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  1. Article: Enteric glia regulate Paneth cell secretion and intestinal microbial ecology.

    Prochera, Aleksandra / Muppirala, Anoohya N / Kuziel, Gavin A / Soualhi, Salima / Shepherd, Amy / Sun, Liang / Issac, Biju / Rosenberg, Harry J / Karim, Farah / Perez, Kristina / Smith, Kyle H / Archibald, Tonora H / Rakoff-Nahoum, Seth / Hagen, Susan J / Rao, Meenakshi

    bioRxiv : the preprint server for biology

    2024  

    Abstract: Glial cells of the enteric nervous system (ENS) interact closely with the intestinal epithelium and secrete signals that influence epithelial cell proliferation and barrier ... ...

    Abstract Glial cells of the enteric nervous system (ENS) interact closely with the intestinal epithelium and secrete signals that influence epithelial cell proliferation and barrier formation
    Language English
    Publishing date 2024-04-19
    Publishing country United States
    Document type Preprint
    DOI 10.1101/2024.04.15.589545
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  2. Article ; Online: Cross talk between Paneth and tuft cells drives dysbiosis and inflammation in the gut mucosa.

    Coutry, Nathalie / Nguyen, Julie / Soualhi, Salima / Gerbe, François / Meslier, Victoria / Dardalhon, Valérie / Almeida, Mathieu / Quinquis, Benoit / Thirion, Florence / Herbert, Fabien / Gasmi, Imène / Lamrani, Ali / Giordano, Alicia / Cesses, Pierre / Garnier, Laure / Thirard, Steeve / Greuet, Denis / Cazevieille, Chantal / Bernex, Florence /
    Bressuire, Christelle / Winton, Douglas / Matsumoto, Ichiro / Blottière, Hervé M / Taylor, Naomi / Jay, Philippe

    Proceedings of the National Academy of Sciences of the United States of America

    2023  Volume 120, Issue 25, Page(s) e2219431120

    Abstract: Gut microbiota imbalance (dysbiosis) is increasingly associated with pathological conditions, both within and outside the gastrointestinal tract. Intestinal Paneth cells are considered to be guardians of the gut microbiota, but the events linking Paneth ... ...

    Abstract Gut microbiota imbalance (dysbiosis) is increasingly associated with pathological conditions, both within and outside the gastrointestinal tract. Intestinal Paneth cells are considered to be guardians of the gut microbiota, but the events linking Paneth cell dysfunction with dysbiosis remain unclear. We report a three-step mechanism for dysbiosis initiation. Initial alterations in Paneth cells, as frequently observed in obese and inflammatorybowel diseases patients, cause a mild remodeling of microbiota, with amplification of succinate-producing species. SucnR1-dependent activation of epithelial tuft cells triggers a type 2 immune response that, in turn, aggravates the Paneth cell defaults, promoting dysbiosis and chronic inflammation. We thus reveal a function of tuft cells in promoting dysbiosis following Paneth cell deficiency and an unappreciated essential role of Paneth cells in maintaining a balanced microbiota to prevent inappropriate activation of tuft cells and deleterious dysbiosis. This succinate-tuft cell inflammation circuit may also contribute to the chronic dysbiosis observed in patients.
    MeSH term(s) Humans ; Dysbiosis ; Mucous Membrane ; Inflammation ; Paneth Cells ; Succinates ; Succinic Acid
    Chemical Substances Succinates ; Succinic Acid (AB6MNQ6J6L)
    Language English
    Publishing date 2023-06-12
    Publishing country United States
    Document type Journal Article ; Research Support, Non-U.S. Gov't
    ZDB-ID 209104-5
    ISSN 1091-6490 ; 0027-8424
    ISSN (online) 1091-6490
    ISSN 0027-8424
    DOI 10.1073/pnas.2219431120
    Database MEDical Literature Analysis and Retrieval System OnLINE

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    In stock of ZB MED Cologne/Königswinter

    Zs.A 1148: Show issues Location:
    Je nach Verfügbarkeit (siehe Angabe bei Bestand)
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    Jg. 1995 - 2021: Lesesall (1.OG)
    ab Jg. 2022: Lesesaal (EG)

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  3. Article ; Online: Endocytosis of commensal antigens by intestinal epithelial cells regulates mucosal T cell homeostasis.

    Ladinsky, Mark S / Araujo, Leandro P / Zhang, Xiao / Veltri, John / Galan-Diez, Marta / Soualhi, Salima / Lee, Carolyn / Irie, Koichiro / Pinker, Elisha Y / Narushima, Seiko / Bandyopadhyay, Sheila / Nagayama, Manabu / Elhenawy, Wael / Coombes, Brian K / Ferraris, Ronaldo P / Honda, Kenya / Iliev, Iliyan D / Gao, Nan / Bjorkman, Pamela J /
    Ivanov, Ivaylo I

    Science (New York, N.Y.)

    2019  Volume 363, Issue 6431

    Abstract: Commensal bacteria influence host physiology, without invading host tissues. We show that proteins from segmented filamentous bacteria (SFB) are transferred into intestinal epithelial cells (IECs) through adhesion-directed endocytosis that is distinct ... ...

    Abstract Commensal bacteria influence host physiology, without invading host tissues. We show that proteins from segmented filamentous bacteria (SFB) are transferred into intestinal epithelial cells (IECs) through adhesion-directed endocytosis that is distinct from the clathrin-dependent endocytosis of invasive pathogens. This process transfers microbial cell wall-associated proteins, including an antigen that stimulates mucosal T helper 17 (T
    MeSH term(s) Animals ; Antigens, Bacterial/immunology ; Bacteria/immunology ; Endocytosis/genetics ; Endocytosis/immunology ; Gastrointestinal Microbiome/immunology ; Homeostasis/genetics ; Host Microbial Interactions/immunology ; Intestinal Mucosa/immunology ; Intraepithelial Lymphocytes/immunology ; Lymphocyte Activation ; Mice, Inbred BALB C ; Mice, Inbred C57BL ; Mice, Inbred NOD ; Symbiosis ; Th17 Cells/immunology ; cdc42 GTP-Binding Protein/genetics ; cdc42 GTP-Binding Protein/physiology
    Chemical Substances Antigens, Bacterial ; Cdc42 protein, mouse ; cdc42 GTP-Binding Protein (EC 3.6.5.2)
    Language English
    Publishing date 2019-03-09
    Publishing country United States
    Document type Journal Article ; Research Support, N.I.H., Extramural ; Research Support, Non-U.S. Gov't
    ZDB-ID 128410-1
    ISSN 1095-9203 ; 0036-8075
    ISSN (online) 1095-9203
    ISSN 0036-8075
    DOI 10.1126/science.aat4042
    Database MEDical Literature Analysis and Retrieval System OnLINE

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    In stock of ZB MED Cologne/Königswinter

    Zs.A 27: Show issues Location:
    Je nach Verfügbarkeit (siehe Angabe bei Bestand)
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    Zs.MG 77: Show issues

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  4. Article ; Online: Gut-Innervating Nociceptor Neurons Regulate Peyer's Patch Microfold Cells and SFB Levels to Mediate Salmonella Host Defense.

    Lai, Nicole Y / Musser, Melissa A / Pinho-Ribeiro, Felipe A / Baral, Pankaj / Jacobson, Amanda / Ma, Pingchuan / Potts, David E / Chen, Zuojia / Paik, Donggi / Soualhi, Salima / Yan, Yiqing / Misra, Aditya / Goldstein, Kaitlin / Lagomarsino, Valentina N / Nordstrom, Anja / Sivanathan, Kisha N / Wallrapp, Antonia / Kuchroo, Vijay K / Nowarski, Roni /
    Starnbach, Michael N / Shi, Hailian / Surana, Neeraj K / An, Dingding / Wu, Chuan / Huh, Jun R / Rao, Meenakshi / Chiu, Isaac M

    Cell

    2019  Volume 180, Issue 1, Page(s) 33–49.e22

    Abstract: Gut-innervating nociceptor sensory neurons respond to noxious stimuli by initiating protective responses including pain and inflammation; however, their role in enteric infections is unclear. Here, we find that nociceptor neurons critically mediate host ... ...

    Abstract Gut-innervating nociceptor sensory neurons respond to noxious stimuli by initiating protective responses including pain and inflammation; however, their role in enteric infections is unclear. Here, we find that nociceptor neurons critically mediate host defense against the bacterial pathogen Salmonella enterica serovar Typhimurium (STm). Dorsal root ganglia nociceptors protect against STm colonization, invasion, and dissemination from the gut. Nociceptors regulate the density of microfold (M) cells in ileum Peyer's patch (PP) follicle-associated epithelia (FAE) to limit entry points for STm invasion. Downstream of M cells, nociceptors maintain levels of segmentous filamentous bacteria (SFB), a gut microbe residing on ileum villi and PP FAE that mediates resistance to STm infection. TRPV1+ nociceptors directly respond to STm by releasing calcitonin gene-related peptide (CGRP), a neuropeptide that modulates M cells and SFB levels to protect against Salmonella infection. These findings reveal a major role for nociceptor neurons in sensing and defending against enteric pathogens.
    MeSH term(s) Animals ; Epithelium/metabolism ; Female ; Ganglia, Spinal/metabolism ; Ganglia, Spinal/microbiology ; Gastrointestinal Microbiome/physiology ; Host Microbial Interactions/physiology ; Intestinal Mucosa/microbiology ; Male ; Mice ; Mice, Inbred C57BL ; Nociceptors/metabolism ; Nociceptors/physiology ; Peyer's Patches/innervation ; Peyer's Patches/metabolism ; Salmonella Infections/metabolism ; Salmonella typhimurium/metabolism ; Salmonella typhimurium/pathogenicity ; Sensory Receptor Cells/metabolism ; Sensory Receptor Cells/physiology
    Language English
    Publishing date 2019-12-05
    Publishing country United States
    Document type Journal Article ; Research Support, N.I.H., Extramural ; Research Support, Non-U.S. Gov't
    ZDB-ID 187009-9
    ISSN 1097-4172 ; 0092-8674
    ISSN (online) 1097-4172
    ISSN 0092-8674
    DOI 10.1016/j.cell.2019.11.014
    Database MEDical Literature Analysis and Retrieval System OnLINE

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    In stock of ZB MED Cologne/Königswinter

    Zs.A 1167: Show issues Location:
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    Zs.MG 58: Show issues

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