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Book ; Online: Gleaming Coffins

Sousa, Rogerio

2018

Abstract: Egyptian coffin decoration is a complex and multidimensional phenomenon with its own history and evolution. 'Yellow' coffins were crafted in Thebes during a particular critical period in the Egyptian History, witnessing to a situation of political unrest ...

Abstract	Egyptian coffin decoration is a complex and multidimensional phenomenon with its own history and evolution. 'Yellow' coffins were crafted in Thebes during a particular critical period in the Egyptian History, witnessing to a situation of political unrest and severe economic scarcity affecting Egypt, the Near East and the Mediterranean. And yet, there is no evidence for a decline in the production of these outstanding funerary artefacts. On the contrary, the corpus of 'yellow' coffins outnumbers the previous types of Egyptian anthropoid containers and stands out among the most complex and sophisticated objects ever crafted in the Ancient World. Besides this historical paradox, the 'yellow' corpus presents important epistemological challenges for our understanding of Egyptian material culture: what kind of space is created within the walls and forms of an anthropoid coffin? What role plays variability and change in this process? Last but not the least, can we understand the meaning behind the multiple shapes and endless variations adopted in coffin decoration during this period? This book addresses these questions presenting the results of a comparative study on coffin decoration involving an extensive sample of objects from the 'yellow' corpus dispersed in museums around the world. The results of this study reveal the principles of composition that ruled the work of the ancient Theban craftsmen and show how important coffin decoration was for the Theban priesthood of Amun to convey their own corporative values
Keywords	Agriculture
Size	1 electronic resource (280 p.)
Publisher	Coimbra University Press
Document type	Book ; Online
Note	Portuguese ; Open Access
HBZ-ID	HT020103029
ISBN	9789892615882 ; 9892615883
Database	ZB MED Catalogue: Medicine, Health, Nutrition, Environment, Agriculture

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Book ; Online: Arbuscular Mycorrhizal Fungi in Agriculture

Nogueira de Sousa, Rodrigo

New Insights

2023

Keywords	Medical microbiology & virology ; sustainable agriculture ; symbiosis ; biofertilizer ; diversity ; drought ; salinity
Language	English
Size	1 electronic resource (272 pages)
Publisher	IntechOpen
Document type	Book ; Online
Note	English
HBZ-ID	HT030381012
ISBN	9781837680917 ; 1837680914
Database	ZB MED Catalogue: Medicine, Health, Nutrition, Environment, Agriculture

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Book ; Online: Medicina à Cabeceira do Doente & Comunicação Clínica

Sousa, Rita / Silva, Rui / Almeida, Marta / Pereira, Vitor Hugo / Sousa, Nuno

2020

Keywords	Doctor/patient relationship ; Medicina clínica ; comunicação clínica
Size	1 electronic resource (62 pages)
Publishing place	Braga
Document type	Book ; Online
Note	Portuguese ; Open Access
HBZ-ID	HT021233278
Database	ZB MED Catalogue: Medicine, Health, Nutrition, Environment, Agriculture

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Article: Who Needs Values When We Have Valuing? Comments on Jean Moritz Müller,

de Sousa, Ronald

Emotion review : journal of the International Society for Research on Emotion

2022 Volume 14, Issue 4, Page(s) 257–261

Abstract: Müller argues that the perceptual or "Axiological Receptivity" (AR) model of emotions is incoherent, because it requires an emotion to apprehend and respond to its formal object at the same time. He defends a contrasting view of emotions as "Position- ... ...

Abstract	Müller argues that the perceptual or "Axiological Receptivity" (AR) model of emotions is incoherent, because it requires an emotion to apprehend and respond to its formal object at the same time. He defends a contrasting view of emotions as "Position-Takings" (PT) towards "formal objects", aspects of an emotion's target pertinent to the subject's concerns. I first cast doubt on the cogency of Müller's attack on AR as begging questions about the temporal characteristics of perceptual events. I then argue that Müller's version of PT is not radical enough. On my attitudinal view, formal objects are not values but natural properties that justify specific affective or behavioral responses. Values are constituted only by a negotiated social aggregation of individual evaluative attitudes.
Language	English
Publishing date	2022-03-07
Publishing country	England
Document type	Journal Article
ZDB-ID	2474844-4
ISSN	1754-0747 ; 1754-0739
ISSN (online)	1754-0747
ISSN	1754-0739
DOI	10.1177/17540739221085575
Database	MEDical Literature Analysis and Retrieval System OnLINE

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Article ; Online: A Rare Presentation of Pica Disorder in Soap Ingestion Variant: Case Report and Review.

Sousa, Rui / Cunha, Francisco / Abreu, Joana / Cunha, Nuno

The Journal of nervous and mental disease

2024 Volume 212, Issue 2, Page(s) 117–119

Abstract: Abstract: Pica indicates the persistent ingestion of inedible substances over a period of at least 1 month, being discordant to the individual's cognitive development level and not directly attributable to cultural or social normative practices. The ... ...

Abstract	Abstract: Pica indicates the persistent ingestion of inedible substances over a period of at least 1 month, being discordant to the individual's cognitive development level and not directly attributable to cultural or social normative practices. The literature suggests that the prevalence of pica varies significantly according to the social and clinical context. It can co-occur with psychiatric disorders, with its etiology being poorly understood and most likely multifactorial. In this article, we report the case of a patient in her 50s with a clinical setting compatible with soap ingestion variant of pica disorder. In addition to the variety of ingested substances, pica can be associated with heterogeneous behavior, mainly of the obsessive-compulsive spectrum. Despite recent research, this condition is still a target of much speculation. This is a very rare and challenging presentation of a soap ingestion variant of pica with very few similar cases described to date.
MeSH term(s)	Female ; Humans ; Eating ; Pica/complications ; Pica/epidemiology ; Prevalence ; Soaps ; Middle Aged
Chemical Substances	Soaps
Language	English
Publishing date	2024-01-30
Publishing country	United States
Document type	Case Reports ; Journal Article ; Review
ZDB-ID	3020-x
ISSN	1539-736X ; 0022-3018
ISSN (online)	1539-736X
ISSN	0022-3018
DOI	10.1097/NMD.0000000000001716
Database	MEDical Literature Analysis and Retrieval System OnLINE

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Article ; Online: A global synthesis of predation on bivalves.

Meira, Alexandra / Byers, James E / Sousa, Ronaldo

Biological reviews of the Cambridge Philosophical Society

2024 Volume 99, Issue 3, Page(s) 1015–1057

Abstract: Predation is a dominant structuring force in ecological communities. In aquatic environments, predation on bivalves has long been an important focal interaction for ecological study because bivalves have central roles as ecosystem engineers, basal ... ...

Abstract	Predation is a dominant structuring force in ecological communities. In aquatic environments, predation on bivalves has long been an important focal interaction for ecological study because bivalves have central roles as ecosystem engineers, basal components of food webs, and commercial commodities. Studies of bivalves are common, not only because of bivalves' central roles, but also due to the relative ease of studying predatory effects on this taxonomic group. To understand patterns in the interactions of bivalves and their predators we synthesised data from 52 years of peer-reviewed studies on bivalve predation. Using a systematic search, we compiled 1334 studies from 75 countries, comprising 61 bivalve families (N = 2259), dominated by Mytilidae (29% of bivalves), Veneridae (14%), Ostreidae (8%), Unionidae (7%), and Dreissenidae and Tellinidae (6% each). A total of 2036 predators were studied, with crustaceans the most studied predator group (34% of predators), followed by fishes (24%), molluscs (17%), echinoderms (10%) and birds (6%). The majority of studies (86%) were conducted in marine systems, in part driven by the high commercial value of marine bivalves. Studies in freshwater ecosystems were dominated by non-native bivalves and non-native predator species, which probably reflects the important role of biological invasions affecting freshwater biodiversity. In fact, while 81% of the studied marine bivalve species were native, only 50% of the freshwater species were native to the system. In terms of approach, most studies used predation trials, visual analysis of digested contents and exclusion experiments to assess the effects of predation. These studies reflect that many factors influence bivalve predation depending on the species studied, including (i) species traits (e.g. behaviour, morphology, defence mechanisms), (ii) other biotic interactions (e.g. presence of competitors, parasites or diseases), and (iii) environmental context (e.g. temperature, current velocity, beach exposure, habitat complexity). There is a lack of research on the effects of bivalve predation at the population and community and ecosystem levels (only 7% and 0.5% of studies respectively examined impacts at these levels). At the population level, the available studies demonstrate that predation can decrease bivalve density through consumption or the reduction of recruitment. At the community and ecosystem level, predation can trigger effects that cascade through trophic levels or effects that alter the ecological functions bivalves perform. Given the conservation and commercial importance of many bivalve species, studies of predation should be pursued in the context of global change, particularly climate change, acidification and biological invasions.
MeSH term(s)	Animals ; Bivalvia/physiology ; Predatory Behavior/physiology ; Food Chain ; Ecosystem
Language	English
Publishing date	2024-01-31
Publishing country	England
Document type	Journal Article ; Research Support, Non-U.S. Gov't ; Review
ZDB-ID	1423558-4
ISSN	1469-185X ; 0006-3231 ; 1464-7931
ISSN (online)	1469-185X
ISSN	0006-3231 ; 1464-7931
DOI	10.1111/brv.13057
Database	MEDical Literature Analysis and Retrieval System OnLINE

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Article ; Online: Successful operational integration of healthcare analytics at Seattle Children's.

Frisbee, Kathleen L / Sousa, Ryan

Learning health systems

2022 Volume 7, Issue 2, Page(s) e10331

Abstract: Introduction: As the quantity and complexity of health data grows, it is critical for healthcare organizations to devise analytic strategies that power data innovation so they can take advantage of new opportunities and improve outcomes. Seattle ... ...

Abstract	Introduction: As the quantity and complexity of health data grows, it is critical for healthcare organizations to devise analytic strategies that power data innovation so they can take advantage of new opportunities and improve outcomes. Seattle Children's Healthcare System (Seattle Children's) is an example of an organization that has built an operating model that integrates analytics into their business and daily operations. We present a roadmap for how Seattle Children's consolidated its fragmented analytics operations into a unified cohesive ecosystem capable of supporting advanced analytics capabilities and operational integration to transform care and accelerate research. Methods: In-depth interviews were conducted with ten leaders at Seattle Children's who have been instrumental in developing their enterprise analytics program. Interviews included the following leadership roles: Chief Data & Analytics Officer, Director of Research Informatics, Principal Systems Architect, Manager of Bioinformatics and High Throughput Analytics, Director of Neurocritical Care, Strategic Program Manager & Neuron Product Development Lead, Director of Dev Ops,Director of Clinical Analytics, Data Science Manager, and Advance Analytics Product Engineer. The interviews were unstructured and consisted of conversations intended to gather information from leadership about their experiences in building out Enterprise Analytics at Seattle Children's. Results: Seattle Children's has built an advanced enterprise analytics ecosystem that is integrated into its daily operations by applying an entrepreneurial mindset and agile development practices that are common in a startup environment. Analytics efforts were approached iteratively by selecting high-value projects that were delivered through Multidisciplinary Delivery Teams that were integrated into service lines. Service line leadership, in partnership with the Delivery Team leads, were responsible for the success of the team by setting project priorities, determining project budgets, and maintaining overall governance of their analytics endeavors. This organizational structure has led to the development of a wide range of analytic products that have been used to improve both operations and clinical care at Seattle Children's. Conclusions: Seattle Children's has demonstrated how a leading healthcare system can successfully create a robust, scalable, near real-time analytics ecosystem- one that delivers significant value to the organization from the ever-expanding volume of health data we see today.
Language	English
Publishing date	2022-08-19
Publishing country	United States
Document type	Journal Article
ISSN	2379-6146
ISSN (online)	2379-6146
DOI	10.1002/lrh2.10331
Database	MEDical Literature Analysis and Retrieval System OnLINE

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Article: Acute Encephalopathy in a 10-Year-Old Patient With Maple Syrup Urine Disease: A Challenging Diagnosis.

Miragaia, Pedro / Grangeia, Ana / Rodrigues, Esmeralda / Sousa, Raquel / Ribeiro, Augusto

Cureus

2024 Volume 16, Issue 1, Page(s) e53043

Abstract: Maple syrup urine disease (MSUD) is a rare autosomal recessive metabolic disorder characterized by a deficiency in the branched-chain alpha-keto acid dehydrogenase complex, leading to the toxic accumulation of leucine, isoleucine and valine. Acute ... ...

Abstract	Maple syrup urine disease (MSUD) is a rare autosomal recessive metabolic disorder characterized by a deficiency in the branched-chain alpha-keto acid dehydrogenase complex, leading to the toxic accumulation of leucine, isoleucine and valine. Acute encephalopathy (AE) is a severe neurological disorder with diverse etiologies, demanding prompt identification and intervention. We present a unique case of a previously healthy teenage patient who developed AE during an influenza infection. Despite initial inconclusive investigations, the patient's condition rapidly deteriorated, requiring pediatric intensive care unit (PICU) admission. Diagnostic challenges included fluctuating mental status and refractory intracranial hypertension, ultimately necessitating decompressive craniectomy. Empirical treatments, including corticosteroids, tocilizumab, and plasmapheresis, were administered. Finally, clinical exome analysis revealed a pathogenic variant in homozygosity in the BCKDHA gene associated with MSUD type Ia. Her adult sister, experiencing similar symptoms in the same time period, did not survive. This case underscores the importance of considering metabolic disorders in AE etiology, even accounting for its various associated syndromes and usual prolonged diagnostic investigation, as prompt treatment initiation is vital for improved outcomes. Management of AE involves addressing seizures, systemic support and neuromonitoring, namely, intracranial pressure monitoring. Inborn errors of metabolism, like MSUD, should be considered, even if universally screened, as delayed diagnosis can result in prolonged hospitalization and significant morbidity.
Language	English
Publishing date	2024-01-27
Publishing country	United States
Document type	Case Reports
ZDB-ID	2747273-5
ISSN	2168-8184
ISSN	2168-8184
DOI	10.7759/cureus.53043
Database	MEDical Literature Analysis and Retrieval System OnLINE

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Article: Ceftriaxone-Induced Encephalopathy in a Patient With Chronic Kidney Disease.

Martins, Ana Filipa / Dias, Mónica / Matos Sousa, Rita / Regadas, Maria João

Cureus

2024 Volume 16, Issue 2, Page(s) e54476

Abstract: Neurotoxicity is an acknowledged side effect of third and fourth-generation cephalosporins, but its occurrence with ceftriaxone is not widely recognized. This article presents a case involving a 56-year-old woman with multiple comorbidities who sought ... ...

Abstract	Neurotoxicity is an acknowledged side effect of third and fourth-generation cephalosporins, but its occurrence with ceftriaxone is not widely recognized. This article presents a case involving a 56-year-old woman with multiple comorbidities who sought medical attention after experiencing lipothymia. The initial diagnosis suggested a urinary tract infection with acute kidney failure, leading to the initiation of ceftriaxone and hemodialysis. Subsequently, the patient exhibited a progressive deterioration of her neurological state, characterized by agitation and chorea. Metabolic encephalopathy, seizure/nonconvulsive status epilepticus, and acute central nervous system lesions were considered primary differential diagnoses, all of which were subsequently ruled out through thorough investigations. Days later, a remarkable recovery of the patient's neurological state was observed. A retrospective analysis revealed a correlation between the improvement and the fourth day of antimicrobial suspension. Consequently, a presumptive diagnosis of ceftriaxone-induced encephalopathy was made. This unusual case underscores the importance of recognizing the potential for pharmacological encephalopathy, particularly with ceftriaxone, and emphasizes its reversibility upon discontinuation of the implicated drug. Clinicians should remain vigilant to this uncommon adverse effect, promoting timely intervention and improved patient outcomes.
Language	English
Publishing date	2024-02-19
Publishing country	United States
Document type	Case Reports
ZDB-ID	2747273-5
ISSN	2168-8184
ISSN	2168-8184
DOI	10.7759/cureus.54476
Database	MEDical Literature Analysis and Retrieval System OnLINE

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Article ; Online: Targeted Strategies for Degradation of Key Transmembrane Proteins in Cancer.

Sakanyan, Vehary / Iradyan, Nina / Alves de Sousa, Rodolphe

Biotech (Basel (Switzerland))

2023 Volume 12, Issue 3

Abstract: Targeted protein degradation is an attractive technology for cancer treatment due to its ability to overcome the unpredictability of the small molecule inhibitors that cause resistance mutations. In recent years, various targeted protein degradation ... ...

Abstract	Targeted protein degradation is an attractive technology for cancer treatment due to its ability to overcome the unpredictability of the small molecule inhibitors that cause resistance mutations. In recent years, various targeted protein degradation strategies have been developed based on the ubiquitin-proteasome system in the cytoplasm or the autophagy-lysosomal system during endocytosis. In this review, we describe and compare technologies for the targeted inhibition and targeted degradation of the epidermal growth factor receptor (EGFR), one of the major proteins responsible for the onset and progression of many types of cancer. In addition, we develop an alternative strategy, called alloAUTO, based on the binding of new heterocyclic compounds to an allosteric site located in close proximity to the EGFR catalytic site. These compounds cause the targeted degradation of the transmembrane receptor, simultaneously activating both systems of protein degradation in cells. Damage to the EGFR signaling pathways promotes the inactivation of Bim sensor protein phosphorylation, which leads to the disintegration of the cytoskeleton, followed by the detachment of cancer cells from the extracellular matrix, and, ultimately, to cancer cell death. This hallmark of targeted cancer cell death suggests an advantage over other targeted protein degradation strategies, namely, the fewer cancer cells that survive mean fewer chemotherapy-resistant mutants appear.
Language	English
Publishing date	2023-09-06
Publishing country	Switzerland
Document type	Journal Article ; Review
ISSN	2673-6284
ISSN (online)	2673-6284
DOI	10.3390/biotech12030057
Database	MEDical Literature Analysis and Retrieval System OnLINE

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