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  1. Article: Contato precoce pele a pele entre mãe e filho: significado para mães e contribuições para a enfermagem.

    Matos, Thaís Alves / de Souza, Morgana Stefani / dos Santos, Evanguelia Kotzias Atherino / Velho, Manuela Beatriz / Seibert, Eli Rodrigues Camargo / Martins, Nezi Maria

    Revista brasileira de enfermagem

    2011  Volume 63, Issue 6, Page(s) 998–1004

    Abstract: That was a convergent-care study, carried out in a maternity ward in the Southern Region of Brazil from April to May 2009, with the purpose to comprehend the meanings of premature mother-child skin-to-skin contact and relevant nursing contributions. Data ...

    Title translation Precocious skin-to-skin contact between mother and child: meanings to mothers and contributions for nursing.
    Abstract That was a convergent-care study, carried out in a maternity ward in the Southern Region of Brazil from April to May 2009, with the purpose to comprehend the meanings of premature mother-child skin-to-skin contact and relevant nursing contributions. Data were collected through participant observation and interviews involving nine mothers. Four categories were identified: a) predelivery orientation surrounding premature mother-child skin-to-skin contact; b) establishing premature mother-child skin-to-skin contact; c) meanings of premature mother-child skin-to-skin contact for the mother; and d) nursing contributions in establishing premature mother-child skin-to-skin contact. It was concluded that the meanings of premature mother-child skin-to-skin contact attributed by these mothers is positive, and that nursing's contribution in establishing such contact is significant.
    MeSH term(s) Adolescent ; Adult ; Humans ; Infant, Newborn ; Mother-Child Relations ; Neonatal Nursing ; Object Attachment ; Skin ; Time Factors ; Touch ; Young Adult
    Language Portuguese
    Publishing date 2011-02-07
    Publishing country Brazil
    Document type English Abstract ; Journal Article
    ZDB-ID 731983-6
    ISSN 1984-0446 ; 0034-7167
    ISSN (online) 1984-0446
    ISSN 0034-7167
    DOI 10.1590/s0034-71672010000600020
    Database MEDical Literature Analysis and Retrieval System OnLINE

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    In stock of ZB MED Cologne/Königswinter

    Zs.A 3392: Show issues Location:
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  2. Article ; Online: Immunogenicity of the Ad26.COV2.S Vaccine for COVID-19.

    Stephenson, Kathryn E / Le Gars, Mathieu / Sadoff, Jerald / de Groot, Anne Marit / Heerwegh, Dirk / Truyers, Carla / Atyeo, Caroline / Loos, Carolin / Chandrashekar, Abishek / McMahan, Katherine / Tostanoski, Lisa H / Yu, Jingyou / Gebre, Makda S / Jacob-Dolan, Catherine / Li, Zhenfeng / Patel, Shivani / Peter, Lauren / Liu, Jinyan / Borducchi, Erica N /
    Nkolola, Joseph P / Souza, Morgana / Tan, Chen Sabrina / Zash, Rebecca / Julg, Boris / Nathavitharana, Ruvandhi R / Shapiro, Roger L / Azim, Ahmed Abdul / Alonso, Carolyn D / Jaegle, Kate / Ansel, Jessica L / Kanjilal, Diane G / Guiney, Caitlin J / Bradshaw, Connor / Tyler, Anna / Makoni, Tatenda / Yanosick, Katherine E / Seaman, Michael S / Lauffenburger, Douglas A / Alter, Galit / Struyf, Frank / Douoguih, Macaya / Van Hoof, Johan / Schuitemaker, Hanneke / Barouch, Dan H

    JAMA

    2021  Volume 325, Issue 15, Page(s) 1535–1544

    Abstract: Importance: Control of the global COVID-19 pandemic will require the development and deployment of safe and effective vaccines.: Objective: To evaluate the immunogenicity of the Ad26.COV2.S vaccine (Janssen/Johnson & Johnson) in humans, including the ...

    Abstract Importance: Control of the global COVID-19 pandemic will require the development and deployment of safe and effective vaccines.
    Objective: To evaluate the immunogenicity of the Ad26.COV2.S vaccine (Janssen/Johnson & Johnson) in humans, including the kinetics, magnitude, and phenotype of SARS-CoV-2 spike-specific humoral and cellular immune responses.
    Design, setting, and participants: Twenty-five participants were enrolled from July 29, 2020, to August 7, 2020, and the follow-up for this day 71 interim analysis was completed on October 3, 2020; follow-up to assess durability will continue for 2 years. This study was conducted at a single clinical site in Boston, Massachusetts, as part of a randomized, double-blind, placebo-controlled phase 1 clinical trial of Ad26.COV2.S.
    Interventions: Participants were randomized to receive 1 or 2 intramuscular injections with 5 × 1010 viral particles or 1 × 1011 viral particles of Ad26.COV2.S vaccine or placebo administered on day 1 and day 57 (5 participants in each group).
    Main outcomes and measures: Humoral immune responses included binding and neutralizing antibody responses at multiple time points following immunization. Cellular immune responses included immunospot-based and intracellular cytokine staining assays to measure T-cell responses.
    Results: Twenty-five participants were randomized (median age, 42; age range, 22-52; 52% women, 44% male, 4% undifferentiated), and all completed the trial through the day 71 interim end point. Binding and neutralizing antibodies emerged rapidly by day 8 after initial immunization in 90% and 25% of vaccine recipients, respectively. By day 57, binding and neutralizing antibodies were detected in 100% of vaccine recipients after a single immunization. On day 71, the geometric mean titers of spike-specific binding antibodies were 2432 to 5729 and the geometric mean titers of neutralizing antibodies were 242 to 449 in the vaccinated groups. A variety of antibody subclasses, Fc receptor binding properties, and antiviral functions were induced. CD4+ and CD8+ T-cell responses were induced.
    Conclusion and relevance: In this phase 1 study, a single immunization with Ad26.COV2.S induced rapid binding and neutralization antibody responses as well as cellular immune responses. Two phase 3 clinical trials are currently underway to determine the efficacy of the Ad26.COV2.S vaccine.
    Trial registration: ClinicalTrials.gov Identifier: NCT04436276.
    MeSH term(s) Adult ; Antibodies, Neutralizing/blood ; Antibodies, Viral/blood ; COVID-19/immunology ; COVID-19/prevention & control ; COVID-19 Vaccines/administration & dosage ; COVID-19 Vaccines/immunology ; Double-Blind Method ; Female ; Humans ; Immunity, Cellular ; Immunity, Humoral ; Immunogenicity, Vaccine ; Male ; Middle Aged ; Vaccine Potency ; Young Adult
    Chemical Substances Antibodies, Neutralizing ; Antibodies, Viral ; COVID-19 Vaccines
    Language English
    Publishing date 2021-03-11
    Publishing country United States
    Document type Clinical Trial, Phase I ; Comparative Study ; Journal Article ; Randomized Controlled Trial ; Research Support, N.I.H., Extramural
    ZDB-ID 2958-0
    ISSN 1538-3598 ; 0254-9077 ; 0002-9955 ; 0098-7484
    ISSN (online) 1538-3598
    ISSN 0254-9077 ; 0002-9955 ; 0098-7484
    DOI 10.1001/jama.2021.3645
    Database MEDical Literature Analysis and Retrieval System OnLINE

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