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  1. Artikel ; Online: Angiotensin receptors - affinitiy and beyond.

    Sumners, Colin / Souza Silva, Igor Maciel / Steckelings, U Muscha

    Clinical science (London, England : 1979)

    2022  Band 136, Heft 10, Seite(n) 799–802

    Abstract: This commentary on the article "Relative affinity of angiotensin peptides and novel ligands at AT1 and AT2 receptors" by Sanja Bosnyak et al. (Clini. Sci. (Lond.) (2011) 121(7): 297-303. https://doi.org/10.1042/CS20110036) summarises the main findings of ...

    Abstract This commentary on the article "Relative affinity of angiotensin peptides and novel ligands at AT1 and AT2 receptors" by Sanja Bosnyak et al. (Clini. Sci. (Lond.) (2011) 121(7): 297-303. https://doi.org/10.1042/CS20110036) summarises the main findings of the study, followed by a discussion of the findings and their relevance for various aspects of the biology of receptors of the renin-angiotensin system in the context of the current state of knowledge.
    Mesh-Begriff(e) Angiotensin II/metabolism ; Peptides ; Receptors, Angiotensin/metabolism ; Renin-Angiotensin System
    Chemische Substanzen Peptides ; Receptors, Angiotensin ; Angiotensin II (11128-99-7)
    Sprache Englisch
    Erscheinungsdatum 2022-06-19
    Erscheinungsland England
    Dokumenttyp Journal Article
    ZDB-ID 206835-7
    ISSN 1470-8736 ; 0301-0538 ; 0009-0360 ; 0143-5221
    ISSN (online) 1470-8736
    ISSN 0301-0538 ; 0009-0360 ; 0143-5221
    DOI 10.1042/CS20220024
    Datenquelle MEDical Literature Analysis and Retrieval System OnLINE

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  2. Artikel ; Online: Development of an automated, high-throughput assay to detect angiotensin AT

    Souza-Silva, Igor Maciel / Peluso, A Augusto / Mortensen, Christina / Nazarova, Antonina L / Stage, Tore Bjerregaard / Sumners, Colin / Katritch, Vsevolod / Steckelings, U Muscha

    Peptides

    2023  Band 172, Seite(n) 171137

    Abstract: Angiotensin ... ...

    Abstract Angiotensin AT
    Mesh-Begriff(e) Animals ; Cricetinae ; Humans ; Nitric Oxide ; Acetylcholine ; Cricetulus ; Endothelial Cells ; High-Throughput Screening Assays ; Reproducibility of Results ; Receptor, Angiotensin, Type 2 ; Angiotensin II/pharmacology ; Imidazoles ; Sulfonamides ; Thiophenes
    Chemische Substanzen compound 21 (RC2V4W0EYC) ; Nitric Oxide (31C4KY9ESH) ; Acetylcholine (N9YNS0M02X) ; Receptor, Angiotensin, Type 2 ; Angiotensin II (11128-99-7) ; Imidazoles ; Sulfonamides ; Thiophenes
    Sprache Englisch
    Erscheinungsdatum 2023-12-22
    Erscheinungsland United States
    Dokumenttyp Journal Article
    ZDB-ID 769028-9
    ISSN 1873-5169 ; 0196-9781
    ISSN (online) 1873-5169
    ISSN 0196-9781
    DOI 10.1016/j.peptides.2023.171137
    Datenquelle MEDical Literature Analysis and Retrieval System OnLINE

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  3. Artikel ; Online: Peptide fragments of bradykinin show unexpected biological activity not mediated by B

    Souza-Silva, Igor Maciel / de Paula, Cristiane Amorim / Bolais-Ramos, Lucas / Santos, Anderson Kenedy / da Silva, Filipe Alex / de Oliveira, Vívian Louise Soares / da Rocha, Isabella Domingos / Antunes, Maísa Mota / Cordeiro, Lídia Pereira Barbosa / Teixeira, Vanessa Pereira / Scalzo Júnior, Sérgio Ricardo Aluotto / Raabe, Adriana Campezatto / Guimaraes, Pedro Pires Goulart / Amaral, Flávio Almeida / Resende, Jarbas Magalhães / Fontes, Marco Antônio Peliky / Menezes, Gustavo Batista / Guatimosim, Silvia / Santos, Robson Augusto Souza /
    Verano-Braga, Thiago

    British journal of pharmacology

    2022  Band 179, Heft 12, Seite(n) 3061–3077

    Abstract: Background and purpose: Bradykinin (BK-(1-9)) is an endogenous nonapeptide involved in multiple physiological and pathological processes. Peptide fragments of bradykinin are believed to be biologically inactive. We have now tested the two major peptide ... ...

    Abstract Background and purpose: Bradykinin (BK-(1-9)) is an endogenous nonapeptide involved in multiple physiological and pathological processes. Peptide fragments of bradykinin are believed to be biologically inactive. We have now tested the two major peptide fragments of bradykinin in human and animals.
    Experimental approach: BK peptides were quantified by MS in male rats. NO release was quantified from human, mouse and rat cells loaded with DAF-FM. Rat aortic rings were used to measure vascular reactivity. Changes in BP and HR were measured in conscious male rats. To evaluate pro-inflammatory effects both vascular permeability and nociception were measured in adult mice.
    Key results: BK-(1-7) and BK-(1-5) are produced in vivo from BK-(1-9). Both peptides induced NO production in all cell types tested. However, unlike BK-(1-9), NO production elicited by BK-(1-7) or BK-(1-5) was not inhibited by B
    Conclusions and implications: BK-(1-7) and BK-(1-5) are endogenous peptides present in plasma. BK-related peptide fragments show biological activity, not mediated by B
    Mesh-Begriff(e) Animals ; Bradykinin/pharmacology ; Male ; Mice ; Peptide Fragments ; Rats ; Receptor, Bradykinin B1 ; Receptor, Bradykinin B2 ; Receptors, Bradykinin/physiology
    Chemische Substanzen Peptide Fragments ; Receptor, Bradykinin B1 ; Receptor, Bradykinin B2 ; Receptors, Bradykinin ; Bradykinin (S8TIM42R2W)
    Sprache Englisch
    Erscheinungsdatum 2022-02-09
    Erscheinungsland England
    Dokumenttyp Journal Article ; Research Support, Non-U.S. Gov't
    ZDB-ID 80081-8
    ISSN 1476-5381 ; 0007-1188
    ISSN (online) 1476-5381
    ISSN 0007-1188
    DOI 10.1111/bph.15790
    Datenquelle MEDical Literature Analysis and Retrieval System OnLINE

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