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Article ; Online: Cellular Respiration in Thymic Fragments from Mice.

Alshamsi, Mariam / Hassane, Maya / Almarzooqi, Farida / Souid, Abdul-Kader

Frontiers in bioscience (Landmark edition)

2022 Volume 27, Issue 8, Page(s) 230

Abstract: Background: This report aims to detail the use of the phosphorescence oxygen analyzer for : Methods: Thymic fragments from mice were placed in glass vials containing phosphate-buffered saline, bovine albumin, and Pd(II) meso-tetra (sulfophenyl) ... ...

Abstract	Background: This report aims to detail the use of the phosphorescence oxygen analyzer for Methods: Thymic fragments from mice were placed in glass vials containing phosphate-buffered saline, bovine albumin, and Pd(II) meso-tetra (sulfophenyl) tetrabenzoporphyrin. The vials were sealed from air, and the cellular oxygen consumption was monitored as function of time. Results: The decline of dissolved oxygen concentration with time (d[O2]/d Conclusions: Thymocyte respiration can serve as a surrogate biomarker for studying the mode-of-action and the cytotoxicity of immunotoxins and immunosuppressants.
MeSH term(s)	Animals ; Cattle ; Cell Respiration ; Immunosuppressive Agents/pharmacology ; Mice ; Oxygen ; Oxygen Consumption/physiology ; Sirolimus/pharmacology
Chemical Substances	Immunosuppressive Agents ; Oxygen (S88TT14065) ; Sirolimus (W36ZG6FT64)
Language	English
Publishing date	2022-08-30
Publishing country	Singapore
Document type	Journal Article ; Research Support, Non-U.S. Gov't
ZDB-ID	2704569-9
ISSN	2768-6698 ; 2768-6698
ISSN (online)	2768-6698
ISSN	2768-6698
DOI	10.31083/j.fbl2708230
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Article ; Online: Effect of Sirolimus/Metformin Co-Treatment on Hyperglycemia and Cellular Respiration in BALB/c Mice.

Albawardi, Alia / Saraswathiamma, Dhanya / Sharma, Charu / Elomami, Abdulghani / Souid, Abdul-Kader / Almarzooqi, Saeeda

International journal of molecular sciences

2023 Volume 24, Issue 2

Abstract: Sirolimus (SRL) is widely used as an immunosuppressant to prevent graft rejection, despite the risk of impairing glucose metabolism. Metformin (MET) can reduce the detrimental effects of SRL in many patients, including diabetes and renal transplant ... ...

Abstract	Sirolimus (SRL) is widely used as an immunosuppressant to prevent graft rejection, despite the risk of impairing glucose metabolism. Metformin (MET) can reduce the detrimental effects of SRL in many patients, including diabetes and renal transplant recipients. Limited in vivo studies have reported on SRL and MET therapy, particularly in relation to cellular bioenergetics, glucose metabolism, and insulin resistance. Herein, we investigated the efficacy of SRL and MET co-treatment in BALB/c mice over 4 weeks. Balb/c mice (4-6 weeks old) were divided into four groups and injected intraperitoneally (i.p.) with water (control, CTRL), MET (200 µg/g), SRL (5 µg/g), or MET (200 µg/g) +SRL (5 µg/g) over a period of one month. We evaluated the body weight, food consumption rate, random blood glucose (BG), insulin levels, serum biochemistry parameters (ALT, Albumin, BUN, Creatinine), and histomorphology in all groups using standardized techniques and assays. All drug-treated groups showed a statistically significant decrease in weight gain compared to the CTRL group, despite normal food intake. Treatment with SRL caused elevated BG and insulin levels, which were restored with SRL + MET combination. Serum biochemical parameters were within the normal range in all the studied groups. SRL+ MET co-treatment decreased liver cellular respiration and increased cellular ATP levels in the liver. In the pancreas, co-treatment resulted in increased cellular respiration and decreased cellular ATP levels. Liver and pancreatic histology were unchanged in all groups. This study showed that co-treatment of SRL with MET alleviates hyperglycemia induced by SRL without any deleterious effects. These results provide initial insights into the potential use of SRL + MET therapy in various settings.
MeSH term(s)	Animals ; Mice ; Sirolimus/pharmacology ; Metformin/pharmacology ; Mice, Inbred BALB C ; Immunosuppressive Agents ; Hyperglycemia/drug therapy ; Hyperglycemia/chemically induced ; Cell Respiration ; Glucose ; Insulins ; Adenosine Triphosphate ; Graft Rejection/drug therapy ; Graft Rejection/prevention & control
Chemical Substances	Sirolimus (W36ZG6FT64) ; Metformin (9100L32L2N) ; Immunosuppressive Agents ; Glucose (IY9XDZ35W2) ; Insulins ; Adenosine Triphosphate (8L70Q75FXE)
Language	English
Publishing date	2023-01-08
Publishing country	Switzerland
Document type	Journal Article
ZDB-ID	2019364-6
ISSN	1422-0067 ; 1422-0067 ; 1661-6596
ISSN (online)	1422-0067
ISSN	1422-0067 ; 1661-6596
DOI	10.3390/ijms24021223
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Article ; Online: Ozanimod-mediated remission in experimental autoimmune encephalomyelitis is associated with enhanced activity of CNS CD27

Kamyan, Doua / Hassane, Maya / Alnaqbi, Alanood / Souid, Abdul-Kader / Rasbi, Zakeya Al / Tahrawi, Abeer Al / Shamsi, Mariam Al

Frontiers in immunology

2024 Volume 15, Page(s) 1230735

Abstract: Background: Ozanimod (RPC1063) is an immunomodulator that has been recently approved by the FDA (2020) for the treatment of relapsing-remitting multiple sclerosis (RRMS). It is a selective agonist of the sphingosine-1-phophate receptors 1 and 5, ... ...

Abstract	Background: Ozanimod (RPC1063) is an immunomodulator that has been recently approved by the FDA (2020) for the treatment of relapsing-remitting multiple sclerosis (RRMS). It is a selective agonist of the sphingosine-1-phophate receptors 1 and 5, expressed on naïve and central memory T and B cells, as well as natural killer (NK) cells, and is involved in lymphocyte trafficking. Oral administration of ozanimod was reported to result in rapid and reversible reduction in circulating lymphocytes in multiple sclerosis (MS) patients, however, only minimal effect on NK cells was observed. In this study, we sought to investigate the effect of ozanimod on NK cells and assess whether they play any role in ozanimod-induced remission in experimental autoimmune encephalomyelitis (EAE), the animal model of MS. Methods: Active EAE induction was done in C57BL/6 female mice, followed by daily oral treatment with ozanimod (0.6mg/kg) starting at disease onset (score 1). Flow cytometry of blood and CNS was performed 24 hours after the last oral dose of ozanimod treatment in diseased mice. Histological analysis of lumbar spinal cord was performed for evaluating the level of inflammation and demyelination. Depletion of peripheral NK cells was done using anti-NK1.1 mouse antibody (mAb) at day 5 post-EAE induction. Results: Ozanimod was effective in reducing the clinical severity of EAE and reducing the percentage of autoreactive CD4 Conclusion: The current study demonstrated that ozanimod treatment significantly improved clinical symptoms in EAE mice. Ozanimod and anti-NK1.1 mAb appear to function in opposition to one another. Collectively, our data suggest that ozanimod-mediated remission is associated with an increased percentage of total NK cells and CD27
MeSH term(s)	Humans ; Female ; Mice ; Animals ; Encephalomyelitis, Autoimmune, Experimental ; CD8-Positive T-Lymphocytes ; Mice, Inbred C57BL ; Multiple Sclerosis ; Killer Cells, Natural ; Indans ; Oxadiazoles
Chemical Substances	ozanimod (Z80293URPV) ; Indans ; Oxadiazoles
Language	English
Publishing date	2024-03-12
Publishing country	Switzerland
Document type	Journal Article ; Research Support, Non-U.S. Gov't
ZDB-ID	2606827-8
ISSN	1664-3224 ; 1664-3224
ISSN (online)	1664-3224
ISSN	1664-3224
DOI	10.3389/fimmu.2024.1230735
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Article ; Online: Novel genetic variants of inborn errors of immunity.

Almarzooqi, Farida / Souid, Abdul-Kader / Vijayan, Ranjit / Al-Hammadi, Suleiman

PloS one

2021 Volume 16, Issue 1, Page(s) e0245888

Abstract: Objectives: Inborn errors of immunity (IEI) are prevalent in tribal cultures due to frequent consanguineous marriages. Many of these disorders are autosomal recessive, resulting from founder mutations; hence they are amenable to prevention. The primary ... ...

Abstract	Objectives: Inborn errors of immunity (IEI) are prevalent in tribal cultures due to frequent consanguineous marriages. Many of these disorders are autosomal recessive, resulting from founder mutations; hence they are amenable to prevention. The primary objective of this study was to evaluate the pathogenicity of novel variants of IEI found among Emiratis. Methods: This retrospective data collection study reports novel variants of IEI detected by diagnostic exome sequencing. Pathogenicity prediction was based on scoring tools, amino acid alignment, and Jensen-Shannon divergence values. Results: Twenty-one novel variants were identified; nine were frameshift, three nonsense, four intronic (one pathogenic), and five missense (two pathogenic). Fifteen variants were likely pathogenic, of which 13 were autosomal recessive and two uncertain inheritance. Their clinical spectra included combined immunodeficiency, antibody deficiency, immune dysregulation, defects in intrinsic/innate immunity, and bone marrow failure. Conclusion: The described novel pathogenic variants are core to a planned national screening program that aims toward IEI prevention. Future studies, however, are needed to confirm their natural history in individual patients and estimate their prevalence in the community.
MeSH term(s)	Animals ; Bone Marrow Failure Disorders/genetics ; Computational Biology ; Genetic Diseases, Inborn/genetics ; Genetic Diseases, Inborn/immunology ; Genetic Variation ; Herpesvirus 4, Human/physiology ; Humans ; Immunity, Innate/genetics ; Lymphohistiocytosis, Hemophagocytic/genetics ; Retrospective Studies
Language	English
Publishing date	2021-01-22
Publishing country	United States
Document type	Journal Article
ISSN	1932-6203
ISSN (online)	1932-6203
DOI	10.1371/journal.pone.0245888
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Article: Perception of Cosmetic Procedures among Middle Eastern Youth.

Amiri, Leena / Galadari, Hassan / Al Mugaddam, Fadwa / Souid, Abdul Kader / Stip, Emmanuel / Javaid, Syed Fahad

The Journal of clinical and aesthetic dermatology

2022 Volume 14, Issue 12, Page(s) E74–E83

Abstract: Background: In the past decade, there has been an increase in the number of cosmetic procedures performed globally. About one-third of individuals who undergo cosmetic procedures are under the age of 35. The United Arab Emirates (UAE) has become a ... ...

Abstract	Background: In the past decade, there has been an increase in the number of cosmetic procedures performed globally. About one-third of individuals who undergo cosmetic procedures are under the age of 35. The United Arab Emirates (UAE) has become a regional hub for cosmetic procedures. This cross-sectional study examines the perception of cosmetic procedures among youth in the UAE. Methods: A 63-question survey was electronically disseminated to university students to identify factors associated with the use of cosmetic procedures in this population. Results: Ninety-one percent of the 178 participants were female, and 58 percent of them were aged 19 to 21. The majority of the participants felt cosmetic procedures are gaining acceptance in UAE society. Nearly 70 percent of participants felt that a legal and regulatory framework was important to determine the permissible age for undergoing cosmetic surgeries. Limitations: One limitation of the study lies in a modest response rate of 35.6 percent. There was a small number of male responders, and the assessment of differences between sex was not easy to conduct. Conclusion: Cosmetic procedures are increasingly being accepted among youth in the Middle East, with skin and nasal procedures being the most popular. The youth's concept of ideal body shape is in alignment with the Western ideas of beauty. Future research could characterize these perceptions in other cultures and explore differences in what is perceived to be beautiful in various parts of the world.
Language	English
Publishing date	2022-01-21
Publishing country	United States
Document type	Journal Article
ZDB-ID	2571623-2
ISSN	1941-2789
ISSN	1941-2789
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Article: The use of phosphorescence oxygen analyzer to measure the effects of rotenone and 1-methyl-4-phenylpyridinium on striatal cellular respiration in C57BL6 mice

Al Shamsi, Mariam / Haque, M.Emdadul / Shahin, Allen / Shaban, Sami / Souid, Abdul-Kader

Heliyon. 2021 June, v. 7, no. 6

2021

Abstract: We have previously reported on the use of the phosphorescence oxygen analyzer for measuring spinal cord cellular respiration. This analytical tool is used here to investigate the effects of two inhibitors of NADH:ubiquinone oxidoreductase, rotenone and 1- ...

Abstract	We have previously reported on the use of the phosphorescence oxygen analyzer for measuring spinal cord cellular respiration. This analytical tool is used here to investigate the effects of two inhibitors of NADH:ubiquinone oxidoreductase, rotenone and 1-methyl-4-phenylpyridinium, on cellular respiration in striatal tissue. Both neurotoxins can induce Parkinson's disease-like symptoms, and have been used to study this disease in animals. Our hypothesis is that striatal cellular respiration is a sensitive biomarker for the adverse effects of toxins, and the phosphorescence oxygen analyzer can be used as a screening tool for this purpose.Striatal fragments were collected from C57BL6 mice and immersed in Pd phosphor solution [phosphate-buffered saline, 3.0 μM ‘Pd(II)-meso-tetra (sulfophenyl) tetrabenzoporphyrin’ and 0.5% fat-free albumin, with and without 5.0 mM glucose]. The sample was transferred to a glass vial containing 2-mL Pd phosphor solution. The vial was sealed from air and placed in the instrument that measures dissolved oxygen as function of time. Immunoblots of the studied tissue were positive for the dopamine neuronal cell biomarker tyrosine hydroxylase.Striatal oxygen consumption was linear with time, exhibiting zero-order kinetics of oxygen reduction by cytochrome oxidase. Cyanide sensitive respiration was ≥90%, confirming oxygen was reduced by cytochrome oxidase. The rate of respiration increased by ~2-fold in the presence of glucose. Striatal oxygen consumption in the presence of rotenone or 1-methyl-4-phenylpyridinium was exponential, demonstrating impaired respiration.Striatal cellular mitochondrial oxygen consumption was impaired by the studied inhibitors of complex I of the respiratory chain. This effect is expected to deplete NAD+ (oxidized nicotinamide adenine dinucleotide), a principle driver of glycolysis. In vivo studies are required to determine if these toxin-induced metabolic derangements contribute to the development of sporadic Parkinson's disease. This analytic tool can be used to screen environmental toxins for their in vitro effects on the striatum.
Keywords	NAD (coenzyme) ; Parkinson disease ; air ; albumins ; biomarkers ; cyanide-sensitive respiration ; cytochrome-c oxidase ; dissolved oxygen ; dopamine ; electron transport chain ; glass ; glucose ; glycolysis ; mitochondria ; neurons ; neurotoxins ; oxygen ; oxygen consumption ; phosphorescence ; rotenone ; spinal cord ; tyrosine
Language	English
Dates of publication	2021-06
Publishing place	Elsevier Ltd
Document type	Article
ZDB-ID	2835763-2
ISSN	2405-8440
ISSN	2405-8440
DOI	10.1016/j.heliyon.2021.e07219
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Article ; Online: Early (5-Day) Onset of Diabetes Mellitus Causes Degeneration of Photoreceptor Cells, Overexpression of Incretins, and Increased Cellular Bioenergetics in Rat Retina.

Adeghate, Jennifer O / D'Souza, Crystal / Kántor, Orsolya / Tariq, Saeed / Souid, Abdul-Kader / Adeghate, Ernest

Cells

2021 Volume 10, Issue 8

Abstract: The effects of early (5-day) onset of diabetes mellitus (DM) on retina ultrastructure and cellular bioenergetics were examined. The retinas of streptozotocin-induced diabetic rats were compared to those of non-diabetic rats using light and transmission ... ...

Abstract	The effects of early (5-day) onset of diabetes mellitus (DM) on retina ultrastructure and cellular bioenergetics were examined. The retinas of streptozotocin-induced diabetic rats were compared to those of non-diabetic rats using light and transmission electron microscopy. Tissue localization of glucagon-like-peptide-1 (GLP-1), exendin-4 (EXE-4), and catalase (CAT) in non-diabetic and diabetic rat retinas was conducted using immunohistochemistry, while the retinal and plasma concentration of GLP-1, EXE-4, and CAT were measured with ELISA. Lipid profiles and kidney and liver function markers were measured from the blood of non-diabetic and diabetic rats with an automated biochemical analyzer. Oxygen consumption was monitored using a phosphorescence analyzer, and the adenosine triphosphate (ATP) level was determined using the Enliten ATP assay kit. Blood glucose and cholesterol levels were significantly higher in diabetic rats compared to control. The number of degenerated photoreceptor cells was significantly higher in the diabetic rat retina. Tissue levels of EXE-4, GLP-1 and CAT were significantly (
MeSH term(s)	Adenosine Triphosphate/metabolism ; Animals ; Biomarkers/blood ; Blood Glucose/analysis ; Catalase/blood ; Catalase/metabolism ; Diabetes Mellitus, Experimental/metabolism ; Diabetes Mellitus, Experimental/pathology ; Glucagon-Like Peptide 1/blood ; Glucagon-Like Peptide 1/metabolism ; Incretins/blood ; Incretins/genetics ; Incretins/metabolism ; Male ; Microscopy, Electron, Transmission ; Oxygen Consumption ; Photoreceptor Cells/cytology ; Photoreceptor Cells/metabolism ; Rats ; Rats, Wistar ; Retina/metabolism ; Retina/pathology ; Retina/ultrastructure
Chemical Substances	Biomarkers ; Blood Glucose ; Incretins ; Glucagon-Like Peptide 1 (89750-14-1) ; Adenosine Triphosphate (8L70Q75FXE) ; Catalase (EC 1.11.1.6)
Language	English
Publishing date	2021-08-04
Publishing country	Switzerland
Document type	Journal Article ; Research Support, Non-U.S. Gov't
ZDB-ID	2661518-6
ISSN	2073-4409 ; 2073-4409
ISSN (online)	2073-4409
ISSN	2073-4409
DOI	10.3390/cells10081981
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Article: The use of phosphorescence oxygen analyzer to measure the effects of rotenone and 1-methyl-4-phenylpyridinium on striatal cellular respiration in C57BL6 mice.

Al Shamsi, Mariam / Haque, M Emdadul / Shahin, Allen / Shaban, Sami / Souid, Abdul-Kader

Heliyon

2021 Volume 7, Issue 6, Page(s) e07219

Abstract: Background: We have previously reported on the use of the phosphorescence oxygen analyzer for measuring spinal cord cellular respiration. This analytical tool is used here to investigate the effects of two inhibitors of NADH:ubiquinone oxidoreductase, ... ...

Abstract	Background: We have previously reported on the use of the phosphorescence oxygen analyzer for measuring spinal cord cellular respiration. This analytical tool is used here to investigate the effects of two inhibitors of NADH:ubiquinone oxidoreductase, rotenone and 1-methyl-4-phenylpyridinium, on cellular respiration in striatal tissue. Both neurotoxins can induce Parkinson's disease-like symptoms, and have been used to study this disease in animals. Our hypothesis is that striatal cellular respiration is a sensitive biomarker for the adverse effects of toxins, and the phosphorescence oxygen analyzer can be used as a screening tool for this purpose. Methods: Striatal fragments were collected from C57BL6 mice and immersed in Pd phosphor solution [phosphate-buffered saline, 3.0 μM 'Pd(II)- Results: Striatal oxygen consumption was linear with time, exhibiting zero-order kinetics of oxygen reduction by cytochrome oxidase. Cyanide sensitive respiration was ≥90%, confirming oxygen was reduced by cytochrome oxidase. The rate of respiration increased by ~2-fold in the presence of glucose. Striatal oxygen consumption in the presence of rotenone or 1-methyl-4-phenylpyridinium was exponential, demonstrating impaired respiration. Conclusion: Striatal cellular mitochondrial oxygen consumption was impaired by the studied inhibitors of complex I of the respiratory chain. This effect is expected to deplete NAD+ (oxidized nicotinamide adenine dinucleotide), a principle driver of glycolysis.
Language	English
Publishing date	2021-06-05
Publishing country	England
Document type	Journal Article
ZDB-ID	2835763-2
ISSN	2405-8440
ISSN	2405-8440
DOI	10.1016/j.heliyon.2021.e07219
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Article: Conserved spinal cord bioenergetics in experimental autoimmune encephalomyelitis in C57BL6 mice, measured using phosphorescence oxygen analyzer.

Al Shamsi, Mariam / Shahin, Allen / Kamyan, Doua / Alnaqbi, Alanood / Shaban, Sami / Souid, Abdul-Kader

Heliyon

2021 Volume 7, Issue 10, Page(s) e08111

Abstract: Background: We have previously reported that spinal cord respiration (cellular mitochondrial oxygen consumption) and ATP content are conserved in the studied model of experimental autoimmune encephalomyelitis (EAE), foreseeing a recovery of the diseased ...

Abstract	Background: We have previously reported that spinal cord respiration (cellular mitochondrial oxygen consumption) and ATP content are conserved in the studied model of experimental autoimmune encephalomyelitis (EAE), foreseeing a recovery of the diseased rats. This exemplary lesion of multiple sclerosis is used here to measure spinal cord bioenergetics in C57BL6 mice. Our hypothesis is that, despite the well-known focal axonal mitochondrial pathology, bioenergetics of the CNS is reasonably preserved in this disease. Methods: EAE was induced with an immunodominant Results: The kinetics of spinal cord oxygen consumption was zero-order (linear with time) and inhibited by cyanide, confirming oxygen was reduced by cytochrome oxidase. The rate of respiration (in μM O Conclusions: In vitro
Language	English
Publishing date	2021-10-04
Publishing country	England
Document type	Journal Article
ZDB-ID	2835763-2
ISSN	2405-8440
ISSN	2405-8440
DOI	10.1016/j.heliyon.2021.e08111
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Article ; Online: Forebrain cellular bioenergetics in neonatal mice.

Narchi, Hassib / Thachillath, Pramathan / Souid, Abdul-Kader

Journal of neonatal-perinatal medicine

2018 Volume 11, Issue 1, Page(s) 79–86

Abstract: Background: Hypoglycemia occurs frequently in the neonate and may result in neurologic dysfunction. Its impact on the kinetics of cellular respiration and bioenergetics in the neonatal brain remains to be explored.: Aims: Develop murine model to ... ...

Abstract	Background: Hypoglycemia occurs frequently in the neonate and may result in neurologic dysfunction. Its impact on the kinetics of cellular respiration and bioenergetics in the neonatal brain remains to be explored. Aims: Develop murine model to investigate the effects of hypoglycemia on neonatal brain bioenergetics. Study design: Forebrain fragments were excised from euthanized BALB/c pups aged <24 hours to 14 days. We measured cellular respiration (μM O2 min-1.mg-1) in phosphate-buffered saline with and without glucose, using phosphorescence oxygen analyzer, as well as cellular adenosine triphosphate (ATP, nmol.mg-1) using the luciferin-luciferase system. Results: In the presence of glucose, although cellular respiration was 11% lower in pups ≤3 days compared to those 3- 14 days old (0.48 vs. 0.54), that difference was not statistically significant (p = 0.14). Respiration driven by endogenous metabolic fuels (without added glucose) was 16% lower in pups ≤3 days compared to those 3- 14 days (0.35 vs. 0.42, p = 0.03), confirming their increased dependency on exogenous glucose. Although cellular ATP was similar between the two age groups (14.9 vs. 11.2, p = 0.32), the ATP content was more severely depleted without added glucose in the younger pups, especially in the presence of the cytochrome c oxidase inhibitor cyanide. The first-order rate constant of cellular ATP decay (hydrolysis) was 44% lower in 2-day-old pups compared to 14-day-old mice (0.43 vs. 0.77 min-1, p = 0.03). Conclusions: Forebrain cellular respiration and ATP consumption are lower in young pups than older mice. In the absence of glucose, the support for these processes is reduced in young pups, explaining their brain hypersensitivity to hypoglycemia.
MeSH term(s)	Adenosine Triphosphate/metabolism ; Age Factors ; Animals ; Animals, Newborn/physiology ; Cell Respiration/drug effects ; Disease Models, Animal ; Electron Transport Complex IV/antagonists & inhibitors ; Energy Metabolism ; Glucose/pharmacology ; Hypoglycemia/physiopathology ; Mice ; Mice, Inbred BALB C ; Oxygen Consumption/drug effects ; Prosencephalon/metabolism ; Prosencephalon/physiopathology ; Sodium Cyanide/pharmacology
Chemical Substances	Adenosine Triphosphate (8L70Q75FXE) ; Electron Transport Complex IV (EC 1.9.3.1) ; Glucose (IY9XDZ35W2) ; Sodium Cyanide (O5DDB9Z95G)
Language	English
Publishing date	2018-03-29
Publishing country	Netherlands
Document type	Journal Article
ZDB-ID	2435387-5
ISSN	1878-4429 ; 1934-5798
ISSN (online)	1878-4429
ISSN	1934-5798
DOI	10.3233/NPM-181737
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