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Article ; Online: A Comprehensive Study on the Antimicrobial Properties of Resveratrol as an Alternative Therapy

Ehsan Abedini / Ehsaneh Khodadadi / Elham Zeinalzadeh / Seyyed Reza Moaddab / Mohammad Asgharzadeh / Bahareh Mehramouz / Sounkalo Dao / Hossein Samadi Kafil

Evidence-Based Complementary and Alternative Medicine, Vol

2021 Volume 2021

Abstract: Resveratrol is a polyphenolic antioxidant whose possible health benefits include anticarcinogenic, antiaging, and antimicrobial properties that have gained significant attention. The compound is well accepted by individuals and has been commonly used as ... ...

Abstract	Resveratrol is a polyphenolic antioxidant whose possible health benefits include anticarcinogenic, antiaging, and antimicrobial properties that have gained significant attention. The compound is well accepted by individuals and has been commonly used as a nutraceutical in recent decades. Its widespread usage makes it essential to study as a single agent as well as in combination with traditional prescription antibiotics as regards to antimicrobial properties. Resveratrol demonstrates the action of antimicrobials against a remarkable bacterial diversity, viruses, and fungus. This report explains resveratrol as an all-natural antimicrobial representative. It may modify the bacterial virulence qualities resulting in decreased toxic substance production, biofilm inhibition, motility reduction, and quorum sensing disturbance. Moreover, in conjunction with standard antibiotics, resveratrol improves aminoglycoside efficacy versus Staphylococcus aureus, while it antagonizes the deadly function of fluoroquinolones against S. aureus and also Escherichia coli. The present study aimed to thoroughly review and study the antimicrobial potency of resveratrol, expected to help researchers pave the way for solving antimicrobial resistance.
Keywords	Other systems of medicine ; RZ201-999
Language	English
Publishing date	2021-01-01T00:00:00Z
Publisher	Hindawi Limited
Document type	Article ; Online
Database	BASE - Bielefeld Academic Search Engine (life sciences selection)

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Article ; Online: Current Advances in DNA Methylation Analysis Methods

Ehsan Khodadadi / Leila Fahmideh / Ehsaneh Khodadadi / Sounkalo Dao / Mehdi Yousefi / Sepehr Taghizadeh / Mohammad Asgharzadeh / Bahman Yousefi / Hossein Samadi Kafil

BioMed Research International, Vol

2021 Volume 2021

Abstract: DNA methylation is one of the epigenetic changes, which plays a major role in regulating gene expression and, thus, many biological processes and diseases. There are several methods for determining the methylation of DNA samples. However, selecting the ... ...

Abstract	DNA methylation is one of the epigenetic changes, which plays a major role in regulating gene expression and, thus, many biological processes and diseases. There are several methods for determining the methylation of DNA samples. However, selecting the most appropriate method for answering biological questions appears to be a challenging task. The primary methods in DNA methylation focused on identifying the state of methylation of the examined genes and determining the total amount of 5-methyl cytosine. The study of DNA methylation at a large scale of genomic levels became possible following the use of microarray hybridization technology. The new generation of sequencing platforms now allows the preparation of genomic maps of DNA methylation at the single-open level. This review includes the majority of methods available to date, introducing the most widely used methods, the bisulfite treatment, biological identification, and chemical cutting along with their advantages and disadvantages. The techniques are then scrutinized according to their robustness, high throughput capabilities, and cost.
Keywords	Medicine ; R
Subject code	310
Language	English
Publishing date	2021-01-01T00:00:00Z
Publisher	Hindawi Limited
Document type	Article ; Online
Database	BASE - Bielefeld Academic Search Engine (life sciences selection)

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Article ; Online: Estimation of Drug Pharmacokinetics from Breast Feeding: A Simple Method Based on Meta-analysis.

Alassane, Oumar Aboubacar / Carlos, De Pablos-Martinez / Mamoudou, Maiga / Sounkalo, Dao / Etienne, Chatelut / Peggy, Gandia

Journal of advances in medical and pharmaceutical sciences

2019 Volume 21, Issue 2

Abstract: Background: In resource-limited settings, breastfeeding is the healthiest source of nutrition for newborns. For economic/cultural reasons, breastfeeding is the preferred option for the majority of mothers, including HIV-positive mothers.: Objective: ... ...

Abstract	Background: In resource-limited settings, breastfeeding is the healthiest source of nutrition for newborns. For economic/cultural reasons, breastfeeding is the preferred option for the majority of mothers, including HIV-positive mothers. Objective: The objective of this review is to document parameters characterizing antiretroviral therapy (ARV) diffusion into breast milk associated with the estimated ARV amount ingested by breastfed infant and clinical/biological abnormalities. Data source and eligibility criteria: Twenty seven (27) published articles on the aspects of Pharmacokinetic parameters on ARV diffusion into breast milk have shown a large variability without clear interpretation on drugs diffusion. Using PubMed and Embase, we conducted a search to identify all published studies at 2015 that characterized antiretroviral drug diffusion from mother to infant via breast milk. We identified 27 published studies that characterized antiretroviral drug passage from mother to infant (drug concentrations in mother's milk and breastfed plasma). Information was sufficiently complete for inclusion in the present analysis for only six antiretroviral drugs. Results: Finally, only data for nevirapine and efavirenz were exploitable because some of the studies found null or non-detectable levels, which were not suitable for simulations. Median (IQR) nevirapine CL/F were 0.022 (0.013-0.038) for newborns, 0.121 (0.116-0.125) for children and 0.056 (0.045-0.070) for mothers, all in L/h/kg. Efavirenz CL/F were 0.025 (0.016-0.039) for newborns, 0.273 (0.261-0.285) for children and 0.160 (0.153-0.167) for mothers, also in L/h/kg. Conclusion: Pharmacokinetics parameters of efavirenz and nevirapine are important to be determined in breastfed newborns.
Language	English
Publishing date	2019-08-03
Publishing country	India
Document type	Journal Article
ISSN	2394-1111
ISSN (online)	2394-1111
DOI	10.9734/jamps/2019/v21i230126
Database	MEDical Literature Analysis and Retrieval System OnLINE

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Article ; Online: Supplémentation en farine fortifiée " Misola " chez les personnes vivant avec le VIH sous traitement ARV au Mali

Hammadoun Ali sango / Aboubacar Alassane Oumar / Mariam Tall / Fanta Sangho / Sidy Sangho / Fatoumata Ouattara / Jean Testa / Sounkalo Dao

Revue Malienne d’Infectiologie et de Microbiologie, Iss

2018 Volume 1

Abstract: Position du problème: Tester l'apport d'une supplémentation en farine fortifiée chez les personnes vivant avec le VIH sous traitement antirétroviral au Mali. Méthodes : Nous avons réalisé une étude prospective longitudinale chez 52 patients infectés par ... ...

Abstract	Position du problème: Tester l'apport d'une supplémentation en farine fortifiée chez les personnes vivant avec le VIH sous traitement antirétroviral au Mali. Méthodes : Nous avons réalisé une étude prospective longitudinale chez 52 patients infectés par le VIH en ambulatoire sous traitement antirétroviral. A l'introduction de la farine "Misola", les paramètres de suivi à 3 mois ont été : (poids/taille), le taux de CD4 et la numération formule sanguine. Résultats : La majorité de nos patients était des femmes (69%). L'âge moyen était de 38 ans avec des extrêmes de 20 à 58 ans. La normalisation de l'indice de masse corporel de J15 à J60 était de 100%. L'augmentation de la reprise pondérale était significative (p=0,0001). Les paramètres biologiques étudiés étaient également augmentés à J60. Conclusion : La supplémentation en farine Misola semble être un facteur de gain pondéral rapide chez les PVIH sous ARV. Nous recommandons une étude randomisée sur un grand échantillon pour confirmer ces résultats
Keywords	Farine'Misola ; gain ponderal ; VIH ; Mali ; Medicine ; R ; Microbiology ; QR1-502
Language	French
Publishing date	2018-06-01T00:00:00Z
Publisher	SOMAPIT
Document type	Article ; Online
Database	BASE - Bielefeld Academic Search Engine (life sciences selection)

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Article ; Online: Impact on patient health outcomes after the implementation of free and anonymous HIV care and treatment at a community-run clinic in Bamako, Mali

Anne De Groot / Karamoko Tounkara / Zoumana Koty / Yssouf Kone / Lassina Diarra / Sarah Beseme / Eliza Squibb / FantaSiby Diallo / Sounkalo Dao

Journal of Virus Eradication, Vol 4, Iss , Pp 32- (2018)

2018

Keywords	Microbiology ; QR1-502 ; Public aspects of medicine ; RA1-1270
Language	English
Publishing date	2018-05-01T00:00:00Z
Publisher	Elsevier
Document type	Article ; Online
Database	BASE - Bielefeld Academic Search Engine (life sciences selection)

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Article ; Online: Co-infection tuberculose-VIH compliquée d´une sur infection nosocomiale à Klebsiella pneumoniae

Hermine Meli / Yacouba Cissoko / Issa Konaté / Mariam Soumaré / Assetou Fofana / Jean Paul Dembélé / Mikaila Kaboré / Mohamed Aly Cissé / Abdoulaye Zaré / Sounkalo Dao

The Pan African Medical Journal, Vol 37, Iss

à propos de 4 observations dans un Service de Maladies Infectieuses au Mali

2020 Volume 141

Abstract: Les infections nosocomiales constituent un problème majeur de santé publique dans le monde. La co-infection VIH-Tuberculose pulmonaire augmente la fréquence des infections nosocomiales, du fait de l´immunodépression et des hospitalisations itératives. ... ...

Abstract	Les infections nosocomiales constituent un problème majeur de santé publique dans le monde. La co-infection VIH-Tuberculose pulmonaire augmente la fréquence des infections nosocomiales, du fait de l´immunodépression et des hospitalisations itératives. Nous présentons quatre (04) patients âgés de 28, 36, 42 et 52 ans, co-infectés de VIH et tuberculose, (Tuberculose multifocale chez 2, miliaire tuberculeuse, tuberculose bactériologiquement confirmée), tous ayant un taux CD4 100 cellules/mm3. Ils étaient à la phase intensive du traitement antituberculeux et sous antirétroviral (ARV). Ils avaient été admis au Service de Maladies Infectieuses du CHU du Point G pour toux productive, et/ou hyperthermie après des séjours antérieurs de plus de 48heures en milieux hospitaliers. L´anamnèse avait révélé que l´un n´avait pas été observant au traitement antituberculeux du fait des effets indésirables classés mineurs. Il n´y avait pas eu d´amélioration clinique chez les 3 autres malgré une observance optimale aux différents traitements. L´examen cytobactériologique des expectorations et/ou du liquide de tubage gastrique, les hémocultures, prélèvements spécifiques avaient permis d´isoler Klebsiella pneumoniae multirésistante. Sous antibiothérapie spécifique, l´évolution clinique de ces patients avait été favorable. Les infections nosocomiales peuvent faire penser à tort à une mauvaise réponse thérapeutique lors d´un traitement antituberculeux. L´examen cytobactériologique des liquides biologiques doit être systématique chez les patients co-infectés de VIH-tuberculose. Notamment chez ceux ayant eu des séjours hospitaliers d´au moins 48 heures, et chez qui les signes pulmonaires et/ou la fièvre persistent en dépit d´une bonne observance aux traitements.
Keywords	tuberculose ; klebsiella pneumoniae ; centre hospitalier universitaire du point g ; Medicine ; R
Language	English
Publishing date	2020-10-01T00:00:00Z
Publisher	The Pan African Medical Journal
Document type	Article ; Online
Database	BASE - Bielefeld Academic Search Engine (life sciences selection)

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Article ; Online: Tétanos localisé sans porte d´entrée apparente

Hermine Meli / Mikaila Kaboré / Mohamed Aly Cissé / Abdoulaye Zaré / Mariam Soumaré / Yacouba Cissoko / Jean Paul Dembélé / Issa Konaté / Assetou Fofana / Sounkalo Dao

The Pan African Medical Journal, Vol 36, Iss

à propos d´un cas à Bamako (Mali)

2020 Volume 377

Abstract: Le tétanos demeure un problème majeur de santé publique en Afrique Subsaharienne. La forme localisée semble rare, contrairement à la forme généralisée suffisamment décrite. Nous rapportons un cas de tétanos localisé sans porte d´entrée apparente, pris en ...

Abstract	Le tétanos demeure un problème majeur de santé publique en Afrique Subsaharienne. La forme localisée semble rare, contrairement à la forme généralisée suffisamment décrite. Nous rapportons un cas de tétanos localisé sans porte d´entrée apparente, pris en charge dans un service des Maladies Infectieuses à Bamako. Il s´est agi d´une infirmière à la retraite de 59 ans qui n´avait pas fait de rappel de vaccination antitétanique depuis 10 ans, correspondant à la période de son dernier accouchement. Elle avait été référée dans un tableau clinique associant une dysphagie et impossibilité d´ouvrir la cavité buccale. L´histoire de la maladie avait révélé un long itinéraire thérapeutique marqué par de nombreuses consultations spécialisées sans amélioration aucune. Le diagnostic de tétanos localisé sans porte d´entrée apparente avait été retenu après avoir éliminé toute autre affection locale. L´évolution était déjà favorable dix jours après une prise en charge adéquate. Sous diagnostiqué ou méconnu du personnel de santé, le tétanos localisé peut mimer d´autres affections retardant le diagnostic et la prise en charge. La sensibilisation ciblée de la population doit être renforcée en vue du respect scrupuleux du calendrier des rappels vaccinaux.
Keywords	tétanos localisé ; chu bamako ; afrique subsaharienne ; Medicine ; R
Language	English
Publishing date	2020-08-01T00:00:00Z
Publisher	The Pan African Medical Journal
Document type	Article ; Online
Database	BASE - Bielefeld Academic Search Engine (life sciences selection)

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Article ; Online: Fighting COVID-19 in the West Africa after experiencing the Ebola epidemic

Pourya Gholizadeh / Moussa Sanogo / Amadou Oumarou / Maad Nasser Mohamed / Yacouba Cissoko / Mamadou Saliou Sow / Pasquale Pagliano / Patassi Akouda / Sid’Ahmed Soufiane / Akory Ag Iknane / Mamadou Oury / Safiatou Diallo / Şükran Köse / Sounkalo Dao / Hossein Samadi Kafil

Health Promotion Perspectives, Vol 11, Iss 1, Pp 5-

2021 Volume 11

Abstract: Coronavirus disease 2019 (COVID-19) dissemination occurred from December 2019 and quickly spread to all countries. Infected patients with COVID-19 have had a wide range of symptoms, ranging from mild to severe illness. The most mortality was observed in ... ...

Abstract	Coronavirus disease 2019 (COVID-19) dissemination occurred from December 2019 and quickly spread to all countries. Infected patients with COVID-19 have had a wide range of symptoms, ranging from mild to severe illness. The most mortality was observed in patients with underlying disease and over 45 years. World statistics have shown that the COVID-19 outbreak is most expanded in Middle Eastern, West Asian, European, North, and South American countries, and is least expanded in African countries. Therefore, the aim of the paper was the evaluation of six African countries including Mali, Mauritania, Niger, Guinea, Togo, and Djibouti to find why this disease is least expanded in African countries. Study was conducted by Questioner for countries health organizers to define their different aspect exposure and fight with COVID-19 including epidemiology, clinical aspects of the disease, case definitions, diagnosis laboratory confirmation, and referral of cases by the portal of entry, case management, and disease prevention in these countries. According to this opinion review, due to the low international flights and low domestic travel, the spread, and prevalence of COVID-19 was low and the return of the immigrants of these countries has caused the spread of COVID-19 among these countries. Experience, preparation, and impact of previous infections epidemic such as the Ebola virus epidemic would have beneficial, which have promoted certain reflexes among people that cause low dissemination in these countries.
Keywords	africa ; covid-19 ; sarscov-2 ; epidemiology ; ebola virus ; diagnosis ; pandemic ; Nutrition. Foods and food supply ; TX341-641 ; Public aspects of medicine ; RA1-1270
Language	English
Publishing date	2021-02-01T00:00:00Z
Publisher	Tabriz University of Medical Sciences
Document type	Article ; Online
Database	BASE - Bielefeld Academic Search Engine (life sciences selection)

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Article ; Online: Incidence and Predictors of Imported Cases of COVID-19 in Burkina Faso

Frontiers in Public Health, Vol

2022 Volume 10

Abstract: BackgroundTo limit the spread of COVID-19 due to imported cases, Burkina Faso has set up quarantine measures for arriving passengers. We aimed to determine the incidence and predictors of imported cases of COVID-19 in Burkina Faso.MethodsA prospective ... ...

Abstract	BackgroundTo limit the spread of COVID-19 due to imported cases, Burkina Faso has set up quarantine measures for arriving passengers. We aimed to determine the incidence and predictors of imported cases of COVID-19 in Burkina Faso.MethodsA prospective cohort study was performed using data from passengers arriving at the airport from April 9 to August 31, 2020. The data was extracted from the District Health Information Software 2 (DHIS2) platform. Cox regression was used to identify predictors of imported cases of COVID-19.ResultsAmong 6,332 travelers who arrived in the study period, 173 imported cases (2.7%) were recorded. The incidence rate was 1.9 cases per 1,000 traveler-days (95%CI: 1.6–2.2 per 1,000). Passengers arriving in April (Adjusted hazard ratio [aHR] = 3.56; 95%CI: 1.62–7.81) and May (aHR = 1.92; 95% CI: 1.18–3.12) were more at risk of being tested positive compared to those arriving in August, as well as, passengers presenting with one symptom (aHR = 3.71; 95% CI: 1.63–8.43) and at least two symptoms (aHR = 10.82; 95% CI: 5.24–22,30) compared to asymptomatic travelers.ConclusionsThe incidence of imported cases was relatively low in Burkina Faso between April and August 2020. The period of travel and the presence of symptoms at arrival predicted the risk of being tested positive to severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2). This is essential in the context of the high circulation of virus variants worldwide and the low local capacity to perform genotyping tests to strengthen the surveillance and screening capacities at the points of entry into the country.
Keywords	COVID-19 ; imported cases ; incidence ; predictors ; Burkina Faso ; Public aspects of medicine ; RA1-1270
Subject code	380
Language	English
Publishing date	2022-02-01T00:00:00Z
Publisher	Frontiers Media S.A.
Document type	Article ; Online
Database	BASE - Bielefeld Academic Search Engine (life sciences selection)

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Article ; Online: Patient-provider communication styles in HIV treatment programs in Bamako, Mali

Emily A. Hurley / Steven A. Harvey / Mariam Keita / Caitlin E. Kennedy / Debra Roter / Sounkalo Dao / Seydou Doumbia / Peter J. Winch

SSM: Population Health, Vol 3, Iss C, Pp 539-

A mixed-methods study to define dimensions and measure patient preferences

2017 Volume 548

Abstract: Effective patient-provider communication (PPC) promotes patient adherence and retention in long-term care. Sub-Saharan Africa faces unprecedented demand for chronic care for HIV patients on antiretroviral therapy (ART), yet adherence and retention remain ...

Abstract	Effective patient-provider communication (PPC) promotes patient adherence and retention in long-term care. Sub-Saharan Africa faces unprecedented demand for chronic care for HIV patients on antiretroviral therapy (ART), yet adherence and retention remain challenging. In high-income countries, research describing patient preferences for different PPC styles has guided interventions to improve PPC and patient outcomes. However, research on PPC preferences in sub-Saharan Africa is limited. We sought to define PPC dimensions relevant to ART programs in Bamako, Mali through recordings of clinical interactions, in-depth interviews and focus-group discussions with 69 patients and 17 providers. To assess preferences toward contrasting PPC styles within dimensions, we conducted a vignette-based survey with 141 patients across five ART facilities. Qualitative analysis revealed two PPC dimensions similar to those described in the literature on patient-centered communication (level of psychosocial regard, balance of power), and one unique dimension that emerged from the data (guiding patient behavior: easy/tough/sharp). Significantly more survey participants chose the vignette demonstrating high psychosocial regard (52.2%) compared to a biomedical style (22.5%) (p<0.001). Within balance of power, a statistically similar proportion of participants chose the vignette demonstrating shared power (40.2%) compared to a provider-dominated style (35.8%). In guiding patient behavior, a similar proportion of participants preferred the vignette depicting the “easy” (38.4%) and/or “tough” style (40.6%), but significantly fewer preferred the “sharp” style (14.5%) (p<0.001). Highly educated participants chose biomedical and shared power styles more frequently, while less educated participants more frequently indicated “no preference”. Working to understand, develop, and tailor PPC styles to patients in chronic care may help support patient retention and ultimately, clinical outcomes. Emphasis on developing skills in psychosocial ...
Keywords	Sub-Saharan Africa ; Mali ; Patient-provider communication ; Patient-centeredness ; Patient engagement ; Antiretroviral therapy ; HIV ; Vignette survey ; Public aspects of medicine ; RA1-1270 ; Social sciences (General) ; H1-99
Language	English
Publishing date	2017-12-01T00:00:00Z
Publisher	Elsevier
Document type	Article ; Online
Database	BASE - Bielefeld Academic Search Engine (life sciences selection)

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