Article ; Online: Potential of the Compounds from
Molecules (Basel, Switzerland)
2022 Volume 27, Issue 5
Abstract: Some significant compounds present in annatto are geranylgeraniol and tocotrienols. These compounds have beneficial effects against hyperlipidemia and chronic diseases, where oxidative stress and inflammation are present, but the exact mechanism of ... ...
| Abstract | Some significant compounds present in annatto are geranylgeraniol and tocotrienols. These compounds have beneficial effects against hyperlipidemia and chronic diseases, where oxidative stress and inflammation are present, but the exact mechanism of action of such activities is still a subject of research. This study aimed to evaluate possible mechanisms of action that could be underlying the activities of these molecules. For this, in silico approaches such as ligand topology (PASS and SEA servers) and molecular docking with the software GOLD were used. Additionally, we screened some pharmacokinetic and toxicological parameters using the servers PreADMET, SwissADME, and ProTox-II. The results corroborate the antidyslipidemia and anti-inflammatory activities of geranylgeraniol and tocotrienols. Notably, some new mechanisms of action were predicted to be potentially underlying the activities of these compounds, including inhibition of squalene monooxygenase, lanosterol synthase, and phospholipase A |
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| MeSH term(s) | Bixaceae ; Carotenoids ; Diterpenes ; Dyslipidemias ; Molecular Docking Simulation ; Plant Extracts/pharmacology ; Tocotrienols/pharmacology | |||||
| Chemical Substances | Diterpenes ; Plant Extracts ; Tocotrienols ; Carotenoids (36-88-4) ; annatto (6PQP1V1B6O) ; geranylgeraniol (AIA02AJA3A) | |||||
| Language | English | |||||
| Publishing date | 2022-02-28 | |||||
| Publishing country | Switzerland | |||||
| Document type | Journal Article | |||||
| ZDB-ID | 1413402-0 | |||||
| ISSN | 1420-3049 ; 1431-5165 ; 1420-3049 | |||||
| ISSN (online) | 1420-3049 | |||||
| ISSN | 1431-5165 ; 1420-3049 | |||||
| DOI | 10.3390/molecules27051584 | |||||
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| Database | MEDical Literature Analysis and Retrieval System OnLINE |
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