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  1. Article ; Online: 18F-fluoroestradiol positron emission tomography in patients with breast cancer: a systematic review and meta-analysis.

    Matushita, Cristina S / Coelho, Francisco de Assis Romeiro Figueiroa Benicio / Stasiak, Camila Edith Stachera / Rodrigues, Denise Ferreira / Pianta, Diego Bromfman / Kurkowski, Flávia Dornelas / Silva, Marcelo Moreira da / Souza, Sergio Augusto Lopes de / Lopes, Rafael Willain / Castro, Paulo Henrique Rosado de

    Revista da Associacao Medica Brasileira (1992)

    2023  Volume 69, Issue suppl 1, Page(s) e2023S116

    MeSH term(s) Humans ; Female ; Breast Neoplasms/diagnostic imaging ; Tomography, X-Ray Computed ; Positron-Emission Tomography/methods ; Radiopharmaceuticals ; Patients ; Fluorodeoxyglucose F18 ; Positron Emission Tomography Computed Tomography
    Chemical Substances Radiopharmaceuticals ; Fluorodeoxyglucose F18 (0Z5B2CJX4D)
    Language English
    Publishing date 2023-08-04
    Publishing country Brazil
    Document type Meta-Analysis ; Systematic Review ; Journal Article
    ZDB-ID 731969-1
    ISSN 1806-9282 ; 0104-4230 ; 0004-5241 ; 0102-843X
    ISSN (online) 1806-9282
    ISSN 0104-4230 ; 0004-5241 ; 0102-843X
    DOI 10.1590/1806-9282.2023S116
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  2. Article ; Online: Cytopathologic evaluation of patients submitted to radiotherapy for uterine cervix cancer.

    Padilha, Cátia Martins Leite / Araújo, Mário Lúcio Cordeiro / Souza, Sergio Augusto Lopes de

    Revista da Associacao Medica Brasileira (1992)

    2017  Volume 63, Issue 4, Page(s) 379–385

    Abstract: Cervical cancer is an important public health problem. Pap smear is the leading strategy of screening programs for cervical cancer worldwide. However, delayed diagnosis leads to more aggressive and less effective treatments. Patients with uterine cervix ... ...

    Abstract Cervical cancer is an important public health problem. Pap smear is the leading strategy of screening programs for cervical cancer worldwide. However, delayed diagnosis leads to more aggressive and less effective treatments. Patients with uterine cervix malignancies who are referred for radiotherapy have advanced-stage disease, which results in high rates of locoregional recurrence. The use of radiotherapy as a treatment for cervical cancer causes morphological changes in neoplastic and non-neoplastic epithelial cells, as well as in stromal cells, which make it difficult to diagnose the residual lesion, resulting in a dilemma in cytopathological routine. Based on the difficulties of cytopathologic evaluation for the follow-up of patients treated with radiotherapy for cervical cancer, our objective was to describe the actinic cytopathic effects. Our paper was based on a structured review including the period from June 2015 to April 2016, aiming at an exploratory-descriptive study. Bibliographic investigations were carried out through selection and analysis of articles, list of authors and keywords, selection of new articles focused on the analysis of bibliographic references to previously selected documents, as well as textbooks of recognized merit. The most incident actinic cytopathological alterations as described in the literature are: cellular gigantism, nuclear and cytoplasmic vacuolization, dyskeratosis, bi- and multinucleated (B/M) cells, macro and multiple nucleoli, anisokaryosis, anisonucleolosis and nuclear pyknosis. To date, a protocol has not been established that can precisely differentiate the morphological characteristics between benign cells with actinic effects from recurrent malignant cells on post-radiotherapy smears.
    MeSH term(s) Carcinoma/pathology ; Carcinoma/radiotherapy ; Cervix Uteri/pathology ; Cervix Uteri/radiation effects ; Diagnosis, Differential ; Female ; Humans ; Neoplasm Recurrence, Local/pathology ; Treatment Outcome ; Uterine Cervical Neoplasms/pathology ; Uterine Cervical Neoplasms/radiotherapy ; Vaginal Smears
    Language English
    Publishing date 2017-04
    Publishing country Brazil
    Document type Journal Article ; Review
    ZDB-ID 2027973-5
    ISSN 1806-9282 ; 0104-4230
    ISSN (online) 1806-9282
    ISSN 0104-4230
    DOI 10.1590/1806-9282.63.04.379
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  3. Article ; Online: A cost-effective way to reduce the equivalent eye lens dose fromYttrium-90 radiopharmaceuticals.

    Oliveira, Susie Medeiros / Thomas, Sylvia / Sá, Lidia Vasconcellos de / Berdeguez, Mirta Barbara Torres / Mauricio, Claudia Lucia Pinho / Souza, Sergio Augusto Lopes de

    Zeitschrift fur medizinische Physik

    2020  Volume 31, Issue 1, Page(s) 16–22

    Abstract: Purpose: We analyzed the effect of the use of Eye Protective Equipment (EPE) and the best position to use individual dosimeters to estimate the eye lens radiation dose to a medical staff that works with yttrium-90.: Methods: Three Alderson-Head- ... ...

    Abstract Purpose: We analyzed the effect of the use of Eye Protective Equipment (EPE) and the best position to use individual dosimeters to estimate the eye lens radiation dose to a medical staff that works with yttrium-90.
    Methods: Three Alderson-Head-Phantoms were exposed to 58MBq of
    Results: Doses received by dosimeters on both lenses were more closely represented by the ones placed between the eyes than those on the temples, which underestimated the doses by a factor of 3. Also, the transmission factors showed that the EPE was able to reduce the H
    Conclusions: This study demonstrated that the use of EPE can optimize the
    MeSH term(s) Cost-Benefit Analysis ; Lens, Crystalline/radiation effects ; Radiation Dosage ; Radiopharmaceuticals ; Yttrium Radioisotopes
    Chemical Substances Radiopharmaceuticals ; Yttrium Radioisotopes ; Yttrium-90 (1K8M7UR6O1)
    Language English
    Publishing date 2020-11-13
    Publishing country Germany
    Document type Journal Article
    ZDB-ID 1104517-6
    ISSN 1876-4436 ; 0939-3889 ; 0040-5973
    ISSN (online) 1876-4436
    ISSN 0939-3889 ; 0040-5973
    DOI 10.1016/j.zemedi.2020.09.006
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    In stock of ZB MED Cologne/Königswinter

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  4. Article ; Online: Monitoring bone changes due to calcium, magnesium, and phosphorus loss in rat femurs using Quantitative Ultrasound.

    Fontes-Pereira, Aldo / Rosa, Paulo / Barboza, Thiago / Matusin, Daniel / Freire, Aline Soares / Braz, Bernardo Ferreira / Machado, Christiano Bittencourt / von Krüger, Marco Antônio / Souza, Sergio Augusto Lopes de / Santelli, Ricardo Erthal / Pereira, Wagner Coelho de Albuquerque

    Scientific reports

    2018  Volume 8, Issue 1, Page(s) 11963

    Abstract: Bone mineral density is an important parameter for the diagnosis of bone diseases, as well as for predicting fractures and treatment monitoring. Thus, the aim of the present study was to evaluate the potential of Quantitative Ultrasound (QUS) to monitor ... ...

    Abstract Bone mineral density is an important parameter for the diagnosis of bone diseases, as well as for predicting fractures and treatment monitoring. Thus, the aim of the present study was to evaluate the potential of Quantitative Ultrasound (QUS) to monitor bone changes after calcium, phosphorus, and magnesium loss in rat femurs in vitro during a demineralization process. Four quantitative ultrasound parameters were estimated from bone surface echoes in eight femur diaphysis of rats. The echo signals were acquired during a decalcification process by Ethylenediaminetetraacetic Acid (EDTA). The results were compared to Quantitative Computed Tomography (QCT) and inductively coupled plasma optical emission spectrometry measurements for validation. Integrated Reflection Coefficient (IRC) reflection parameters and Frequency Slope of Reflection Transfer Function (FSRTF) during demineralization tended to decrease, while the backscattering parameter Apparent Integrated Backscatter (AIB) increased and Frequency Slope of Apparent Backscatter (FSAB) showed an oscillatory behavior with no defined trend. Results indicate a clear relation between demineralization and the corresponding decrease in the reflection parameters and increase in the scattering parameters. The trend analysis of the fall curve of the chemical elements showed a better relationship between IRC and QCT. It was possible to monitor bone changes after ions losses, through the QUS. Thus, it is an indication that the proposed protocol has potential to characterize bone tissue in animal models, providing consistent results towards standardization of bone characterization studies by QUS endorsing its use in humans.
    MeSH term(s) Animals ; Bone Density ; Bone and Bones/diagnostic imaging ; Bone and Bones/metabolism ; Calcium/metabolism ; Femur ; Magnesium/metabolism ; Phosphorus/metabolism ; Rats ; Ultrasonography/methods
    Chemical Substances Phosphorus (27YLU75U4W) ; Magnesium (I38ZP9992A) ; Calcium (SY7Q814VUP)
    Language English
    Publishing date 2018-08-10
    Publishing country England
    Document type Journal Article ; Research Support, Non-U.S. Gov't
    ZDB-ID 2615211-3
    ISSN 2045-2322 ; 2045-2322
    ISSN (online) 2045-2322
    ISSN 2045-2322
    DOI 10.1038/s41598-018-30327-7
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  5. Article ; Online: Reduced activation and CD3 lymphocyte recruitment after TNF-inhibitor use: evaluation of clinical and 99mTc-OKT3 scintigraphic response in a patient with juvenile idiopathic arthritis.

    Lopes, Flavia Paiva Proença Lobo / Souza, Sergio Augusto Lopes de / Bica, Blanca Elena Rios Gomes / Fonseca, Lea Mirian Barbosa da / Azevedo, Mario Newton Leitão de / Gutfilen, Bianca

    Revista brasileira de reumatologia

    2015  

    Title translation Redução da ativação e do recrutamento de linfócito CD3 com o uso de anticorpo anti‐TNF‐alfa: avaliação da resposta clínica e cintilográfica com 99mTc‐OKT3 em paciente com artrite idiopática juvenil.
    Language Portuguese
    Publishing date 2015-07-26
    Publishing country Brazil
    Document type Journal Article
    ZDB-ID 2223192-4
    ISSN 1809-4570 ; 0482-5004
    ISSN (online) 1809-4570
    ISSN 0482-5004
    DOI 10.1016/j.rbr.2015.03.007
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  6. Article ; Online: 99mTc-thymine scintigraphy may be a promising method in the diagnosis of breast cancer.

    Ribeiro, Monica Pires / Souza, Sergio Augusto Lopes de / Lopes, Flavia Paiva Proença Lobo / Rosado-de-Castro, Paulo Henrique / Fonseca, Lea Mirian Barbosa da / Gutfilen, Bianca

    Clinics (Sao Paulo, Brazil)

    2012  Volume 68, Issue 3, Page(s) 283–289

    Abstract: Objective: Mammography has been established as the gold standard for the detection of breast cancer, and imaging techniques such as ultrasonography, magnetic resonance imaging, scintigraphy and positron emission tomography may be useful to improve its ... ...

    Abstract Objective: Mammography has been established as the gold standard for the detection of breast cancer, and imaging techniques such as ultrasonography, magnetic resonance imaging, scintigraphy and positron emission tomography may be useful to improve its sensitivity and specificity. The objective of this study with breast scintigraphy was to evaluate the uptake of 99mTc-thymine in mammary lesions.
    Methods: A total of 45 patients were included in this study. Thirty-three patients (73%) were subjected to surgery or percutaneous biopsy, providing histopathological data. The other 12 patients who remained under surveillance received clinical examinations and biannual mammography with a normal follow-up of at least three years, the data from which were used for comparison with the scintimammography results.
    Results: The majority of patients (64.4%) had clinically impalpable lesions with a mammogram diagnosis of microcalcifications, impalpable nodules, or focal asymmetry. Of the studied lesions, 87% were smaller or equal to 20 mm in diameter, and 22% had malignant histopathological findings. Scintigraphy with 99mTc-thymine had a sensitivity of 70%, a specificity of 85.7%, positive and negative predictive values of 58.3% and 90.9%, respectively, and an accuracy of 82.2%.
    Conclusions: The results of this study are consistent with those previously reported by other authors. The good specificity and high negative predictive value of this technique and the absence of uptake in the heart indicate that it may be a promising complementary method in clinical practice and that it may contribute to reducing unnecessary benign biopsies.
    MeSH term(s) Adult ; Aged ; Aged, 80 and over ; Biopsy ; Breast Neoplasms/diagnostic imaging ; Breast Neoplasms/pathology ; Female ; Humans ; Mammography/methods ; Middle Aged ; Organotechnetium Compounds ; Predictive Value of Tests ; Radionuclide Imaging ; Radiopharmaceuticals ; Reproducibility of Results ; Thymine/analogs & derivatives
    Chemical Substances Organotechnetium Compounds ; Radiopharmaceuticals ; technetium Tc 99m-thymine ; Thymine (QR26YLT7LT)
    Language English
    Publishing date 2012-07-30
    Publishing country United States
    Document type Journal Article ; Research Support, Non-U.S. Gov't
    ZDB-ID 2182801-5
    ISSN 1980-5322 ; 1807-5932
    ISSN (online) 1980-5322
    ISSN 1807-5932
    DOI 10.6061/clinics/2013(03)oa01
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  7. Article ; Online: Reduced activation and CD3 lymphocyte recruitment after TNF-inhibitor use: evaluation of clinical and 99mTc-OKT3 scintigraphic response in a patient with juvenile idiopathic arthritis.

    Lopes, Flavia Paiva Proença Lobo / Souza, Sergio Augusto Lopes de / Bica, Blanca Elena Rios Gomes / da Fonseca, Lea Mirian Barbosa / de Azevedo, Mario Newton Leitão / Gutfilen, Bianca

    Revista brasileira de reumatologia

    2015  Volume 57, Issue 6, Page(s) 616–619

    MeSH term(s) Adolescent ; Arthritis, Juvenile/drug therapy ; Female ; Humans ; Lymphocyte Activation/drug effects ; Muromonab-CD3/drug effects ; Radionuclide Imaging ; Treatment Outcome ; Tumor Necrosis Factor-alpha/administration & dosage ; Tumor Necrosis Factor-alpha/antagonists & inhibitors ; Whole Body Imaging
    Chemical Substances Muromonab-CD3 ; Tumor Necrosis Factor-alpha
    Language Portuguese
    Publishing date 2015-09-08
    Publishing country Brazil
    Document type Case Reports ; Journal Article
    ISSN 2255-5021
    ISSN (online) 2255-5021
    DOI 10.1016/j.rbre.2015.08.011
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  8. Article ; Online: Avaliação de transplantes renais utilizando-se 99mTc-leucócitos mononucleares

    Souza Sergio Augusto Lopes de / Martins Flávia Paiva Proença / Gonçalves Renato Torres / Pontes Daniela Salomão / Carvalho Antonio Carlos Pires / Fonseca Léa Mirian Barbosa da / Gutfilen Bianca

    Radiologia Brasileira, Vol 37, Iss 1, Pp 15-

    2004  Volume 20

    Abstract: A rejeição aguda do enxerto renal deve ser diagnosticada precocemente, uma vez que a reversibilidade da rejeição está relacionada com a rapidez na qual o tratamento é iniciado. Os objetivos deste estudo foram: 1) estabelecer um método quantitativo para ... ...

    Abstract A rejeição aguda do enxerto renal deve ser diagnosticada precocemente, uma vez que a reversibilidade da rejeição está relacionada com a rapidez na qual o tratamento é iniciado. Os objetivos deste estudo foram: 1) estabelecer um método quantitativo para avaliação da rejeição e necrose tubular aguda (NTA) do rim transplantado; 2) determinar o papel em potencial da cintilografia com leucócitos mononucleares marcados com tecnécio-99m no diagnóstico precoce da rejeição do rim transplantado e no diagnóstico diferencial da NTA. Cento e sessenta estudos cintilográficos foram realizados no primeiro e no quinto dia pós-operatório em 80 pacientes transplantados. Células autólogas foram utilizadas para marcação. Imagens foram obtidas 30 minutos, 3 horas e 24 horas após injeção de 444 MBq (12 mCi) das células marcadas. Houve captação anormal das células marcadas em 27 de 31 casos de rejeição e em seis de oito casos de NTA. Os resultados foram comparados com a clínica de cada paciente. Ultra-sonografias com Doppler detectaram 18 de 31 casos de rejeição. A sensibilidade e a especificidade para rejeição foram, respectivamente, de 87,1% e 100% para a cintilografia e 58,1% e 100% para a ultra-sonografia. Foram realizadas biópsias em oito pacientes, que mostraram sete rejeições e uma NTA. Os resultados sugerem que a cintilografia com leucócitos mononucleares marcados com tecnécio-99m pode ser útil no diagnóstico de rejeição e diagnóstico diferencial de NTA.
    Keywords 99mTc-leucócitos mononucleares ; Transplante renal ; Rejeição ; Diagnóstico ; Medical physics. Medical radiology. Nuclear medicine ; R895-920
    Language English
    Publishing date 2004-01-01T00:00:00Z
    Publisher Colégio Brasileiro de Radiologia e Diagnóstico por Imagem
    Document type Article ; Online
    Database BASE - Bielefeld Academic Search Engine (life sciences selection)

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