ; Patient Reported Outcome Measures ; Patients/psychology ; Psychometrics/instrumentation ; Psychometrics/methods ; Quality of Life/psychology ; Social Support ; Surveys and Questionnaires/standards
Language	English
Publishing date	2019-06-12
Publishing country	England
Document type	Journal Article ; Research Support, N.I.H., Extramural ; Research Support, Non-U.S. Gov't
ZDB-ID	1012651-x
ISSN	1360-0451 ; 0954-0121
ISSN (online)	1360-0451
ISSN	0954-0121
DOI	10.1080/09540121.2019.1612005
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Article ; Online: How Do Treatment Priorities Differ Between Patients in HIV Care and Their Providers? A Mixed-Methods Study.

Fredericksen, Rob J / Fitzsimmons, Emma / Gibbons, Laura E / Loo, Stephanie / Dougherty, Sarah / Avendano-Soto, Sonia / Anderson, Will A / Gutierrez, Cristina / Shurbaji, Sally / Burleson, Savannah / Christopoulos, Katerina / Poceta, Joanna / Mayer, Kenneth H / Mugavero, Michael J / Mathews, William C / Crane, Paul K / Crane, Heidi M

AIDS and behavior

2019 Volume 24, Issue 4, Page(s) 1170–1180

Abstract: Evidence suggests priorities differ between patients in HIV care and their providers regarding topics most important to address in care. At five U.S. sites, we asked patients and providers to prioritize 25 potential topic areas to address during routine ... ...

Abstract	Evidence suggests priorities differ between patients in HIV care and their providers regarding topics most important to address in care. At five U.S. sites, we asked patients and providers to prioritize 25 potential topic areas to address during routine visits, and invited patients to discuss selection rationale. Patients (n = 206) and providers (n = 17) showed high discordance in rank order priorities (X
MeSH term(s)	European Continental Ancestry Group ; Female ; Goals ; HIV Infections/drug therapy ; Health Behavior ; Hispanic Americans ; Humans ; Male ; Professional-Patient Relations ; Social Stigma
Language	English
Publishing date	2019-12-12
Publishing country	United States
Document type	Journal Article
ZDB-ID	1339885-4
ISSN	1573-3254 ; 1090-7165
ISSN (online)	1573-3254
ISSN	1090-7165
DOI	10.1007/s10461-019-02746-8
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Article: Jurassic Coastal Park: A great diversity of palaeoenvironments for the dinosaurs of the Villar del Arzobispo Formation (Teruel, eastern Spain)

Campos-Soto, Sonia / Alberto Cobos / Esmeralda Caus / I. Emma Quijada / Laura Fernández-Labrador / Luis Alcalá / M. Isabel Benito / Pablo Suarez-Gonzalez / Rafael Royo-Torres / Ramón Mas

Palaeogeography, palaeoclimatology, palaeoecology. 2017 Nov. 01, v. 485

2017

Abstract: The Villar del Arzobispo Formation, cropping out in the western Peñagolosa sub-basin (Late Jurassic, eastern Spain), includes abundant dinosaur tracksites and bones, which occur in diverse mixed siliciclastic and carbonate facies deposited from shallow ... ...

Abstract	The Villar del Arzobispo Formation, cropping out in the western Peñagolosa sub-basin (Late Jurassic, eastern Spain), includes abundant dinosaur tracksites and bones, which occur in diverse mixed siliciclastic and carbonate facies deposited from shallow marine to coastal and alluvial paleoenvironments. The lower part of the unit, mainly composed of bioclastic and oolitic limestone, was deposited in an inner carbonate platform, which underwent episodic subaerial exposure and siliciclastic inputs from the emergent areas, and includes scarce dinosaur tracks. This environment evolved into a siliciclastic coastal and alluvial plain that was crossed by channels and affected by periodic flooding events, producing the deposition of splay lobes. Upward, the siliciclastic coastal and alluvial deposits are interbedded with inter- to supratidal limestone beds. These tidal and coastal deposits show the highest abundance, diversity and best preservation of dinosaur tracks and bones of the unit. This setting gradually evolved upward into an inner carbonate platform, producing the deposition of shallow marine bioclastic and oolitic limestone, which includes very scarce dinosaur tracks.The highest abundance, diversity and best preservation of theropod, sauropod, thyreophoran and ornithopod tracks occur at the top of tidal carbonate beds. Tracks also occur in the siliciclastic coastal and alluvial plain deposits, especially in the flood plain deposits, preserved, mainly, as infillings or natural casts. Additionally, very scarce and poorly-preserved tracks occur at the top of shallow marine carbonate beds. Bones may be articulated and/or associated in the flood plain deposits, whereas they are isolated and dispersed in the splay lobe deposits.Although this unit has been previously assigned to the Tithonian-Berriasian, the analysis of larger benthic foraminifera suggests a Kimmeridgian-Tithonian age for the Villar del Arzobispo Formation. This is consistent with the dinosaur assemblages present in the unit, which are strongly related to other European Late Jurassic faunas.
Keywords	alluvial plains ; alluvium ; bones ; dinosaurs ; floodplains ; limestone ; paleoecology ; Retaria ; Spain
Language	English
Dates of publication	2017-1101
Size	p. 154-177.
Publishing place	Elsevier B.V.
Document type	Article
ZDB-ID	417718-6
ISSN	0031-0182
ISSN	0031-0182
DOI	10.1016/j.palaeo.2017.06.010
Database	NAL-Catalogue (AGRICOLA)

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